Optimal Impulsive Control For Cancer Therapy

Author : João P. Belfo,João M. Lemos
Publisher : Unknown
Page : 0 pages
File Size : 51,5 Mb
Release : 2021
Category : Electronic
ISBN : 3030504891

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Optimal Impulsive Control for Cancer Therapy by João P. Belfo,João M. Lemos Pdf

This Springer brief discusses the use of control engineering methods to plan a cancer therapy which tends to reduce tumour size in patients, striking a balance that minimizes the toxic effects of the treatment. The authors address the design and computation of impulsive control therapies, a methodology previously underexplored in the application of control methods to medical modelling. This allows simulation of such discrete events as taking a pill rather than relying on the supply of therapy being continuous and steady. The book begins with an introduction to the topic, before moving onto pharmacokinetic, pharmacodynamical and tumour-growth models and explaining how they describe the relationship between a certain therapy plan and the evolution of cancer. This is placed firmly in the context of work introducing impulsive differential equations. The final chapter summarizes the research presented and suggests future areas of research to encourage readers in taking the subject forward. This book is of interest to biomedical engineers, researchers and students, particularly those with a background in systems and control engineering.

Author : João P. Belfo,João M. Lemos
Publisher : Springer Nature
Page : 108 pages
File Size : 42,8 Mb
Release : 2020-06-19
Category : Technology & Engineering
ISBN : 9783030504885

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Optimal Impulsive Control for Cancer Therapy by João P. Belfo,João M. Lemos Pdf

This Springer brief discusses the use of control engineering methods to plan a cancer therapy which tends to reduce tumour size in patients, striking a balance that minimizes the toxic effects of the treatment. The authors address the design and computation of impulsive control therapies, a methodology previously underexplored in the application of control methods to medical modelling. This allows simulation of such discrete events as taking a pill rather than relying on the supply of therapy being continuous and steady. The book begins with an introduction to the topic, before moving onto pharmacokinetic, pharmacodynamical and tumour-growth models and explaining how they describe the relationship between a certain therapy plan and the evolution of cancer. This is placed firmly in the context of work introducing impulsive differential equations. The final chapter summarizes the research presented and suggests future areas of research to encourage readers in taking the subject forward. This book is of interest to biomedical engineers, researchers and students, particularly those with a background in systems and control engineering.

Author : Peng Shi,Jovan Stefanovski,Janusz Kacprzyk
Publisher : Springer Nature
Page : 551 pages
File Size : 51,8 Mb
Release : 2022-09-18
Category : Technology & Engineering
ISBN : 9783031009785

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Complex Systems: Spanning Control and Computational Cybernetics: Applications by Peng Shi,Jovan Stefanovski,Janusz Kacprzyk Pdf

This book, dedicated to Professor Georgi M. Dimirovski on his anniversary, contains new research directions, challenges, and many relevant applications related to many aspects within the broadly perceived areas of systems and control, including signal analysis and intelligent systems. The project comprises two volumes with papers written by well known and very active researchers and practitioners. The first volume is focused on more foundational aspects related to general issues in systems science and mathematical systems, various problems in control and automation, and the use of computational and artificial intelligence in the context of systems modeling and control. The second volume is concerned with a presentation of relevant applications, notably in robotics, computer networks, telecommunication, fault detection/diagnosis, as well as in biology and medicine, and economic, financial, and social systems too.

Author : Dana Copot
Publisher : Academic Press
Page : 338 pages
File Size : 48,6 Mb
Release : 2020-04-29
Category : Science
ISBN : 9780128159767

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Automated Drug Delivery in Anesthesia by Dana Copot Pdf

Automated Drug Delivery in Anesthesia provides a full review of available tools and methods on the drug delivery of anesthesia, bridging the gap between academic development, research and clinical practice. The book takes an interdisciplinary approach, pulling information about tools developed in other disciplines such as mathematics, physics, biology and system engineering and applying them to drug delivery. The book's authors discuss the missing element of complete regulatory loop of anesthesia: the sensor and model for pain pathway assessment. This is the only book which focuses specifically on the delivery of anesthesia. Revisits the standard TCI anesthesia regulatory loop Provides complementary measurement devices and protocols for hypnosis, analgesia and neuromuscular blockade (the three components for anesthesia) Describes the link between existing and emerging tools

Author : Walter Lacarbonara,Balakumar Balachandran,Michael J. Leamy,Jun Ma,J. A. Tenreiro Machado,Gabor Stepan
Publisher : Springer Nature
Page : 598 pages
File Size : 47,8 Mb
Release : 2022-03-01
Category : Technology & Engineering
ISBN : 9783030811709

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Advances in Nonlinear Dynamics by Walter Lacarbonara,Balakumar Balachandran,Michael J. Leamy,Jun Ma,J. A. Tenreiro Machado,Gabor Stepan Pdf

This third of three volumes includes papers from the second series of NODYCON, which was held virtually in February of 2021. The conference papers reflect a broad coverage of topics in nonlinear dynamics, ranging from traditional topics from established streams of research to those from relatively unexplored and emerging venues of research. These include · Complex dynamics of COVID-19: modeling, prediction and control · Nonlinear phenomena in bio-systems and eco-systems · Energy harvesting · MEMS/NEMS · Multifunctional structures, materials and metamaterials · Nonlinear waves · Chaotic systems, stochasticity, and uncertainty

Author : Heinz Schättler,Urszula Ledzewicz
Publisher : Springer
Page : 496 pages
File Size : 53,6 Mb
Release : 2015-09-15
Category : Mathematics
ISBN : 9781493929726

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Optimal Control for Mathematical Models of Cancer Therapies by Heinz Schättler,Urszula Ledzewicz Pdf

This book presents applications of geometric optimal control to real life biomedical problems with an emphasis on cancer treatments. A number of mathematical models for both classical and novel cancer treatments are presented as optimal control problems with the goal of constructing optimal protocols. The power of geometric methods is illustrated with fully worked out complete global solutions to these mathematically challenging problems. Elaborate constructions of optimal controls and corresponding system responses provide great examples of applications of the tools of geometric optimal control and the outcomes aid the design of simpler, practically realizable suboptimal protocols. The book blends mathematical rigor with practically important topics in an easily readable tutorial style. Graduate students and researchers in science and engineering, particularly biomathematics and more mathematical aspects of biomedical engineering, would find this book particularly useful.

Author : Esteban A. Hernandez-Vargas
Publisher : Academic Press
Page : 256 pages
File Size : 50,7 Mb
Release : 2019-02-15
Category : Technology & Engineering
ISBN : 9780128130520

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Modeling and Control of Infectious Diseases in the Host by Esteban A. Hernandez-Vargas Pdf

Modeling and Control of Infectious Diseases in the Host: With MATLAB and R provides a holistic understanding of health and disease by presenting topics on quantitative decision-making that influence the development of drugs. The book presents modeling advances in different viral infections, dissecting detailed contributions of key players, along with their respective interactions. By combining tailored in vivo experiments and mathematical modeling approaches, the book clarifies the relative contributions of different underlying mechanisms within hosts of the most lethal viral infections, including HIV, influenza and Ebola. Illustrative examples for parameter fitting, modeling and control applications are explained using MATLAB and R. Provides a multi-scale framework to link within-host infection dynamics (individual level) to between-host transmission fitness (epidemiological level) in viral infectious diseases Includes PK/PD modeling and simulation approaches to improve efficiency and decision-making at preclinical development phases Presents a theoretic approach to schedule drug treatments

Author : Boris M. Miller,Evgeny Y. Rubinovich
Publisher : Springer Science & Business Media
Page : 454 pages
File Size : 53,6 Mb
Release : 2012-12-06
Category : Mathematics
ISBN : 9781461500957

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Impulsive Control in Continuous and Discrete-Continuous Systems by Boris M. Miller,Evgeny Y. Rubinovich Pdf

Impulsive Control in Continuous and Discrete-Continuous Systems is an up-to-date introduction to the theory of impulsive control in nonlinear systems. This is a new branch of the Optimal Control Theory, which is tightly connected to the Theory of Hybrid Systems. The text introduces the reader to the interesting area of optimal control problems with discontinuous solutions, discussing the application of a new and effective method of discontinuous time-transformation. With a large number of examples, illustrations, and applied problems arising in the area of observation control, this book is excellent as a textbook or reference for a senior or graduate-level course on the subject, as well as a reference for researchers in related fields.

Author : Aram Arutyunov,Dmitry Karamzin,Fernando Lobo Pereira
Publisher : Springer
Page : 174 pages
File Size : 48,8 Mb
Release : 2018-12-17
Category : Technology & Engineering
ISBN : 9783030022600

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Optimal Impulsive Control by Aram Arutyunov,Dmitry Karamzin,Fernando Lobo Pereira Pdf

Optimal Impulsive Control explores the class of impulsive dynamic optimization problems—problems that stem from the fact that many conventional optimal control problems do not have a solution in the classical setting—which is highly relevant with regard to engineering applications. The absence of a classical solution naturally invokes the so-called extension, or relaxation, of a problem, and leads to the notion of generalized solution which encompasses the notions of generalized control and trajectory; in this book several extensions of optimal control problems are considered within the framework of optimal impulsive control theory. In this framework, the feasible arcs are permitted to have jumps, while the conventional absolutely continuous trajectories may fail to exist. The authors draw together various types of their own results, centered on the necessary conditions of optimality in the form of Pontryagin’s maximum principle and the existence theorems, which shape a substantial body of optimal impulsive control theory. At the same time, they present optimal impulsive control theory in a unified framework, introducing the different paradigmatic problems in increasing order of complexity. The rationale underlying the book involves addressing extensions increasing in complexity from the simplest case provided by linear control systems and ending with the most general case of a totally nonlinear differential control system with state constraints. The mathematical models presented in Optimal Impulsive Control being encountered in various engineering applications, this book will be of interest to both academic researchers and practising engineers.

Author : Solym Mawaki Manou-Abi,Sophie Dabo-Niang,Jean-Jacques Salone
Publisher : John Wiley & Sons
Page : 259 pages
File Size : 46,9 Mb
Release : 2020-02-19
Category : Mathematics
ISBN : 9781119706915

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Mathematical Modeling of Random and Deterministic Phenomena by Solym Mawaki Manou-Abi,Sophie Dabo-Niang,Jean-Jacques Salone Pdf

This book highlights mathematical research interests that appear in real life, such as the study and modeling of random and deterministic phenomena. As such, it provides current research in mathematics, with applications in biological and environmental sciences, ecology, epidemiology and social perspectives. The chapters can be read independently of each other, with dedicated references specific to each chapter. The book is organized in two main parts. The first is devoted to some advanced mathematical problems regarding epidemic models; predictions of biomass; space-time modeling of extreme rainfall; modeling with the piecewise deterministic Markov process; optimal control problems; evolution equations in a periodic environment; and the analysis of the heat equation. The second is devoted to a modelization with interdisciplinarity in ecological, socio-economic, epistemological, demographic and social problems. Mathematical Modeling of Random and Deterministic Phenomena is aimed at expert readers, young researchers, plus graduate and advanced undergraduate students who are interested in probability, statistics, modeling and mathematical analysis.

Author : Pat Price,Karol Sikora
Publisher : CRC Press
Page : 1029 pages
File Size : 45,5 Mb
Release : 2020-11-24
Category : Medical
ISBN : 9780429649004

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Treatment of Cancer by Pat Price,Karol Sikora Pdf

Treatment of Cancer is a multi-author work and comprehensive guide on modern cancer treatment that aims to give clinician and student alike the framework for an integrated approach to patient care, including radiotherapy, chemotherapy, and surgery. Much information is presented in tables and charts for easy assimilation, and clear algorithms for patient pathways are included to make decisions straightforward while allowing for sound clinical judgement.

Author : Consultant Geriatrician and Adjunct Professor Duncan R Forsyth,Stephen J. Wallis
Publisher : Oxford Speciality Training;Revision Texts
Page : 289 pages
File Size : 47,6 Mb
Release : 2020-06-25
Category : Electronic
ISBN : 9780198833055

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Best of Five MCQs for the Geriatric Medicine SCE by Consultant Geriatrician and Adjunct Professor Duncan R Forsyth,Stephen J. Wallis Pdf

Candidates can prepare with confidence for the Geriatric Medicine Specialty Certificate Examination with this revision guide designed specifically for the exam. Containing 300 Best of Five questions, the content is carefully mapped to the curriculum ensuring comprehensive preparation. The questions mirror the format of those candidates can expect to find in the exam, and cover all of the key topics, including dementia and delirium, palliative care, nutrition, and stroke. Explanatory answers include references to guidelines and other sources to enable further reading and study. The second edition addresses the latest clinical guidelines and supporting literature, Non-vitamin K Antagonist Oral Anticoagulants (NOACs), and changes in health and social care policy. This new edition is also suitable for candidates preparing for the Diploma in Geriatric Medicine exam. Providing a thorough assessment of the reader's geriatric medicine knowledge, this is the only revision guide candidates will need to pass the Geriatric Medicine Specialty Certificate Examination first time.

Author : Plamen Ch. Ivanov,Andras Eke,Olga Sosnovtseva
Publisher : Frontiers Media SA
Page : 842 pages
File Size : 47,6 Mb
Release : 2022-02-17
Category : Science
ISBN : 9782889714353

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The New Frontier of Network Physiology: From Temporal Dynamics to the Synchronization and Principles of Integration in Networks of Physiological Systems by Plamen Ch. Ivanov,Andras Eke,Olga Sosnovtseva Pdf

Author : Allen Kent,James G. Williams
Publisher : CRC Press
Page : 446 pages
File Size : 47,5 Mb
Release : 1990-08-20
Category : Computers
ISBN : 0824722736

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Encyclopedia of Computer Science and Technology by Allen Kent,James G. Williams Pdf

"This comprehensive reference work provides immediate, fingertip access to state-of-the-art technology in nearly 700 self-contained articles written by over 900 international authorities. Each article in the Encyclopedia features current developments and trends in computers, software, vendors, and applications...extensive bibliographies of leading figures in the field, such as Samuel Alexander, John von Neumann, and Norbert Wiener...and in-depth analysis of future directions."

Author : Robert David Thomas
Publisher : University of Pennsylvania Press
Page : 212 pages
File Size : 49,9 Mb
Release : 2016-11-11
Category : Biography & Autobiography
ISBN : 9781512807592

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The Man Who Would Be Perfect by Robert David Thomas Pdf

John Humphrey Noyes, founder of utopian communities in Putney, Vermont, and Oneida, New York, remain one of the most enigmatic reformers of the nineteenth century. The last biography, written over forty years ago, portrayed Noyes as a "Yankee Saint," a man of progressive ideas and religious vision. Yet he has also been called a "Vermont Casanova" whose elaborate theology of Perfection is simply justified the license he took with the women in his communities. Robert David Thomas makes a convincing case that Noyes, though riven by conflict and full of contradictions, had his finger on the social and cultural problems that were bothering a great many Americans of his time. Studied out of context, Noyes must remain a mystery-radical yet conservative, shy yet arrogant, retiring, and passive yet forceful, even oppressive, in his leadership. But against the background of nineteenth-century American activism and religious enthusiasm, John Humphrey Noyes emerges as a man who overcame a tortured personal life and marshaled his inner resources to grapple with a confusing and rapidly changing social world. Using modern theories of the ego, Thomas provides a psychologically consistent portrait of Noyes and therein a new perspective on the roots of nineteenth-century Perfectionism, utopian, reform, sexual ideology, and family theory. More than a conventional psycho-biography, this study assumes a sociological theme in its explanations of the social tensions of the era and the sources of "disorder" now so frequently mentioned in studies of the previous century.