Paediatric Drug Optimization For Tuberculosis

Author : World Health Organization
Publisher : World Health Organization
Page : 56 pages
File Size : 46,6 Mb
Release : 2024-05-30
Category : Medical
ISBN : 9789240094826

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Paediatric drug optimization for tuberculosis by World Health Organization Pdf

Paediatric drug optimization (PADO) exercises have been convened by the World Health Organization (WHO) for various diseases, demonstrating their potential and impact to accelerate access to optimal formulations in the context of fragmented small markets for medicines for children. The WHO Global Tuberculosis Programme has convened PADO-TB meetings since February 2019 (PADO-TB1), followed by an interim review of the PADO-TB1 priorities in September 2020. Optimization of paediatric TB medicines forms part of the key actions in the Roadmap towards ending TB in children and adolescents, third edition and contributes to the achievement of the targets for ending TB in children and adolescents set out at the second United Nations High-level Meeting on the Fight Against TB in 2023. Considering the latest WHO recommendations on drug-susceptible TB, drug-resistant TB and TB preventive treatment, recent developments in new TB medicines and formulations made available, results of clinical trials and studies, and advancements of key medicines in the TB R&D pipeline, WHO convened the second PADO-TB meeting (PADO-TB2) on 3–5 October 2023. This meeting report summarizes the proceedings, discussions and the main consensus-based outputs of the PADO-TB2 meeting: - PADO-TB2 priority list (priority formulations to be investigated/developed in the short term and essential formulations to be developed in the longer term) - PADO-TB2 watch list (promising candidates for investigation/development for children within 5–10 years) - Priority research questions.

Author : Anonim
Publisher : World Health Organization
Page : 24 pages
File Size : 46,8 Mb
Release : 2021-11-19
Category : Medical
ISBN : 9789240039520

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Paediatric drug optimization standard procedure by Anonim Pdf

The aim of this document is to provide guidance on how to undertake a paediatric drug optimization (PADO) exercise and identify key priority products for research and development. This guidance is for all technical units undertaking a PADO exercise, all stakeholders involved in PADO processes as well as interested organizations and experts involved in the research and development of therapeutics in the public and private sectors.

Author : Anonim
Publisher : World Health Organization
Page : 46 pages
File Size : 50,9 Mb
Release : 2021-03-25
Category : Medical
ISBN : 9789240022157

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Report of the meeting to review the paediatric antituberculosis drug optimization priority list by Anonim Pdf

The Paediatric Antituberculosis Drug Optimization (PADO-TB) meetings provide a forum for clinicians, researchers, financial and technical partners and other relevant key stakeholders to work together, to ensure that priority optimal paediatric formulations of TB medicines are investigated, developed and made available to children in a timely manner. After the first meeting (PADO-TB1) in February 2019, WHO hosted an interim review of the PADO-TB1 priorities. The review considered the latest WHO recommendations and other relevant developments since February 2019, such as results of clinical trials, results of pharmacokinetics and pharmacodynamics studies, new formulations available and advancements of key drugs in the TB research and development pipeline. The 4.5-hour virtual review was attended by more than 50 experts including clinicians, researchers, representatives of national TB programmes (NTPs) from high TB burden countries, community representatives, financial and technical partners, members of the Child and Adolescent TB Working Group and representatives from various international agencies, including WHO. This report summarizes the main developments presented for various TB medicines and the decisions taken with regard to the PADO-TB priority list.

Author : World Health Organization
Publisher : Unknown
Page : 0 pages
File Size : 54,7 Mb
Release : 2022
Category : Electronic
ISBN : 9240047727

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WHO Consolidated Guidelines on Tuberculosis by World Health Organization Pdf

The WHO Consolidated Guidelines on Tuberculosis, Module 4: Treatment - Tuberculosis Care and Support informs health care professionals in Member States on how to improve treatment and care for patients with TB. These guidelines group all recommendations on TB care and support in one document and are complemented by an operational handbook. The guidelines are to be used primarily by national TB programmes, or their equivalents in Ministries of Health, stakeholders and technical organizations working on TB care in the public and private sectors and in the community.

Author : World Health Organization
Publisher : World Health Organization
Page : 27 pages
File Size : 50,8 Mb
Release : 2023-03-22
Category : Medical
ISBN : 9789240068933

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Paediatric drug optimization for antibiotics by World Health Organization Pdf

Author : World Health Organization
Publisher : World Health Organization
Page : 56 pages
File Size : 53,5 Mb
Release : 2023-11-21
Category : Business & Economics
ISBN : 9789240085176

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Paediatric drug optimization for neglected tropical diseases by World Health Organization Pdf

Priority-setting is the first step to enable a targeted approach to research and development. Developing a prioritized drug portfolio of the most needed formulations for children is essential to streamline researchers’ and supplier’s efforts and resources around specific dosage forms and formulations that address most urgent needs for children. In general, due to limited financial incentives, few new drugs are being developed for Neglected Tropical Diseases (NTDs). Several NTDs disproportionately affect children compared to adults and, as is the case like for most diseases affecting adults and children, the burden to children is compounded by lack of inclusion of paediatric populations in clinical trials and/or lack of age-appropriate dosing regimens and formulations. The PADO-NTD exercise concluded with a final meeting organized in September 2023 with representatives from the four prioritized disease areas to reach consensus on a final PADO-NTD priority list, watch list and research questions and discuss transversal issues for the way forward. The meeting report will include summaries of the background, discussions and deliberations of all PADO exercises, and final conclusions and outputs of the overall PADO for NTD exercises.

Author : World Health Organization
Publisher : World Health Organization
Page : 27 pages
File Size : 49,6 Mb
Release : 2023-03-23
Category : Medical
ISBN : 9789240068193

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Paediatric drug optimization for COVID-19 by World Health Organization Pdf

This meeting report summarizes the prioritization exercise for COVID-19 medications using the Paediatric Drug Optimization (PADO) process to identify research gaps and accelerate formulations under the umbrella of the Global Accelerator for Paediatric formulations (GAP-f). The target audience are policy makers, academic institutions, and NGOs.

Author : World Health Organization
Publisher : Unknown
Page : 0 pages
File Size : 55,7 Mb
Release : 2015-02-05
Category : Medical
ISBN : 9241548746

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Guidance for National Tuberculosis Programmes on the Management of Tuberculosis in Children by World Health Organization Pdf

It is estimated that one third of the world's population is infected with Mycobacterium tuberculosis (the bacterium that causes tuberculosis (TB)), and that each year, about 9 million people develop TB, of whom about 2 million die. Of the 9 million annual TB cases, about 1 million (11%) occur in children (under 15 years of age). Of these childhood cases, 75% occur annually in 22 high-burden countries that together account for 80% of the world's estimated incident cases. In countries worldwide, the reported percentage of all TB cases occurring in children varies from 3% to more than 25%. The Stop TB Strategy, which builds on the DOTS strategy developed by the World Health Organization (WHO) and the International Union Against TB and Lung Disease, has a critical role in reducing the worldwide burden of disease and thus in protecting children from infection and disease. The management of children with TB should be in line with the Stop TB Strategy, taking into consideration the particular epidemiology and clinical presentation of TB in children. These consensus guidelines were produced to help the National Tuberculosis Programmes on the management of tuberculosis in children.

Author : World Health Organization,Kerri Viney
Publisher : World Health Organization
Page : 52 pages
File Size : 50,8 Mb
Release : 2023-11-14
Category : Medical
ISBN : 9789240084254

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Roadmap towards ending TB in children and adolescents by World Health Organization,Kerri Viney Pdf

Author : World Health Organization
Publisher : World Health Organization
Page : 56 pages
File Size : 45,6 Mb
Release : 2022-08-26
Category : Medical
ISBN : 9789240056909

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Shaping the global innovation and access landscape for better paediatric medicines by World Health Organization Pdf

Author : Anonim
Publisher : World Health Organization
Page : 87 pages
File Size : 48,8 Mb
Release : 2021-07-28
Category : Medical
ISBN : 9789240030862

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Report of the technical consultation on innovative clinical trial designs for development of new TB treatments by Anonim Pdf

The Global Tuberculosis Programme of the World Health Organization (WHO) convened a virtual technical consultation on “Innovative Clinical Trial Designs for Development of New TB Treatments” on 5 days between 20 August and 13 October 2021. The main objective of the meeting was to establish evidence-based approaches to trial designs and use of data to inform policy guidance of new regimens for the treatment of TB with the view to accelerate future regimen development. The consultation brought together researchers, academics, technical partners, TB drugs and regimens developers including pharmaceutical industry, trialists, regulators, guideline developers, programme managers, nongovernmental organizations and civil society.

Author : Anonim
Publisher : World Health Organization
Page : 24 pages
File Size : 55,6 Mb
Release : 2021-04-30
Category : Medical
ISBN : 9789240024397

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WHO consultation on the translation of tuberculosis research into global policy guidelines by Anonim Pdf

Regular review of evidence, and assessment of country needs for policy across the cascade of care is part of the core function of the Global Tuberculosis Programme of the World Health Organization (WHO/GTB). In this regard, GTB organized a consultation (2-4 March 2021) assembling scientists, public health experts, partners, civil society and countries to exchange views on emerging needs of Member States for policy guidance; to discuss critical evidence gaps related to emerging global TB policy development needs; and, to identify topical strategies best positioned to enhance the implementation and evaluation of global TB policy guidance. The present report summarizes the discussions from this meeting.

Author : World Health Organization
Publisher : World Health Organization
Page : 264 pages
File Size : 49,9 Mb
Release : 2022-03-21
Category : Medical
ISBN : 9789240046832

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WHO operational handbook on tuberculosis. Module 5 by World Health Organization Pdf

The aim of this operational handbook is to provide practical guidance on the implementation of the World Health Organization (WHO) policy recommendations on the prevention and management of TB in children and adolescents under programmatic circumstances and at different levels of the health system. The practical guidance aims to inform the development or revision of national policies and related implementation guidance (e.g. handbooks, standard operating procedures) on the management of TB in children and adolescents. This handbook can also help countries adequately plan for the uptake of interventions to better address the specific needs of children and adolescents with or at risk of TB. It can contribute to national efforts to build capacity among national and subnational programme managers and among health workers at all levels of the health care system. The target audience for this handbook includes NTPs and other child health programmes that provide care for children with or at risk of TB, including maternal, newborn, child and adolescent health programmes, HIV services, and PHC programmes. The handbook also targets paediatricians and other health care workers (HCWs) in the public and private sectors, school health services, civil society and community-based organizations, and health care educators.

Author : Nunzio Denora,Antonio Lopalco
Publisher : MDPI
Page : 205 pages
File Size : 53,7 Mb
Release : 2021-09-02
Category : Science
ISBN : 9783036507408

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Paediatric Formulation by Nunzio Denora,Antonio Lopalco Pdf

The development of paediatric medicines can be challenging since this is a different patient population with specific needs. A medicine designed for use in paediatric patients must consider the following aspects: patient population variability; the need for dose flexibility; route of administration; patient compliance; excipient tolerability. For example, the toxicity of excipients may differ in children compared to adults and children have different taste preferences. Globally, about 75% of drugs do not carry regulatory approval for use in children; worldwide, many medications prescribed for the treatment of paediatric diseases are used off-label, and less than 20% of package inserts have sufficient information for treating children. This book provides an update on both state-of-the-art methodology and operational challenges in paediatric formulation design and development. It aims at re-evaluating what is needed for more progress in the design and development of age-appropriate treatments for paediatric diseases, focusing on: formulation development; drug delivery design; efficacy, safety, and tolerability of drugs and excipients.

Author : Anonim
Publisher : World Health Organization
Page : 73 pages
File Size : 52,8 Mb
Release : 2021-11-10
Category : Medical
ISBN : 9789240008182

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Innovative delivery systems for paediatric medicines by Anonim Pdf