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Author : World Health Organization
Publisher : World Health Organization
Page : 27 pages
File Size : 50,6 Mb
Release : 2023-03-22
Category : Medical
ISBN : 9789240068933
Author : World Health Organization
Publisher : World Health Organization
Page : 56 pages
File Size : 51,5 Mb
Release : 2024-05-30
Category : Medical
ISBN : 9789240094826
Paediatric drug optimization (PADO) exercises have been convened by the World Health Organization (WHO) for various diseases, demonstrating their potential and impact to accelerate access to optimal formulations in the context of fragmented small markets for medicines for children. The WHO Global Tuberculosis Programme has convened PADO-TB meetings since February 2019 (PADO-TB1), followed by an interim review of the PADO-TB1 priorities in September 2020. Optimization of paediatric TB medicines forms part of the key actions in the Roadmap towards ending TB in children and adolescents, third edition and contributes to the achievement of the targets for ending TB in children and adolescents set out at the second United Nations High-level Meeting on the Fight Against TB in 2023. Considering the latest WHO recommendations on drug-susceptible TB, drug-resistant TB and TB preventive treatment, recent developments in new TB medicines and formulations made available, results of clinical trials and studies, and advancements of key medicines in the TB R&D pipeline, WHO convened the second PADO-TB meeting (PADO-TB2) on 3–5 October 2023. This meeting report summarizes the proceedings, discussions and the main consensus-based outputs of the PADO-TB2 meeting: - PADO-TB2 priority list (priority formulations to be investigated/developed in the short term and essential formulations to be developed in the longer term) - PADO-TB2 watch list (promising candidates for investigation/development for children within 5–10 years) - Priority research questions.
Author : World Health Organization
Publisher : World Health Organization
Page : 56 pages
File Size : 55,6 Mb
Release : 2023-11-21
Category : Business & Economics
ISBN : 9789240085176
Priority-setting is the first step to enable a targeted approach to research and development. Developing a prioritized drug portfolio of the most needed formulations for children is essential to streamline researchers’ and supplier’s efforts and resources around specific dosage forms and formulations that address most urgent needs for children. In general, due to limited financial incentives, few new drugs are being developed for Neglected Tropical Diseases (NTDs). Several NTDs disproportionately affect children compared to adults and, as is the case like for most diseases affecting adults and children, the burden to children is compounded by lack of inclusion of paediatric populations in clinical trials and/or lack of age-appropriate dosing regimens and formulations. The PADO-NTD exercise concluded with a final meeting organized in September 2023 with representatives from the four prioritized disease areas to reach consensus on a final PADO-NTD priority list, watch list and research questions and discuss transversal issues for the way forward. The meeting report will include summaries of the background, discussions and deliberations of all PADO exercises, and final conclusions and outputs of the overall PADO for NTD exercises.
Author : Wei Zhao,Johannes Nicolaas Van Den Anker
Publisher : Frontiers Media SA
Page : 160 pages
File Size : 43,8 Mb
Release : 2021-10-01
Category : Science
ISBN : 9782889714506
Topic Editor Johannes N. van den Anker is the Chief Medical Officer at Reveragen Biopharma, as well as holding his positions at academic institutions. The other Topic Editor declares no competing interests with regard to the Research Topic subject.
Author : World Health Organization
Publisher : World Health Organization
Page : 8 pages
File Size : 45,5 Mb
Release : 2023-11-16
Category : Business & Economics
ISBN : 9789240084599
In November-December 2022, WHO undertook a Paediatric Drug Optimization (PADO) exercise for antibiotics, to: identify antibiotics with an approved indication for children for which age-appropriate formulations are missing that need to be given priority for development (PADO priority list); and pipeline or approved antibiotics without an indication for children to be given priority for further investigation and development for children (PADO watch list). Cefiderocol was included in the PADO priority list considering its efficacy against multiple pathogens in the WHO Bacterial Priority Pathogens List, its favorable resistance and cross-resistance profile and considering that clinical trials involving children are ongoing. This information note aims to provide a summary of cefiderocol’s characteristics (regulatory approvals, current formulations, inclusion in the WHO EML etc), current and planned paediatric studies (including neonates) and initiatives to ensure prompt access for all people in need, as well as lay out interventions that should be prioritized by researchers and funders for cefiderocol development, as well as, more broadly for antibiotics that are much needed in children.
Author : World Health Organization
Publisher : World Health Organization
Page : 940 pages
File Size : 53,8 Mb
Release : 2024-04-19
Category : Medical
ISBN : 9789240089266
The 24th meeting of the WHO Expert Committee on Selection and Use of Essential Medicines was held in Geneva, Switzerland, from 24 to 28 April 2023. The Committee considered 85 applications proposing additions, changes and deletions of medicines, medicine classes and formulations on the Model Lists of Essential Medicines. The Committee evaluated the scientific evidence for effectiveness, safety and cost- effectiveness of the medicines in question. The Committee also considered a review of the age-appropriateness of formulations of essential medicines for children, the AWaRe classification of antibiotics, and other matters relevant to the selection and use of essential medicines.
Author : John C. Rotschafer,David R. Andes,Keith A. Rodvold
Publisher : Humana
Page : 0 pages
File Size : 49,6 Mb
Release : 2016-03-30
Category : Medical
ISBN : 1493933213
This text offers state of the art contributions written by world renown experts which provide an extensive background on specific classes of antibiotics and summarize our understanding as to how these antibiotics might be optimally used in a clinical situation. The book explores pharmacodynamics methods for anti-infective agents, pharmacodynamics of antibacterial agents and non-antibacterial agents, as well as pharmacodynamic considerations and special populations. As part of the Methods in Pharmacology and Toxicology series, chapters include detailed insight and practical information for the lab. Comprehensive and cutting-edge, Antibiotic Pharmacodynamics serves as an ideal reference for scientists investigating advances in antibiotic pharmacodynamics now finding their way into the antibiotic development process used for licensing new antibiotics.
Author : Mike Sharland,Andrew Cant,E. Graham Davies,David A. C. Elliman,Susanna Esposito,Delane Shingadia,Adam Finn
Publisher : Oxford University Press, USA
Page : 913 pages
File Size : 45,5 Mb
Release : 2011-04-07
Category : Medical
ISBN : 9780199573585
This manual gives information on the causative organisms, epidemiology and clinical features of all important childhood infections. It includes guidance on the clinical management of the infections and on steps to be taken to prevent future cases.
Author : The Hospital for Sick Children,Shawna Silver,Deborah Schonfeld,Siobhán Neville,Catherine Diskin
Publisher : Elsevier Health Sciences
Page : 1347 pages
File Size : 40,9 Mb
Release : 2020-09-03
Category : Medical
ISBN : 9780323713412
Practical and pocket sized, The Hospital for Sick Children Handbook of Pediatrics has been a trusted clinical reference for more than 50 years. The fully revised 12th Edition continues this tradition of excellence with succinct, easily accessible, and evidence-based answers for the diagnosis and management of pediatric patients. Get the reliable information you need from staff pediatricians, specialists, residents, and fellows at one of the top pediatric hospitals in the world. Provides the most up-to-date diagnostic and therapeutic approaches to pediatric clinical problems using evidence-based guidelines. Contains new chapters on mental health and technology and medical complexity. Offers quick access to comprehensive information on urgent situations in a six-chapter Acute Care section devoted to pediatric emergencies. Includes abundant algorithms for bedside diagnoses and management of various scenarios. Offers fast access to key information such as normal reference values for various ages and sizes of pediatric patients, common equations and normal vital signs, and resuscitation drugs. Widely used by medical students, residents, practicing pediatricians, family physicians, emergency physicians, nurses, and other interdisciplinary practitioners.
Author : World Health Organization
Publisher : World Health Organization
Page : 31 pages
File Size : 55,7 Mb
Release : 2024-04-19
Category : Business & Economics
ISBN : 9789240091276
The Paediatric Regulatory Network was initially created as a global paediatric working group in February 2010 in response to a recommendation from the 2008 International Conference on Drug Regulatory Authorities and as part of the World Health Organization (WHO) Better Medicines for Children Project in collaboration with the Bill & Melinda Gates Foundation, to offer a platform for discussion on paediatric regulatory considerations for national regulatory authorities. The Network was reactivated in December 2019 as a global paediatric network supporting the availability of quality-assured medical products for children, by facilitating communication, collaboration, training and regulatory harmonization across the development, registration and pharmacovigilance of paediatric medical products. The Network’s activities contribute efficiently to the implementation of World Health Assembly resolutions WHA60.20 (2007) on better medicines for children, WHA69.20 (2016) on promoting innovation and access to quality, safe, efficacious and affordable medicines for children, WHA67.20 (2014) on regulatory system strengthening for medical products and WHA67.22 (2014) on access to essential medicines.
Author : Nunzio Denora,Antonio Lopalco
Publisher : MDPI
Page : 205 pages
File Size : 45,8 Mb
Release : 2021-09-02
Category : Science
ISBN : 9783036507408
The development of paediatric medicines can be challenging since this is a different patient population with specific needs. A medicine designed for use in paediatric patients must consider the following aspects: patient population variability; the need for dose flexibility; route of administration; patient compliance; excipient tolerability. For example, the toxicity of excipients may differ in children compared to adults and children have different taste preferences. Globally, about 75% of drugs do not carry regulatory approval for use in children; worldwide, many medications prescribed for the treatment of paediatric diseases are used off-label, and less than 20% of package inserts have sufficient information for treating children. This book provides an update on both state-of-the-art methodology and operational challenges in paediatric formulation design and development. It aims at re-evaluating what is needed for more progress in the design and development of age-appropriate treatments for paediatric diseases, focusing on: formulation development; drug delivery design; efficacy, safety, and tolerability of drugs and excipients.
Author : Marc Fischer,Sarah S. Long,Charles G. Prober
Publisher : Elsevier Health Sciences
Page : 2253 pages
File Size : 53,7 Mb
Release : 2017-05-09
Category : Medical
ISBN : 9780323461320
Comprehensive in scope, yet concise and easy to manage, Principles and Practice of Pediatric Infectious Diseases, 5th Edition, by Drs. Sarah Long, Charles Prober, and Marc Fischer, is your go-to resource for authoritative information on infectious diseases in children and adolescents. A veritable "who's who" of global authorities provides the practical knowledge you need to understand, diagnose, and manage almost any pediatric infectious disease you may encounter. Features a consistent, easy-access format with high-yield information boxes, highlighted key points, and an abundance of detailed illustrations and at-a-glance tables. Allows quick look-up by clinical presentation, pathogen, or type of host. Includes coverage of the latest vaccine products, recommendations, and effectiveness as well as expanded diagnostics and therapies for autoinflammatory/periodic fever syndromes. Covers emerging viruses such as Zika, Ebola, and EV-D68, as well as infectious risks of immunomodulating drugs and expanding antimicrobial resistance patterns. Discusses expanding antimicrobial resistance patterns and new therapies for viral and fungal infections and resistant bacterial infections. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos (including video updates), glossary, and references from the book on a variety of devices.
Author : Richard E. Behrman,John M. Driscoll,A. Elmore Seeds
Publisher : Mosby
Page : 1040 pages
File Size : 55,6 Mb
Release : 1977
Category : Medical
ISBN : UOM:39015000858848
Author : World Health Organization
Publisher : World Health Organization
Page : 48 pages
File Size : 50,5 Mb
Release : 2022-03-25
Category : Medical
ISBN : 9789240044647
GAP-f’s three-year strategic plan (2022-2024) builds from the work undertaken to date by the network of leading partners, both individually and collectively, through GAP-f. With this strategy, GAP-f is excited to increase its footprint into a broader set of diseases to bring it closer to its vision of all children having equitable access to the medicines they need.
Author : Raffaele Simeoli,Erwin Dreesen,Thomas Dorlo,L. M. Hanff,Alwin Huitema
Publisher : Frontiers Media SA
Page : 166 pages
File Size : 44,5 Mb
Release : 2022-06-07
Category : Science
ISBN : 9782889763559