Novel Technologies For Vaccine Development

Author : Igor S Lukashevich,Haval Shirwan
Publisher : Springer
Page : 393 pages
File Size : 50,8 Mb
Release : 2014-11-13
Category : Medical
ISBN : 9783709118184

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Novel Technologies for Vaccine Development by Igor S Lukashevich,Haval Shirwan Pdf

This book presents a detailed overview of the development of new viral vector-based vaccines before discussing two major applications: preventive vaccines for infectious diseases and therapeutic cancer vaccines. Viral vector-based vaccines hold a great potential for development into successful pharmaceutical products and several examples at the advanced pre-clinical or clinical stage are presented. Nevertheless, the most efforts were focused on novel and very innovative technologies for new generation of vector-based vaccines. Furthermore, specific topics such as delivery and adjuvant and protection strategies for cell-mediated-based vaccines are presented. Given its scope, the book is a “must read” for all those involved in vaccine development, both in academia and industrial vaccine development.

Author : Emily P. Wen,Ronald Ellis,Narahari S. Pujar
Publisher : John Wiley & Sons
Page : 452 pages
File Size : 49,6 Mb
Release : 2014-11-17
Category : Technology & Engineering
ISBN : 9780470261941

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Vaccine Development and Manufacturing by Emily P. Wen,Ronald Ellis,Narahari S. Pujar Pdf

Vaccine Manufacturing and Production is an invaluable reference on how to produce a vaccine - from beginning to end - addressing all classes of vaccines from a processing, production, and regulatory viewpoint. It will provide comprehensive information on the various fields involved in the production of vaccines, from fermentation, purification, formulation, to regulatory filing and facility designs. In recent years, there have been tremendous advances in all aspects of vaccine manufacturing. Improved technology and growth media have been developed for the production of cell culture with high cell density or fermentation. Vaccine Manufacturing and Production will serve as a reference on all aspects of vaccine production by providing an in-depth description of the available technologies for making different types of vaccines and the current thinking in facility designs and supply issues. This book will provide insight to the issues scientists face when producing a vaccine, the steps that are involved, and will serve as a reference tool regarding state-of-the-art vaccine manufacturing technologies and facility set-up. Highlights include: Comprehensive coverage of vaccine production : from a process point of view- fermentation to purification to formulation developments; from a production point of view - from facility design to manufacturing; and from a regulatory point of view - requirements from government agencies Authors from different major pharmaceutical and biotechnology companies Describes the challenges and issues involved in vaccine production and manufacturing of the different classes of vaccines, an area not covered by other books currently on the market

Author : Parag Kolhe,Satoshi Ohtake
Publisher : Elsevier
Page : 386 pages
File Size : 55,6 Mb
Release : 2021-09-08
Category : Business & Economics
ISBN : 9780128143575

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Practical Aspects of Vaccine Development by Parag Kolhe,Satoshi Ohtake Pdf

Formulation, Development and Manufacturing of Vaccines: The Practical Aspects provides an industry perspective on vaccine product development and manufacture that covers their formulation development, manufacture and delivery/in-use considerations of vaccine production. With the increasing complexity of vaccine products in development, there is a need for a comprehensive review of the current state of the industry and its challenges. While formulation scientists working in biotherapeutic development may be familiar with proteins, vaccines present unique challenges, including the wide range of vaccine components that may comprise proteins, polysaccharides, protein-polysaccharide conjugates, adjuvants, etc. and the varying stability and behavior of solution- and suspension-based systems. This book is an essential resource for formulation scientists, researchers in vaccine development throughout medical and life sciences, and advanced students. Includes formulation considerations for various vaccine types, including proteins, polysaccharides, conjugates and live vaccines Considers process development for solution, suspension and lyophilized products Explores the future potential of vaccines, including multi-component vaccines and novel delivery mechanisms/devices

Author : Alexander von Gabain,Christoph Klade
Publisher : Springer Science & Business Media
Page : 318 pages
File Size : 53,6 Mb
Release : 2012-04-23
Category : Medical
ISBN : 9783709107096

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Development of Novel Vaccines by Alexander von Gabain,Christoph Klade Pdf

“Development of novel vaccines” gives an overview of the tasks in basic research leading to the final product – the vaccine and its applications, belonging to the most complex biologics in the pharmaceutical field. Distinct from most textbooks in the vaccine arena, the current issue focuses on the translational aspect, namely, how research results can be transformed into life-saving medical interventions. Each chapter of the book deals with one important paradigm for the development of novel vaccines, along the value chain towards the final vaccine, and furthermore, with the inevitable tools required for this process. Contributions are prepared by teams of scientists, all of whom are experts in the field, most of them anchored in biomedical organizations devoted to translational culture, thereby lighting the certain topics from different views. This volume is a must read for researchers engaged in vaccine development and who really want to see their research results to become a product.

Author : Manmohan Singh
Publisher : Springer Science & Business Media
Page : 369 pages
File Size : 44,7 Mb
Release : 2013-03-03
Category : Medical
ISBN : 9781461453802

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Novel Immune Potentiators and Delivery Technologies for Next Generation Vaccines by Manmohan Singh Pdf

Development of new-generation vaccines is now more challenging than ever, as identifying, purifying and evaluating vaccine antigens is a complex undertaking. Most importantly, once the relevant antigens have been identified, key focus then shifts to the development of suitable delivery systems and formulations to achieve maximum in vivo potency with minimum potential side effects. These novel formulations—many of which will be nanoparticulates—can deliver the antigens to the desired site, to the relevant antigen presenting cells, and prevent systemic exposure of the immune potentiators. The proposed book will outline all the critical steps that need to be considered for successful development of various types of nanoparticulate delivery systems for vaccine antigens. These contributions from leading experts in the area of vaccine formulation and delivery systems will tie in what is the most current status, including clinical evaluations with these novel vaccine technologies.​

Author : Parag Kolhe,Satoshi Ohtake
Publisher : Academic Press
Page : 388 pages
File Size : 45,7 Mb
Release : 2021-09-10
Category : Business & Economics
ISBN : 9780128143582

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Practical Aspects of Vaccine Development by Parag Kolhe,Satoshi Ohtake Pdf

Practical Aspects of Vaccine Development provides an academic and industry perspective on vaccine development and manufacturing. With the increasing complexity of vaccine products in development, there is a need for a comprehensive review of the current state of the industry and challenges being encountered. While formulation scientists working in biotherapeutic development may be familiar with proteins, vaccines present unique challenges. Vaccines include a wide range of components including proteins, polysaccharides, protein-polysaccharide conjugates, adjuvants, and more. The container closure system may also be unique, and the product may require freezing storage or lyophilization based on the stability of the vaccine components. Based on the route of delivery, novel technologies and devices may be required. Covering formulation development, manufacture, and delivery considerations of vaccine production, this book is essential to formulation scientists, researchers in vaccine development throughout medical and life sciences, and advanced students. Includes formulation considerations for various vaccine types, including proteins, polysaccharides, conjugates, and live vaccines Covers process development for solution, suspension, and lyophilized products Explores the future of vaccines, including multi-component vaccines and novel delivery mechanisms/devices

Author : Mariusz Skwarczynski,Istvan Toth
Publisher : William Andrew
Page : 460 pages
File Size : 45,9 Mb
Release : 2016-09-20
Category : Medical
ISBN : 9780323400299

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Micro- and Nanotechnology in Vaccine Development by Mariusz Skwarczynski,Istvan Toth Pdf

This book provides a comprehensive overview of how use of micro- and nanotechnology (MNT) has allowed major new advance in vaccine development research, and the challenges that immunologists face in making further progress. MNT allows the creation of particles that exploit the inherent ability of the human immune system to recognize small particles such as viruses and toxins. In combination with minimal protective epitope design, this permits the creation of immunogenic particles that stimulate a response against the targeted pathogen. The finely tuned response of the human immune system to small particles makes it unsurprising that many of the lead adjuvants and vaccine delivery systems currently under investigation are based on nanoparticles. Provides a comprehensive and unparalleled overview of the role of micro- and nanotechnology in vaccine development Allows researchers to quickly familiarize themselves with the broad spectrum of vaccines and how micro- and nanotechnologies are applied to their development Includes a combination of overview chapters setting out general principles, and focused content dealing with specific vaccines, making it useful to readers from a variety of disciplines

Author : Anonim
Publisher : Springer
Page : 320 pages
File Size : 40,5 Mb
Release : 2012-04-24
Category : Electronic
ISBN : 3709107105

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Development of Novel Vaccines by Anonim Pdf

Author : Stefan H. E. Kaufmann
Publisher : John Wiley & Sons
Page : 670 pages
File Size : 55,5 Mb
Release : 2006-01-24
Category : Science
ISBN : 9783527606092

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Novel Vaccination Strategies by Stefan H. E. Kaufmann Pdf

The protection mode of most available vaccines is based on antibody responses. Since efficient immune responses to many pathogens rely on activating all arms of the immune system, traditional vaccine development does not provide efficient protection against many diseases. Novel vaccination strategies need to allow presentation of antigens that activate the full array of the immune response in the right composition and should prevent pathogen entry by mobilizing the mucosal immune response. New technological advances optimize the immunogenicity of 'live' and sub-unit vaccines. This book offers an interdisciplinary overview on research and future strategies for rational vaccine design based on recent developments in molecular biology and immunology. It covers new aspects of the immunological interplay between prokaryotic and eukaryotic systems as well as achievements in the development of novel vaccine candidates. Chapters on edible vaccines, on vaccines against bioterror agents and on economical and safety aspects of novel vaccine development round off this title.

Author : Tarun Kumar Bhatt,Surendra Nimesh
Publisher : Academic Press
Page : 310 pages
File Size : 55,8 Mb
Release : 2021-01-21
Category : Business & Economics
ISBN : 9780128214756

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The Design and Development of Novel Drugs and Vaccines by Tarun Kumar Bhatt,Surendra Nimesh Pdf

The Design and Development of Novel Drugs and Vaccines: Principles and Protocols presents both in silico methods and experimental protocols for vaccine and drug design and development, critically reviewing the most current research and emphasizing approaches and technologies that accelerate and lower the cost of product development. Sections review the technologies and approaches used to identify, characterize and establish a protein as a new drug and vaccine target, cover several molecular methods for in vitro studies of the desired target, and present various physiological parameters for in vivo studies. The book includes preclinical trials and research, along with information on FDA approval. Covers both in silico methods and experimental protocols for vaccine and drug development in a single, accessible volume Offers a holistic accounting of how developments in bioinformatics and large experimental datasets can be used in the development of vaccines and drugs Shows researchers the entire gamut of current therapies, ranging from computational inputs to animal studies Reviews the most current, cutting-edge research available on vaccine and drug design and development

Author : Selene Baschieri
Publisher : Springer Science & Business Media
Page : 294 pages
File Size : 46,5 Mb
Release : 2012-07-20
Category : Medical
ISBN : 9789400745438

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Innovation in Vaccinology by Selene Baschieri Pdf

Prevention of infectious diseases by vaccination is one of the most significant achievements of modern medicine. During the 20th century, the average human life span in the developed world was about 70 years and it is expected to increase, with a significant portion of this increase directly attributed to vaccination. Since the first empiric vaccination trials, knowledge and technology have enormously evolved and new vaccination strategies are emerging on the market. Indeed, in spite of the great success, conventional vaccination strategies sometimes may result ineffective and, above all, may raise safety concerns. The aim of this book is to provide an overview of some of the technology platforms that have been realized or are currently under development to try to address unsolved and new issues in the field of vaccine development. Common denominator of all thematic areas described herein is the multidisciplinary teamwork. Most of the enabling technologies have been established by putting in the “melting pot” expertise in fields that, at first glance, may appear very far apart. I hope that this collection of articles will make the readers aware that vaccinology is rapidly taking a new direction, ceasing to be an empirical science.

Author : Ronald W. Ellis
Publisher : CRC Press
Page : 332 pages
File Size : 47,6 Mb
Release : 2001-06-01
Category : Medical
ISBN : 1587060507

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New Vaccine Technologies by Ronald W. Ellis Pdf

This book systematically addresses all the major available direct and enabling technologies which have contributed to the revolutionized research and development, thus improvements to existing vaccines. Its target audience is both research and development workers in the field, as well as health-care personnel who use vaccines. It should serve as an invaluable source-book in the vaccine field.

Author : Institute of Medicine,Division of Health Promotion and Disease Prevention,Committee to Study Priorities for Vaccine Development
Publisher : National Academies Press
Page : 472 pages
File Size : 47,6 Mb
Release : 2001-02-21
Category : Medical
ISBN : 9780309174985

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Vaccines for the 21st Century by Institute of Medicine,Division of Health Promotion and Disease Prevention,Committee to Study Priorities for Vaccine Development Pdf

Vaccines have made it possible to eradicate the scourge of smallpox, promise the same for polio, and have profoundly reduced the threat posed by other diseases such as whooping cough, measles, and meningitis. What is next? There are many pathogens, autoimmune diseases, and cancers that may be promising targets for vaccine research and development. This volume provides an analytic framework and quantitative model for evaluating disease conditions that can be applied by those setting priorities for vaccine development over the coming decades. The committee describes an approach for comparing potential new vaccines based on their impact on morbidity and mortality and on the costs of both health care and vaccine development. The book examines: Lessons to be learned from the polio experience. Scientific advances that set the stage for new vaccines. Factors that affect how vaccines are used in the population. Value judgments and ethical questions raised by comparison of health needs and benefits. The committee provides a way to compare different forms of illness and set vaccine priorities without assigning a monetary value to lives. Their recommendations will be important to anyone involved in science policy and public health planning: policymakers, regulators, health care providers, vaccine manufacturers, and researchers.

Author : Vasso Apostolopoulos,Lalitkumar K. Vora,Vivek P. Chavda
Publisher : Elsevier
Page : 530 pages
File Size : 55,6 Mb
Release : 2024-03-25
Category : Medical
ISBN : 9780443185656

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Advanced Vaccination Technologies for Infectious and Chronic Diseases by Vasso Apostolopoulos,Lalitkumar K. Vora,Vivek P. Chavda Pdf

The role of vaccines is emerging and even critical to ending infectious and chronic diseases and pandemics alike. The design and development of new vaccines could lead to improved health. Handbook on Advanced Vaccination Technologies for Infectious and Chronic Disease discusses these new developments and introduces the reader to the current state of the science and the outlook going forward from the discovery of vaccines to the clinical trials of personalized vaccines. Handbook on Advanced Vaccination Technologies for Infectious and Chronic Diseases is a valuable reference for occupational health professionals whose role involves supervision of immunization programs such as those working in the National Health Service, some sectors of higher education and the pharmaceutical industry. Offers comprehensive coverage of different vaccine platforms and their development Includes information on the regulatory perspective of vaccine development Describes different delivery approaches for vaccinology Explains the clinical development of vaccines along with novel platforms Covers all recent developments of vaccine production technologies, new types of vaccines, and ongoing research that could prevent future pandemics

Author : Kayvon Modjarrad,Wayne C. Koff
Publisher : Academic Press
Page : 186 pages
File Size : 46,8 Mb
Release : 2016-10-15
Category : Medical
ISBN : 9780128025420

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Human Vaccines by Kayvon Modjarrad,Wayne C. Koff Pdf

Human Vaccines: Emerging Technologies in Design and Development discusses the advances in molecular biology, biophysics, and informatics—among other disciplines—that have provided scientists with the tools to create new vaccines against emerging and re-emerging pathogens. For example, the virus-like particle technologies that led to licensing of highly efficacious HPV vaccines have only come into full realization in the last 10 years. Their success has, in turn, accelerated the pace with which nanoparticle vaccines are being developed Given the rapidity with which the field is changing and the absence of any text documenting this change, there is a need for a resource that surveys these new vaccine technologies, assesses their potential, and describes their applications. This book provides that resource and complements traditional vaccinology books, but also serves as an excellent standalone for researchers and students with basic knowledge in immunology. Introduces new topics in vaccine immunology in the context vaccine design and production Consolidates the growing body of knowledge on new vaccine technologies that have only emerged in the past 2 – 3 decades Reviews the currently licensed vaccines that have utilized leading-edge technologies and how this has translated into improved efficacy and safety Provides a broad overview of innovative vaccine technologies, including immunological aspects