Organic Chemistry Concepts And Applications For Medicinal Chemistry

Author : Joseph E. Rice
Publisher : Academic Press
Page : 224 pages
File Size : 55,7 Mb
Release : 2014-04-14
Category : Science
ISBN : 9780128008324

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Organic Chemistry Concepts and Applications for Medicinal Chemistry by Joseph E. Rice Pdf

Organic Chemistry Concepts and Applications for Medicinal Chemistry provides a valuable refresher for understanding the relationship between chemical bonding and those molecular properties that help to determine medicinal activity. This book explores the basic aspects of structural organic chemistry without going into the various classes of reactions. Two medicinal chemistry concepts are also introduced: partition coefficients and the nomenclature of cyclic and polycyclic ring systems that comprise a large number of drug molecules. Given the systematic name of a drug, the reader is guided through the process of drawing an accurate chemical structure. By emphasizing the relationship between structure and properties, this book gives readers the connections to more fully comprehend, retain, apply, and build upon their organic chemistry background in further chemistry study, practice, and exams. Focused approach to review those organic chemistry concepts that are most important for medicinal chemistry practice and understanding Accessible content to refresh the reader's knowledge of bonding, structure, functional groups, stereochemistry, and more Appropriate level of coverage for students in organic chemistry, medicinal chemistry, and related areas; individuals seeking content review for graduate and medical courses and exams; pharmaceutical patent attorneys; and chemists and scientists requiring a review of pertinent material

Author : Thomas Haldane
Publisher : Unknown
Page : 243 pages
File Size : 49,8 Mb
Release : 2018-02-26
Category : Medical
ISBN : 1632385864

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Medicinal Chemistry: Concepts and Applications by Thomas Haldane Pdf

Medicinal chemistry studies the design and development of pharmaceutical drugs. It is a multi-disciplinary subject that combines pharmacology, synthetic organic chemistry, toxicology, molecular biology, etc. Discovery of newer pharmaceutical agents by studying existing drugs with pathological or biological targets is the main concern of this field. Performing clinical trials and assessing the effectiveness of drugs is another significant facet of medicinal chemistry. The topics covered in this extensive book deal with the core aspects of medicinal chemistry. It aims to equip students and experts with the advanced topics and upcoming concepts in this area.

Author : Allan D. Headley
Publisher : John Wiley & Sons
Page : 626 pages
File Size : 52,5 Mb
Release : 2020-01-02
Category : Science
ISBN : 9781119504580

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Organic Chemistry by Allan D. Headley Pdf

Provides an in-depth study of organic compounds that bridges the gap between general and organic chemistry Organic Chemistry: Concepts and Applications presents a comprehensive review of organic compounds that is appropriate for a two-semester sophomore organic chemistry course. The text covers the fundamental concepts needed to understand organic chemistry and clearly shows how to apply the concepts of organic chemistry to problem-solving. In addition, the book highlights the relevance of organic chemistry to the environment, industry, and biological and medical sciences. The author includes multiple-choice questions similar to aptitude exams for professional schools, including the Medical College Admissions Test (MCAT) and Dental Aptitude Test (DAT) to help in the preparation for these important exams. Rather than categorize content information by functional groups, which often stresses memorization, this textbook instead divides the information into reaction types. This approach bridges the gap between general and organic chemistry and helps students develop a better understanding of the material. A manual of possible solutions for chapter problems for instructors and students is available in the supplementary websites. This important book: • Provides an in-depth study of organic compounds with division by reaction types that bridges the gap between general and organic chemistry • Covers the concepts needed to understand organic chemistry and teaches how to apply them for problem-solving • Puts a focus on the relevance of organic chemistry to the environment, industry, and biological and medical sciences • Includes multiple choice questions similar to aptitude exams for professional schools Written for students of organic chemistry, Organic Chemistry: Concepts and Applications is the comprehensive text that presents the material in clear terms and shows how to apply the concepts to problem solving.

Author : Saul Rowen
Publisher : Unknown
Page : 242 pages
File Size : 52,5 Mb
Release : 2017-05-16
Category : Science
ISBN : 1632385511

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Concepts and Applications of Organic Chemistry by Saul Rowen Pdf

Since twentieth century, organic chemistry emerged and has been rapidly expanding throughout without deceleration in the progress of this field. Foundations of medicine and biotechnology are built on organic compounds. It is contributing to the research in medicinal chemistry, polymer chemistry, as well as several aspects of materials science. This book discusses the fundamentals and concentrates on the applications of organic chemistry. It presents the concepts and applications in a concise manner for a better understanding of the subject. Students, researchers, experts and all associated with organic chemistry will benefit alike from this book.

Author : Wei Zhang,Berkeley W. Cue
Publisher : John Wiley & Sons
Page : 769 pages
File Size : 54,6 Mb
Release : 2012-07-23
Category : Medical
ISBN : 9780470711514

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Green Techniques for Organic Synthesis and Medicinal Chemistry by Wei Zhang,Berkeley W. Cue Pdf

Green chemistry is a new way of looking at organic synthesis and the design of drug molecules, offering important environmental and economic advantages over traditional synthetic processes. Pharmaceutical companies are increasingly turning to the principles of green chemistry in an effort to reduce waste, reduce costs and develop environmentally benign processes. Green Techniques for Organic Synthesis and Medicinal Chemistry presents an overview of the established and emerging techniques in green organic chemistry, highlighting their applications in medicinal chemistry. The book is divided into four parts: Introduction: Introduces the reader to the toxicology of organic chemicals,their environmental impact, and the concept of green chemistry. Green Catalysis: Covers a variety of green catalytic techniques including organocatalysis, supported catalysis, biocatalysis, fluorous catalysis, and catalytic direct C-H bond activation reactions. Green Synthetic Techniques: Presents a series of new techniques, assessing the green chemistry aspects and limitations (i.e. cost, equipment, expertise). Techniques include reactions in alternative solvents, atom economic multicomponent reactions, microwave and ultrasonic reactions, solid-supported synthesis, fluorous and ionic liquid-based recycling techniques, and flow reactors. Green Techniques in Pharmaceutical Industry: Covers applications of green chemistry concepts and special techniques for medicinal chemistry, including synthesis, analysis, separation, formulation, , and drug delivery. Process and business case studies are included to illustrate the applications in the pharmaceutical industry. Green Techniques for Organic Synthesis and Medicinal Chemistry is an essential resource on green chemistry technologies for academic researchers, R&D professionals and students working in organic chemistry and medicinal chemistry.

Author : Philip S. Bailey,Christina A. Bailey
Publisher : Unknown
Page : 0 pages
File Size : 42,7 Mb
Release : 2000
Category : Chemistry, Organic
ISBN : 0139241191

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Organic Chemistry by Philip S. Bailey,Christina A. Bailey Pdf

This application-based book presents essential, core concepts of basic organic chemistry in an engaging, easy-to-read format. It is ideal for the individual seeking a hands-on approach to understanding structure, nomenclature, physical properties, uses and applications, and chemical reactions of organic compounds.Unique engaging techniques get the reader involved in the learning process, such as a "Getting Involved" feature at the end of each section and several dozen mini-essays which connect theory to real life issues.Ideal for medical health professionals and anyone involved in consumer health issues.

Author : Francesca Hopkins
Publisher : Murphy & Moore Publishing
Page : 245 pages
File Size : 47,7 Mb
Release : 2021-11-16
Category : Science
ISBN : 1639874984

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Selected Topics in Organic Chemistry by Francesca Hopkins Pdf

The branch of chemistry that includes the study of structures, properties, composition, reaction and preparation of organic compounds is known as organic chemistry. Organic compounds are covalently bonded carbon containing compounds including hydrogen, halogen and other elements. They are classified on the basis of functional groups, aliphatic groups, aromaticity and the size of molecule. Organic compounds are structurally diverse and form the functional and structural basis of all living beings and many commercial products. Organic chemistry is an umbrella science which overlaps organometallic chemistry, biochemistry, medicinal chemistry, materials science and polymer chemistry. Organic chemistry is applied in a large number of industries such as pharmaceutical industry, petroleum industry, and chemical industry. This book traces the progress of this field and highlights some of its key concepts and applications. The topics included in this book on organic chemistry are of utmost significance and bound to provide incredible insights to readers. It aims to serve as a resource guide for students and experts alike and contribute to the growth of the discipline.

Author : Thomas L. Lemke
Publisher : Unknown
Page : 156 pages
File Size : 45,6 Mb
Release : 1988
Category : Science
ISBN : UOM:39015013200848

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Review of Organic Functional Groups by Thomas L. Lemke Pdf

Author : M. O. Faruk Khan,Ashok Philip
Publisher : Bentham Science Publishers
Page : 349 pages
File Size : 49,8 Mb
Release : 2018-06-01
Category : Medical
ISBN : 9781681086873

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Fundamentals of Medicinal Chemistry and Drug Metabolism by M. O. Faruk Khan,Ashok Philip Pdf

The primary objective of this 4-volume book series is to educate PharmD students on the subject of medicinal chemistry. The book set serves as a reference guide to pharmacists on aspects of chemical basis of drug action. This first volume of the series is comprised of 8 chapters focusing on basic background information about medicinal chemistry. It takes a succinct and conceptual approach to introducing important fundamental concepts required for a clear understanding of various facets of pharmacotherapeutic agents, drug metabolism and important biosynthetic pathways that are relevant to drug action. Notable topics covered in this first volume include the scope and importance of medicinal chemistry in pharmacy education, a comprehensive discussion of the organic functional groups present in drugs, and information about four major types of biomolecules (proteins, carbohydrates, lipids, nucleic acids) and key heterocyclic ring systems. The concepts of acid-base chemistry and salt formation, and their applications to the drug action and design follow thereafter. These include concepts of solubility and lipid-water partition coefficient (LWPC), isosterism, stereochemical properties, mechanisms of drug action, drug receptor interactions critical for pharmacological responses of drugs, and much more. Students and teachers will be able to integrate the knowledge presented in the book and apply medicinal chemistry concepts to understand the pharmacodynamics and pharmacokinetics of therapeutic agents in the body.

Author : Avianna Stokes
Publisher : Unknown
Page : 222 pages
File Size : 48,7 Mb
Release : 2019-06-25
Category : Electronic
ISBN : 1632415356

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Medicinal Chemistry and Pharmacology by Avianna Stokes Pdf

Medicinal chemistry and pharmacology are closely associated fields. They are concerned with the design and synthesis of drugs for the pharmaceutical industry. These drugs are generally organic compounds and can be divided into classes of biologics and small organic compounds. Medicinal chemistry is focused on the production of small organic molecules such as atorvastatin, fluticasone, clopidogrel, etc. The principles of synthetic organic chemistry, computational chemistry, enzymology, structural biology and chemical biology are integrated in medicinal chemistry. The study of drugs and their effects on the living body are explored in pharmacology. It involves the research, discovery and characterization of the chemicals that exhibit a biological effect. All therapies that are designed to target diseases, defects and pathogens and also advance preventive care, diagnostics and personalized medicine are a result of tremendous research in pharmacology. This book is a compilation of chapters that discuss the most vital concepts and emerging trends in the fields of medicinal chemistry and pharmacology. The various advancements in these fields are glanced at and their applications as well as ramifications are looked at in detail. This book is a vital tool for all researching and studying pharmaceutical science and medicinal chemistry.

Author : Marc W. Harrold,Robin M. Zavod
Publisher : American Society of Health-System Pharmacists
Page : 0 pages
File Size : 48,6 Mb
Release : 2023
Category : Medical
ISBN : 158528694X

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Basic Concepts in Medicinal Chemistry by Marc W. Harrold,Robin M. Zavod Pdf

Designed to help students incrementally build their knowledge of fundamental concepts of medicinal chemistry and their applications to therapeutic decisions, it is progressively organized. Specific sections of the text have been updated to make potentially confusing concepts easier to understand. Numerous examples and review questions further reinforce learning and analytical skills. This updated and expanded edition of the popular textbook, Basic Concepts in Medicinal Chemistry,, has been enhanced with new subject material, numerous self-assessment tools, and special features to advance and strengthen the learning process. New in the Third Edition Enhanced explanations, discussions, and examples in many key chapters. Additional summary tables to help readers better select the proper drug binding interaction. Expanded discussion on Pharmacogenomics, including multiple specific examples. Updated examples throughout the text to include a wider range of drugs and drug classes Increased focus on application of concepts to therapeutic decisions and pharmacy practice.

Author : Professor Satyajit D. Sarker,Lutfun Nahar
Publisher : John Wiley & Sons
Page : 397 pages
File Size : 55,7 Mb
Release : 2013-05-28
Category : Science
ISBN : 9781118687536

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Chemistry for Pharmacy Students by Professor Satyajit D. Sarker,Lutfun Nahar Pdf

"This book has succeeded in covering the basic chemistry essentials required by the pharmaceutical science student... the undergraduate reader, be they chemist, biologist or pharmacist will find this an interesting and valuable read." –Journal of Chemical Biology, May 2009 Chemistry for Pharmacy Students is a student-friendly introduction to the key areas of chemistry required by all pharmacy and pharmaceutical science students. The book provides a comprehensive overview of the various areas of general, organic and natural products chemistry (in relation to drug molecules). Clearly structured to enhance student understanding, the book is divided into six clear sections. The book opens with an overview of general aspects of chemistry and their importance to modern life, with particular emphasis on medicinal applications. The text then moves on to a discussion of the concepts of atomic structure and bonding and the fundamentals of stereochemistry and their significance to pharmacy- in relation to drug action and toxicity. Various aspects of aliphatic, aromatic and heterocyclic chemistry and their pharmaceutical importance are then covered with final chapters looking at organic reactions and their applications to drug discovery and development and natural products chemistry. accessible introduction to the key areas of chemistry required for all pharmacy degree courses student-friendly and written at a level suitable for non-chemistry students includes learning objectives at the beginning of each chapter focuses on the physical properties and actions of drug molecules

Author : Oleg I. Kolodiazhnyi
Publisher : John Wiley & Sons
Page : 568 pages
File Size : 45,5 Mb
Release : 2008-09-26
Category : Science
ISBN : 9783527613915

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Phosphorus Ylides by Oleg I. Kolodiazhnyi Pdf

When Wittig first developed and described phosphorus ylides, nobody could have imagined how useful and versatile this class of compounds could be. This book provides a comprehensive and up-to-date compilation of the chemistry and applications of phosphorus ylides in organic synthesis. The ylides are discussed as reagents in the synthesis of a broad range of substances, amongst them olefins, acetylenes, cyclic and heterocyclic compounds, in such naturally occurring compounds as pheromones, steroids and carotenoids, and pharmaceutically and biologically active compounds such as antibiotics and prostaglandins. A particularly beneficial feature of this book is the 150 key experimental procedures with all the necessary data, allowing the preparation to start immediately without the need for an extremely time-consuming literature search. But should a search prove inevitable, around 2,500 references provide easy access to the primary literature. Every chemist in academia and industry working in organic, bioorganic, inorganic, and medicinal chemistry will welcome this book as an inspiration of concepts, ideas and practical syntheses.

Author : Stéphane Caron
Publisher : John Wiley & Sons
Page : 848 pages
File Size : 45,6 Mb
Release : 2020-01-31
Category : Science
ISBN : 9781119448884

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Practical Synthetic Organic Chemistry by Stéphane Caron Pdf

This book is a hands-on guide for the organic chemist. Focusing on the most reliable and useful reactions, the chapter authors provide the information necessary for a chemist to strategically plan a synthesis, as well as repeat the procedures in the laboratory. Consolidates all the key advances/concepts in one book, covering the most important reactions in organic chemistry, including substitutions, additions, eliminations, rearrangements, oxidations, reductions Highlights the most important reactions, addressing basic principles, advantages/disadvantages of the methodology, mechanism, and techniques for achieving laboratory success Features new content on recent advances in CH activation, photoredox and electrochemistry, continuous chemistry, and application of biocatalysis in synthesis Revamps chapters to include new and additional examples of chemistry that have been demonstrated at a practical scale

Author : Francis A. Carey,Richard J. Sundberg
Publisher : Springer Science & Business Media
Page : 829 pages
File Size : 52,8 Mb
Release : 2013-11-11
Category : Science
ISBN : 9781461397953

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Advanced Organic Chemistry by Francis A. Carey,Richard J. Sundberg Pdf

The purpose of this edition, like that of the earlier ones, is to provide the basis for a deeper understanding of the structures of organic compounds and the mechanisms of organic reactions. The level is aimed at advanced undergraduates and beginning graduate students. Our goals are to solidify the student's understanding of basic concepts provided by an introduction to organic chemistry and to present more information and detail, including quantitative information, than can be presented in the first course in organic chemistry. The first three chapters consider the fundamental topi~s of bonding theory, stereochemistry, and conformation. Chapter 4 discusses the techniques that are used to study and characterize reaction mechanisms. Chapter 9 focuses on aromaticity and the structural basis of aromatic stabilization. The remaining chapters consider basic reaction types, including substituent effects and stereochemistry. As compared to the earlier editions, there has been a modest degree of reorganization. The emergence of free-radical reactions in synthesis has led to the inclusion of certain aspects of free-radical chemistry in Part B. The revised chapter, Chapter 12, empha sizes the distinctive mechanistic and kinetic aspects of free-radical reactions. The synthetic applications will be considered in Part B. We have also split the topics of aromaticity and the reactions of aromatic compounds into two separate chapters, Chapters 9 and 10. This may facilitate use of Chapter 9, which deals with the nature of aromaticity, at an earlier stage if an instructor so desires.