Open Channel Microfluidics

Author : Jean Berthier,Ashleigh B Theberge,Erwin Berthier
Publisher : Unknown
Page : 172 pages
File Size : 45,8 Mb
Release : 2019-09-02
Category : Electronic
ISBN : 1643276662

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Open-Channel Microfluidics by Jean Berthier,Ashleigh B Theberge,Erwin Berthier Pdf

Open microfluidics - the study of microflows having a boundary with surrounding air - encompasses paper- or thread-based microfluidics, droplet microfluidics and open-channel microfluidics. Open-channel microflow is a flow at the micro-scale, guided by solid structures, and having at least a free boundary (with air or vapor) other than the advancing meniscus. This book is devoted to the study of open-channel microfluidics which, contrary to paper or thread or droplet microfluidics, is still very sparsely documented, but bears many new applications in biology, biotechnology, medicine, material and space sciences. Capillarity being the principal force triggering an open microflow, the principles of capillarity are first recalled. The onset of open-channel microflow is next analyzed and the fundamental notion of generalized Cassie angle - the apparent contact angle which accounts for the presence of air - is presented. The theory of the dynamics of open-channel microflows is then developed, using the notion of averaged friction length, which accounts for the presence of air along the boundaries of the flow domain. Different channel morphologies are studied and geometrical features, such as valves and capillary pumps, are examined. An introduction to two-phase open-channel microflows is also presented, showing that immiscible plugs can be transported by an open-channel flow. Finally, a selection of interesting applications in the domains of space, materials, medicine and biology is provided, showing the potentialities of open-channel microfluidics.

Author : Jean Berthier,Ashleigh B Theberge,Erwin Berthier
Publisher : Morgan & Claypool Publishers
Page : 171 pages
File Size : 47,9 Mb
Release : 2019-09-04
Category : Technology & Engineering
ISBN : 9781643276649

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Open-Channel Microfluidics by Jean Berthier,Ashleigh B Theberge,Erwin Berthier Pdf

Open microfluidics, the study of microflows having a boundary with surrounding air, encompasses different aspects such as paper or thread-based microfluidics, droplet microfluidics and open-channel microfluidics. Open-channel microflow is a flow at the micro-scale, guided by solid structures, and having at least a free boundary (with air or vapor) other than the advancing meniscus. This book is devoted to the study of open-channel microfluidics which (contrary to paper or thread or droplet microfluidics) is still very sparsely documented, but bears many new applications in biology, biotechnology, medicine, material and space sciences. Capillarity being the principal force triggering an open microflow, the principles of capillarity are first recalled. The onset of open-channel microflow is next analyzed and the fundamental notion of generalized Cassie angle (the apparent contact angle which accounts for the presence of air) is presented. The theory of the dynamics of open-channel microflows is then developed, using the notion of averaged friction length which accounts for the presence of air along the boundaries of the flow domain. Different channel morphologies are studied and geometrical features such as valves and capillary pumps are examined. An introduction to two-phase open-channel microflows is also presented showing that immiscible plugs can be transported by an open-channel flow. Finally, a selection of interesting applications in the domains of space, materials, medicine and biology is presented, showing the potentialities of open-channel microfluidics.

Author : Jean Berthier,Kenneth A. Brakke,Erwin Berthier
Publisher : John Wiley & Sons
Page : 336 pages
File Size : 52,6 Mb
Release : 2016-07-20
Category : Science
ISBN : 9781118720820

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Open Microfluidics by Jean Berthier,Kenneth A. Brakke,Erwin Berthier Pdf

Open microfluidics or open-surface is becoming fundamental in scientific domains such as biotechnology, biology and space. First, such systems and devices based on open microfluidics make use of capillary forces to move fluids, without any need for external energy. Second, the “openness” of the flow facilitates the accessibility to the liquid in biotechnology and biology, and reduces the weight in space applications. This book has been conceived to give the reader the fundamental basis of open microfluidics. It covers successively The theory of spontaneous capillary flow, with the general conditions for spontaneous capillary flow, and the dynamic aspects of such flows. The formation of capillary filaments which are associated to small contact angles and sharp grooves. The study of capillary flow in open rectangular, pseudo-rectangular and trapezoidal open microchannels. The dynamics of open capillary flows in grooves with a focus on capillary resistors. The case of very viscous liquids is analyzed. An analysis of suspended capillary flows: such flows move in suspended channels devoid of top cover and bottom plate. Their accessibility is reinforced, and such systems are becoming fundamental in biology. An analysis of “rails” microfluidics, which are flows that move in channels devoid of side walls. This geometry has the advantage to be compatible with capillary networks, which are now of great interest in biotechnology, for molecular detection for example. Paper-based microfluidics where liquids wick flat paper matrix. Applications concern bioassays such as point of care devices (POC). Thread-based microfluidics is a new domain of investigation. It is seeing presently many new developments in the domain of separation and filtration, and opens the way to smart bandages and tissue engineering. The book is intended to cover the theoretical aspects of open microfluidics, experimental approaches, and examples of application.

Author : Jean (University of Washington) Berthier,Ashleigh B (University of Washington) Theberge,Erwin (University of Washington) Berthier
Publisher : IOP ebooks
Page : 0 pages
File Size : 42,9 Mb
Release : 2024-03-13
Category : Science
ISBN : 0750355050

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Open-Channel Microfluidics (Second Edition) by Jean (University of Washington) Berthier,Ashleigh B (University of Washington) Theberge,Erwin (University of Washington) Berthier Pdf

The development of open microfluidics is relatively recent and is an emerging sub-domain of capillarity, with many applications. This second edition research text presents the recent advances in open microfluidics, the science that describes capillary microflows guided by solid structures and partly open to the surrounding air.

Author : Berthier Jean
Publisher : Unknown
Page : 0 pages
File Size : 50,5 Mb
Release : 1901
Category : Electronic
ISBN : 1643276638

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Open-channel Microfluidics by Berthier Jean Pdf

Author : Jean Berthier,Kenneth A. Brakke,Erwin Berthier
Publisher : John Wiley & Sons
Page : 331 pages
File Size : 42,6 Mb
Release : 2016-07-11
Category : Science
ISBN : 9781118720868

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Open Microfluidics by Jean Berthier,Kenneth A. Brakke,Erwin Berthier Pdf

Open microfluidics or open-surface is becoming fundamental in scientific domains such as biotechnology, biology and space. First, such systems and devices based on open microfluidics make use of capillary forces to move fluids, without any need for external energy. Second, the "openness" of the flow facilitates the accessibility to the liquid in biotechnology and biology, and reduces the weight in space applications. This book has been conceived to give the reader the fundamental basis of open microfluidics. It covers successively The theory of spontaneous capillary flow, with the general conditions for spontaneous capillary flow, and the dynamic aspects of such flows. The formation of capillary filaments which are associated to small contact angles and sharp grooves. The study of capillary flow in open rectangular, pseudo-rectangular and trapezoidal open microchannels. The dynamics of open capillary flows in grooves with a focus on capillary resistors. The case of very viscous liquids is analyzed. An analysis of suspended capillary flows: such flows move in suspended channels devoid of top cover and bottom plate. Their accessibility is reinforced, and such systems are becoming fundamental in biology. An analysis of “rails” microfluidics, which are flows that move in channels devoid of side walls. This geometry has the advantage to be compatible with capillary networks, which are now of great interest in biotechnology, for molecular detection for example. Paper-based microfluidics where liquids wick flat paper matrix. Applications concern bioassays such as point of care devices (POC). Thread-based microfluidics is a new domain of investigation. It is seeing presently many new developments in the domain of separation and filtration, and opens the way to smart bandages and tissue engineering. The book is intended to cover the theoretical aspects of open microfluidics, experimental approaches, and examples of application.

Author : Xiao-Ying Yu
Publisher : BoD – Books on Demand
Page : 424 pages
File Size : 54,7 Mb
Release : 2016-11-23
Category : Science
ISBN : 9789535127857

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Advances in Microfluidics by Xiao-Ying Yu Pdf

Increasing innovations and applications make microfluidics a versatile choice for researchers in many disciplines. This book consists of multiple review chapters that aim to cover recent advances and new applications of microfluidics in biology, electronics, energy, and materials sciences. It provides comprehensive views of various aspects of microfluidics ranging from fundamentals of fabrication, flow control, and droplet manipulation to the most recent exploration in emerging areas such as material synthesis, imaging and novel spectroscopy, and marriage with electronics. The chapters have many illustrations showcasing exciting results. This book should be useful for those who are eager to learn more about microfluidics as well as researchers who want to pick up new concepts and developments in this fast-growing field.

Author : Emmanuel Delamarche,Govind V. Kaigala
Publisher : John Wiley & Sons
Page : 440 pages
File Size : 54,8 Mb
Release : 2018-04-30
Category : Technology & Engineering
ISBN : 9783527340385

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Open-Space Microfluidics by Emmanuel Delamarche,Govind V. Kaigala Pdf

Summarizing the latest trends and the current state of this research field, this up-to-date book discusses in detail techniques to perform localized alterations on surfaces with great flexibility, including microfluidic probes, multifunctional nanopipettes and various surface patterning techniques, such as dip pen nanolithography. These techniques are also put in perspective in terms of applications and how they can be transformative of numerous (bio)chemical processes involving surfaces. The editors are from IBM Zurich, the pioneers and pacesetters in the field at the forefront of research in this new and rapidly expanding area.

Author : Fouad Sabry
Publisher : One Billion Knowledgeable
Page : 477 pages
File Size : 42,9 Mb
Release : 2022-01-16
Category : Technology & Engineering
ISBN : PKEY:6610000334544

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Microfluidics by Fouad Sabry Pdf

What Is Microfluidics Microfluidics refers to the behavior, precise control, and manipulation of fluids that are geometrically constrained to a small scale at which surface forces dominate volumetric forces. It is a multidisciplinary field that involves engineering, physics, chemistry, biochemistry, nanotechnology, and biotechnology. It has practical applications in the design of systems that process low volumes of fluids to achieve multiplexing, automation, and high-throughput screening. Microfluidics emerged in the beginning of the 1980s and is used in the development of inkjet printheads, DNA chips, lab-on-a-chip technology, micro-propulsion, and micro-thermal technologies. How You Will Benefit (I) Insights, and validations about the following topics: Chapter 1: Microfluidics Chapter 2: Droplet-based microfluidics Chapter 3: Digital microfluidics Chapter 4: Paper-based microfluidics Chapter 5: Microfluidic cell culture Chapter 6: Electroosmotic pump Chapter 7: Materials science (II) Answering the public top questions about microfluidics. (III) Real world examples for the usage of microfluidics in many fields. (IV) 17 appendices to explain, briefly, 266 emerging technologies in each industry to have 360-degree full understanding of microfluidics' technologies. Who This Book Is For Professionals, undergraduate and graduate students, enthusiasts, hobbyists, and those who want to go beyond basic knowledge or information for any kind of microfluidics.

Author : P. V. Mohanan
Publisher : Springer Nature
Page : 712 pages
File Size : 48,7 Mb
Release : 2022-07-11
Category : Medical
ISBN : 9789811913792

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Microfluidics and Multi Organs on Chip by P. V. Mohanan Pdf

This book highlights the application of microfluidics in cell biology research, chemical biology, and drug discovery. It covers the recent breakthroughs and prospects of organ-on-a-chip, human-on-a-chip, multi-organ-on-a-chip for personalized medicine. The book presents the preclinical studies of organs-on-a-chip, concepts of multiple vascularized organ-on-chips, application of organ-on-a-chip in blood-brain barrier model, culture and co-culture of cells on multi-organ-on-chip and parameter measurements in microfluidic devices. It underscores the advantage of microfluidic devices for developing efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Further, it entails human-on-a-chip for measuring the systemic response as well as immediate effects of an organ reaction on other organs. In summary, this book reviews the development of a microfluidic-based organ-on-a-chip device for the preclinical evaluation, ADME studies of drugs, chemicals, and medical devices. This book is a valuable source for pharma companies, product developers, students, researchers, academicians, and practitioners.

Author : Shantanu Bhattacharya,Sanjay Kumar,Avinash K Agarwal
Publisher : Springer Nature
Page : 225 pages
File Size : 54,8 Mb
Release : 2019-10-08
Category : Medical
ISBN : 9789811504891

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Paper Microfluidics by Shantanu Bhattacharya,Sanjay Kumar,Avinash K Agarwal Pdf

This volume provides an overview of the recent advances in the field of paper microfluidics, whose innumerable research domains have stimulated considerable efforts to the development of rapid, cost-effective and simplified point-of-care diagnostic systems. The book is divided into three parts viz. theoretical background of paper microfluidics, fabrication techniques for paper-based devices, and broad applications. Each chapter of the book is self-explanatory and focuses on a specific topic and its relation to paper microfluidics and starts with a brief description of the topic’s physical background, essential definitions, and a short story of the recent progress in the relevant field. The book also covers the future outlook, remaining challenges, and emerging opportunities. This book shall be a tremendous up-to-date resource for researchers working in the area globally.

Author : Sibel A. Ozkan,Nurgul K. Bakirhan,Fariba Mollarasouli
Publisher : Academic Press
Page : 615 pages
File Size : 55,9 Mb
Release : 2021-12-05
Category : Medical
ISBN : 9780128230756

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The Detection of Biomarkers by Sibel A. Ozkan,Nurgul K. Bakirhan,Fariba Mollarasouli Pdf

Reliable, precise and accurate detection and analysis of biomarkers remains a significant challenge for clinical researchers. Methods for the detection of biomarkers are rather complex, requiring pre-treatment steps before analysis can take place. Moreover, comparing various biomarker assays and tracing research progress in this area systematically is a challenge for researchers. The Detection of Biomarkers presents developments in biomarker detection, including methods tools and strategies, biosensor design, materials, and applications. The book presents methods, materials and procedures that are simple, precise, sensitive, selective, fast and economical, and therefore highly practical for use in clinical research scenarios. This volume situates biomarker detection in its research context and sets out future prospects for the area. Its 20 chapters offer a comprehensive coverage of biomarkers, including progress on nanotechnology, biosensor types, synthesis, immobilization, and applications in various fields. The book also demonstrates, for students, how to synthesize and immobilize biosensors for biomarker assay. It offers researchers real alternative and innovative ways to think about the field of biomarker detection, increasing the reliability, precision and accuracy of biomarker detection. Locates biomarker detection in its research context, setting out present and future prospects Allows clinical researchers to compare various biomarker assays systematically Presents new methods, materials and procedures that are simple, precise, sensitive, selective, fast and economical Gives innovative biomarker assays that are viable alternatives to current complex methods Helps clinical researchers who need reliable, precise and accurate biomarker detection methods

Author : Anonim
Publisher : Academic Press
Page : 328 pages
File Size : 41,8 Mb
Release : 2022-01-13
Category : Science
ISBN : 9780323989008

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Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications - Part A by Anonim Pdf

Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications, Volume 185, Part A represents the collation of chapters written by eminent scientists worldwide. Chapters in this updated release include An introduction to microfluidics and their applications, Design and fabrication of Micro/Nanofluidics devices and systems, Detection and separation of proteins using Micro/Nanofluidics devices, Micro/Nanofluidics devices for DNA/RNA detection and separation, Paper based microfluidics a forecast towards the most affordable and rapid point-of-care devices, Paper based micro/Nanofluidics devices for biomedical applications, Advances of Microfluidics Devices and their Applications in Personalized Medicine, and much more. Additional chapters cover Microfluidics for single cell analysis, Fluorescence Based Miniaturized Microfluidic and Nanofluidic Systems for Biomedical Applications, Active Matter Dynamics in Confined Microfluidic Environments, Challenges and opportunities in micro/nanofluidics and lab-on-a-chip, and Paper-microfluidic signal-enhanced immunoassays. Offers basic understanding of the state-of-the-art design and fabrication of microfluidics/ nanofluidics and lab-on-chip Explains how to develop microfluidics/nanofluidics for biomedical application such as high throughout biological screening and separation Discusses the applications, challenges and opportunities in biomedical and translational research applications of microfluidics/nanofluidics

Author : Yu Song,Daojian Cheng,Liang Zhao
Publisher : John Wiley & Sons
Page : 576 pages
File Size : 52,5 Mb
Release : 2018-05-07
Category : Science
ISBN : 9783527341061

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Microfluidics by Yu Song,Daojian Cheng,Liang Zhao Pdf

The first book offering a global overview of fundamental microfluidics and the wide range of possible applications, for example, in chemistry, biology, and biomedical science. As such, it summarizes recent progress in microfluidics, including its origin and development, the theoretical fundamentals, and fabrication techniques for microfluidic devices. The book also comprehensively covers the fluid mechanics, physics and chemistry as well as applications in such different fields as detection and synthesis of inorganic and organic materials. A useful reference for non-specialists and a basic guideline for research scientists and technicians already active in this field or intending to work in microfluidics.

Author : Michael R. Hamblin,Mahdi Karimi
Publisher : Academic Press
Page : 352 pages
File Size : 50,8 Mb
Release : 2020-11-12
Category : Technology & Engineering
ISBN : 9780128187920

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Biomedical Applications of Microfluidic Devices by Michael R. Hamblin,Mahdi Karimi Pdf

Biomedical Applications of Microfluidic Devices introduces the subject of microfluidics and covers the basic principles of design and synthesis of actual microchannels. The book then explores how the devices are coupled to signal read-outs and calibrated, including applications of microfluidics in areas such as tissue engineering, organ-on-a-chip devices, pathogen identification, and drug/gene delivery. This book covers high-impact fields (microarrays, organ-on-a-chip, pathogen detection, cancer research, drug delivery systems, gene delivery, and tissue engineering) and shows how microfluidics is playing a key role in these areas, which are big drivers in biomedical engineering research. This book addresses the fundamental concepts and fabrication methods of microfluidic systems for those who want to start working in the area or who want to learn about the latest advances being made. The subjects covered are also an asset to companies working in this field that need to understand the current state-of-the-art. The book is ideal for courses on microfluidics, biosensors, drug targeting, and BioMEMs, and as a reference for PhD students. The book covers the emerging and most promising areas of biomedical applications of microfluidic devices in a single place and offers a vision of the future. Covers basic principles and design of microfluidics devices Explores biomedical applications to areas such as tissue engineering, organ-on-a-chip, pathogen identification, and drug and gene delivery Includes chemical applications in organic and inorganic chemistry Serves as an ideal text for courses on microfluidics, biosensors, drug targeting, and BioMEMs, as well as a reference for PhD students