Osteosarcoma In Adolescents And Young Adults New Developments And Controversies

Author : G. Bennett Humphrey,H. Schraffordt Koops,W.M. Molenaar,A. Postma
Publisher : Springer Science & Business Media
Page : 407 pages
File Size : 42,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461535188

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Osteosarcoma in Adolescents and Young Adults: New Developments and Controversies by G. Bennett Humphrey,H. Schraffordt Koops,W.M. Molenaar,A. Postma Pdf

Osteosarcoma in Adolescents and Young Adults: New Developments and Controversies is the fifth volume in the series `Cancer Treatment, and Research' devoted to pediatric oncology. Like its immediate predecessor, Hodgkin's Disease in Children: Controversies and Current Practice, this volume also deals with the current state of affairs: where do researchers differ in opinions or firmly held beliefs? What does the future hold for research or for the patients who have benefited from research and are now cured? etc. The first part deals with preclinical and clinical issues that relate to the disease and the second part deals with the results of recent trials and in some cases ongoing trials. It could be argued that section B Pharmacology, Section D Radiotherapy and Section E Surgery of part one belong to part two; however in these sections we have tried to focus on one discipline and in part two, we have tried to focus on the results of multidisciplinary trials. A third part includes a few critiques and editorial comments. This volume was prepared and planned for both basic and clinical oncologists. It is hoped that the basic scientists will gain some insight into the problems of their clinical colleagues and that the clinicians will be willing to read to the more basic articles. It is not a text for students (or for that matter physicians) who want all things to be laid out in `black and white'. But it is a text for those students who want to know how vibrant this field of research is and are willing to stand in awe of how much research needs to be done.

Author : David O. Walterhouse,Susan L. Cohn
Publisher : Springer Science & Business Media
Page : 388 pages
File Size : 52,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461557678

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Diagnostic and Therapeutic Advances in Pediatric Oncology by David O. Walterhouse,Susan L. Cohn Pdf

The purpose of Diagnostic and Therapeutic Advances in Pediatric Oncology for the Cancer Treatment and Research Series is to provide an up-to-date summary of how recent advances in cancer research are being applied to the care of children with solid tumors. The interface of cancer research with clinical practice in pediatric oncology has never been more intimate than today. While researchers are identifying oncogenes and tumor suppressor genes and are studying their specific functions, clinicians are using knowledge of oncogenes and tumor suppressor genes for diagnosing cancer in children, for therapeutic decision-making purposes, and for prognostic purposes. The first three chapters in this book describe models for understanding the causes of childhood cancer that were perhaps initially identified by clinicians and that are now being studied and understood by researchers. These chapters will describe research evidence that supports roles for the involvement of normal developmental regulatory genes in childhood oncogenesis, of abnormal immune regulation in childhood oncogenesis, and of heredity in childhood oncogenesis. The next eight chapters are devoted to descriptions of the appli cation of new research developments to clinical practice with reference to the most common forms of solid tumors of childhood outside the central nervous system. The final chapter will describe late effects of childhood cancer and its therapy and the impact research is having on understanding and perhaps preventing these late effects.

Author : Louis S. Constine,Nancy J. Tarbell,Edward C. Halperin
Publisher : Lippincott Williams & Wilkins
Page : 512 pages
File Size : 53,7 Mb
Release : 2016-07-05
Category : Medical
ISBN : 9781496365682

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Pediatric Radiation Oncology by Louis S. Constine,Nancy J. Tarbell,Edward C. Halperin Pdf

Pediatric Radiation Oncology, Sixth Edition continues to be the premier reference that offers comprehensive coverage of this challenging area for the radiation oncologist in training or practice, medical radiation physicists and dosimetrists, as well as pediatric oncologists and others interested in understanding childhood malignancies. This definitive text has been completely updated to reflect recent advances in the field. Manageable in size and engaging to read, it efficiently synthesizes data on pathogenesis, pathology, diagnostic workup, staging, treatment approaches (particularly radiation therapy—indications, doses, volumes, and treatment planning), and toxic outcomes, as well as guidance on decision making when data is lacking. For 30 years, this standard reference has helped demystify radiation therapy for childhood cancer and contributed to the quality and quantity of life for children affected by this disease.

Author : Peter F. Thall
Publisher : Springer Science & Business Media
Page : 263 pages
File Size : 43,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461520092

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Recent Advances in Clinical Trial Design and Analysis by Peter F. Thall Pdf

Clinical trials have two purposes -- to treat the patients in the trial, and to obtain information which increases our understanding of the disease and especially how patients respond to treatment. Statistical design provides a means to achieve both these aims, while statistical data analysis provides methods for extracting useful information from the trial data. Recent advances in statistical computing have enabled statisticians to implement very rapidly a broad array of methods which previously were either impractical or impossible. Biostatisticians are now able to provide much greater support to medical researchers working in both clinical and laboratory settings. As our collective toolkit of techniques for analyzing data has grown, it has become increasingly difficult for biostatisticians to keep up with all the developments in our own field. Recent Advances in Clinical Trial Design and Analysis brings together biostatisticians doing cutting-edge research and explains some of the more recent developments in biostatistics to clinicians and scientists who work in clinical trials.

Author : Edward C. Halperin,Louis S. Constine,Nancy J. Tarbell,Larry E. Kun
Publisher : Lippincott Williams & Wilkins
Page : 480 pages
File Size : 50,7 Mb
Release : 2012-03-28
Category : Medical
ISBN : 9781451148695

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Pediatric Radiation Oncology by Edward C. Halperin,Louis S. Constine,Nancy J. Tarbell,Larry E. Kun Pdf

Established since 1986 as the definitive text and reference on use of radiation therapy for childhood cancer, Pediatric Radiation Oncology is now in its thoroughly revised and updated Fifth Edition. This edition reviews all significant recent clinical trials—including, for the first time, significant European clinical trials—and provides increased coverage of international and Third World issues. The latest cancer staging guidelines are included. New chapters cover psychosocial aspects of radiotherapy for the child and family and medical management of pain, nausea, nutritional problems, and blood count depression in the child with cancer. This edition also has full-color illustrations throughout. A companion website includes the full text and an image bank.

Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 824 pages
File Size : 54,5 Mb
Release : 1993
Category : Medicine
ISBN : UOM:39015074107684

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Current Catalog by National Library of Medicine (U.S.) Pdf

First multi-year cumulation covers six years: 1965-70.

Author : Anonim
Publisher : Unknown
Page : 1356 pages
File Size : 49,6 Mb
Release : 1993
Category : Medicine
ISBN : UIUC:30112023523266

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Cumulated Index Medicus by Anonim Pdf

Author : Manish Agarwal
Publisher : BoD – Books on Demand
Page : 186 pages
File Size : 41,6 Mb
Release : 2012-04-11
Category : Medical
ISBN : 9789535105060

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Osteosarcoma by Manish Agarwal Pdf

This book is aimed at quickly updating the reader on osteosarcoma, a dreaded primary bone cancer. Progress in management of osteosarcoma has been slow after the evolution of chemotherapy and limb salvage surgery. Research is now directed towards identifying molecular targets for systemic therapy. Availability of chemotherapy drugs and low cost implants in developing world have allowed limb salvage surgery to develop. This book looks at current basic knowledge on osteosarcoma and some of the developments in research which have the potential to change the prognosis.

Author : Richard K. Burt,Mary M. Brush
Publisher : Springer
Page : 419 pages
File Size : 53,9 Mb
Release : 2012-11-28
Category : Medical
ISBN : 9781461549871

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Advances in Allogeneic Hematopoietic Stem Cell Transplantation by Richard K. Burt,Mary M. Brush Pdf

The field of hematopoietic stem cell transplantation is rapidly evolving. Realization that hematopoietic stem cells give rise to the immune compartment has resulted in clinical trials of hematopoietic stem cell transplantation for patients with autoimmune diseases. Allogeneic hematopoietic transplants are a form of adoptive immunotherapy resulting in beneficial graft versus tumor effects. Large numbers of hematopoietic cells can be collected with ease. Therefore, a renewable source of cells for ex vivo genetic manipulations is readily available. Multiple trials combining hematopoietic transplants and gene therapy are in progress. One such application is the infusion of allogeneic lymphocytes containing a suicide gene to abort graft versus host disease. Hematopoietic stem cell transplantation is in reality the clinical and practical application of cellular therapy. Hematopoietic transplant physicians are by design or by practical application evolving into cell and gene therapy specialists. The excitement and enthusiasm in hematopoietic transplantation is that it offers a door to the future. A future not of drugs or titrating poisonous chemotherapy but rather of cellular and gene therapy. 1 ALLOGENEIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FOR HEMATOLOGIC DISEASES Martin Korbling University o/Texas MD. Anderson Cancer Center, Houston, Texas 77030 INTRODUCTION Circulating hematopoietic stem cells have emerged as an alternative to bone marrow (BM) stem cells for allografting. For many years the reconstitutive potential of circulating stem cells was questioned; peripheral blood stem cells (PBSC) were even characterized a waste product (1).

Author : Martin S. Tallman,Leo I. Gordon
Publisher : Springer Science & Business Media
Page : 383 pages
File Size : 55,5 Mb
Release : 2007-11-23
Category : Medical
ISBN : 9780585385716

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Diagnostic and Therapeutic Advances in Hematologic Malignancies by Martin S. Tallman,Leo I. Gordon Pdf

There is no field of medicine in which advances in therapy have been so closely linked to a better understanding of molecular medicine than in the area of hematologic malignancies. Diagnostic and Therapeutic Advances in Hematologic Malignancies will provide practitioners and academic clinicians with a better understanding of the constant evolving concepts in this area.

Author : Bharat B. Mittal,James A. Purdy,K.K. Ang
Publisher : Springer Science & Business Media
Page : 308 pages
File Size : 55,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461557692

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Advances in Radiation Therapy by Bharat B. Mittal,James A. Purdy,K.K. Ang Pdf

Recent advances in radiation oncology have depended upon and are intertwined with subsequent scientific discoveries and the development of new techniques in the fields of radiation and molecular biology, physics, electrical engineering, surgery, and medical oncology. This volume describes how some of the recent discoveries in the radiological sciences have influenced the way radiation oncology is practised. As there are many advances in this field, the Editors have chosen to concentrate on selected topics in clinical radiotherapy, radiation physics and biology, and technical innovations that have had a major impact on radiation oncology in the past twenty years. It is hoped that the techniques described in this volume will increase tumor control and prolong patient survival and at the same time decrease radiation-induced side effects and complications.

Author : Peter Angelos
Publisher : Springer Science & Business Media
Page : 155 pages
File Size : 40,5 Mb
Release : 2013-04-17
Category : Medical
ISBN : 9781475730449

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Ethical Issues in Cancer Patient Care by Peter Angelos Pdf

This book addresses a variety of ethical issues that arise in the care of oncology patients. Many volumes have been written on medical ethics in the past 30 years. However, few have focused on ethical issues specific to the care of cancer patients. This book brings together such a focused examination. The contributors are experienced clinicians, ethicists, medical humanists, and medical educators. The issues raised have direct relevance to the care of oncology patients in treatment as well as research settings. The chapters address issues that are central to contemporary medical practice and medical ethics inquiry. Any practicing clinician will be well aware of the problems of communication and how uncertainty, cross-cultural issues, and religious influences can impact patient care. The limits of care and the role of advance directives and palliative care are common issues that must be addressed in treating patients at the end of life. For oncologists and oncology patients, participation in clinical trials may be a thomy topic, especially when phase I clinical trials are being considered. The impact of managed care and reimbursement issues cannot be avoided in the contemporary patient care and similarly cannot be neglected when considering the ethical ramifications raised. No discussion of ethics in oncology can be complete without attention to the specific challenges raised by the pediatric patient with cancer. All of these topics are explored by the contributors to this book.

Author : Waun Ki Hong,Randal S. Weber
Publisher : Springer Science & Business Media
Page : 310 pages
File Size : 44,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461520238

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Head and Neck Cancer by Waun Ki Hong,Randal S. Weber Pdf

Throughout the world, head and neck cancer is a major threat to public health and a significant challenge to both clinicians and basic scientists. Despite extensive efforts in primary prevention, screening, early detection, and therapy, long-term survival rates have not improved substantially in the last three decades. This book covers a wide range of exciting new findings in both clinical and basic sciences as they are relevant to head and neck cancer. These findings have recently enhanced our understanding of head and neck carcinogenesis at the genetic and molecular levels, offering the promise of improved preventive and therapeutic strategies. This book will also present information on the important clinical advances that have been made in chemoprevention, organ preservation, and the simultaneous use of chemo therapy and radiotherapy. The first part provides an overview of the etiology and biology of head and neck cancer, including an examination of human papillomaviruses in both benign and malignant lesions. This section also discusses the carcinogenic process at the genetic and molecular levels, as well as aberrant squamous differentiation; increased understanding of these areas has great potential to translate into new strategies for cancer prevention. The second part describes recent advances in developing a risk model for head and neck cancer, as well as the application of genetic susceptibility data in chemoprevention. This section also includes overviews of the status of chemoprevention trials and of the process of invasion and metastasis in head and neck cancer.

Author : Robert B. Dickson,Marc E. Lippman
Publisher : Springer Science & Business Media
Page : 432 pages
File Size : 55,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461312598

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Mammary Tumor Cell Cycle, Differentiation, and Metastasis by Robert B. Dickson,Marc E. Lippman Pdf

Mammary Tumor Cell Cycle, Differentiation and Metastasis is the fifth volume since 1988 in a series designed to broadly examine current advances in the cellular and molecular biology of breast cancer. As in previous volumes, the editors have invited recognized experts in cutting-edge topics to provide a chapter focused on their area of research. The editors have turned to the researchers who study rodent models of the disease and to those who study the cellular and molecular basis of human breast cancer. The first section of the book is devoted to new mouse models of mammary development and tumorigenesis. The second section moves to studies of human breast cancer and focuses on receptors, signalling, and the cell cycle. The final section deals with defective tissue interactions in human breast cancer. We are now in a period of extremely rapid accumulation of data on the molecular and cellular biology of breast cancer. These findings are highlighted in chapters from Mammary Tumor Cell Cycle, Differentiation and Metastasis: Advances in Cellular and Molecular Biology of Breast Cancer.

Author : Kenneth A. Foon,Hyman B. Muss
Publisher : Springer Science & Business Media
Page : 293 pages
File Size : 48,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461561897

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Biological and Hormonal Therapies of Cancer by Kenneth A. Foon,Hyman B. Muss Pdf

This volume, Biological and Hormonal Therapies of Cancer, which is part of the series Cancer Treatment and Research, presents selected new information concerning biologic and hormonal therapy of cancer. We have attempted to provide the reader with topics of major interest in a timely fashion. There is renewed interest in biologic therapy of cancer. Two chapters review the role of interferon in the hematologic malignancies and in solid tumors. Vaccine therapies have come to the forefront of cancer therapy re cently, and two chapters approach different strategies of vaccine therapies; one reviews the cellular vaccine therapies and another the anti-idiotype ap proach. The hormonal therapy chapters focus on current uses of endocrine therapy in endometrial, breast, and prostate cancer. In addition, hormonal strategies for the prevention of breast cancer and endometrial cancer, including excit ing information relating to phytochemicals, are presented. The effects of tamoxifen on endometrium is a topic of major interest and is discussed in detail. Finally, there is a chapter on estrogen receptor expression and regula tion in human breast cancer. These chapters are all written by experts in the field and contain timely and relevant information of interest to laboratory and clinical scientists and practitioners alike. Biologic and endocrine therapies represent major areas of cancer research interest. The advent of newer biologic therapies, including new antibody targeted treatments, and the use of biologics as tumor modulators to enhance the effects of other treatment regimens is an exploding avenue of research.