High Throughput Screening

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High Throughput Screening

William P. Janzen
High Throughput Screening Book PDF

Author : William P. Janzen
Publisher : Humana Press
Page : 265 pages
File Size : 52,9 Mb
Release : 2002-04-18
Category : Medical
ISBN : 0896038890

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High Throughput Screening by William P. Janzen Pdf

In High Throughput Screening, leading scientists and researchers expert in molecular discovery explain the diverse technologies and key techniques used in HTS and demonstrate how they can be applied generically. Writing to create precisely the introductory guidebook they wish had been available when they started in HTS, these expert seasoned authors illuminate the HTS process with richly detailed tutorials on the biological techniques involved, the management of compound libraries, and the automation and engineering approaches needed. Extensive discussions provide readers with all those key elements of pharmacology, molecular biology, enzymology, and biochemistry that will ensure the identification of suitable targets and screens, and detail the technology necessary to mine millions of data points for meaningful knowledge.

High Throughput Screening

John P. Devlin
High Throughput Screening Book PDF

Author : John P. Devlin
Publisher : CRC Press
Page : 704 pages
File Size : 55,6 Mb
Release : 1997-05-06
Category : Science
ISBN : 0824700678

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High Throughput Screening by John P. Devlin Pdf

Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high throughput screening (HTS) systems and provides a solid foundation for the implementation and development of HTS in bio-based industries and associated academic environments.

High-Throughput Screening in Drug Discovery

Jörg Hüser
High Throughput Screening in Drug Discovery Book PDF

Author : Jörg Hüser
Publisher : John Wiley & Sons
Page : 362 pages
File Size : 55,7 Mb
Release : 2006-12-13
Category : Science
ISBN : 9783527609369

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High-Throughput Screening in Drug Discovery by Jörg Hüser Pdf

Backed by leading authorities, this is a professional guide to successful compound screening in pharmaceutical research and chemical biology, including the chemoinformatic tools needed for correct data evaluation. Chapter authors from leading pharmaceutical companies as well as from Harvard University discuss such factors as chemical genetics, binding, cell-based and biochemical assays, the efficient use of compound libraries and data mining using cell-based assay results. For both academics and professionals in the pharma and biotech industries working on small molecule screening.

High Throughput Screening Methods

Joshua A. Bittker,Nathan T. Ross
High Throughput Screening Methods Book PDF

Author : Joshua A. Bittker,Nathan T. Ross
Publisher : Royal Society of Chemistry
Page : 416 pages
File Size : 49,9 Mb
Release : 2016-12-08
Category : Medical
ISBN : 9781782624714

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High Throughput Screening Methods by Joshua A. Bittker,Nathan T. Ross Pdf

High throughput screening remains a key part of early stage drug and tool compound discovery, and methods and technologies have seen many fundamental improvements and innovations over the past 20 years. This comprehensive book provides a historical survey of the field up to the current state-of-the-art. In addition to the specific methods, this book also considers cultural and organizational questions that represent opportunities for future success. Following thought-provoking foreword and introduction from Professor Stuart Schreiber and the editors, chapters from leading experts across academia and industry cover initial considerations for screening, methods appropriate for different goals in small molecule discovery, newer technologies that provide alternative approaches to traditional miniaturization procedures, and practical aspects such as cost and resourcing. Within the context of their historical development, authors explain common pitfalls and their solutions. This book will serve as both a practical reference and a thoughtful guide to the philosophy underlying technological change in such a fast-moving area for postgraduates and researchers in academia and industry, particularly in the areas of chemical biology, pharmacology, structural biology and assay development.

High Throughput Screening for Food Safety Assessment

Arun K. Bhunia,Moon S. Kim,Chris R. Taitt
High Throughput Screening for Food Safety Assessment Book PDF

Author : Arun K. Bhunia,Moon S. Kim,Chris R. Taitt
Publisher : Elsevier
Page : 550 pages
File Size : 54,7 Mb
Release : 2014-09-06
Category : Technology & Engineering
ISBN : 9780857098078

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High Throughput Screening for Food Safety Assessment by Arun K. Bhunia,Moon S. Kim,Chris R. Taitt Pdf

Recent advances in array-based detectors and imaging technologies have provided high throughput systems that can operate within a substantially reduced timeframe and other techniques that can detect multiple contaminants at one time. These technologies are revolutionary in terms of food safety assessment in manufacturing, and will also have a significant impact on areas such as public health and food defence. This book summarizes the latest research and applications of sensor technologies for online and high throughput screening of food. The book first introduces high throughput screening strategies and technology platforms, and discusses key issues in sample collection and preparation. The subsequent chapters are then grouped into four sections: Part I reviews biorecognition techniques; Part II covers the use of optical biosensors and hyperspectral imaging in food safety assessment; Part III focuses on electrochemical and mass-based transducers; and finally Part IV deals with the application of these safety assessment technologies in specific food products, including meat and poultry, seafood, fruits and vegetables. Summarises the latest research on sensor technologies for online and high-throughput screening of food Covers high-throughput screening and the current and forecast state of rapid contaminant detection technologies Looks at the use of optical and electrochemical biosensors and hyperspectral imaging in food safety assessment and the application of these technologies in specific food products

A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery

Taosheng Chen
A Practical Guide to Assay Development and High Throughput Screening in Drug Discovery Book PDF

Author : Taosheng Chen
Publisher : CRC Press
Page : 291 pages
File Size : 46,9 Mb
Release : 2009-12-21
Category : Medical
ISBN : 9781420070514

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A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery by Taosheng Chen Pdf

The development of suitable assays, the integration of appropriate technology, and the effective management of the essential infrastructure are all critical to the success of any high-throughput screening (HTS) endeavor. However, few scientists have the multidisciplinary experience needed to control all aspects of an HTS drug discovery project. A P

Cell-Based Assays for High-Throughput Screening

Paul A. Clemons,Nicola J. Tolliday,Bridget K. Wagner
Cell Based Assays for High Throughput Screening Book PDF

Author : Paul A. Clemons,Nicola J. Tolliday,Bridget K. Wagner
Publisher : Humana Press
Page : 0 pages
File Size : 54,6 Mb
Release : 2014-11-27
Category : Science
ISBN : 1627039074

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Cell-Based Assays for High-Throughput Screening by Paul A. Clemons,Nicola J. Tolliday,Bridget K. Wagner Pdf

As the use of high-throughput screening expands and creates more interest in the academic community, the need for detailed reference materials becomes ever more pressing. Cell-Based Assays for High-Throughput Screening: Methods and Protocols aims to fill an important part of this need by providing an easily accessible reference volume for cell-based phenotypic screening. Leading researchers in the field contribute state-of-the-art methods with actionable protocols covering four major areas of study: model biological systems, screening modalities and assay systems, detection technologies, and approaches to data analysis. Written in the highly successful Methods in Molecular BiologyTM series format, each chapter includes a brief introduction to the subject, lists of necessary materials and reagents, step-by-step laboratory protocols, and a Notes section detailing tips on troubleshooting and avoiding known pitfalls. Cutting-edge and easy-to-use, Cell-Based Assays for High-Throughput Screening: Methods and Protocols presents an overview of relevant approaches, enabling the direct application of existing methods to new discoveries while also inspiring researchers to approach their screening projects in a conceptually modular fashion, enhancing the power to discover through new combinations of existing approaches.

Optimal High-Throughput Screening

Xiaohua Douglas Zhang
Optimal High Throughput Screening Book PDF

Author : Xiaohua Douglas Zhang
Publisher : Cambridge University Press
Page : 223 pages
File Size : 41,8 Mb
Release : 2011-02-21
Category : Medical
ISBN : 9781139498371

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Optimal High-Throughput Screening by Xiaohua Douglas Zhang Pdf

This concise, self-contained and cohesive book focuses on commonly used and recently developed methods for designing and analyzing high-throughput screening (HTS) experiments from a statistically sound basis. Combining ideas from biology, computing and statistics, the author explains experimental designs and analytic methods that are amenable to rigorous analysis and interpretation of RNAi HTS experiments. The opening chapters are carefully presented to be accessible both to biologists with training only in basic statistics and to computational scientists and statisticians with basic biological knowledge. Biologists will see how new experiment designs and rudimentary data-handling strategies for RNAi HTS experiments can improve their results, whereas analysts will learn how to apply recently developed statistical methods to interpret HTS experiments.

High-Throughput Screening Assays in Toxicology

Hao Zhu,Menghang Xia
High Throughput Screening Assays in Toxicology Book PDF

Author : Hao Zhu,Menghang Xia
Publisher : Humana
Page : 0 pages
File Size : 42,8 Mb
Release : 2023-03-31
Category : Medical
ISBN : 1071622153

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High-Throughput Screening Assays in Toxicology by Hao Zhu,Menghang Xia Pdf

This second edition volume expands on the previous edition by exploring the latest advancements in high throughput screening (HTS) in toxicity studies by using in vitro, ex vivo, and in vivo models. This volume also covers the application of artificial intelligence (AI) and data science to curate, manage, and use HTS data. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, High Throughput Screening Assays in Modern Toxicology, Second Edition is a valuable resource for scientists pursuing chemical toxicology research. This book will aid scientists and researchers in translating new HTS techniques into standardized chemical toxicology assessment tools that can refine, reduce, and replace animal testing.

High Throughput Screening

Mark Wigglesworth
High Throughput Screening Book PDF

Author : Mark Wigglesworth
Publisher : Unknown
Page : 362 pages
File Size : 49,5 Mb
Release : 2020
Category : Technology & Engineering
ISBN : 1536172537

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High Throughput Screening by Mark Wigglesworth Pdf

"High Throughput Screening (HTS) is one of several hit identification approaches that are part of a developing and evolving toolbox for the discovery of pharmaceutical start points. HTS remains one of the most successful approaches, and therefore an important foundation of drug discovery. In High Throughput Screening: Methods, Techniques and Applications, leading industrial and academic experts in screening and drug discovery explain key technologies and methods while demonstrating how they can be applied to successful hit identification. Describing both traditional and emerging methods in detail, this book provides an overview of these methods to the reader that will serve both those new to the field and expert scientists alike. High Throughput Screening: Methods, Techniques and Applications provides readers with an outline of key elements in the areas of assay development, detailed descriptions of a range of both biochemical and cell-based screening methodologies and strategies, as well as highlighting important steps in data analysis. By describing the basic principles of methods commonly used in HTS, High Throughput Screening: Methods, Techniques and Applications provides an illuminating introduction to HTS, capturing established good practice within the field, thereby imparting both the industrial and academic researcher with the knowledge required to work effectively in both today's and the hit identification laboratories of the future"--

High-Throughput Screening in Chemical Catalysis

Alfred Hagemeyer,Peter Strasser,Anthony F. Volpe, Jr.
High Throughput Screening in Chemical Catalysis Book PDF

Author : Alfred Hagemeyer,Peter Strasser,Anthony F. Volpe, Jr.
Publisher : John Wiley & Sons
Page : 339 pages
File Size : 53,7 Mb
Release : 2006-03-06
Category : Science
ISBN : 9783527604302

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High-Throughput Screening in Chemical Catalysis by Alfred Hagemeyer,Peter Strasser,Anthony F. Volpe, Jr. Pdf

In this first book to present every important aspect of this fascinating and developing field, the three editors A. Hagemeyer, P. Strasser and A. F. Volpe Jr. from Symyx Technologies have chosen a perfect mixture of distinguished, international authors from both academia and industry. Each chapter is devoted to a major topic - high-throughput experimentation methodologies, integrated combinatorial synthesis and screening workflow, and applications to chemical catalysts with an emphasis on heterogeneous catalysis, olefin polymerization and electrocatalysis for fuel cells. An indispensable source for everyone working in the field.

Next Steps for Functional Genomics

National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences
Next Steps for Functional Genomics Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences
Publisher : National Academies Press
Page : 201 pages
File Size : 47,9 Mb
Release : 2020-12-18
Category : Science
ISBN : 9780309676731

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Next Steps for Functional Genomics by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences Pdf

One of the holy grails in biology is the ability to predict functional characteristics from an organism's genetic sequence. Despite decades of research since the first sequencing of an organism in 1995, scientists still do not understand exactly how the information in genes is converted into an organism's phenotype, its physical characteristics. Functional genomics attempts to make use of the vast wealth of data from "-omics" screens and projects to describe gene and protein functions and interactions. A February 2020 workshop was held to determine research needs to advance the field of functional genomics over the next 10-20 years. Speakers and participants discussed goals, strategies, and technical needs to allow functional genomics to contribute to the advancement of basic knowledge and its applications that would benefit society. This publication summarizes the presentations and discussions from the workshop.

Drug Discovery and Development

Omboon Vallisuta,Suleiman Olimat
Drug Discovery and Development Book PDF

Author : Omboon Vallisuta,Suleiman Olimat
Publisher : BoD – Books on Demand
Page : 332 pages
File Size : 47,9 Mb
Release : 2015-06-03
Category : Medical
ISBN : 9789535121282

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Drug Discovery and Development by Omboon Vallisuta,Suleiman Olimat Pdf

It is very important for scientists all over the globe to enhance drug discovery research for better human health. This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identification, drug metabolism, pharmacodynamic and pharmacokinetic research. The following 5 sections cover diverse chapter topics in drug discovery: Natural Products as Sources of Leading Molecules in Drug Discovery; Oncology and Drug Discovery; Receptors Involvement in Drug Discovery; Management and Development of Drugs against Infectious Diseases; Advanced Methodology.

Chemical Genomics

Haian Fu
Chemical Genomics Book PDF

Author : Haian Fu
Publisher : Cambridge University Press
Page : 359 pages
File Size : 45,5 Mb
Release : 2012-02-13
Category : Science
ISBN : 9781107377585

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Chemical Genomics by Haian Fu Pdf

Advances in chemistry, biology and genomics coupled with laboratory automation and computational technologies have led to the rapid emergence of the multidisciplinary field of chemical genomics. This edited text, with contributions from experts in the field, discusses the new techniques and applications that help further the study of chemical genomics. The beginning chapters provide an overview of the basic principles of chemical biology and chemical genomics. This is followed by a technical section that describes the sources of small-molecule chemicals; the basics of high-throughput screening technologies; and various bioassays for biochemical-, cellular- and organism-based screens. The final chapters connect the chemical genomics field with personalized medicine and the druggable genome for future discovery of new therapeutics. This book will be valuable to researchers, professionals and graduate students in many fields, including biology, biomedicine and chemistry.

NMR of Biomolecules

Ivano Bertini,Kathleen S. McGreevy,Giacomo Parigi
NMR of Biomolecules Book PDF

Author : Ivano Bertini,Kathleen S. McGreevy,Giacomo Parigi
Publisher : John Wiley & Sons
Page : 15 pages
File Size : 40,8 Mb
Release : 2012-04-16
Category : Science
ISBN : 9783527328505

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NMR of Biomolecules by Ivano Bertini,Kathleen S. McGreevy,Giacomo Parigi Pdf

NMR is one of the most powerful methods for imaging of biomolecules. This book is the ultimate NMR guide for researchers in the biomedical community and gives not only background and practical tips but also a forward looking view on the future of NMR in systems biology.