Nuclear Localization Of Growth Factors And Of Monoclonal Antibodies

Author : Ewa Rakowicz-Szulczynska
Publisher : CRC Press
Page : 224 pages
File Size : 44,5 Mb
Release : 1993-10-13
Category : Medical
ISBN : 0849347130

Get Book

Nuclear Localization of Growth Factors and of Monoclonal Antibodies by Ewa Rakowicz-Szulczynska Pdf

Nuclear Localization of Growth Factors and of Monoclonal Antibodies focuses on how an additional class of chromatin receptors is directly involved in mediation of the action of growth factors on the gene regulation level. The book describes a new intracellular pathway of growth factors and presents methods for identifying nuclear antigens with an epitopic homology of the cell surface antigens. It teaches how to distinguish monoclonal antibodies that penetrate the cell and localize in the nucleus from those that act only on the cell surface. New light is shed on the mechanisms of malignant transformation, and new approaches to developing anti-cancer and anti-HIV drugs are covered. The book will be important for oncologists, biochemists, cell biologists, pharmaceutical researchers, investigative pathologists, neurochemists, and immunologists.

Author : Rakesh Kumar
Publisher : Springer Science & Business Media
Page : 442 pages
File Size : 45,7 Mb
Release : 2013-08-23
Category : Medical
ISBN : 9781461480396

Get Book

Nuclear Signaling Pathways and Targeting Transcription in Cancer by Rakesh Kumar Pdf

At the moment, there is no dedicated book to summarize the roles, the significance, and potential therapeutic targeting of transcriptional factors from the perspective of signaling cascade, and thus, directly impacting the functionality of transcriptional factors in cancer. In addition, this book will offer a comprehensive basic and clinical science behind the functions of representative core transcriptional factors. These chapters will serve as a treasure for all those who have an interest in the basis, progression, and targeting of human cancer. Each chapter will be intended to provide comprehensive, up-to-date information by the leaders about the physiologic and pathologic roles of TFs in specific representative organ systems of prime importance. The book will consist of chapters that will give biomedical students, under and graduate students, basic sciences and clinical cancer fellows, residents and researchers, and oncology educators will get a thorough summary of the overall subject. The readers will be able to understand the important current information and views on specific TFs and its role in cancer in areas outside their own expertise or experience. A special emphasis will be also placed on the "classic" papers as well as perspectives on future directions for the field.

Author : Peter Lonai
Publisher : CRC Press
Page : 406 pages
File Size : 47,7 Mb
Release : 1996-09-01
Category : Nature
ISBN : 3718659204

Get Book

Mammalian Development by Peter Lonai Pdf

"This book aims to provide a survey of the developmental biology of mammals--Pref.

Author : Antonio Llombart-Bosch,José A. López-Guerrero,Vicente Felipo
Publisher : Springer
Page : 0 pages
File Size : 40,8 Mb
Release : 2010-11-18
Category : Medical
ISBN : 904817239X

Get Book

New Trends in Cancer for the 21st Century by Antonio Llombart-Bosch,José A. López-Guerrero,Vicente Felipo Pdf

This volume contains the lectures held at the International Symposium on Cancer "New Trends in Cancer for the 21st Century". Fundamental researchers, politicians and representatives from patient coalitions share their knowledge and interests as well as their concerns and experiences. Not only do these papers provide state-of-the-art information on cancer, they are also an opportunity to look at the problem from different points of view.

Author : Anonim
Publisher : Academic Press
Page : 225 pages
File Size : 51,9 Mb
Release : 1998-10-19
Category : Science
ISBN : 9780080584652

Get Book

Cumulative Subject Index by Anonim Pdf

This Series provides a comprehensive survey of the major topics in the field of developmental biology. The volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The Series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology.

Author : Raymond M. Reilly
Publisher : John Wiley & Sons
Page : 849 pages
File Size : 45,9 Mb
Release : 2010-12-28
Category : Science
ISBN : 9781118035153

Get Book

Monoclonal Antibody and Peptide-Targeted Radiotherapy of Cancer by Raymond M. Reilly Pdf

Oncology Book of 2011, British Medical Association's Medical Book Awards Awarded first prize in the Oncology category at the 2011 BMA Medical Book Awards, Monoclonal Antibody and Peptide-Targeted Radiotherapy of Cancer helps readers understand this hot pharmaceutical field with up-to-date developments. Expert discussion covers a range of diverse topics associated with this field, including the optimization of design of biomolecules and radiochemistry, cell and animal models for preclinical evaluation, discoveries from key clinical trials, radiation biology and dosimetry, and considerations in regulatory approval. With chapters authored by internationally renowned experts, this book delivers a wealth of information to push future discovery.

Author : Adam B. Glick,Carter Van Waes
Publisher : Springer Science & Business Media
Page : 471 pages
File Size : 50,9 Mb
Release : 2010-11-25
Category : Medical
ISBN : 9781441972033

Get Book

Signaling Pathways in Squamous Cancer by Adam B. Glick,Carter Van Waes Pdf

Squamous epithelia form the lining surface of tissues in contact with the environment: the skin, oral mucosa, esophagus and respiratory tract, the genital tract, and several other specialized tissues. These tissues are at highest risk for exposure to environmental carcinogens such as UV, tobacco smoke and infectious agents. Cancers that form in squamous epithelia are among the most common human solid tumors and have high morbidity and mortality. These cancers include squamous cell carcinoma of the skin, oral cancer, head and neck and esophageal cancer, certain lung cancers and cervical cancer. We propose to organize the book so that the early chapters will focus on individual pathways and more specific mechanisms in both normal function and cancer, while the later chapters will be more integrative and include overviews of biomarkers and therapeutic development. This should increase interest for clinically oriented researchers. All authors will be encouraged to provide a balanced review in addition to highlighting their own work.

Author : Enrique Pimentel
Publisher : CRC Press
Page : 274 pages
File Size : 52,7 Mb
Release : 1987-06-30
Category : Medical
ISBN : 0849353467

Get Book

Hormones Growth Factors & Oncogenes by Enrique Pimentel Pdf

This text examines the hormones and peptide growth factors involved in the regulation of metabolism, growth and differentiation in metazoan organisms and proto-oncogene expression. Investigates protein products of some proto-oncogenes for involvement in the transductional and post-transductional and mechanisms of hormones and peptide growth factors.

Author : Andreas Hoeflich,John Pintar,Briony Forbes
Publisher : Frontiers Media SA
Page : 148 pages
File Size : 52,7 Mb
Release : 2019-02-06
Category : Electronic
ISBN : 9782889457182

Get Book

Current Perspectives on Insulin-like Growth Factor Binding Protein (IGFBP) Research by Andreas Hoeflich,John Pintar,Briony Forbes Pdf

The family of IGFBPs has been developed by the duplication of genes and genomes and contributes to genetic and functional diversity. Due to the different protein domains present in the molecule, IGFBPs can be seen as mediators of tissue-specific IGF-functions. However, IGFBPs also have IGF-independent functions both inside and outside the cell. These diverse genetic, molecular and functional aspects of IGFBPs are discussed within this Research Topic. Accumulating data provide evidence for the regulation of IGFBP-functions by proteases, which may acutely regulate bioactivity of the IGFs. However, during proteolytic degradation IGFBP-fragments with novel functions can also be formed and are located both intra- and extracellularly. Distinct IGFBP-fragments can even be found in the perinuclear compartment or within the nucleus, where they can impact on gene expression. Several contributions presented in the current Research Topic particularly stress the relevance of structural aspects in IGFBP research. The current lack of comprehensive structural information is dramatically limiting the biomarker potential of particular IGFBPs. Finally, the Research Topic also provides novel functions of the IGFBP family from model organisms, farm animals and humans. Thereby, the biomarker potential not only relates to normal and malignant growth but also to metabolism and animal welfare. One important aim of the Research Topic is to encourage next generation IGFBP research reflecting subject-individual, conditional, and hormonal parameters but also structural aspects of the IGFBPs.

Author : Anonim
Publisher : Elsevier
Page : 581 pages
File Size : 47,9 Mb
Release : 2001-04-18
Category : Medical
ISBN : 9780080493381

Get Book

Drug Discovery and Design by Anonim Pdf

Strategies to reduce medical uncertainty and build evidence have become critical to the advancement of medical knowledge and modern medical practice. As new techniques and strategies have arisen, so has the need for a current reference work. Drug Discovery and Design examines the latest research in the development of these new strategies. Some of the topics covered include angiotensin converting enzyme inhibitors, HIV protease inhibitors, PPAR agonists for diabetes, and glucan synthase antifungal agents.

Author : Peter E. Angel,Peter Herrlich
Publisher : CRC Press
Page : 324 pages
File Size : 41,9 Mb
Release : 1994-09-29
Category : Medical
ISBN : 0849345731

Get Book

The FOS and JUN Families of Transcription Factors by Peter E. Angel,Peter Herrlich Pdf

This book introduces and analyzes the crucial role of AP-1 in cell growth, proliferation, differentiation, and apoptosis. AP-1 is the endpoint of several pathways of signal transduction, including one that triggers cancerous growth. The control of its activity is an issue of basic science, cancer therapy, and other diseases. The chapters provide multiple viewpoints of the emerging data on AP-1, including its role as a factor regulating genes involved in the metastatic properties of cancer, as a factor that interacts with viral gene products, and as a part of the mechanism by which steroid and retinoic acid receptors function as anti-inflammatory proteins.

Author : Anonim
Publisher : Unknown
Page : 1764 pages
File Size : 52,5 Mb
Release : 2000
Category : Medicine
ISBN : OSU:32436010864831

Get Book

Cumulated Index Medicus by Anonim Pdf

Author : Shi Hu
Publisher : Academic Press
Page : 258 pages
File Size : 53,8 Mb
Release : 2022-11-11
Category : Science
ISBN : 9780128215852

Get Book

Novel Sensitizing Agents for Therapeutic Anti-EGFR Antibodies by Shi Hu Pdf

Novel Sensitizing Agents for Therapeutic Anti-EGFR Antibodies presents a description of the sensitizers used to overcome resistance to anti-EGFR targeted antibody therapies in cancer, including novel engineered antibody drugs and other sensitizers. The book gives insights into the landscape of anti-EGFR based cancer treatments, the challenges of targeted therapy, and a glimpse into the future of antibody therapy. It offers pertinent science information on strategies used for the rational design and discovery of novel sensitizing agents, and in addition, translational studies involving pre-clinical and clinical design. This book is an indispensable resource for cancer researchers, medicinal chemists and other biomedical scientists.Finally, the book covers basic science strategies used in drug discovery and preclinical evaluation focused on EGFR blockage resistance, as well as clinical trial methodology, including clinical pharmacokinetics and imaging to address issues of efficacy evaluation of the new anticancer sensitizers for anti-EGFR drug resistance. Presents detailed descriptions on the history, chemistry, mechanism of action, structure-function relationships, pharmacology, side effects, dosing and formulation of new sensitizers to anti-EGFR antibodies Provides molecular structures for all novel anticancer drugs, along with strategies to overcome resistance to anti-EGFR antibodies Encompasses up-to-date information on the cancer drug discovery process, including new research tools, tumor-targeting strategies, and fundamental concepts in emerging areas of precision medicine

Author : H.M. Pinedo,J. Verweij
Publisher : Springer Science & Business Media
Page : 143 pages
File Size : 46,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461317579

Get Book

Treatment of Soft Tissue Sarcomas by H.M. Pinedo,J. Verweij Pdf

One of the major advances of the last decade concerning the treatment of patients with soft tissue sarcomas is that an increased number of patients are being discussed in multidisciplinary teams prior to the initial treatment. The present volume on soft tissue sarcomas in the series Cancer Treatment and Research reflects the multidisciplinary approach with a focus on recent developments. The availability of new histopathologic techniques has reduced the number of unclassified sarcomas and has furhter increased the importance of the histo pathologist in providing estimates of the prognosis of the patient as well as data for the planning of treatment strategy. Further data for this strategy will be provided by diagnostic imaging. In this field, the role of magnetic reson ance imaging has been further defined. Of utmost importance is the recent trend toward consensus in staging. The modification of the staging system of the American Joint Commission for Cancer Staging and End Results Report ing brings the possibility of a single staging system within reach in the next decade. As surgery still provides the only chance for cure, the importance of being the most sparing as possible is obvious. For this reason, radiotherapy has been applied with success. The introduction of relatively new radiation tech niques is therefore being observed with interest.

Author : Anonim
Publisher : Academic Press
Page : 174 pages
File Size : 50,5 Mb
Release : 2010-10-27
Category : Science
ISBN : 0080962602

Get Book

Tissue-Specific Vascular Endothelial Signals and Vector Targeting by Anonim Pdf

The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in knowledge gained from genetics research. This serial continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Includes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, providing researchers an overview and synthesis of the latest findings in the area Presents up-to-date research from leaders in the field