Optimal High Throughput Screening

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Optimal High-Throughput Screening

Xiaohua Douglas Zhang
Optimal High Throughput Screening Book PDF

Author : Xiaohua Douglas Zhang
Publisher : Cambridge University Press
Page : 223 pages
File Size : 46,7 Mb
Release : 2011-02-21
Category : Medical
ISBN : 9781139498371

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Optimal High-Throughput Screening by Xiaohua Douglas Zhang Pdf

This concise, self-contained and cohesive book focuses on commonly used and recently developed methods for designing and analyzing high-throughput screening (HTS) experiments from a statistically sound basis. Combining ideas from biology, computing and statistics, the author explains experimental designs and analytic methods that are amenable to rigorous analysis and interpretation of RNAi HTS experiments. The opening chapters are carefully presented to be accessible both to biologists with training only in basic statistics and to computational scientists and statisticians with basic biological knowledge. Biologists will see how new experiment designs and rudimentary data-handling strategies for RNAi HTS experiments can improve their results, whereas analysts will learn how to apply recently developed statistical methods to interpret HTS experiments.

High Throughput Screening

William P. Janzen,Paul Bernasconi
High Throughput Screening Book PDF

Author : William P. Janzen,Paul Bernasconi
Publisher : Methods in Molecular Biology
Page : 290 pages
File Size : 51,6 Mb
Release : 2009-07-09
Category : Juvenile Nonfiction
ISBN : UOM:39015075677206

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High Throughput Screening by William P. Janzen,Paul Bernasconi Pdf

Featuring new screening technologies as well as many well established methods, this book offers comprehensive treatment of the activities directly related to High Throughput Screening (HTS), such as compound library management, data handling, and robotics.

High Throughput Screening

William P. Janzen
High Throughput Screening Book PDF

Author : William P. Janzen
Publisher : Humana Press
Page : 265 pages
File Size : 41,5 Mb
Release : 2002-04-18
Category : Medical
ISBN : 0896038890

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High Throughput Screening by William P. Janzen Pdf

In High Throughput Screening, leading scientists and researchers expert in molecular discovery explain the diverse technologies and key techniques used in HTS and demonstrate how they can be applied generically. Writing to create precisely the introductory guidebook they wish had been available when they started in HTS, these expert seasoned authors illuminate the HTS process with richly detailed tutorials on the biological techniques involved, the management of compound libraries, and the automation and engineering approaches needed. Extensive discussions provide readers with all those key elements of pharmacology, molecular biology, enzymology, and biochemistry that will ensure the identification of suitable targets and screens, and detail the technology necessary to mine millions of data points for meaningful knowledge.

High Throughput Screening

John P. Devlin
High Throughput Screening Book PDF

Author : John P. Devlin
Publisher : CRC Press
Page : 704 pages
File Size : 51,5 Mb
Release : 1997-05-06
Category : Science
ISBN : 0824700678

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High Throughput Screening by John P. Devlin Pdf

Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high throughput screening (HTS) systems and provides a solid foundation for the implementation and development of HTS in bio-based industries and associated academic environments.

Drug Discovery and Development

Omboon Vallisuta,Suleiman Olimat
Drug Discovery and Development Book PDF

Author : Omboon Vallisuta,Suleiman Olimat
Publisher : BoD – Books on Demand
Page : 332 pages
File Size : 45,5 Mb
Release : 2015-06-03
Category : Medical
ISBN : 9789535121282

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Drug Discovery and Development by Omboon Vallisuta,Suleiman Olimat Pdf

It is very important for scientists all over the globe to enhance drug discovery research for better human health. This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identification, drug metabolism, pharmacodynamic and pharmacokinetic research. The following 5 sections cover diverse chapter topics in drug discovery: Natural Products as Sources of Leading Molecules in Drug Discovery; Oncology and Drug Discovery; Receptors Involvement in Drug Discovery; Management and Development of Drugs against Infectious Diseases; Advanced Methodology.

High-Throughput Screening in Chemical Catalysis

Alfred Hagemeyer,Peter Strasser,Anthony F. Volpe, Jr.
High Throughput Screening in Chemical Catalysis Book PDF

Author : Alfred Hagemeyer,Peter Strasser,Anthony F. Volpe, Jr.
Publisher : John Wiley & Sons
Page : 339 pages
File Size : 53,6 Mb
Release : 2006-03-06
Category : Science
ISBN : 9783527604302

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High-Throughput Screening in Chemical Catalysis by Alfred Hagemeyer,Peter Strasser,Anthony F. Volpe, Jr. Pdf

In this first book to present every important aspect of this fascinating and developing field, the three editors A. Hagemeyer, P. Strasser and A. F. Volpe Jr. from Symyx Technologies have chosen a perfect mixture of distinguished, international authors from both academia and industry. Each chapter is devoted to a major topic - high-throughput experimentation methodologies, integrated combinatorial synthesis and screening workflow, and applications to chemical catalysts with an emphasis on heterogeneous catalysis, olefin polymerization and electrocatalysis for fuel cells. An indispensable source for everyone working in the field.

Cell-Based Assays for High-Throughput Screening

Paul A. Clemons,Nicola J. Tolliday,Bridget K. Wagner
Cell Based Assays for High Throughput Screening Book PDF

Author : Paul A. Clemons,Nicola J. Tolliday,Bridget K. Wagner
Publisher : Humana Press
Page : 0 pages
File Size : 47,9 Mb
Release : 2014-11-27
Category : Science
ISBN : 1627039074

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Cell-Based Assays for High-Throughput Screening by Paul A. Clemons,Nicola J. Tolliday,Bridget K. Wagner Pdf

As the use of high-throughput screening expands and creates more interest in the academic community, the need for detailed reference materials becomes ever more pressing. Cell-Based Assays for High-Throughput Screening: Methods and Protocols aims to fill an important part of this need by providing an easily accessible reference volume for cell-based phenotypic screening. Leading researchers in the field contribute state-of-the-art methods with actionable protocols covering four major areas of study: model biological systems, screening modalities and assay systems, detection technologies, and approaches to data analysis. Written in the highly successful Methods in Molecular BiologyTM series format, each chapter includes a brief introduction to the subject, lists of necessary materials and reagents, step-by-step laboratory protocols, and a Notes section detailing tips on troubleshooting and avoiding known pitfalls. Cutting-edge and easy-to-use, Cell-Based Assays for High-Throughput Screening: Methods and Protocols presents an overview of relevant approaches, enabling the direct application of existing methods to new discoveries while also inspiring researchers to approach their screening projects in a conceptually modular fashion, enhancing the power to discover through new combinations of existing approaches.

High-Throughput Screening in Drug Discovery

Jörg Hüser
High Throughput Screening in Drug Discovery Book PDF

Author : Jörg Hüser
Publisher : John Wiley & Sons
Page : 362 pages
File Size : 46,7 Mb
Release : 2006-12-13
Category : Science
ISBN : 9783527609369

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High-Throughput Screening in Drug Discovery by Jörg Hüser Pdf

Backed by leading authorities, this is a professional guide to successful compound screening in pharmaceutical research and chemical biology, including the chemoinformatic tools needed for correct data evaluation. Chapter authors from leading pharmaceutical companies as well as from Harvard University discuss such factors as chemical genetics, binding, cell-based and biochemical assays, the efficient use of compound libraries and data mining using cell-based assay results. For both academics and professionals in the pharma and biotech industries working on small molecule screening.

High Throughput Screening Methods

Joshua A Bittker,Nathan T Ross
High Throughput Screening Methods Book PDF

Author : Joshua A Bittker,Nathan T Ross
Publisher : Royal Society of Chemistry
Page : 396 pages
File Size : 47,6 Mb
Release : 2016-12-05
Category : Medical
ISBN : 9781782626770

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High Throughput Screening Methods by Joshua A Bittker,Nathan T Ross Pdf

High throughput screening remains a key part of early stage drug and tool compound discovery, and methods and technologies have seen many fundamental improvements and innovations over the past 20 years. This comprehensive book provides a historical survey of the field up to the current state-of-the-art. In addition to the specific methods, this book also considers cultural and organizational questions that represent opportunities for future success. Following thought-provoking foreword and introduction from Professor Stuart Schreiber and the editors, chapters from leading experts across academia and industry cover initial considerations for screening, methods appropriate for different goals in small molecule discovery, newer technologies that provide alternative approaches to traditional miniaturization procedures, and practical aspects such as cost and resourcing. Within the context of their historical development, authors explain common pitfalls and their solutions. This book will serve as both a practical reference and a thoughtful guide to the philosophy underlying technological change in such a fast-moving area for postgraduates and researchers in academia and industry, particularly in the areas of chemical biology, pharmacology, structural biology and assay development.

High Throughput Screening: Methods, Techniques and Applications

Geoff Holdgate,Mark Wigglesworth
High Throughput Screening Methods Techniques and Applications Book PDF

Author : Geoff Holdgate,Mark Wigglesworth
Publisher : Unknown
Page : 490 pages
File Size : 45,9 Mb
Release : 2020-04-25
Category : Electronic
ISBN : 1536172480

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High Throughput Screening: Methods, Techniques and Applications by Geoff Holdgate,Mark Wigglesworth Pdf

High Throughput Screening (HTS) is one of several hit identification approaches that are part of a developing and evolving toolbox for the discovery of pharmaceutical start points. HTS remains one of the most successful approaches, and therefore an important foundation of drug discovery. In this book leading industrial and academic experts in screening and drug discovery explain key technologies and methods while demonstrating how they can be applied to successful hit identification. Describing both traditional and emerging methods in detail, this book provides an overview of these methods to the reader that will serve both those new to the field and expert scientists alike. The book provides readers with an outline of key elements in the areas of assay development, detailed descriptions of a range of both biochemical and cell-based screening methodologies and strategies, as well as highlighting important steps in data analysis. By describing the basic principles of methods commonly used in HTS, this book provides an illuminating introduction to HTS, capturing established good practice within the field, thereby imparting both the industrial and academic researcher with the knowledge required to work effectively in both todays and the hit identification laboratories of the future.

High Throughput Screening

William P. Janzen
High Throughput Screening Book PDF

Author : William P. Janzen
Publisher : Springer Science & Business Media
Page : 269 pages
File Size : 47,5 Mb
Release : 2008-02-05
Category : Medical
ISBN : 9781592591800

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High Throughput Screening by William P. Janzen Pdf

In High Throughput Screening, leading scientists and researchers expert in molecular discovery explain the diverse technologies and key techniques used in HTS and demonstrate how they can be applied generically. Writing to create precisely the introductory guidebook they wish had been available when they started in HTS, these expert seasoned authors illuminate the HTS process with richly detailed tutorials on the biological techniques involved, the management of compound libraries, and the automation and engineering approaches needed. Extensive discussions provide readers with all those key elements of pharmacology, molecular biology, enzymology, and biochemistry that will ensure the identification of suitable targets and screens, and detail the technology necessary to mine millions of data points for meaningful knowledge.

A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery

Taosheng Chen
A Practical Guide to Assay Development and High Throughput Screening in Drug Discovery Book PDF

Author : Taosheng Chen
Publisher : CRC Press
Page : 291 pages
File Size : 43,8 Mb
Release : 2009-12-21
Category : Medical
ISBN : 9781420070514

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A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery by Taosheng Chen Pdf

The development of suitable assays, the integration of appropriate technology, and the effective management of the essential infrastructure are all critical to the success of any high-throughput screening (HTS) endeavor. However, few scientists have the multidisciplinary experience needed to control all aspects of an HTS drug discovery project. A P

High-Throughput Screening Methods in Toxicity Testing

Pablo Steinberg
High Throughput Screening Methods in Toxicity Testing Book PDF

Author : Pablo Steinberg
Publisher : John Wiley & Sons
Page : 432 pages
File Size : 54,9 Mb
Release : 2013-02-26
Category : Science
ISBN : 9781118538241

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High-Throughput Screening Methods in Toxicity Testing by Pablo Steinberg Pdf

Explores the benefits and limitations of the latest high-throughput screening methods With its expert coverage of high-throughput in vitro screening methods for toxicity testing, this book makes it possible for researchers to accelerate and streamline the evaluation and risk assessment of chemicals and drugs for toxicity. Moreover, it enables them to comply with the latest standards set forth by the U.S. National Research Council's "Toxicity Testing in the 21st Century: A Vision and Strategy" and the E.U.'s REACH legislation. Readers will discover a variety of state-of-the-science, high-throughput screening methods presented by a group of leading authorities in toxicology and toxicity testing. High-Throughput Screening Methods in Toxicity Testing is divided into five parts: General aspects, including predicting the toxicity potential of chemicals and drugs via high-throughput bioactivity profiling Assessing different cytotoxicity endpoints Assessing DNA damage and carcinogenesis Assessing reproductive toxicity, cardiotoxicity, and haematotoxicity Assessing drug metabolism and receptor-related toxicity Each chapter describes method principles and includes detailed information about data generation, data analysis, and applications in risk assessment. The authors not only enumerate the advantages of each high-throughput method over comparable conventional methods, but also point out the high-throughput method's limitations and potential pitfalls. In addition, the authors describe current research efforts to make high-throughput toxicity screening even more cost effective and streamlined. Throughout the book, readers will find plenty of figures and illustrations to help them understand and perform the latest high-throughput toxicity screening methods. This book is ideal for toxicologists and other researchers who need to implement high-throughput screening methods for toxicity testing in their laboratories as well as for researchers who need to evaluate the data generated by these methods.

Bayesian Optimization for Materials Science

Daniel Packwood
Bayesian Optimization for Materials Science Book PDF

Author : Daniel Packwood
Publisher : Springer
Page : 42 pages
File Size : 45,7 Mb
Release : 2017-10-04
Category : Technology & Engineering
ISBN : 9789811067815

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Bayesian Optimization for Materials Science by Daniel Packwood Pdf

This book provides a short and concise introduction to Bayesian optimization specifically for experimental and computational materials scientists. After explaining the basic idea behind Bayesian optimization and some applications to materials science in Chapter 1, the mathematical theory of Bayesian optimization is outlined in Chapter 2. Finally, Chapter 3 discusses an application of Bayesian optimization to a complicated structure optimization problem in computational surface science.Bayesian optimization is a promising global optimization technique that originates in the field of machine learning and is starting to gain attention in materials science. For the purpose of materials design, Bayesian optimization can be used to predict new materials with novel properties without extensive screening of candidate materials. For the purpose of computational materials science, Bayesian optimization can be incorporated into first-principles calculations to perform efficient, global structure optimizations. While research in these directions has been reported in high-profile journals, until now there has been no textbook aimed specifically at materials scientists who wish to incorporate Bayesian optimization into their own research. This book will be accessible to researchers and students in materials science who have a basic background in calculus and linear algebra.

Combinatorial and High-Throughput Discovery and Optimization of Catalysts and Materials

Radislav A. Potyrailo,Wilhelm F. Maier
Combinatorial and High Throughput Discovery and Optimization of Catalysts and Materials Book PDF

Author : Radislav A. Potyrailo,Wilhelm F. Maier
Publisher : CRC Press
Page : 504 pages
File Size : 44,8 Mb
Release : 2006-07-19
Category : Science
ISBN : 9781420005387

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Combinatorial and High-Throughput Discovery and Optimization of Catalysts and Materials by Radislav A. Potyrailo,Wilhelm F. Maier Pdf

The development of parallel synthesis and high-throughput characterization tools offer scientists a time-efficient and cost-effective solution for accelerating traditional synthesis processes and developing the structure-property relationships of multiple materials under variable conditions. Written by renowned contributors to the field, Combina