Oxidative Cross Coupling Reactions

Author : Aiwen Lei,Wei Shi,Chao Liu,Wei Liu,Hua Zhang,Chuan He
Publisher : John Wiley & Sons
Page : 243 pages
File Size : 45,8 Mb
Release : 2016-11-14
Category : Technology & Engineering
ISBN : 9783527336883

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Oxidative Cross-Coupling Reactions by Aiwen Lei,Wei Shi,Chao Liu,Wei Liu,Hua Zhang,Chuan He Pdf

The first handbook on this emerging field provides a comprehensive overview of transition metal-catalyzed coupling reactions in the presence of an oxidant. Following an introduction to the general concept and mechanism of this reaction class, the team of authors presents chapters on C-C cross-coupling reactions using organometallic partners, C-Heteroatom bond forming reactions via oxidative couplings, and C-H couplings via C-H activation. The text also covers such groundbreaking topics as recent achievements in the fields of C-C and C-X bond formation reactions as well as C-H activation involving oxidative couplings. With its novel and concise approach towards important building blocks in organic chemistry and its focus on synthetic applications, this handbook is of great interest to all synthetic chemists in academia and industry alike.

Author : Aiwen Lei
Publisher : Unknown
Page : 128 pages
File Size : 41,6 Mb
Release : 2019
Category : SCIENCE
ISBN : 3662581035

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Transition Metal Catalyzed Oxidative Cross-coupling Reactions by Aiwen Lei Pdf

This book is a comprehensive text covering the research and development trends in the booming field of transition metal catalyzed oxidative cross-coupling reactions. Oxidative cross-coupling reaction is a new method to forming chemical bonds besides the traditional cross-coupling reactions. This book provides the answers to how this coupling reaction occurs and what its advantages are. The palladium, copper and iron catalyzed oxidative cross-coupling reactions as the main focuses of interest are described in detail. The oxidative cross-coupling reactions catalyzed by other metals and transition-metal-free oxidative coupling reactions are also introduced.This book provides a useful reference source for researchers and graduates in the field of transition metal catalyzed coupling reactions. It is also valuable to researchers working in pharmaceutical companies, fine organic chemical companies, and etc.

Author : Manas Sutradhar,Armando J L Pombeiro,José Armando L da Silva
Publisher : Royal Society of Chemistry
Page : 513 pages
File Size : 41,9 Mb
Release : 2020-11-05
Category : Science
ISBN : 9781839160899

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Vanadium Catalysis by Manas Sutradhar,Armando J L Pombeiro,José Armando L da Silva Pdf

Vanadium is one of the more abundant elements in the Earth’s crust and exhibits a wide range of oxidation states in its compounds making it potentially a more sustainable and more economical choice as a catalyst than the noble metals. A wide variety of reactions have been found to be catalysed by homogeneous, supported and heterogeneous vanadium complexes and the number of applications is growing fast. Bringing together the research on the catalytic uses of this element into one essential resource, including theoretical perspectives on proposed mechanisms for vanadium catalysis and an overview of its relevance in biological processes, this book is a useful reference for industrial and academic chemists alike.

Author : Yasushi Nishihara
Publisher : Springer Science & Business Media
Page : 245 pages
File Size : 51,7 Mb
Release : 2012-12-14
Category : Science
ISBN : 9783642323683

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Applied Cross-Coupling Reactions by Yasushi Nishihara Pdf

“Applied Cross-Coupling Reactions” provides students and teachers of advanced organic chemistry with an overview of the history, mechanisms and applications of cross-coupling reactions. Since the discovery of the transition-metal-catalyzed cross-coupling reactions in 1972, numerous synthetic uses and industrial applications have been developed. The mechanistic studies of the cross-coupling reactions have disclosed that three fundamental reactions: oxidative addition, transmetalation, and reductive elimination, are involved in a catalytic cycle. Cross-coupling reactions have allowed us to produce a variety of compounds for industrial purposes, such as natural products, pharmaceuticals, liquid crystals and conjugate polymers for use in electronic devices. Indeed, the Nobel Prize for Chemistry in 2010 was awarded for work on cross-coupling reactions. In this book, the recent trends in cross-coupling reactions are also introduced from the point of view of synthesis design and catalytic activities of transition-metal catalysts.

Author : Gwilherm Evano,Nicolas Blanchard
Publisher : John Wiley & Sons
Page : 0 pages
File Size : 40,9 Mb
Release : 2013-11-11
Category : Science
ISBN : 9781118060452

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Copper-Mediated Cross-Coupling Reactions by Gwilherm Evano,Nicolas Blanchard Pdf

Providing comprehensive insight into the use of copper in cross-coupling reactions, Copper-Mediated Cross-Coupling Reactions provides a complete up-to-date collection of the available reactions and catalytic systems for the formation of carbon-heteroatom and carbon-carbon bonds. This essential reference covers a broad scope of copper-mediated reactions, their variations, key advances, improvements, and an array of academic and industrial applications that have revolutionized the field of organic synthesis. The text also discusses the mechanism of these transformations, the use of copper as cost-efficient alternative to palladium, as well as recently developed methods for conducting copper-mediated reactions with supported catalysts.

Author : José Pérez Sestelo,Luis A. Sarandeses
Publisher : MDPI
Page : 234 pages
File Size : 42,8 Mb
Release : 2020-12-03
Category : Science
ISBN : 9783039435678

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Advances in Cross-Coupling Reactions by José Pérez Sestelo,Luis A. Sarandeses Pdf

In this Special Issue, recent advances in cross-coupling reactions are presented in the form of original research articles, reviews, and short communications. These contributions cover different topics in this area, including novel coupling reactions, reaction conditions, synthetic alternatives, metal ligands, and applications for new pharmaceutical compounds and organic materials. In particular, the reviews deal with methodologies such as the synthesis of diarylketones through palladium catalysis and the most relevant examples of Suzuki–Miyaura and Buchwald–Hartwig coupling reactions in the synthesis of bioactive compounds. The synthetic utility of cross-coupling reactions for the synthesis of medium-size rings and the utility of Stille and Suzuki coupling reactions for the synthesis of new molecular machines based on sterically hindered anthracenyl trypticenyl units are also summarized. The original research articles present the synthesis of 2-alkynylpyrrols by inverse Sonogashira coupling and the synthesis of indoles under oxidative dearomative cross-dehydrogenative conditions. The efficient combination of iridium-catalyzed C–H borylation of aryl halides with the Sonogashira coupling and a sequential iridium-catalyzed borylation of NH-free pyrroles followed by a Suzuki–Miyaura reaction are included. The synthesis of aryl propionic acids, a common structural motif in medicinal chemistry, and the synthesis of new organic dyes are also covered.

Author : Norio Miyaura
Publisher : Springer
Page : 248 pages
File Size : 41,6 Mb
Release : 2003-07-01
Category : Science
ISBN : 9783540453130

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Cross-Coupling Reactions by Norio Miyaura Pdf

In 1972, a very powerful catalytic cycle for carbon-carbon bond formation was 2 first discovered by the coupling reaction of Grignard reagents at the sp -carbon. Over the past 30 years, the protocol has been substantially improved and expanded to other coupling reactions of Li,B,N,O,Al,Si,P,S,Cu,Mn,Zn,In,Sn, and Hg compounds. These reactions provided an indispensable and simple methodology for preparative organic chemists. Due to the simplicity and rel- bility in the carbon-carbon, carbon-heteroatom, and carbon-metalloid bo- formations,as well as high efficiency of the catalytic process,the reactions have been widely employed by organic chemists in various fields. Application of the protocol ranges from various syntheses of complex natural products to the preparation of biologically relevant molecules including drugs, and of sup- molecules, and to functional materials. The reactions on solid surfaces allow robot synthesis and combinatorial synthesis. Now, many organic chemists do not hesitate to use transition metal complexes for the transformation of org- ic molecules. Indeed, innumerable organic syntheses have been realized by the catalyzed reactions of transition metal complexes that are not achievable by t- ditional synthetic methods. Among these, the metal-catalyzed cross-coupling reactions have undoubtedly contributed greatly to the development of such a new area of “metal-catalyzed organic syntheses”. An excellent monograph for the cross-coupling reactions and other met- catalyzed C-C bond-forming reactions recently appeared in Metal-catalyzed Cross-coupling Reactions (Wiley-VCH,1998).

Author : Joffrey Vrijdag
Publisher : Nova Science Publishers
Page : 268 pages
File Size : 54,5 Mb
Release : 2020
Category : Aromatic compounds
ISBN : 1536176788

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Cross-coupling Reactions by Joffrey Vrijdag Pdf

"Cross-Coupling Reactions: An Overview opens with an overview of the fundamentals and applications of the young and fast developing area of transition metal catalyzed/mediated oxidative (dehydrogenative) C-H/C-H coupling reactions between two (hetero)arenes. Continuing, the authors highlight the recent advances regarding the ligand supported transition metal-catalyzed domino (cascade) or one-pot syntheses of various heterocycles involving cross-coupling reactions. The recent advances in Cu catalyzed tandem reactions for heterocycle synthesis are also addressed. Cu metal chemistry has garnered attention as a potential alternative to precious transition metals, being cheaper, more sustainable and more easily available. A comprehensive account of research on green chemical routes is provided, involving various palladium metal-based catalysts utilized in facilitating cross-coupling reaction in aqueous media. Reported decarboxylative cross-coupling reactions are discussed along with suitable examples, focusing on their mechanism of action"--

Author : Qazi Naveed Ahmed
Publisher : Unknown
Page : 228 pages
File Size : 50,6 Mb
Release : 2017-05-02
Category : Electronic
ISBN : 3330858273

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2-Oxoiminium Promoted Oxidative Cross Coupling Reactions by Qazi Naveed Ahmed Pdf

Author : Aristidis Vasilopoulos
Publisher : Unknown
Page : 0 pages
File Size : 48,7 Mb
Release : 2021
Category : Electronic
ISBN : OCLC:1315489773

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Transition Metal-catalyzed Oxidative Cross Coupling for Synthesis and Functionalization of Diverse Molecules by Aristidis Vasilopoulos Pdf

Modular C-H functionalization methods offer a direct approach to molecular derivatization. In "radical relay" C-H functionalization reactions, a C(sp3)-H bond can be abstracted by an H atom transfer (HAT) reagent to form an alkyl radical. It has been demonstrated that alkyl radicals can be cross coupled with nucleophilic coupling partners in the presence of transition metal catalysts or reacted directly with compatible radical traps to form new bonds. Such oxidative coupling reactions allow bond construction from otherwise unreactive C-H sites enabling conversion of simple molecular building blocks into value added product libraries and generation of structural analogues of important molecules that can be tested for improved properties. This thesis discloses the development, mechanistic understanding, and application of several oxidative cross coupling methods including C(sp3)-H arylation, fluorination, and methylation reactions as well as an aerobic oxidative amidation reaction between alcohols and amines. Collectively, these methods contribute to the breadth of oxidation reactions available for the synthesis and functionalization of diverse molecules. The C-H arylation, fluorination/fluoride displacement, and amide coupling all are opportunities to apply oxidative coupling directly to the synthesis of important molecules. Complementarily, the fluorination and methylation reactions present opportunities to functionalize existing molecules to allow derivatized compositions of matter to be accessed for testing. Both forms of methodology are appealing for application in synthesis-driven specialties, where rapid and direct access to new structures is essential to solving complex challenges

Author : François Diederich,Peter J. Stang
Publisher : John Wiley & Sons
Page : 540 pages
File Size : 42,8 Mb
Release : 2008-07-11
Category : Science
ISBN : 9783527612208

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Metal-catalyzed Cross-coupling Reactions by François Diederich,Peter J. Stang Pdf

Carbon-carbon bond forming reactions are arguably the most important processes in chemistry, as they represent key steps in the building of complex molecules from simple precursors. Among these reactions, metal-catalyzed cross-coupling reactions are extensively employed in a wide range of areas of preparative organic chemistry, ranging from the synthesis of complex natural products, to supramolecular chemistry, and materials science. In this work, a dozen internationally renowned experts and leaders in the field bring the reader up to date by documenting and critically analyzing current developments and uses of metal-catalyzed cross-coupling reactions. A particularly attractive and useful feature, that enhances the practical value of this monograph, is the inclusion of key synthetic protocols, in experimental format, chosen for broad utility and application. This practice-oriented book can offer the practitioner short cuts to ensure they remain up-to-date with the latest developments.

Author : Arkaitz Correa
Publisher : Springer
Page : 338 pages
File Size : 54,5 Mb
Release : 2016-11-26
Category : Science
ISBN : 9783319497846

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Ni- and Fe-Based Cross-Coupling Reactions by Arkaitz Correa Pdf

The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.

Author : Vittorio Farina,Venkat Krishnamurthy,William J. Scott
Publisher : John Wiley & Sons
Page : 676 pages
File Size : 41,8 Mb
Release : 1998-09-18
Category : Science
ISBN : 0471312738

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The Stille Reaction by Vittorio Farina,Venkat Krishnamurthy,William J. Scott Pdf

Die Stille-Reaktion ist eine der sehr wenigen Reaktionen, in denen unter milden Bedingungen Kohlenstoff-Kohlenstoff-Bindungen geknüpft werden können. Man verwendet die Reaktion häufig in der Synthese komplizierter Moleküle zur Verknüpfung größerer Molekülbausteine. Die Autoren diskutieren vom präparativen Standpunkt aus Grenzen, Einflüsse, strukturelle Effekte und die Wahl der geeigneten Reaktionsbedingungen. Mit ausführlichen Vorschriften und vielen Beispielen. (11/98)

Author : Aiwen Lei
Publisher : Springer
Page : 192 pages
File Size : 50,8 Mb
Release : 2018-12-14
Category : Science
ISBN : 9783662581049

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Transition Metal Catalyzed Oxidative Cross-Coupling Reactions by Aiwen Lei Pdf

This book is a comprehensive text covering the research and development trends in the booming field of transition metal catalyzed oxidative cross-coupling reactions. Oxidative cross-coupling reaction is a new method to forming chemical bonds besides the traditional cross-coupling reactions. This book provides the answers to how this coupling reaction occurs and what its advantages are. The palladium, copper and iron catalyzed oxidative cross-coupling reactions as the main focuses of interest are described in detail. The oxidative cross-coupling reactions catalyzed by other metals and transition-metal-free oxidative coupling reactions are also introduced.This book provides a useful reference source for researchers and graduates in the field of transition metal catalyzed coupling reactions. It is also valuable to researchers working in pharmaceutical companies, fine organic chemical companies, and etc.

Author : Armin de Meijere,Stefan Bräse,Martin Oestreich
Publisher : John Wiley & Sons
Page : 1640 pages
File Size : 44,5 Mb
Release : 2013-12-04
Category : Science
ISBN : 9783527655601

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Metal Catalyzed Cross-Coupling Reactions and More by Armin de Meijere,Stefan Bräse,Martin Oestreich Pdf

This three volume book is the follow-up handbook to the bestselling volume "Metal-Catalyzed Cross-Coupling Reactions", the definitive reference in the field. In line with the enormous developments in this area, this is not a new edition, but rather a new book in three volumes with over 50% more content. This new content includes C-H activation, shifting the focus away from typical cross-coupling reactions, while those topics and chapters found in de Meijere/Diederich's book have been updated and expanded. With its highly experienced editor team and the list of authors reading like an international Who's-Who in the field, this work will be of great interest to every synthetic chemist working in academia and industry.