Novel Immune Potentiators And Delivery Technologies For Next Generation Vaccines

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Novel Immune Potentiators and Delivery Technologies for Next Generation Vaccines

Manmohan Singh
Novel Immune Potentiators and Delivery Technologies for Next Generation Vaccines Book PDF

Author : Manmohan Singh
Publisher : Springer Science & Business Media
Page : 369 pages
File Size : 55,7 Mb
Release : 2013-03-03
Category : Medical
ISBN : 9781461453802

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Novel Immune Potentiators and Delivery Technologies for Next Generation Vaccines by Manmohan Singh Pdf

Development of new-generation vaccines is now more challenging than ever, as identifying, purifying and evaluating vaccine antigens is a complex undertaking. Most importantly, once the relevant antigens have been identified, key focus then shifts to the development of suitable delivery systems and formulations to achieve maximum in vivo potency with minimum potential side effects. These novel formulations—many of which will be nanoparticulates—can deliver the antigens to the desired site, to the relevant antigen presenting cells, and prevent systemic exposure of the immune potentiators. The proposed book will outline all the critical steps that need to be considered for successful development of various types of nanoparticulate delivery systems for vaccine antigens. These contributions from leading experts in the area of vaccine formulation and delivery systems will tie in what is the most current status, including clinical evaluations with these novel vaccine technologies.​

Novel Technologies for Vaccine Development

Igor S Lukashevich,Haval Shirwan
Novel Technologies for Vaccine Development Book PDF

Author : Igor S Lukashevich,Haval Shirwan
Publisher : Springer
Page : 393 pages
File Size : 40,5 Mb
Release : 2014-11-13
Category : Medical
ISBN : 9783709118184

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Novel Technologies for Vaccine Development by Igor S Lukashevich,Haval Shirwan Pdf

This book presents a detailed overview of the development of new viral vector-based vaccines before discussing two major applications: preventive vaccines for infectious diseases and therapeutic cancer vaccines. Viral vector-based vaccines hold a great potential for development into successful pharmaceutical products and several examples at the advanced pre-clinical or clinical stage are presented. Nevertheless, the most efforts were focused on novel and very innovative technologies for new generation of vector-based vaccines. Furthermore, specific topics such as delivery and adjuvant and protection strategies for cell-mediated-based vaccines are presented. Given its scope, the book is a “must read” for all those involved in vaccine development, both in academia and industrial vaccine development.

Immunopotentiators in Modern Vaccines

Virgil Schijns,Derek O'Hagan
Immunopotentiators in Modern Vaccines Book PDF

Author : Virgil Schijns,Derek O'Hagan
Publisher : Academic Press
Page : 508 pages
File Size : 46,5 Mb
Release : 2016-11-02
Category : Science
ISBN : 9780128040959

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Immunopotentiators in Modern Vaccines by Virgil Schijns,Derek O'Hagan Pdf

Immunopotentiators in Modern Vaccines, Second Edition, provides in-depth insights and overviews of the most successful adjuvants, those that have been included in licensed products, also covering the most promising technologies that have emerged in recent years. In contrast to existing books on the subject, the chapters here provide summaries of key data on the mechanisms of action of the individual vaccine adjuvants. In addition, the book covers key aspects of how the technologies might be further developed and what might be their limitations, while also giving an overview of what made the most advanced adjuvant technologies successful. Provides contributions from leading international authorities in the field Features immunopotentiators classified by function, with well-illustrated, informative figures presenting the interaction between the immunopotentiators and the host immune system Lists advantages and potential hurdles for achieving a practical application for each specific immunopotentiator Offers US FDA perspectives which highlight how future adjuvants will be approved for new generation vaccines

Vaccine Adjuvants and Delivery Systems

Manmohan Singh
Vaccine Adjuvants and Delivery Systems Book PDF

Author : Manmohan Singh
Publisher : John Wiley & Sons
Page : 470 pages
File Size : 49,8 Mb
Release : 2007-08-03
Category : Science
ISBN : 9780470134924

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Vaccine Adjuvants and Delivery Systems by Manmohan Singh Pdf

The authoritative reference on recent developments in vaccinology New technologies, including recombinant protein and DNA, have sparked phenomenal progress in vaccine development and delivery systems. This unique resource brings scientists up to date on recent advances and provides the information they need to select candidate adjuvants. With chapters written by leading experts in their fields, Vaccine Adjuvants and Delivery Systems: * Provides a comprehensive overview of the rapidly evolving field and developing formulation methods * Covers cutting-edge technologies and gives the current status of adjuvants in clinical trials and those still in the pre-clinical stage * Includes detailed information on specific vaccine adjuvants, including MF59, TLR4 agonists, new iscoms, cytokines, polyphosphazenes, and more * Provides a historical perspective on the development of vaccine adjuvants and discusses the mechanisms of adjuvant actions * Covers some novel adjuvants and delivery systems and the safety evaluation of adjuvants A great reference for researchers, scientists, and students in vaccinology, biotechnology, immunology, and molecular biology, this resource is also valuable for researchers and scientists in veterinary medicine who work to prevent diseases in animals.

The Role of the Study Director in Nonclinical Studies

William J. Brock,Barbara Mounho,Lijie Fu
The Role of the Study Director in Nonclinical Studies Book PDF

Author : William J. Brock,Barbara Mounho,Lijie Fu
Publisher : John Wiley & Sons
Page : 568 pages
File Size : 53,6 Mb
Release : 2014-05-02
Category : Science
ISBN : 9781118874080

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The Role of the Study Director in Nonclinical Studies by William J. Brock,Barbara Mounho,Lijie Fu Pdf

A single-source reference with a broad and holistic overview of nonclinical studies, this book offers critical training material and describes regulations of nonclinical testing through guidelines, models, case studies, practical examples, and worldwide perspectives. The book: Provides a complete overview of nonclinical study organization, conduct, and reporting and describes the roles and responsibilities of a Study Director to manage an effective study Covers regulatory and scientific concepts, including international testing and Good Laboratory Practice (GLP), compliance with guidelines, and animal models Features a concluding chapter that compiles case studies / lessons learned from those that have served as a Study Director for many years Addresses the entire spectrum of nonclinical testing, making it applicable to those in the government, laboratories and those actively involved in in all sectors of industry

Probiotic Research in Therapeutics

Sandip V. Pawar,Praveen Rishi
Probiotic Research in Therapeutics Book PDF

Author : Sandip V. Pawar,Praveen Rishi
Publisher : Springer Nature
Page : 367 pages
File Size : 45,7 Mb
Release : 2021-02-01
Category : Medical
ISBN : 9789813362369

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Probiotic Research in Therapeutics by Sandip V. Pawar,Praveen Rishi Pdf

In a normal physiological state, several bacteria are present in the human gut that is essential to maintain the normal to healthy gastrointestinal function. Disturbances in this “normal flora” lead to gut inflammation and infection. This volume explores the potential of probiotics, the healthy bacteria, to manage gut-related diseases including gastrointestinal cancers, ulcerative colitis, H. pylori infections, and diarrhea; vaginosis; oral health; airway inflammation; and atopic dermatitis. The concept of designer probiotics, edible vaccines and future scope of research in the field is also presented. The animal models used for studying the benefits of probiotics in gut inflammation are described for beginners.

Subunit Vaccine Delivery

Camilla Foged,Thomas Rades,Yvonne Perrie,Sarah Hook
Subunit Vaccine Delivery Book PDF

Author : Camilla Foged,Thomas Rades,Yvonne Perrie,Sarah Hook
Publisher : Springer
Page : 433 pages
File Size : 43,5 Mb
Release : 2014-11-22
Category : Medical
ISBN : 9781493914173

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Subunit Vaccine Delivery by Camilla Foged,Thomas Rades,Yvonne Perrie,Sarah Hook Pdf

This comprehensive volume compiles the concepts essential for the understanding of the pharmaceutical science and technology associated with the delivery of subunit vaccines. Twenty-one chapters are divided into four main parts: (I) Background; (2) Delivery Systems for Subunit Vaccines; (3) Delivery Routes, Devices and Dosage Forms; and (4) Pharmaceutical Analysis and Quality Control of Vaccines. Part one provide a basic background with respect to immunology and general vaccine classification. In part two, it presents representative types of vaccine delivery systems individually with focus on the physicochemical properties of the systems and their significance for the immune response they stimulate. These delivery systems include aluminum adjuvants, emulsions, liposomes, bilosomes, cubosomes/hexosomes, ISCOMs, virus-like particles, polymeric nano- and microparticles, gels, implants and cell-based delivery systems. Following these chapters, part three addresses the challenges associated with vaccine delivery via specific routes of administration—in particular subcutaneous, intramuscular, oral, nasal, pulmonary, transdermal and vaginal administration. Furthermore, the specific administration routes are discussed in combination with device technologies relevant for the respective routes as well as dosage forms appropriate for the device technology. Finally, the fourth part concerns pharmaceutical analysis and quality control of subunit vaccines.

Comprehensive Toxicology

Anonim
Comprehensive Toxicology Book PDF

Author : Anonim
Publisher : Elsevier
Page : 8639 pages
File Size : 41,6 Mb
Release : 2017-12-01
Category : Science
ISBN : 9780081006122

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Comprehensive Toxicology by Anonim Pdf

Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts

Nanobiomaterials

Anil K. Sharma,Raj K. Keservani,Rajesh K. Kesharwani
Nanobiomaterials Book PDF

Author : Anil K. Sharma,Raj K. Keservani,Rajesh K. Kesharwani
Publisher : CRC Press
Page : 528 pages
File Size : 54,7 Mb
Release : 2018-01-03
Category : Medical
ISBN : 9781351792455

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Nanobiomaterials by Anil K. Sharma,Raj K. Keservani,Rajesh K. Kesharwani Pdf

This new volume focuses on the ever-growing and ever-sophisticated use of nanobiomaterials in drug delivery. There have been significant developments in the delivery of the active pharmaceutical ingredients to target sites, thereby sparing the normal functioning biological systems from damage, and this volume highlights some of the most important developments in the field. The book first provides an overview of nanobiomaterials and then goes on to report on new developments in drug delivery and nanotechnology, nanobiomaterials as carriers in cancer therapy, and the diverse uses of nanobiomaterials. Broken into sections, the chapters cover: an overview of nanobiomaterials drug delivery and nanotechnology nanobiomaterials as carriers in cancer therapeutics diverse uses of nanobiomaterials This volume will be a valuable resource on drug delivery for pharmaceutical manufacturers, healthcare personnel, and researchers.

Pharmaceutical Biotechnology

Daan J. A. Crommelin,Robert D. Sindelar
Pharmaceutical Biotechnology Book PDF

Author : Daan J. A. Crommelin,Robert D. Sindelar
Publisher : CRC Press
Page : 456 pages
File Size : 55,5 Mb
Release : 2002-11-14
Category : Medical
ISBN : 0415285011

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Pharmaceutical Biotechnology by Daan J. A. Crommelin,Robert D. Sindelar Pdf

The field of pharmaceutical biotechnology is evolving rapidly. A whole new arsenal of protein pharmaceuticals is being produced by recombinant techniques for cancer, viral infections, cardiovascular and hereditary disorders, and other diseases. In addition, scientists are confronted with new technologies such as polymerase chain reactions, combinatorial chemistry and gene therapy. This introductory textbook provides extensive coverage of both the basic science and the applications of biotechnology-produced pharmaceuticals, with special emphasis on their clinical use. Pharmaceutical Biotechnology serves as a complete one-stop source for undergraduate pharmacists, and it is valuable for researchers and professionals in the pharmaceutical industry as well.

Immunopotentiators in Modern Vaccines

Virgil Schijns,Derek O'Hagan
Immunopotentiators in Modern Vaccines Book PDF

Author : Virgil Schijns,Derek O'Hagan
Publisher : Elsevier
Page : 384 pages
File Size : 51,8 Mb
Release : 2005-12-19
Category : Medical
ISBN : 0080457215

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Immunopotentiators in Modern Vaccines by Virgil Schijns,Derek O'Hagan Pdf

Immunopotentiators in Modern Vaccines provides an in-depth insight and overview of a number of most promising immunopotentiators in modern vaccines. In contrast to existing books on the subject it provides recent data on the critical mechanisms governing the activity of vaccine adjuvants and delivery systems. Knowledge of immunological pathways and scenarios of the cells and molecules involved is described and depicted in comprehensive illustrations. Contributions from leading international authorities in the field Well-illustrated, informative figures present the interactions between immunopotentiators and the host immune system Each chapter lists advantages and potential hurdles for achieving a practical application for the specific immunopentiator

Translational Medicine

Joy A. Cavagnaro,Mary Ellen Cosenza
Translational Medicine Book PDF

Author : Joy A. Cavagnaro,Mary Ellen Cosenza
Publisher : CRC Press
Page : 952 pages
File Size : 49,8 Mb
Release : 2021-11-26
Category : Medical
ISBN : 9781000471854

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Translational Medicine by Joy A. Cavagnaro,Mary Ellen Cosenza Pdf

Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.

Veterinary Vaccinology

Paul-Pierre Pastoret
Veterinary Vaccinology Book PDF

Author : Paul-Pierre Pastoret
Publisher : Elsevier Science & Technology
Page : 0 pages
File Size : 55,6 Mb
Release : 1997
Category : Animaux
ISBN : 0444819681

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Veterinary Vaccinology by Paul-Pierre Pastoret Pdf

Hardbound. Vaccination is widely recognised as one of the most efficient tools in public health, showing obvious cost-benefit advantages for all target populations involved.Vaccines in the veterinary field can contribute greatly to the welfare of domestic and wild animals and, indirectly, to environmental protection. The aim of animal vaccination will increasingly be to prevent dissemination of zoonoses (such as rabies, taeniosis, salmonellosis, etc.) rather than to protect the animal itself, especially when infection or infestation is not harmful to the reservoir (cysticercosis)At present there is insufficient overall understanding of some important aspects of veterinary vaccines. Literature on the subject exists, but often consists of either research communications or 'catalogue-type' descriptive works. This unique book fills a gap within the already available literature. The scope is broad and covers all aspects of vaccines and vaccination in the

Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies

Manmohan Singh,Maya Salnikova
Novel Approaches and Strategies for Biologics Vaccines and Cancer Therapies Book PDF

Author : Manmohan Singh,Maya Salnikova
Publisher : Academic Press
Page : 520 pages
File Size : 51,8 Mb
Release : 2014-12-30
Category : Medical
ISBN : 9780124166615

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Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies by Manmohan Singh,Maya Salnikova Pdf

Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies takes a look at the current strategies, successes and challenges involved with the development of novel formulations of biologics, vaccines and cancer therapy. This thorough reference on the latest trends in the development of diverse modalities will appeal to a broad community of scientists, students and clinicians. Written by leading authors across academia and industry, this book covers important topics such as unique drug delivery devices, non-parenteral delivery trends, novel approaches to the treatment of cancer, immunotherapy and more. It includes real-world cases and examples which highlight formulations with therapeutic proteins, monoclonal antibodies, peptides and biobetters, as well as cases on novel vaccines formulations including evolving pathogens, novel modalities of vaccines, universal vaccines. This book is a thorough and useful resource on the development of novel biologics, vaccines and cancer therapies. Provides strategies for the development of safe and efficacious novel formulations for various modalities of biologics, vaccines and for cancer therapy Highlights novel cases from current clinical trials as well as marketed products Reviews overall successes and challenges in the development of novel formulations, including new molecular targets for the treatment of diseases, design of target-specific therapies, regulatory considerations, individualized therapies

Dermal Drug Delivery

Tapash K. Ghosh
Dermal Drug Delivery Book PDF

Author : Tapash K. Ghosh
Publisher : CRC Press
Page : 409 pages
File Size : 50,8 Mb
Release : 2020-01-21
Category : Medical
ISBN : 9781315356648

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Dermal Drug Delivery by Tapash K. Ghosh Pdf

With the continued advancement of better-quality control and patient outcome reporting systems, changes in the development, control, and regulation of all pharmaceutical delivery systems including transdermal and topical products have been happening on a continuous basis. In light of various quality issues that have been reported by patients and practitioners resulting in the recall or removal of products from the market, both the pharmaceutical industries and regulatory agencies have been adopting new measures to address these issues. With chapters written by experts in this field, this book takes a 21st century multidisciplinary and cross-functional look at these dosage forms to improve the development, design, manufacturing, quality, clinical performance, safety, and regulation of these products. This book offers a wealth of up-to-date information organized in a logical sequence corresponding to various stages of research, development, and commercialization of dermal drug delivery products. The authors have been carefully selected from different sectors of pharmaceutical science for their expertise in their selected areas to present objectively a balanced view of the current state of these products development and commercialization via regulatory approval. Their insights will provide useful information to others to ensure the successful development of the next generation dermal drug products. Key Features: Presents current advancements including new technologies of transdermal and topical dosage forms. Presents challenges in the development of the new generation of transdermal and topical dosage forms. Introduces new technologies and QbD (quality by design) aspects of manufacturing and control strategies. Includes new perspectives on pre-clinical and clinical development, regulatory considerations, safety and quality. Discusses regulatory challenges, gaps, and future considerations for dermal drug delivery systems.