Nutrients And Cell Signaling

Author : Janos Zempleni,Krishnamurti Dakshinamurti
Publisher : CRC Press
Page : 760 pages
File Size : 50,6 Mb
Release : 2019-08-30
Category : Electronic
ISBN : 0367393077

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Nutrients and Cell Signaling by Janos Zempleni,Krishnamurti Dakshinamurti Pdf

Cell signaling is at the core of most biological processes from the simplest to the most complex. In addition to unicellular organisms possessing the essential ability to receive inputs with regard to nutrient availability and noxious stimuli, the cells in multicellular organisms require signaling from adjacent, as well as distant cells to maintain normal internal function, including growth, differentiation, and homeostasis. Conversely, the etiology of many disease processes, such as those involving immune system dysfunction and tumor development, have been traced to aberrant cell signaling. Nutrients and Cell Signaling, in presenting contributions from a wide array of experts in the field, fully delineates the role of nutrients in cell signaling. The text emphasizes broad concepts and covers all major groups of nutrients. Contributors discuss the role of carbohydrates, amino acids, lipids, vitamins, minerals, and trace elements in essential processes such as cell proliferation, immune function, and DNA repair. The editors have organized the work to provide select examples organized under these contemporary research areas: Nuclear receptors, transcription factors, and signaling cascades Amino acids, lipids, and glycation Insulin release, signaling, and insulin resistance Calcium-dependent signaling Feeding and nutrient homeostasis Nutrients and Cell Signaling answers the need in the post-genomic era, for an authoritative resource that provides an in-depth understanding of how these complex and dynamic biomolecular networks control cell function. Those professionals and students in molecular biology, nutrition, biochemistry, as well as any branch involved with cell signaling and function will find this book to be an invaluable tool in promoting both understanding and further inquiry.

Author : Zigang Dong,Young-Joon Surh
Publisher : CRC Press
Page : 504 pages
File Size : 48,9 Mb
Release : 2008-09-26
Category : Medical
ISBN : 9780849381492

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Dietary Modulation of Cell Signaling Pathways by Zigang Dong,Young-Joon Surh Pdf

A consequence of rapid progress in the science of nutrigenomics and nutrigenetics is the substantial accumulation of data covering nutrienal modulation of gene expression at the cellular and subcellular levels. Current research is increasingly focused on the role of nutrition and diet in modifying oxidative damage in the progression of disease. Die

Author : Zhiyong Cheng
Publisher : Royal Society of Chemistry
Page : 353 pages
File Size : 49,6 Mb
Release : 2020-09-04
Category : Medical
ISBN : 9781788015578

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Nutritional Signaling Pathway Activities in Obesity and Diabetes by Zhiyong Cheng Pdf

This book disseminates the cutting-edge knowledge pertaining to nutritional signaling activities in obesity and diabetes, including the regulatory mechanisms and perspectives of nutritional interventions for disease prevention.

Author : Joris Winderickx,Peter M. Taylor
Publisher : Springer Science & Business Media
Page : 340 pages
File Size : 43,5 Mb
Release : 2004-03-29
Category : Science
ISBN : 3540209174

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Nutrient-Induced Responses in Eukaryotic Cells by Joris Winderickx,Peter M. Taylor Pdf

Cells of all living organisms have the ability to respond to altered nutritional conditions. They have developed mechanisms to sense nutrient availability and to produce appropriate responses, which involve changes in gene expression and the production or degradation of certain enzymes and other proteins. In recent years, the understanding of nutrient-induced signal transduction has greatly advanced and the emerging picture is that nutrient signalling mechanisms evolved early in evolution. This book provides a detailed presentation and comparison of the key nutritional regulatory mechanisms in lower as well as higher eukaryotes, written by recognised experts in this expanding field.

Author : Rüdiger Hell,Ralf-Rainer Mendel
Publisher : Springer Science & Business Media
Page : 312 pages
File Size : 55,6 Mb
Release : 2010-03-10
Category : Science
ISBN : 9783642106132

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Cell Biology of Metals and Nutrients by Rüdiger Hell,Ralf-Rainer Mendel Pdf

Plants are composed of 17 essential and at least 5 beneficial elements, and these must be taken up as metal or nutrient ions to allow for growth and cell division. Much effort has been devoted to studying the physiology and biochemistry of metals and nutrients in plants. The aspect of cell biology, however, is an emerging new field and much needs to be learned about sensing, long-distance communication within plants, and cellular signal transduction chains in response to environmental stress. Cellular malfunction and consequently disease result when any of the key steps in metal and nutrient homeostasis are disrupted. Working together, leading experts in their respective fields provide a new concept that reaches beyond plant nutrition and plasmalemma transport into cellular physiology. Each chapter contains basic information on uptake, physiological function, deficiency and toxicity syndromes, long-distance and intracellular transport. The discussion is devoted to metals and nutrients where recent progress has been made and highlights the aspects of homeostasis and sensing, signaling and regulation, drawing parallels to other organisms including humans. Finally, the book identifies gaps in our current knowledge and lays out future research directions.

Author : Robert E. Rhoads
Publisher : Springer Science & Business Media
Page : 186 pages
File Size : 41,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642566882

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Signaling Pathways for Translation by Robert E. Rhoads Pdf

The articles in the present volume are by major contributors to our under standing of signaling pathways affecting protein synthesis. They focus pri marily on two extracellular anabolic signals, although others are included as well. Insulin is one of the best-studied extracellular regulators of protein syn thesis. Several of the known pathways for regulation of protein synthesis were elucidated using insulin-dependent systems. Regulation of protein synthesis by amino acids, by contrast, is an emerging field that has recently received a great deal of attention. The dual role of amino acids as substrates for protein syn thesis and regulators of the overall process has only recently been recognized. Since amino acids serve as precursors for proteins, one might expect that with holding an essential amino acid would inhibit the elongation phase. Surpris ingly, research has shown that it is the initiation phase of protein synthesis that is restricted during amino acid starvation. Understanding the mechanisms by which the biosynthesis of proteins is reg ulated is important for several reasons. Protein synthesis consumes a major portion of the cellular ATP that is generated. Therefore, small changes in protein synthesis can have great consequences for cellular energy metabolism. Translation is also a major site for control of gene expression, since messenger RNAs differ widely in translational efficiency, and changes to the protein syn thesis machinery can differentially affect recruitment of individual mRNAs.

Author : Janos Zempleni,Krishnamurti Dakshinamurti
Publisher : CRC Press
Page : 757 pages
File Size : 43,9 Mb
Release : 2005-04-04
Category : Medical
ISBN : 9781420028362

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Nutrients and Cell Signaling by Janos Zempleni,Krishnamurti Dakshinamurti Pdf

Cell signaling is at the core of most biological processes from the simplest to the most complex. In addition to unicellular organisms possessing the essential ability to receive inputs with regard to nutrient availability and noxious stimuli, the cells in multicellular organisms require signaling from adjacent, as well as distant cells to maintain

Author : Rüdiger Hell,Ralf-Rainer Mendel
Publisher : Springer
Page : 306 pages
File Size : 45,5 Mb
Release : 2010-03-05
Category : Science
ISBN : 3642106129

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Cell Biology of Metals and Nutrients by Rüdiger Hell,Ralf-Rainer Mendel Pdf

Plants are composed of 17 essential and at least 5 beneficial elements, and these must be taken up as metal or nutrient ions to allow for growth and cell division. Much effort has been devoted to studying the physiology and biochemistry of metals and nutrients in plants. The aspect of cell biology, however, is an emerging new field and much needs to be learned about sensing, long-distance communication within plants, and cellular signal transduction chains in response to environmental stress. Cellular malfunction and consequently disease result when any of the key steps in metal and nutrient homeostasis are disrupted. Working together, leading experts in their respective fields provide a new concept that reaches beyond plant nutrition and plasmalemma transport into cellular physiology. Each chapter contains basic information on uptake, physiological function, deficiency and toxicity syndromes, long-distance and intracellular transport. The discussion is devoted to metals and nutrients where recent progress has been made and highlights the aspects of homeostasis and sensing, signaling and regulation, drawing parallels to other organisms including humans. Finally, the book identifies gaps in our current knowledge and lays out future research directions.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 51,6 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Lester Packer
Publisher : Unknown
Page : 434 pages
File Size : 47,6 Mb
Release : 2009
Category : Brain
ISBN : 0429146787

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Micronutrients and Brain Health by Lester Packer Pdf

Under the direction of leading experts in oxidative stress, this book addresses cutting-edge areas of research regarding micronutrients and the brain. It discusses identification of brain-specific micronutrients that support function and molecular mechanisms underlying neuroprotectant activity. The book covers age-related metabolic pathways, mitochondrial nutrients, and neurodegeneration. Additional chapters cover flavonoids, cell signaling, and neuronal functions, as well as the role of choline, amino acids, metals, and other micronutrients in brain health and function. The text places a particular emphasis on lipoic acid, which is shown to be a therapeutic agent in neuropathologies.--Publisher's description.

Author : National Research Council,Division on Earth and Life Studies,Board on Agriculture and Natural Resources,Committee on Animal Nutrition
Publisher : National Academies Press
Page : 101 pages
File Size : 51,8 Mb
Release : 2002-02-07
Category : Technology & Engineering
ISBN : 9780309169912

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Scientific Advances in Animal Nutrition by National Research Council,Division on Earth and Life Studies,Board on Agriculture and Natural Resources,Committee on Animal Nutrition Pdf

The science of animal nutrition has made significant advances in the past century. In looking back at the discoveries of the 20th century, we can appreciate the tremendous impact that animal nutrition has had on our lives. From the discovery of vitamins and the sweeping shift in the use of oilseeds to replace animal products as dietary protein sources for animals during the war times of the 1900s-to our integral understanding of nutrients as regulators of gene expression today-animal nutrition has been the cornerstone for scientific advances in many areas. At the milestone of their 70th year of service to the nation, the National Research Council's (NRC) Committee on Animal Nutrition (CAN) sought to gain a better understanding of the magnitude of recent discoveries and directions in animal nutrition for the new century we are embarking upon. With financial support from the NRC, the committee was able to organize and host a symposium that featured scientists from many backgrounds who were asked to share their ideas about the potential of animal nutrition to address current problems and future challenges.

Author : Guoyao Wu
Publisher : Springer Nature
Page : 218 pages
File Size : 42,7 Mb
Release : 2020-08-06
Category : Medical
ISBN : 9783030453282

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Amino Acids in Nutrition and Health by Guoyao Wu Pdf

This edited volume comprehensively highlights recent advances in the metabolism, nutrition, physiology, and pathobiology of amino acids in all the systems of humans and other animals (including livestock, poultry, companion animals, and fish). It enables readers to understand the crucial roles of amino acids and their metabolites in the health and diseases of the circulatory, digestive, endocrine, immune, muscular, nervous, reproductive, respiratory, skeletal, and urinary systems, as well as the sense organs (eyes, ears, nose, skin, and tongue). Readers will learn that amino acids are not only the building blocks of protein, but are also signalling molecules, as well as regulators of gene expression, metabolic processes and developmental changes in the body. This knowledge will guide nutritional practices to improve the growth, development and health of humans and other animals, as well as prevent and treat chronic (e.g., obesity, diabetes, and cardiovascular disorders) and infectious (e.g., bacterial, fungal, parasite, and viral) diseases. Editor of this volume is an internationally recognized expert in nutritional biochemistry. He has over 38 years of experience with research and teaching at world-class universities in the area of amino acid biochemistry, nutrition, and physiology. He has published more than 625 papers in peer-reviewed journals, 62 chapters in books, and authored two text/reference books, with an H-index of 117 and more than 55,000 citations in Google Scholar. This publication is a useful reference for professionals as well as undergraduate and graduate students in animal science, biochemistry, biomedical engineering, biology, human medicine, food science, kinesiology, nursing, nutrition, pharmacology, physiology, toxicology, veterinary medicine, and other related disciplines. In addition, all chapters provide general and specific references to amino acids in systems health for researchers and practitioners in biomedicine, animal and plant agriculture, and aquaculture, and for government policy makers.

Author : Vinood B. Patel
Publisher : Academic Press
Page : 792 pages
File Size : 55,8 Mb
Release : 2019-08-24
Category : Technology & Engineering
ISBN : 9780128119365

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Molecular Nutrition by Vinood B. Patel Pdf

Molecular Nutrition: Vitamins presents the nutritional and molecular aspects of vitamins with a specific focus on vitamins A, B1 (thiamine), B2 (riboflavin), B# (niacin), B5 (pantothenic acid), B6, (pyridoxine), B7 (biotin), B9 (folate), B12 (colbamin), C, D, E, and K. As part of the Molecular Nutrition series, this book discusses introductory aspects and general coverage of vitamins and nutrition, the molecular biology of the cell, including signaling, transporters, oxidative stress, receptors, uptake, immunity, proliferation, endoplasmic reticulum, differentiation, carcinogenesis and apoptosis. Final sections cover genetic machinery and its function, transcriptional processes, homeostasis genes, cancer, gene expression, mutations, and more. Emerging fields of molecular biology and important discoveries related to diet and nutritional health are also covered, rounding out the book. Summarizes molecular nutrition in health as related to vitamins Includes material on signaling, transporters, oxidative stress, receptors, uptake, immunity, proliferation, endoplasmic reticulum, differentiation, carcinogenesis and apoptosis Presents transcriptional processes, homeostasis genes, cancer, gene expression, mutations, the sodium-dependent multivitamin transporter, p53, p21, microRNAs, one carbon metabolism, nucleic acids, DNA methylation and polymorphisms Addresses emerging fields of molecular biology and presents important discoveries related to diet and nutritional health Covers Vitamins A, B, C, D, E, and K Discusses their impact on health relating to cancer, diabetes, arthritis, and aging Includes key facts, a mini dictionary of terms, and summary points

Author : Roland N. Pittman
Publisher : Biota Publishing
Page : 117 pages
File Size : 53,6 Mb
Release : 2016-08-18
Category : Medical
ISBN : 9781615047215

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Regulation of Tissue Oxygenation, Second Edition by Roland N. Pittman Pdf

This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.

Author : Tom Brody
Publisher : Academic Press
Page : 1044 pages
File Size : 53,7 Mb
Release : 1999
Category : Medical
ISBN : 0121348369

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Nutritional Biochemistry by Tom Brody Pdf

This "real-world" approach allows students to come away with a realistically informed view of the basis for much of our understanding of nutritional biochemistry.