Assessing Ocular Toxicology In Laboratory Animals

Author : Andrea B Weir,Margaret Collins
Publisher : Springer Science & Business Media
Page : 327 pages
File Size : 45,5 Mb
Release : 2012-12-04
Category : Medical
ISBN : 9781627031646

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Assessing Ocular Toxicology in Laboratory Animals by Andrea B Weir,Margaret Collins Pdf

Ocular toxicity is routinely assessed in toxicology studies conducted for regulatory purposes. Ocular anatomy and physiology and the assessment of ocular toxicity itself can be challenging to scientists involved in the safety assessment of pharmaceuticals, pesticides and other agents. Anatomical and physiological differences between species can impact the nature of ocular effects observed following intended or unintended exposure of ocular tissues to xenobiotics. Ocular Toxicity in Laboratory Animals provides a concise reference addressing ocular anatomy and physiology across species that will enhance the design and interpretation of toxicology studies conducted for regulatory purposes. The book provides an overview of routine and advanced techniques that are used to assess ocular toxicity including slit lamp biomicroscopy, indirect ophthalmoscopy, electrophysiology and imaging methods for the anterior and posterior segments of the eye. Additionally, the book defines the regulatory expectations for pharmaceuticals intended to treat ocular diseases and for other non-pharmaceutical regulated chemicals. With contributions from experts in the field, Ocular Toxicity in Laboratory Animals is an authoritative, accessible guide for toxicologists and other scientists involved in conducting toxicology studies for regulatory purposes and/or reviewing data from such studies.

Author : Brian C. Gilger,Cynthia S. Cook,Michael H. Brown
Publisher : Springer
Page : 212 pages
File Size : 49,5 Mb
Release : 2018-08-31
Category : Medical
ISBN : 9783319783642

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Standards for Ocular Toxicology and Inflammation by Brian C. Gilger,Cynthia S. Cook,Michael H. Brown Pdf

This book is an international effort to standardize the language, terms, and methods used in ocular toxicology.With over 300 color illustrations this consensus volume provides standards and harmonization for procedures, terminology, and scoring schemes for ocular toxicology. it is essential for industry, pharmaceutical companies, and governmental agencies to help improve the drug development process and to reduce and refine the use of animals in research. Standards for Ocular Toxicology and Inflammation is endorsed by the American College of Veterinary Ophthalmologists.

Author : Chirukandath Gopinath,Vasanthi Mowat
Publisher : Springer
Page : 291 pages
File Size : 49,8 Mb
Release : 2014-05-13
Category : Medical
ISBN : 9781627039987

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Atlas of Toxicological Pathology by Chirukandath Gopinath,Vasanthi Mowat Pdf

This atlas contains more than 700 illustrations that the authors have collected over the years as well as references and information pertaining to recently developed drug classes, including biologics. It is a useful bench reference for practicing pathologists and may also be used as a reference text by other experts from related fields. The atlas is organised into different chapters based on systemic pathology. Each chapter has illustrations with legends, and the atlas includes some rare examples of unique lesions found during toxicity studies over many years.

Author : G. C. Y. Chiou
Publisher : CRC Press
Page : 379 pages
File Size : 54,6 Mb
Release : 1999-07-01
Category : Medical
ISBN : 9781439809983

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Ophthalmic Toxicology by G. C. Y. Chiou Pdf

Thoroughly revised and updates, this new edition of Ophthalmic Toxicology retains its uniqueness in covering all aspects of ophthalmic toxicology. With chapters from leading authorities incorporating the latest developments in the field, including a new chapter on the molecular basis of ophthalmic toxicity, this edition covers such topics as: *t

Author : National Research Council (U.S.). Committee for the Revision of NAS publication 1138, Principles and Procedures for Evaluating the Toxicity of Household Substances,National Research Council (U.S.). Committee on Toxicology
Publisher : Unknown
Page : 148 pages
File Size : 50,9 Mb
Release : 1977
Category : Medical
ISBN : NAP:13840

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Principles and Procedures for Evaluating the Toxicity of Household Substances by National Research Council (U.S.). Committee for the Revision of NAS publication 1138, Principles and Procedures for Evaluating the Toxicity of Household Substances,National Research Council (U.S.). Committee on Toxicology Pdf

Author : OECD
Publisher : OECD Publishing
Page : 39 pages
File Size : 42,5 Mb
Release : 2002-05-10
Category : Electronic
ISBN : 9789264078376

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OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Guidance Document on the Recognition, Assessment and Use of Clinical Signs as Human Endpoints for Experimental Animals Used in Safety Evaluation by OECD Pdf

The purpose of this Guidance Document is to apply the principles of the Three Rs to the use of animals in regulatory toxicity tests.

Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee for the Update of the Guide for the Care and Use of Laboratory Animals
Publisher : National Academies Press
Page : 246 pages
File Size : 53,5 Mb
Release : 2011-01-27
Category : Science
ISBN : 9780309154000

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Guide for the Care and Use of Laboratory Animals by National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee for the Update of the Guide for the Care and Use of Laboratory Animals Pdf

A respected resource for decades, the Guide for the Care and Use of Laboratory Animals has been updated by a committee of experts, taking into consideration input from the scientific and laboratory animal communities and the public at large. The Guide incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. It is organized around major components of animal use: Key concepts of animal care and use. The Guide sets the framework for the humane care and use of laboratory animals. Animal care and use program. The Guide discusses the concept of a broad Program of Animal Care and Use, including roles and responsibilities of the Institutional Official, Attending Veterinarian and the Institutional Animal Care and Use Committee. Animal environment, husbandry, and management. A chapter on this topic is now divided into sections on terrestrial and aquatic animals and provides recommendations for housing and environment, husbandry, behavioral and population management, and more. Veterinary care. The Guide discusses veterinary care and the responsibilities of the Attending Veterinarian. It includes recommendations on animal procurement and transportation, preventive medicine (including animal biosecurity), and clinical care and management. The Guide addresses distress and pain recognition and relief, and issues surrounding euthanasia. Physical plant. The Guide identifies design issues, providing construction guidelines for functional areas; considerations such as drainage, vibration and noise control, and environmental monitoring; and specialized facilities for animal housing and research needs. The Guide for the Care and Use of Laboratory Animals provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates.

Author : Keith Green,O. Hockwin,Ramesh C. Tripathi,I. Weisse
Publisher : Springer Science & Business Media
Page : 365 pages
File Size : 44,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461518877

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Ocular Toxicology by Keith Green,O. Hockwin,Ramesh C. Tripathi,I. Weisse Pdf

On behalf of the editorial board and the organizing committee of the 4th congress of the International Society of Ocular Toxicology (I SOT), held in AnnecyNeyrier du Lac, France, October 9 -13, 1994, we are pleased to present to the ocular toxicology community this indexed volume of our congress proceedings. The 4th congress was designed primarily to facilitate and update the knowledge in ocular electrophysiology and ocular pharmacokinetics, in both the clinical and preclinical aspects. The outcome of this 4th congress, established in this volume, is a useful contribution to the meth odology in both fields and will hopefully assist in the evaluation and interpretation of ocular findings recorded in animal studies on drugs and other chemicals, in order to protect human health. Undoubtedly, work on the mechanisms of ocular toxicology in the process of pharmaceutical development must continue and these proceedings, embodying the presented papers, will add to the data base. The editors, the congress organizing committee and the members of the International Society of Ocular Toxicology thank the speakers who gave their time, knowledge, and expertise to assist us in this project. The following manuscripts contain the main substance of each of the platform presentations and, in some cases, much more. Moreover, our thanks go to all the participants coming from a range of background- regulatory, academic and industrial -for their attention and excellent contributions during the discussion.

Author : Wanda M. Haschek,Brad Bolon,Colin G. Rousseaux,Matthew A. Wallig
Publisher : Academic Press
Page : 902 pages
File Size : 50,9 Mb
Release : 2017-10-25
Category : Medical
ISBN : 9780128098424

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Fundamentals of Toxicologic Pathology by Wanda M. Haschek,Brad Bolon,Colin G. Rousseaux,Matthew A. Wallig Pdf

Fundamentals of Toxicologic Pathology, Third Edition, presents an essential overview of systems toxicologic pathology in a clear-and-concise manner. Toxicologic pathology integrates toxicology and its interdisciplinary components, including biochemistry, pharmacodynamics and risk assessment to pathology and its related disciplines, such as physiology, microbiology, immunology and molecular biology. This wholly revised and updated edition presents the newest information on the topic, and is an essential reference for advanced students, early career researchers, toxicologic pathologists, pharmaceutical scientists, medical pathologists and clinicians, and anyone involved with drug and device development. The book includes a new section describing the application of toxicologic pathology, such as diagnostic and forensic toxicologic pathology, environmental toxicologic pathology, experimental and industrial toxicologic pathology, and pathology issues in the design of toxicology studies. There are also new chapters on special senses (the eye and ear) and the biochemical and molecular basis of toxicity, among others. Presents revised and updated information for each chapter on systems Contains expanded sections on applied toxicologic pathology Includes the essential information necessary to understand toxicologic pathology in an accessible language

Author : Kirk N. Gelatt,Gil Ben-Shlomo,Brian C. Gilger,Diane V. H. Hendrix,Thomas J. Kern,Caryn E. Plummer
Publisher : John Wiley & Sons
Page : 6078 pages
File Size : 41,9 Mb
Release : 2021-01-26
Category : Medical
ISBN : 9781119441816

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Veterinary Ophthalmology by Kirk N. Gelatt,Gil Ben-Shlomo,Brian C. Gilger,Diane V. H. Hendrix,Thomas J. Kern,Caryn E. Plummer Pdf

Diese vollständig aktualisierte und überarbeitete Ausgabe des Standardwerks der veterinärmedizinischen Augenheilkunde präsentiert die neuesten Diagnose- und Therapieverfahren. Das Fachbuch deckt die Grundlagenwissenschaften und klinische Behandlungsmethoden ab, spiegelt den aktuellen Stand der Forschung wider und beschäftigt sich mit der Augenheilkunde sämtlicher Tierarten, darunter Hunde, Katzen, Pferde, Großtiere und Exoten. Augenerkrankungen bei Katzen, Pferden und Vögeln werden noch ausführlicher und anhand von nahezu zweitausend Farbfotos erläutert. Dieses Fachbuch ist ein Muss für Veterinärmediziner in der Behandlung von Augenkrankheiten. - Die 6. Auflage von Veterinary Ophthalmology präsentiert alle Aspekte, die für die Diagnose, Behandlung und das Management von Augenkrankheiten relevant sind. Zu dieser Auflage gehören auch eine begleitende Website mit Videoclips und Abbildungen aus der Printausgabe im PowerPoint-Format, weiterhin das wohl umfassendste Literaturverzeichnis zu dem Fachgebiet. - Neue Auflage des Standardwerks der Augenheilkunde für Veterinärmediziner. - Bietet noch mehr Inhalte zu Augenerkrankungen bei Katzen, Pferden und Vögeln. - Mit mehr als 2000 Farbfotos, die die Inhalte verdeutlichen. - Die Autoren sind international renommierte Experten des Fachgebiets. - Begleitende Website mit Videoclips und Bildermaterial im PowerPoint-Format zum Herunterladen. Die 6. Auflage von Veterinary Ophthalmology darf in der Handbibliothek von Fachtierärzten mit Spezialisierung auf Augenheilkunde und Veterinärmedizinern, die Augenerkrankungen behandeln, nicht fehlen.

Author : Frederick T. Fraunfelder,Frederick W. Fraunfelder,Wiley A. Chambers
Publisher : Elsevier Health Sciences
Page : 425 pages
File Size : 53,6 Mb
Release : 2014-09-19
Category : Medical
ISBN : 9780323319850

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Drug-Induced Ocular Side Effects: Clinical Ocular Toxicology E-Book by Frederick T. Fraunfelder,Frederick W. Fraunfelder,Wiley A. Chambers Pdf

Ideal for ophthalmologists, optometrists and busy clinicians, Drug-Induced Ocular Side Effects provides the clinically relevant information you need to diagnose and manage chemical and drug-related ocular problems. An easily accessible format, meticulous revisions and comprehensive coverage of all drugs’ generic and trade names, primary uses, ocular and systemic side effects, and clinical significance make this best-selling resource the ideal reference for quick, on-the-spot consultation. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Manage any challenge in ocular toxicology with extensive coverage of principles of therapy; ocular drug delivery; methods to evaluate drug-induced visual side effects; and the role of electrophysiology and psychophysics. Benefit from the masterful guidance and global perspective of world authorities in the field who provide need-to-know information on all aspects of ocular toxicology—all in one concise reference. Confer with the WHO classification system to determine whether a particular side effect is certain, probable, or likely to occur. Zero in on the key information you need to know with highly templated, concise chapters. Apply the latest knowledge and treatments for newly recognized Adverse Drug Reactions (ADR). Identify which ADR’s are clinically relevant and what to do about them. Experience clinical scenarios with vivid clarity through a wealth of new and updated clinical photographs that provide unmatched, visual diagnostic guidance. Recognize and avoid drug-induced ocular side effects with data from the National Registry of Drug Induced Ocular Side-Effects (Casey Eye Institute, Portland, OR) and the World Health Organization (Uppsala, Sweden). Stay up to date and provide state-of-the-art care with the latest information on approved medications. Access the complete contents online at Expert Consult.

Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Guidelines for the Use of Animals in Neuroscience and Behavioral Research
Publisher : National Academies Press
Page : 223 pages
File Size : 51,9 Mb
Release : 2003-08-22
Category : Science
ISBN : 9780309167857

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Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research by National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Guidelines for the Use of Animals in Neuroscience and Behavioral Research Pdf

Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.

Author : G. C. Y. Chiou
Publisher : CRC Press
Page : 398 pages
File Size : 51,8 Mb
Release : 1999-07-01
Category : Medical
ISBN : 1439809984

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Ophthalmic Toxicology by G. C. Y. Chiou Pdf

Thoroughly revised and updates, this new edition of Ophthalmic Toxicology retains its uniqueness in covering all aspects of ophthalmic toxicology. With chapters from leading authorities incorporating the latest developments in the field, including a new chapter on the molecular basis of ophthalmic toxicity, this edition covers such topics as: *t

Author : George A. Parker
Publisher : Springer
Page : 826 pages
File Size : 48,9 Mb
Release : 2017-03-27
Category : Medical
ISBN : 9783319473857

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Immunopathology in Toxicology and Drug Development by George A. Parker Pdf

This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide organ system–based summaries of spontaneous pathology and common responses to xenobiotics. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 1, Immunobiology, Investigative Techniques, and Special Studies, offers an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system.

Author : Thomas J. Steinbach,Daniel J. Patrick,Mary Ellen Cosenza
Publisher : Springer Nature
Page : 919 pages
File Size : 52,7 Mb
Release : 2019-10-31
Category : Medical
ISBN : 9781493997770

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Toxicologic Pathology for Non-Pathologists by Thomas J. Steinbach,Daniel J. Patrick,Mary Ellen Cosenza Pdf

This extensive volume began as a short course primarily geared toward toxicologists who want to expand their understanding of toxicologic pathology in order to be better study directors while also proving to be of great interest to other drug development scientists and regulatory reviewers. The overall goal is to help non-pathologists understand, contextualize, and communicate the pathology data and interpretations from the study pathologist in a practical and usable format. Within the book, readers will find an overview of general pathology concepts that include fundamental vocabulary and the basics of pathophysiological processes, along with numerous chapters devoted to pathology in specific organ systems as well as topics such as biomarkers, correlation of clinical pathology endpoints (chemistry and hematology) with microscopic changes, and well-known pathology findings for classes of toxic substances. Authoritative, practical, and comprehensive, Toxicologic Pathology for Non-Pathologists aims to help non-pathologists understand, converse in, and apply a basic understanding of pathology in their day-to-day careers.