Microfluidics And Multi Organs On Chip

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Microfluidics and Multi Organs on Chip

P. V. Mohanan

Author : P. V. Mohanan
Publisher : Springer Nature
Page : 712 pages
File Size : 42,5 Mb
Release : 2022-07-11
Category : Medical
ISBN : 9789811913792

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Microfluidics and Multi Organs on Chip by P. V. Mohanan Pdf

This book highlights the application of microfluidics in cell biology research, chemical biology, and drug discovery. It covers the recent breakthroughs and prospects of organ-on-a-chip, human-on-a-chip, multi-organ-on-a-chip for personalized medicine. The book presents the preclinical studies of organs-on-a-chip, concepts of multiple vascularized organ-on-chips, application of organ-on-a-chip in blood-brain barrier model, culture and co-culture of cells on multi-organ-on-chip and parameter measurements in microfluidic devices. It underscores the advantage of microfluidic devices for developing efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Further, it entails human-on-a-chip for measuring the systemic response as well as immediate effects of an organ reaction on other organs. In summary, this book reviews the development of a microfluidic-based organ-on-a-chip device for the preclinical evaluation, ADME studies of drugs, chemicals, and medical devices. This book is a valuable source for pharma companies, product developers, students, researchers, academicians, and practitioners.

Organs-on-chips

Yu-suke Torisawa,Yi-Chung Tung

Author : Yu-suke Torisawa,Yi-Chung Tung
Publisher : MDPI
Page : 262 pages
File Size : 55,7 Mb
Release : 2020-05-27
Category : Technology & Engineering
ISBN : 9783039289172

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Organs-on-chips by Yu-suke Torisawa,Yi-Chung Tung Pdf

Recent advances in microsystems technology and cell culture techniques have led to the development of organ-on-chip microdevices that produce tissue-level functionality, not possible with conventional culture models, by recapitulating natural tissue architecture and microenvironmental cues within microfluidic devices. Since the physiological microenvironments in living systems are mostly microfluidic in nature, the use of microfluidic devices facilitates engineering cellular microenvironments; the microfluidic devices allow for control of local chemical gradients and dynamic mechanical forces, which play important roles in cellular viability and function. The organ-on-chip microdevices have great potential to promote drug discovery and development, to model human physiology and disease, and to replace animal models for efficacy and toxicity testing. Recently, induced pluripotent stem (iPS) cells have been leveraged to develop organs-on-chips, which enable various types of organ models and disease models not possible with primary cells and cell lines. This Special Issue seeks to showcase research papers, short communications, and review articles that focus on: (1) microdevices to mimic or control cellular microenvironment; (2) microdevices to evaluate interactions between different organ models; (3) microdevices to maintain iPS cells or iPSC-derived cells; and (4) sensors and techniques to evaluate drug efficacy or toxicity.

Microfluidics in Cell BiologyPart A: Microfluidics for multicellular systems

Anonim

Author : Anonim
Publisher : Academic Press
Page : 273 pages
File Size : 42,5 Mb
Release : 2018-07-20
Category : Science
ISBN : 9780128142813

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Microfluidics in Cell BiologyPart A: Microfluidics for multicellular systems by Anonim Pdf

Microfluidics in Cell Biology Part A: Volume 146, the latest release in the Methods in Cell Biology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Unique to this updated volume are sections on Cell monolayers/spheroids, Collective migration in microtubes, Leukocyte adhesion dynamics on endothelial monolayers under flow, Constrained spheroid for perfusion culture, Cells in droplet arrays, Heart on chips, Kidney on chips, Liver on chips and hepatic immune responses, Gut on chips, 3D microvascular model-based lymphoma model, Blood brain barrier on chips, Multi-organ-on-a-chip for pharmacokinetic analysis, Cancer immunotherapy on chips, and more. Contains contributions from experts in the field from across the globe Covers a wide array of topics on both mitosis and meiosis Includes relevant, analysis based topics

Principles of Human Organs-on-Chips

Masoud Mozafari

Author : Masoud Mozafari
Publisher : Woodhead Publishing
Page : 492 pages
File Size : 55,8 Mb
Release : 2023-01-17
Category : Medical
ISBN : 9780128236109

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Principles of Human Organs-on-Chips by Masoud Mozafari Pdf

Principles of Human Organs-on-Chips covers all aspects of microfluidic organ-on-a-chip systems, from fabrication to application and commercialization. Organ-on-a-chip models are created to mimic the structural, microenvironmental and physiological functions of human organs, providing the potential to bypass some cell and animal testing methods. This is a useful platform with widespread applications, frequently in drug screening and pathological studies. This book offers a comprehensive and authoritative reference on microfluidic organs-on-chips, spanning all key aspects from fabrication methods, cell culture systems and cell-based analysis, to dedicated chapters on specific tissue types and their associated organ-on-a-chip models, as well as their use as disease models, drug screening platforms and more. Principles of Human Organs-on-Chips helps materials scientists and biomedical engineers to better understand the specific requirements and challenges in the design and fabrication of organ-on-a-chip devices. This book also bridges the knowledge gap between medical device design and subsequent clinical applications, allowing medical professionals to easily learn about related engineering concepts and techniques. Describes various microfluidic systems and fabrication methods Covers models and applications for a broad range of tissue types, including liver, eye, immune, gut, and more Offers an interdisciplinary approach, combining engineering techniques and clinical applications of organs-on-chips

Microfluidics in Cell Biology Part C: Microfluidics for Cellular and Subcellular Analysis

Anonim

Author : Anonim
Publisher : Academic Press
Page : 266 pages
File Size : 46,7 Mb
Release : 2018-11-22
Category : Science
ISBN : 9780128142851

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Microfluidics in Cell Biology Part C: Microfluidics for Cellular and Subcellular Analysis by Anonim Pdf

Microfluidics in Cell Biology Part C, Volume 148, a new release in the Methods in Cell Biology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Unique to this updated volume are three sections on microfluidics in various multi-cellular models, including microfluidics in cell monolayers/spheroids, microfluidics in organ on chips, and microfluidics in model organisms. Specific chapters discuss collective migration in microtubes, leukocyte adhesion dynamics on endothelial monolayers under flow, constrained spheroid for perfusion culture, cells in droplet arrays, heart on chips, kidney on chips, liver on chips, and more. Contains contributions from experts in the field from across the world Covers a wide array of topics on both mitosis and meiosis Includes relevant, analysis based topics

Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications - Part B

Anonim

Author : Anonim
Publisher : Academic Press
Page : 370 pages
File Size : 46,9 Mb
Release : 2022-01-28
Category : Science
ISBN : 9780323853040

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Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications - Part B by Anonim Pdf

Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications - Part B, Volume 187 represents the collation of chapters written by eminent scientists worldwide. Chapters in this new release include Design and fabrication of microfluidics devices for molecular biology applications, Micro/Nanofluidics devices for drug delivery, From organ-on-chip to body-on-chip: the next generation of microfluidics platforms for in vitro drug toxicity testing, Micro/Nanofluidics for high throughput drug screening, Design, fabrication and assembly of lab-on-a-chip and its uses, Advances in microfluidic 3D cell culture for pre-clinical drug development, Tissue and organ culture on lab-on-a chip for biomedical applications, and much more. Offers a basic understanding of the state-of-the-art design and fabrication of microfluidics/ nanofluidics and lab on chip Explains how to develop microfluidics/nanofluidic for advanced application such as healthcare, high throughout drug screening, 3D cell culture and organ-on-chip Discusses the emerging demands and research of micro/nanofluidic based devices in biomedical and translational research applications

Microfluidic Cell Culture Systems

Jeffrey T Borenstein,Vishal Tandon,Sarah L Tao,Joseph L. Charest

Author : Jeffrey T Borenstein,Vishal Tandon,Sarah L Tao,Joseph L. Charest
Publisher : Elsevier
Page : 396 pages
File Size : 51,5 Mb
Release : 2018-09-12
Category : Science
ISBN : 9780128136720

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Microfluidic Cell Culture Systems by Jeffrey T Borenstein,Vishal Tandon,Sarah L Tao,Joseph L. Charest Pdf

Techniques for microfabricating intricate microfluidic structures that mimic the microenvironment of tissues and organs, combined with the development of biomaterials with carefully engineered surface properties, have enabled new paradigms in and cell culture-based models for human diseases. The dimensions of surface features and fluidic channels made accessible by these techniques are well-suited to the size scale of biological cells. Microfluidic Cell Culture Systems applies design and experimental techniques used in in microfluidics, and cell culture technologies to organ-on-chip systems. This book is intended to serve as a professional reference, providing a practical guide to design and fabrication of microfluidic systems and biomaterials for use in cell culture systems and human organ models. The book covers topics ranging from academic first principles of microfluidic design, to clinical translation strategies for cell culture protocols. The goal is to help professionals coming from an engineering background to adapt their expertise for use in cell culture and organ models applications, and likewise to help biologists to design and employ microfluidic technologies in their cell culture systems. This 2nd edition contains new material that strengthens the focus on in vitro models useful for drug discovery and development. One new chapter reviews liver organ models from an industry perspective, while others cover new technologies for scaling these models and for multi-organ systems. Other new chapters highlight the development of organ models and systems for specific applications in disease modeling and drug safety. Previous chapters have been revised to reflect the latest advances. Provides design and operation methodology for microfluidic and microfabricated materials and devices for organ-on-chip disease and safety models. This is a rapidly expanding field that will continue to grow along with advances in cell biology and microfluidics technologies. Comprehensively covers strategies and techniques ranging from academic first principles to industrial scale-up approaches. Readers will gain insight into cell-material interactions, microfluidic flow, and design principles. Offers three fundamental types of information: 1) design principles, 2) operation techniques, and 3) background information/perspectives. The book is carefully designed to strike a balance between these three areas, so it will be of use to a broad range of readers with different technical interests and educational levels.

Lab-on-a-Chip Fabrication and Application

Margarita Stoytcheva,Roumen Zlatev

Author : Margarita Stoytcheva,Roumen Zlatev
Publisher : BoD – Books on Demand
Page : 210 pages
File Size : 52,6 Mb
Release : 2016-06-29
Category : Science
ISBN : 9789535124573

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Lab-on-a-Chip Fabrication and Application by Margarita Stoytcheva,Roumen Zlatev Pdf

The necessity of on-site, fast, sensitive, and cheap complex laboratory analysis, associated with the advances in the microfabrication technologies and the microfluidics, made it possible for the creation of the innovative device lab-on-a-chip (LOC), by which we would be able to scale a single or multiple laboratory processes down to a chip format. The present book is dedicated to the LOC devices from two points of view: LOC fabrication and LOC application.

Human Organs-on-a-Chip

Javier Ramón-Azcón,Artur Rydosz

Author : Javier Ramón-Azcón,Artur Rydosz
Publisher : Elsevier
Page : 380 pages
File Size : 40,6 Mb
Release : 2023-11-15
Category : Science
ISBN : 9780443153853

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Human Organs-on-a-Chip by Javier Ramón-Azcón,Artur Rydosz Pdf

Human Organs-on-Chip: Novel Organ-on-a-Chip Techniques in Medicine paves the way for novel approaches that push forward in-vitro and in-vivo studies and fills a gap between laboratory and clinical use. These experienced authors share the knowledge they’ve developed with over a decade of experience and research with organ-on-chips and multi-organ-on-chips. This book collects all of the developments in the field and sheds new light on possibilities to develop human on-chip measurement methods with the utilization of currently available measurement techniques including both invasive and non-invasive tests. Human Organs-on-Chip: Novel Organ-on-a-Chip Techniques in Medicine serves as a starting point for young researchers who are beginning their scientific journeys. Provides an overview of the progress suborgan-on-chips development has made in recent years Introduces the fundamentals needed to understand lab-on-chip ideas with references and in-depth explanations Presents commercial achievements obtained and future perspectives

Microfluidics and Lab-on-a-Chip

Andreas Manz,Giuseppina Simone,Jonathan S. O'Connor,Pavel Neuzil

Author : Andreas Manz,Giuseppina Simone,Jonathan S. O'Connor,Pavel Neuzil
Publisher : Royal Society of Chemistry
Page : 307 pages
File Size : 40,6 Mb
Release : 2020-09-24
Category : Science
ISBN : 9781782628330

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Microfluidics and Lab-on-a-Chip by Andreas Manz,Giuseppina Simone,Jonathan S. O'Connor,Pavel Neuzil Pdf

Responding to the need for an affordable, easy-to-read textbook that introduces microfluidics to undergraduate and postgraduate students, this concise book will provide a broad overview of the important theoretical and practical aspects of microfluidics and lab-on-a-chip, as well as its applications.

Biomedical Applications of Microfluidic Devices

Michael R. Hamblin,Mahdi Karimi

Author : Michael R. Hamblin,Mahdi Karimi
Publisher : Academic Press
Page : 352 pages
File Size : 55,8 Mb
Release : 2020-11-12
Category : Technology & Engineering
ISBN : 9780128187920

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Biomedical Applications of Microfluidic Devices by Michael R. Hamblin,Mahdi Karimi Pdf

Biomedical Applications of Microfluidic Devices introduces the subject of microfluidics and covers the basic principles of design and synthesis of actual microchannels. The book then explores how the devices are coupled to signal read-outs and calibrated, including applications of microfluidics in areas such as tissue engineering, organ-on-a-chip devices, pathogen identification, and drug/gene delivery. This book covers high-impact fields (microarrays, organ-on-a-chip, pathogen detection, cancer research, drug delivery systems, gene delivery, and tissue engineering) and shows how microfluidics is playing a key role in these areas, which are big drivers in biomedical engineering research. This book addresses the fundamental concepts and fabrication methods of microfluidic systems for those who want to start working in the area or who want to learn about the latest advances being made. The subjects covered are also an asset to companies working in this field that need to understand the current state-of-the-art. The book is ideal for courses on microfluidics, biosensors, drug targeting, and BioMEMs, and as a reference for PhD students. The book covers the emerging and most promising areas of biomedical applications of microfluidic devices in a single place and offers a vision of the future. Covers basic principles and design of microfluidics devices Explores biomedical applications to areas such as tissue engineering, organ-on-a-chip, pathogen identification, and drug and gene delivery Includes chemical applications in organic and inorganic chemistry Serves as an ideal text for courses on microfluidics, biosensors, drug targeting, and BioMEMs, as well as a reference for PhD students

Human Organs-on-a-Chip Technology

P.V. Mohanan

Author : P.V. Mohanan
Publisher : Elsevier
Page : 632 pages
File Size : 52,9 Mb
Release : 2024-06-28
Category : Science
ISBN : 9780443137839

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Human Organs-on-a-Chip Technology by P.V. Mohanan Pdf

Human Organs-on-a-Chip Technology focuses on the technology advancement from “organ-on-a-chip to “multi organs-on-a-chip to the newest stage of “human organs-on-a-chip. Chapters investigate the design, simulation studies, device development and application of microfluidic systems. They also offer expert perspectives on the development of an alternative test system in the biological evaluation of drugs, cosmetics, chemicals, medical devices and many others. Lastly, the book addresses issues related to the development of microfluidic devices and alternative test systems in biological and biomedical research. Explores organs-on-a-chip technology, from the basics, to advanced developments and existing challenges and recent research trends and applications Reviews every aspect of microfluidic devices, including biological evaluation and targeted delivery Includes the latest information on regulatory updates

Biomaterials- and Microfluidics-Based Tissue Engineered 3D Models

J. Miguel Oliveira,Rui L. Reis

Author : J. Miguel Oliveira,Rui L. Reis
Publisher : Springer Nature
Page : 176 pages
File Size : 45,5 Mb
Release : 2020-04-13
Category : Medical
ISBN : 9783030365882

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Biomaterials- and Microfluidics-Based Tissue Engineered 3D Models by J. Miguel Oliveira,Rui L. Reis Pdf

This contributed volume reviews the latest advances on relevant 3D tissue engineered in vitro models of disease making use of biomaterials and microfluidics. The main focus of this book is on advanced biomaterials and microfluidics technologies that have been used in in vitro mimetic 3D models of human diseases and show great promise in revolutionizing personalized medicine. Readers will discover important topics involving biomaterials and microfluidics design, advanced processing techniques, and development and validation of organ- and body-on-a-chip models for bone, liver, and cancer research. An in depth discussion of microfabrication methods for microfluidics development is also provided. This work is edited by two truly multidisciplinary scientists and includes important contributions from well-known experts in their fields. The work is written for both early stage and experienced researchers, and well-established scientists enrolled in the fields of biomaterials, microfluidics, and tissue engineering, and is especially suited to those who wish to become acquainted with the principles and latest developments of in vitro models of diseases, such as professionals working in pharma, medicine, and engineering.

Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip

Xiujun (James) Li,Chaoyong Yang,Paul C. H. Li

Author : Xiujun (James) Li,Chaoyong Yang,Paul C. H. Li
Publisher : Newnes
Page : 486 pages
File Size : 48,9 Mb
Release : 2021-09-19
Category : Science
ISBN : 9780444594617

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Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip by Xiujun (James) Li,Chaoyong Yang,Paul C. H. Li Pdf

Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip: Principles and Applications provides chemists, biophysicists, engineers, life scientists, biotechnologists, and pharmaceutical scientists with the principles behind the design, manufacture, and testing of life sciences microfluidic systems. This book serves as a reference for technologies and applications in multidisciplinary areas, with an emphasis on quickly developing or new emerging areas, including digital microfluidics, nanofluidics, papers-based microfluidics, and cell biology. The book offers practical guidance on how to design, analyze, fabricate, and test microfluidic devices and systems for a wide variety of applications including separations, disease detection, cellular analysis, DNA analysis, proteomics, and drug delivery. Calculations, solved problems, data tables, and design rules are provided to help researchers understand microfluidic basic theory and principles and apply this knowledge to their own unique designs. Recent advances in microfluidics and microsystems for life sciences are impacting chemistry, biophysics, molecular, cell biology, and medicine for applications that include DNA analysis, drug discovery, disease research, and biofluid and environmental monitoring. Provides calculations, solved problems, data tables and design rules to help understand microfluidic basic theory and principles Gives an applied understanding of the principles behind the design, manufacture, and testing of microfluidic systems Emphasizes on quickly developing and emerging areas, including digital microfluidics, nanofluidics, papers-based microfluidics, and cell biology

Microfluidic Technologies for Human Health

Utkan Demirci,Robert Langer,Ali Khademhosseini,Jeffrey Blander

Author : Utkan Demirci,Robert Langer,Ali Khademhosseini,Jeffrey Blander
Publisher : World Scientific
Page : 495 pages
File Size : 51,7 Mb
Release : 2012
Category : Medical
ISBN : 9789814405515

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Microfluidic Technologies for Human Health by Utkan Demirci,Robert Langer,Ali Khademhosseini,Jeffrey Blander Pdf

Ch. 1. A microscale bioinspired cochlear-like sensor / Robert D. White, Robert Littrell, and Karl Grosh -- ch. 2. Systematic evaluation of the efficiencies of proteins and chemicals in pharmaceutical applications / Morgan Hamon and Jong Wook Hong -- ch. 3. Microfluidic glucose sensors / Jithesh V. Veetil [und weitere] -- ch. 4. Applications of microfabrication and microfluidic techniques in mesenchymal stem cell research / Abhijit Majumder [und weitere] -- ch. 5. Patient-specific modeling of low-density lipoprotein transport in coronary arteries / Ufuk Olgac -- ch. 6. Point-of-care microdevices for global health diagnostics of infectious diseases / Sau Yin Chin [und weitere] -- ch. 7. Integrated microfluidic sample preparation for chip-based molecular diagnostics / Jane Y. Zhang [und weitere] -- ch. 8. Microfluidic devices for cellular proteomic studies / Yihong Zhan and Chang Lu -- ch. 9. Microfluidics for neuroscience: novel tools and future implications / Vivian M. Hernandez and P. Hande Ozdinler -- ch. 10. Microfluidics: on-chip platforms as in vitro disease models / Shan Gao, Erkin Seker, and Martin L. Yarmush -- ch. 11. Application of microfluidics in stem cell and tissue engineering / Sasha H. Bakhru, Christopher Highley, and Stefan Zappe -- ch. 12. Microfluidic "on-the-fly" fabrication of microstructures for biomedical applications / Edward Kang, Sau Fung Wong, and Sang-Hoon Lee -- ch. 13. Microfluidics as a promising tool toward distributed viral detection / Elodie Sollier and Dino Di Carlo -- ch. 14. Electrophoresis and dielectrophoresis for lab-on-a-chip (LOC) analyses / Yagmur Demircan, Gurkan Yilmaz, and Haluk Kulah -- ch. 15. Ultrasonic embossing of carbon nanotubes for the fabrication of polymer microfluidic chips for DNA sample purification / Puttachat Khuntontong, Min Gong, and Zhiping Wang -- ch. 16. Ferrofluidics / A. Rezzan Kose and Hur Koser -- ch. 17. Antibody-based blood bioparticle capture and separation using microfluidics for global health / ZhengYuan Luo [und weitere] -- ch. 18. Applications of quantum dots for fluorescence imaging in biomedical research / ShuQi Wang [und weitere]

Microfluidics And Multi Organs On Chip

Microfluidics and Multi Organs on Chip by P. V. Mohanan Pdf

Organs-on-chips by Yu-suke Torisawa,Yi-Chung Tung Pdf

Microfluidics in Cell BiologyPart A: Microfluidics for multicellular systems by Anonim Pdf

Principles of Human Organs-on-Chips by Masoud Mozafari Pdf

Microfluidics in Cell Biology Part C: Microfluidics for Cellular and Subcellular Analysis by Anonim Pdf

Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications - Part B by Anonim Pdf

Microfluidic Cell Culture Systems by Jeffrey T Borenstein,Vishal Tandon,Sarah L Tao,Joseph L. Charest Pdf

Lab-on-a-Chip Fabrication and Application by Margarita Stoytcheva,Roumen Zlatev Pdf

Human Organs-on-a-Chip by Javier Ramón-Azcón,Artur Rydosz Pdf

Microfluidics and Lab-on-a-Chip by Andreas Manz,Giuseppina Simone,Jonathan S. O'Connor,Pavel Neuzil Pdf

Biomedical Applications of Microfluidic Devices by Michael R. Hamblin,Mahdi Karimi Pdf

Human Organs-on-a-Chip Technology by P.V. Mohanan Pdf

Biomaterials- and Microfluidics-Based Tissue Engineered 3D Models by J. Miguel Oliveira,Rui L. Reis Pdf

Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip by Xiujun (James) Li,Chaoyong Yang,Paul C. H. Li Pdf

Microfluidic Technologies for Human Health by Utkan Demirci,Robert Langer,Ali Khademhosseini,Jeffrey Blander Pdf

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