Opportunities For Organ Donor Intervention Research

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Opportunities for Organ Donor Intervention Research

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Committee on Issues in Organ Donor Intervention Research
Publisher : National Academies Press
Page : 171 pages
File Size : 47,9 Mb
Release : 2018-01-21
Category : Medical
ISBN : 9780309464871

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Opportunities for Organ Donor Intervention Research by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Committee on Issues in Organ Donor Intervention Research Pdf

The organ donation and transplantation system strives to honor the gift of donated organs by fully using those organs to save and improve the quality of the lives of their recipients. However, there are not enough donated organs to meet the demand and some donated organs may not be recovered, some recovered organs may not be transplanted, and some transplanted organs may not function adequately. Organ donor intervention research can test and assess interventions (e.g., medications, devices, and donor management protocols) to maintain or improve organ quality prior to, during, and following transplantation. The intervention is administered either while the organ is still in the deceased donor or after it is recovered from the donor but before it is transplanted into a recipient. Organ donor intervention research presents new challenges to the organ donation and transplantation community because of ethical questions about who should be considered a human subject in a research study, whose permission and oversight are needed, and how to ensure that such research does not threaten the equitable distribution of a scarce and valuable resource. Opportunities for Organ Donor Intervention Research focuses on the ethical, legal, regulatory, policy, and organizational issues relevant to the conduct of research in the United States involving deceased organ donors. This report provides recommendations for how to conduct organ donor intervention research in a manner that maintains high ethical standards, that ensures dignity and respect for deceased organ donors and their families, that provides transparency and information for transplant candidates who might receive a research organ, and that supports and sustains the public's trust in the process of organ donation and transplantation.

Opportunities for Organ Donor Intervention Research

Author : Engineering and Medicine National Academies of Sciences,Health and Medicine Division,Board on Health Sciences Policy,National Academies of Sciences, Engineering, and Medicine (U.S.). Health and Medicine Division,Committee on Issues in Organ Donor Intervention Research
Publisher : Unknown
Page : 170 pages
File Size : 41,7 Mb
Release : 2017-12-21
Category : Medical
ISBN : 0309464889

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Opportunities for Organ Donor Intervention Research by Engineering and Medicine National Academies of Sciences,Health and Medicine Division,Board on Health Sciences Policy,National Academies of Sciences, Engineering, and Medicine (U.S.). Health and Medicine Division,Committee on Issues in Organ Donor Intervention Research Pdf

Opportunities for Organ Donor Intervention Research focuses on the ethical, legal, regulatory, policy, and organizational issues relevant to the conduct of research in the United States involving deceased organ donors. This report provides recommendations for how to conduct organ donor intervention research in a manner that maintains high ethical standards, that ensures dignity and respect for deceased organ donors and their families, that provides transparency and information for transplant candidates who might receive a research organ, and that supports and sustains the public's trust in the process of organ donation and transplantation--

Organ Donation

Author : Institute of Medicine,Board on Health Sciences Policy,Committee on Increasing Rates of Organ Donation
Publisher : National Academies Press
Page : 358 pages
File Size : 44,5 Mb
Release : 2006-08-24
Category : Medical
ISBN : 9780309164641

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Organ Donation by Institute of Medicine,Board on Health Sciences Policy,Committee on Increasing Rates of Organ Donation Pdf

Rates of organ donation lag far behind the increasing need. At the start of 2006, more than 90,000 people were waiting to receive a solid organ (kidney, liver, lung, pancreas, heart, or intestine). Organ Donation examines a wide range of proposals to increase organ donation, including policies that presume consent for donation as well as the use of financial incentives such as direct payments, coverage of funeral expenses, and charitable contributions. This book urges federal agencies, nonprofit groups, and others to boost opportunities for people to record their decisions to donate, strengthen efforts to educate the public about the benefits of organ donation, and continue to improve donation systems. Organ Donation also supports initiatives to increase donations from people whose deaths are the result of irreversible cardiac failure. This book emphasizes that all members of society have a stake in an adequate supply of organs for patients in need, because each individual is a potential recipient as well as a potential donor.

Living Donor Advocacy

Author : JENNIFER STEEL
Publisher : Springer Science & Business Media
Page : 362 pages
File Size : 41,6 Mb
Release : 2013-11-22
Category : Medical
ISBN : 9781461491439

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Living Donor Advocacy by JENNIFER STEEL Pdf

The inadequate supply of organs in the United States and other countries continues to drive the reliance on living donor transplantation. In 2000, representatives of the transplant community convened for a meeting on living donation in an effort to provide guidelines to promote the welfare of living donors. The consensus statement that resulted from this meeting recommended that transplant centers retain an Independent Living Donor Advocate (ILDA) to focus on the best interest of the donor. A decade later, nearly every transplant center in the United States, performing living donor surgeries, has incorporated an ILDA into their living donor screening and/or evaluation process Living Donor Advocate provides an overview of living donation and its risks, ethical challenges and future developments​, as well as details about the role a Living Donor Advocate plays in the transplantation process. This book will interest health professionals across various disciplines and patients undergoing transplantation or living donor surgery.

Organ Donation and Transplantation

Author : Georgios Tsoulfas
Publisher : BoD – Books on Demand
Page : 454 pages
File Size : 41,6 Mb
Release : 2018-07-25
Category : Medical
ISBN : 9781789233407

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Organ Donation and Transplantation by Georgios Tsoulfas Pdf

One of the most interesting and at the same time most challenging fields of medicine and surgery has been that of organ donation and transplantation. It is a field that has made tremendous strides during the last few decades through the combined input and efforts of scientists from various specialties. What started as a dream of pioneers has become a reality for the thousands of our patients whose lives can now be saved and improved. However, at the same time, the challenges remain significant and so do the expectations. This book will be a collection of chapters describing these same challenges involved including the ethical, legal, and medical issues in organ donation and the technical and immunological problems the experts are facing involved in the care of these patients.The authors of this book represent a team of true global experts on the topic. In addition to the knowledge shared, the authors provide their personal clinical experience on a variety of different aspects of organ donation and transplantation.

Transplantation of Marginal Organs: Immunological Aspects and Therapeutic Perspectives

Author : Caner Süsal,Christophe Legendre,Thomas Friedrich Mueller,Peter Schemmer
Publisher : Frontiers Media SA
Page : 183 pages
File Size : 49,7 Mb
Release : 2020-12-28
Category : Medical
ISBN : 9782889662876

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Transplantation of Marginal Organs: Immunological Aspects and Therapeutic Perspectives by Caner Süsal,Christophe Legendre,Thomas Friedrich Mueller,Peter Schemmer Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Introduction to Organ Transplantation

Author : Nadey Hakim
Publisher : World Scientific
Page : 265 pages
File Size : 46,9 Mb
Release : 2012
Category : Medical
ISBN : 9781848168541

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Introduction to Organ Transplantation by Nadey Hakim Pdf

This second edition of the introduction to the field of organ transplantation provides an excellent overview of the tremendous progress made in recent decades, and gives a clear description of the current status of transplant surgery for students and trainees with an interest in this field. It opens with introductory chapters on the history of transplantation and the basic science of immunobiology, and then examines through an organ-based structure the practice of transplantation in each major system, from skin to intestine. There is a 13-year gap between the first and second edition, and this is highlighted in the new collection of chapters of this updated version. This is a timely publication produced in line with the rapidly advancing field of transplantation. The editor, Nadey S Hakim, is a consultant transplant and general surgeon at Imperial College Healthcare NHS Trust, London, England, and has put together this second volume that will serve as an invaluable guide for transplant surgeons as well as trainees.

Organ Shortage

Author : Anne-Maree Farrell,David Price,Muireann Quigley
Publisher : Cambridge University Press
Page : 329 pages
File Size : 52,7 Mb
Release : 2011-03-10
Category : Law
ISBN : 9781139500104

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Organ Shortage by Anne-Maree Farrell,David Price,Muireann Quigley Pdf

Organ shortage is an ongoing problem in many countries. The needless death and suffering which have resulted necessitate an investigation into potential solutions. This examination of contemporary ethical means, both practical and policy-oriented, of reducing the shortfall in organs draws on the experiences of a range of countries. The authors focus on the resolution and negotiation of ethical conflict, examine systems approaches such as the 'Spanish model' and the US Breakthrough Collaboratives, evaluate policy proposals relating to incentives, presumed consent, and modifications regarding end-of-life care, and evaluate the greatly increased use of (non-heart-beating) donors suffering circulatory death, as well as living donors. The proposed strategies and solutions are not only capable of resolving the UK's own organ-shortage crisis, but also of being implemented in other countries grappling with how to address the growing gap between supply and demand for organs.

Non-Heart-Beating Organ Transplantation

Author : Institute of Medicine,Division of Health Care Services,Committee on Non-Heart-Beating Transplantation II: The Scientific and Ethical Basis for Practice and Protocols
Publisher : National Academies Press
Page : 174 pages
File Size : 49,8 Mb
Release : 2000-04-19
Category : Medical
ISBN : 9780309183550

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Non-Heart-Beating Organ Transplantation by Institute of Medicine,Division of Health Care Services,Committee on Non-Heart-Beating Transplantation II: The Scientific and Ethical Basis for Practice and Protocols Pdf

In 1997, the Institute of Medicine published a report entitled Non-Heart- Beating Organ Transplantation: Medical and Ethical Issues in Procurement. The findings and recommendations of that study defined the ethical and scientific basis for non-heart-beating organ donation and transplantation, and provided specific recommendations for practices that affirm patient welfare, promote patient and family choice, and avoid conflicts of interest. Following the 1997 study, the Department of Health and Human Services requested a follow up study to promote such efforts. The central activity for this study was a workshop held in Washington, D.C., on May 24-25, 1999. The workshop provided the opportunity for extensive dialogue on non-heart-beating organ donation among hospitals and organ procurement organizations (OPOs) that are actively involved in non-heartbeating organ and tissue donation and those with concerns about whether and how to proceed. The findings and recommendations of this report are based in large measure on the discussions and insights from that workshop. Non-Heart-Beating Organ Transplantation includes seven recommendations for developing and implementing non-heart-beating-donor protocols. These recommendations were based on the findings and recommendations from the 1997 IOM report and consensus achieved among participants at the national workshop. The committee developed these recommendations as steps towards an approach to non-heart-beating-donor organ donation and procurement consistent with underlying scientific and ethical guidelines, patient and family options and choices, and public trust in organ donation.

Non-Heart-Beating Organ Transplantation

Author : Institute of Medicine,Roger Herdman,John T. Potts
Publisher : National Academies Press
Page : 103 pages
File Size : 53,7 Mb
Release : 1998-01-18
Category : Medical
ISBN : 9780309064248

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Non-Heart-Beating Organ Transplantation by Institute of Medicine,Roger Herdman,John T. Potts Pdf

Non-heart-beating donors (individuals whose deaths are determined by cessation of heart and respiratory function rather than loss of whole brain function) could potentially be of major importance in reducing the gap between the demand for and available supply of organs for transplantation. Prompted by questions concerning the medical management of such donorsâ€"specifically, whether interventions undertaken to enhance the supply and quality of potentially transplantable organs (i.e. the use of anticoagulants and vasodilators) were in the best interests of the donor patientâ€"the U.S. Department of Health and Human Services asked the Institute of Medicine to examine from scientific and ethical points of view "alternative medical approaches that can be used to maximize the availability of organs from [a] donor [in an end-of-life situation] without violating prevailing ethical norms...." This book examines transplantation supply and demand, historical and modern conceptions of non-heart-beating donors, and organ procurement organizations and transplant program policies, and contains recommendations concerning the principles and ethical issues surrounding the topic.

Organ Procurement and Transplantation

Author : Institute of Medicine,Committee on Organ Procurement and Transplantation Policy
Publisher : National Academies Press
Page : 254 pages
File Size : 50,6 Mb
Release : 1999-12-09
Category : Medical
ISBN : 9780309172776

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Organ Procurement and Transplantation by Institute of Medicine,Committee on Organ Procurement and Transplantation Policy Pdf

Each day, nearly 60 Americans receive a transplanted kidney, liver, or other organâ€"a literal "second chance at life"â€"but 11 others die waiting for an organ transplant. The number of donors, although rising, is not growing fast enough to meet the increasing demand. Intended to improve the current system of organ procurement and allocation, the "Final Rule," a 1998 regulation issued by the U.S. Department of Health and Human Services, sparked further controversy with its attempts to eliminate the apparent geographic disparities in the time an individual must wait for an organ. This book assesses the potential impact of the Final Rule on organ transplantation. It also presents new, original analyses of data, and assesses medical practices, social and economic observations, and other information on: access to transplantation services for low-income populations and racial and ethnic minority groups; organ donation rates; waiting times for transplantation; patient survival rates and organ failure rates leading to retransplantation; and cost of organ transplantation services.

Organ Transplantation in Times of Donor Shortage

Author : Ralf J. Jox,Galia Assadi,Georg Marckmann
Publisher : Springer
Page : 352 pages
File Size : 52,8 Mb
Release : 2015-08-06
Category : Philosophy
ISBN : 9783319164410

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Organ Transplantation in Times of Donor Shortage by Ralf J. Jox,Galia Assadi,Georg Marckmann Pdf

This book analyzes the reasons for organ shortage and ventures innovative ideas for approaching this problem. It presents 29 contributions from a highly interdisciplinary group of world experts and upcoming professionals in the field. Every year thousands of patients die while waiting for organ transplantation. Health authorities, medical professionals and bioethicists worldwide point to the urgent and yet unsolved problem of organ shortage, which will be even intensified due to the increasing life expectancy. Even though the practical problem seems to be well known, the search for suitable solutions continues and often restricts itself by being limited through disciplinary and national borders. Combining philosophical reflection with empirical results, this volume enables a unique insight in the ethics of organ transplantation and offers fresh ideas for policymakers, health care professionals, academics and the general public.

The Transplant Patient

Author : Paula T. Trzepacz,Andrea F. DiMartini
Publisher : Cambridge University Press
Page : 328 pages
File Size : 50,8 Mb
Release : 2000-03-16
Category : Medical
ISBN : 1139429124

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The Transplant Patient by Paula T. Trzepacz,Andrea F. DiMartini Pdf

Organ transplantation is an essential element of treatment for a wide range of diseases, but despite increasing surgical success rates there remain many other issues affecting selection of patients and clinical outcome with which clinicians and patients themselves must be familiar. Originally published in 2000, this book reviews psychosocial, psychiatric and ethical aspects of organ transplantation in a uniquely authoritative way. Drawing heavily on the pioneering work of the Pittsburgh transplant team, it surveys the essentials of transplantation biology before engaging with a range of topics fundamental to the success of the procedure and the quality of life of recipients and donors alike. The interdisciplinary approach and the authority of the contributors will make this book of value to anyone with an interest in organ transplantation procedures.

The Brain-Dead Organ Donor

Author : Dimitri Novitzky,David K. C. Cooper
Publisher : Springer Science & Business Media
Page : 369 pages
File Size : 45,9 Mb
Release : 2012-10-26
Category : Medical
ISBN : 9781461443049

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The Brain-Dead Organ Donor by Dimitri Novitzky,David K. C. Cooper Pdf

Addressing all aspects of brain death and thoroughly detailing how a potential organ donor should be maintained to ensure maximum use of the organs and cells, The Brain-Dead Organ Donor: Pathophysiology and Management is a landmark addition to the literature. This first-of-its-kind, multidisciplinary volume will be of interest to a large section of the medical community. The first section of the book reviews the historical, medical, legal, and ethical aspects of brain death. That is followed by two chapters on the pathophysiology of brain death as investigated in small and large animal models. This includes a review of the many hormonal changes, including the neuroendocrine- adrenergic ‘storm’, that takes place during and following the induction of brain death, and how they impact metabolism. The next section of the book reviews various effects of brain death, namely its impact on thyroid function, the inflammatory response that develops, and those relating to innate immunity. The chapters relating to assessment and management of potential organ donors will be of interest to a very large group of transplant surgeons and physicians as well as critical care and neurocritical care physicians and nurses. Neurologists, endocrinologists, neurosurgeons, and pathologists will also be interested, especially in the more basic science sections on various aspects of brain-death and hormonal therapy. Organ procurement organizations and transplant coordinators worldwide will also be interested in this title. Other chapters will be of interest to medical historians, medico-legal experts, and ethicists.

New Organs Within Us

Author : Aslihan Sanal,Aslıhan Sanal
Publisher : Duke University Press
Page : 265 pages
File Size : 51,5 Mb
Release : 2011-07
Category : Law
ISBN : 9780822349129

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New Organs Within Us by Aslihan Sanal,Aslıhan Sanal Pdf

An ethnographic analysis of organ transplantation in Turkey, based on the stories of kidney-transplant patients and physicians in Istanbul.