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Thoroughly revised and updates, this new edition of Ophthalmic Toxicology retains its uniqueness in covering all aspects of ophthalmic toxicology. With chapters from leading authorities incorporating the latest developments in the field, including a new chapter on the molecular basis of ophthalmic toxicity, this edition covers such topics as: *t
International Society of Ocular Toxicology. Congress
Author : International Society of Ocular Toxicology. Congress Publisher : New York : Dekker Page : 440 pages File Size : 50,9 Mb Release : 1990 Category : Medical ISBN : UOM:39015017962260
Assessing Ocular Toxicology in Laboratory Animals by Andrea B Weir,Margaret Collins Pdf
Ocular toxicity is routinely assessed in toxicology studies conducted for regulatory purposes. Ocular anatomy and physiology and the assessment of ocular toxicity itself can be challenging to scientists involved in the safety assessment of pharmaceuticals, pesticides and other agents. Anatomical and physiological differences between species can impact the nature of ocular effects observed following intended or unintended exposure of ocular tissues to xenobiotics. Ocular Toxicity in Laboratory Animals provides a concise reference addressing ocular anatomy and physiology across species that will enhance the design and interpretation of toxicology studies conducted for regulatory purposes. The book provides an overview of routine and advanced techniques that are used to assess ocular toxicity including slit lamp biomicroscopy, indirect ophthalmoscopy, electrophysiology and imaging methods for the anterior and posterior segments of the eye. Additionally, the book defines the regulatory expectations for pharmaceuticals intended to treat ocular diseases and for other non-pharmaceutical regulated chemicals. With contributions from experts in the field, Ocular Toxicity in Laboratory Animals is an authoritative, accessible guide for toxicologists and other scientists involved in conducting toxicology studies for regulatory purposes and/or reviewing data from such studies.
Keith Green,Henry F. Edelhauser,David S. Hull,David E. Potter,Ramesh C. Tripathi
Author : Keith Green,Henry F. Edelhauser,David S. Hull,David E. Potter,Ramesh C. Tripathi Publisher : Springer Science & Business Media Page : 282 pages File Size : 51,5 Mb Release : 2012-12-06 Category : Medical ISBN : 9781461559375
Advances in Ocular Toxicology by Keith Green,Henry F. Edelhauser,David S. Hull,David E. Potter,Ramesh C. Tripathi Pdf
This volume represents the proceedings of the Fifth Congress of the International Society of Ocular Toxicology (ISOT), which was held at the Grove Park Inn and Resort in Asheville, North Carolina, October 13-17, 1996. We are delighted to present this volume to the ophthalmic community, especially those with a significant interest in ocular toxicol ogy. The Fifth Congress was developed around themes relating to ocular drug metabolism, the ocular pathophysiological effects of nitric oxide, government issues relating to the use of alternative methods for toxicity testing, and a workshop that encompassed comparisons of both in vitro versus in vivo models as well as different animal models. The outcome of this congress, embodied in this volume, is a contribution to the methodologies currently employed or under development and to various drug or physical effects on different ocular tissues. While the focus of this proceedings is on ocular effects of drugs or other materials, many of the contributions deal with topics that have a much broader interest. The workshop concerning the use of different model systems and the choice of the best animal model for drug testing covers a wide range of interests that ex tends far beyond specific ocular effects. This is especially true in the area of alternative methods and in the choice of the best animal model for examination of different disease entities.
Ocular Toxicology by Keith Green,O. Hockwin,Ramesh C. Tripathi,I. Weisse Pdf
On behalf of the editorial board and the organizing committee of the 4th congress of the International Society of Ocular Toxicology (I SOT), held in AnnecyNeyrier du Lac, France, October 9 -13, 1994, we are pleased to present to the ocular toxicology community this indexed volume of our congress proceedings. The 4th congress was designed primarily to facilitate and update the knowledge in ocular electrophysiology and ocular pharmacokinetics, in both the clinical and preclinical aspects. The outcome of this 4th congress, established in this volume, is a useful contribution to the meth odology in both fields and will hopefully assist in the evaluation and interpretation of ocular findings recorded in animal studies on drugs and other chemicals, in order to protect human health. Undoubtedly, work on the mechanisms of ocular toxicology in the process of pharmaceutical development must continue and these proceedings, embodying the presented papers, will add to the data base. The editors, the congress organizing committee and the members of the International Society of Ocular Toxicology thank the speakers who gave their time, knowledge, and expertise to assist us in this project. The following manuscripts contain the main substance of each of the platform presentations and, in some cases, much more. Moreover, our thanks go to all the participants coming from a range of background- regulatory, academic and industrial -for their attention and excellent contributions during the discussion.
Author : Brian C. Gilger,Cynthia S. Cook,Michael H. Brown Publisher : Springer Page : 212 pages File Size : 43,6 Mb Release : 2018-08-31 Category : Medical ISBN : 9783319783642
Standards for Ocular Toxicology and Inflammation by Brian C. Gilger,Cynthia S. Cook,Michael H. Brown Pdf
This book is an international effort to standardize the language, terms, and methods used in ocular toxicology.With over 300 color illustrations this consensus volume provides standards and harmonization for procedures, terminology, and scoring schemes for ocular toxicology. it is essential for industry, pharmaceutical companies, and governmental agencies to help improve the drug development process and to reduce and refine the use of animals in research. Standards for Ocular Toxicology and Inflammation is endorsed by the American College of Veterinary Ophthalmologists.
TOXICOLOGY OF THE EYE by W. Morton Grant,Joel S. Schuman Pdf
The purpose of this book is to present a synopsis of what is known about substances that have toxic properties injurious to the eyes, disturbing to vision, or affecting eyes in other unwanted ways. The coverage is truly comprehensive, encompassing local and systemic, acute and chronic, human and veterinary toxicology of the eye. The text summarizes mechanisms of injury, treatments, and other relevant knowledge for more than 3000 alphabetized substances - essentially all those on which public information is available. Also described are systemic side effects of ophthalmologic drugs, treatment of chemical burns of the eyes, and testing methods and species specificity for toxic effects on the eyes. Facilitating access to this prodigious amount of information is a large index that cross-references substances and effects, including numerous synonyms. This monumental work is a truly definitive text and a highly useful reference book that should be available to every ophthalmologist, emergency room, and medical library.
Author : Frederick T. Fraunfelder,Frederick W. Fraunfelder Publisher : Elsevier Health Sciences Page : 597 pages File Size : 49,6 Mb Release : 2020-06-21 Category : Medical ISBN : 9780323674010
Drug-Induced Ocular Side Effects: Clinical Ocular Toxicology by Frederick T. Fraunfelder,Frederick W. Fraunfelder Pdf
Written by global experts in the field of chemical- and drug-related ocular problems, Drug-Induced Ocular Side Effects, 8th Edition, provides need-to-know information on all aspects of ocular toxicology in one concise reference. This best-selling, user-friendly resource features a templated format, numerous full-color illustrations, and sweeping content updates throughout – all designed to eliminate uncertainty and ensure accurate diagnosis and treatment guidance. Provides comprehensive coverage of drugs’ generic and trade names, primary uses, ocular and systemic side effects, and clinical significance. Features a unique side effect index, a new concise paperback format for portability, and clinical photos of ocular symptoms of adverse drug reactions. Covers dozens of new drugs used in the U.S. and internationally, as well as extensive updates to drug registry information to ensure access to the latest data. Includes expanded sections on how to follow patients with visual adverse drug reactions to chloroquine, hydroxychloroquine, isotretinoin, ethambutol, and more. Guidelines can be copied to use as patient handouts. Offers extensive discussions of principles of therapy, ocular drug delivery, methods to evaluate drug-induced visual side effects, and the role of electrophysiology and psychophysics. Provides the WHO classification system to help you determine whether a particular side effect is certain, probable, or likely to occur. Ideal for ophthalmologists, optometrists, and busy clinicians in primary care, emergency medicine, and more – anyone who needs quick, on-the-spot consultation on ocular toxicology.
Dermal and Ocular Toxicology by David W. Hobson Pdf
Dermal and Ocular Toxicology: Fundamentals and Methods is a procedurally-oriented volume of detailed methods and practical examples discussing the dermal and ocular aspects of toxicology. The book is divided into a dermal section and an ocular section. Each section begins with a chapter on the anatomy and physiology of each organ system and then progresses to more specialized chapters discussing such topics as the toxicological pathology of each system, state-of-the-art in vitro and in vivo evaluatory procedures, statistical considerations for test design and data interpretation, and the utilization of test findings. Test methods are provided for acute dermal exposure effects, dermal hypersensitivity and photoallergy assessment, dermal and ocular 0.pharmacokinetics, skin flap and skin grafting techniques, and in vitro alternative methods. This book can be used as an instructional text or as a sourcebook for practicing toxicologists, pharmacologists, industrial hygienists, occupational health professionals, and graduate students.
Frederick T. Fraunfelder,Frederick W. Fraunfelder,Wiley A. Chambers
Author : Frederick T. Fraunfelder,Frederick W. Fraunfelder,Wiley A. Chambers Publisher : Elsevier Health Sciences Page : 425 pages File Size : 55,8 Mb Release : 2014-09-19 Category : Medical ISBN : 9780323319850
Drug-Induced Ocular Side Effects: Clinical Ocular Toxicology E-Book by Frederick T. Fraunfelder,Frederick W. Fraunfelder,Wiley A. Chambers Pdf
Ideal for ophthalmologists, optometrists and busy clinicians, Drug-Induced Ocular Side Effects provides the clinically relevant information you need to diagnose and manage chemical and drug-related ocular problems. An easily accessible format, meticulous revisions and comprehensive coverage of all drugs’ generic and trade names, primary uses, ocular and systemic side effects, and clinical significance make this best-selling resource the ideal reference for quick, on-the-spot consultation. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Manage any challenge in ocular toxicology with extensive coverage of principles of therapy; ocular drug delivery; methods to evaluate drug-induced visual side effects; and the role of electrophysiology and psychophysics. Benefit from the masterful guidance and global perspective of world authorities in the field who provide need-to-know information on all aspects of ocular toxicology—all in one concise reference. Confer with the WHO classification system to determine whether a particular side effect is certain, probable, or likely to occur. Zero in on the key information you need to know with highly templated, concise chapters. Apply the latest knowledge and treatments for newly recognized Adverse Drug Reactions (ADR). Identify which ADR’s are clinically relevant and what to do about them. Experience clinical scenarios with vivid clarity through a wealth of new and updated clinical photographs that provide unmatched, visual diagnostic guidance. Recognize and avoid drug-induced ocular side effects with data from the National Registry of Drug Induced Ocular Side-Effects (Casey Eye Institute, Portland, OR) and the World Health Organization (Uppsala, Sweden). Stay up to date and provide state-of-the-art care with the latest information on approved medications. Access the complete contents online at Expert Consult.
Frederick T. Fraunfelder,Frederick W. Fraunfelder,Wiley A. Chambers
Author : Frederick T. Fraunfelder,Frederick W. Fraunfelder,Wiley A. Chambers Publisher : Saunders Page : 370 pages File Size : 53,7 Mb Release : 2008 Category : Medical ISBN : 1416046739
Clinical Ocular Toxicology by Frederick T. Fraunfelder,Frederick W. Fraunfelder,Wiley A. Chambers Pdf
Written by international authorities in ocular toxicology, including the Founder of The National Registry of Drug-Induced Side Effects and its current Director, this essential resource provides the clinically relevant information you need to effectively diagnose and manage herbal, chemical, and drug-related ocular problems. Comprehensive coverage of all drugs' generic and trade drug names, primary uses, ocular and systemic side effects, and clinical significance make this book - like its best-selling predecessor, Drug-Induced Ocular Side Effects - the ideal reference for quick, on-the-spot consultation. Leaders in the field provide need-to-know information on all aspects of ocular toxicology-all in one concise reference. Data from the National Registry of Drug Induced Ocular Side-Effects (Casey Eye Institute, Portland, OR) and the World Health Organization (Uppsala, Sweden) help you recognize and avoid drug-induced ocular side effects. A highly templated format makes retrieval of essential knowledge quick and easy. A wealth of full-color photographs provide vivid, visual diagnostic guidance. The latest information on approved medications helps you stay up to date and provide state-of-the-art care. Extensive coverage of principles of therapy, ocular drug delivery, methods to evaluate drug-induced visual side effects, and the role of electrophysiology and psychophysics gives you the knowledge you need to manage any challenge in ocular toxicology Authoritative guidance on ocular drugs and their use in pregnancy helps you safely manage the unique needs of these patients. The inclusion of the WHO classification system helps you determine whether a particular side effect is certain, probable, or likely to occur.
Ocular Pharmacology and Toxicology by Brian C. Gilger Pdf
"Covering ocular pharmacokinetics, pharmacodynamics, and toxicology, Ocular Pharmacology and Toxicology provides ophthalmologists, toxicologists, and pharmacologists with both an introduction to the proper methods for ocular pharmacology and toxicology as well as providing practical methodologies for conducting ocular studies. Expert authors have contributed detailed chapters on study design, analysis, and routes to regulatory approval for various types and routes of ophthalmic drugs. As a volume in the Methods in Pharmacology and Toxicology series, chapters feature the kind of in-depth specifics and implementation advice to ensure successful results. Practical and authoritative, Ocular Pharmacology and Toxicology serves as an ideal basis of training in the proper design and conduct of essential studies to accurately determine pharmacokinetics and ocular toxicity from the systemic, topical, periocular, or intraocular administration of drugs or compounds, from the use of ocular medical devices and from ocular surgical procedures."--Publisher's description.
Thoroughly revised and updates, this new edition of Ophthalmic Toxicology retains its uniqueness in covering all aspects of ophthalmic toxicology. With chapters from leading authorities incorporating the latest developments in the field, including a new chapter on the molecular basis of ophthalmic toxicity, this edition covers such topics as: *t
Thoroughly revised and updates, this new edition of Ophthalmic Toxicology retains its uniqueness in covering all aspects of ophthalmic toxicology. With chapters from leading authorities incorporating the latest developments in the field, including a new chapter on the molecular basis of ophthalmic toxicity, this edition covers such topics as: *the history of ophthalmic toxicology *specific actions/affinities of ophthalmic poisons to various eye tissues and to animal species *research methods in vivo and in vitro *ophthalmic toxicities of representative chemicals via systemic and/or local delivery *medical treatment of chemical ocular injuries This one-of-a-kind reference on ophthalmic toxicology will be invaluable to all professionals in academia, industry, clinics, research laboratories, and government agencies.
Author : Walter Morton Grant Publisher : Charles C. Thomas Publisher Page : 1230 pages File Size : 54,6 Mb Release : 1974 Category : Medical ISBN : UOM:39015015091526
