Pancreas And Islet Transplantation

Author : Nadey S. Hakim,Robert Stratta,Derek Gray
Publisher : Unknown
Page : 400 pages
File Size : 51,7 Mb
Release : 2002
Category : Islands of Langerhans
ISBN : UOM:39015055869286

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Pancreas and Islet Transplantation by Nadey S. Hakim,Robert Stratta,Derek Gray Pdf

Diabetes Mellitus is the principle cause of kidney failure and blindness in adults and leads to more cases of amputation and impotence than any other disease. It is one of the most common chronic diseases in childhood. The aims of pancreas or islet transplantation are to improve the quality of life of patients with insulin dependent diabetes mellitus and to ameliorate secondary complications. This book provides a comprehensive and international review of the recent advances in pancreas and islet transplantation. It covers surgical techniques, issues surrounding organ preservation, immunosuppression and the control of other complications, all of which contribute to the potential for such transplantations to evolve as the treatment of choice for insulin dependent diabetes. The editors have compiled a strong and international team of contribution authors. This book is essential reading for transplant surgeons and all those involved in researching or treating diabetes mellitus.

Author : Camillo Ricordi
Publisher : Landes Bioscience
Page : 502 pages
File Size : 43,9 Mb
Release : 1992
Category : Medical
ISBN : UOM:39015025259535

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Pancreatic Islet Cell Transplantation by Camillo Ricordi Pdf

Intended for researchers and clinicians who work with cell transplantation, this text discusses the latest methods and gives an overall update of the major fields of islet transplantation. Included are reports of recent clinical trials on successful islet transplantation in humans.

Author : Miriam Ramírez-Domínguez
Publisher : Springer
Page : 123 pages
File Size : 52,8 Mb
Release : 2016-09-01
Category : Science
ISBN : 9783319398242

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Pancreatic Islet Isolation by Miriam Ramírez-Domínguez Pdf

Pancreatic islets make up the endocrine pancreas and they contain the only source of insulin in the body, beta cells. Hence, access to high quality preparations of pancreatic islets is fundamental for in vitro studies and to test pre-clinical applications in animal models in vivo. Access to healthy human islets is also crucial to improve transplantation procedures for diabetes. Given the susceptibility of pancreatic islets to the enzymatic digestion and mechanical stress required to obtain them, the isolation of islets is often considered as the delicate “work of a craftsman”. This book, which is aimed at beginners and experts alike, is a survey of the current state-of–the-art in this field and it centres on the challenges, pitfalls and peculiarities of pancreatic islet isolation in the different species used in pre-clinical and clinical applications. It explores the similarities and differences between human islets and those from other relevant species (rodents, pigs and non-human primates), and how these influence islet isolation. The ultimate goal of this book is to improve the outcome of islet isolation and transplantation in pre-clinical and clinical applications.

Author : Giuseppe Orlando,Lorenzo Piemonti,Camillo Ricordi,Robert J. Stratta,Rainer W.G. Gruessner
Publisher : Academic Press
Page : 890 pages
File Size : 50,5 Mb
Release : 2019-11-09
Category : Science
ISBN : 9780128148341

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Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas by Giuseppe Orlando,Lorenzo Piemonti,Camillo Ricordi,Robert J. Stratta,Rainer W.G. Gruessner Pdf

Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas, Volume 1, sets a new standard in transplant and regenerative medicine. The book details the-state-of-the-art in modern whole pancreas and islet transplantation, including donor selection, immunosuppression, complications, allograft pathology, and more. As regenerative medicine is changing the premise of solid organ transplantation, this volume catalogs the technologies being developed and the methods being implemented to bioengineer or regenerate the endocrine pancreas in order to more effectively treat diabetes. Edited and authored by unparalleled leaders in the field, this new volume argues for a much needed synergy between organ transplantation and regenerative medicine. Provides comprehensive and cutting-edge knowledge of whole pancreas and islet transplantation Includes sections that address donor selection, immunosuppression, complications, allograft pathology, and more Offers an update on the progress of regenerative medicine research aimed at beta cells replacement in the treatment of diabetes

Author : Nadey S. Hakim
Publisher : Oxford University Press, USA
Page : 542 pages
File Size : 52,6 Mb
Release : 2010-08-26
Category : Health & Fitness
ISBN : 9780199565863

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Pancreas, Islet and Stem Cell Transplantation for Diabetes by Nadey S. Hakim Pdf

This new edition provides an authoritative account of the current status of whole organ pancreas transplantation and islet and pancreatic stem cell transplantation, reflecting recent advances in the field, including the growing interest in stem cell research applicable to this condition.

Author : Giuseppe Orlando,Lorenzo Piemonti,Camillo Ricordi,Robert J. Stratta,Rainer W.G. Gruessner
Publisher : Academic Press
Page : 560 pages
File Size : 48,6 Mb
Release : 2019-11-10
Category : Science
ISBN : 9780128148327

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Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas by Giuseppe Orlando,Lorenzo Piemonti,Camillo Ricordi,Robert J. Stratta,Rainer W.G. Gruessner Pdf

Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas, Volume 2, sets a new standard in transplant and regenerative medicine. The book details the state-of-the-art in modern islet auto-transplantation, also discussing current progress in regenerative medicine research in diabetes medicine. Regenerative medicine is changing the premise of solid organ transplantation, hence this volume catalogs technologies being developed and methods being implemented. Bioengineering and regenerating beta cells, clinical pancreas and islet transplantation, tissue engineering, biomaterial sciences, stem cell biology and developmental biology are all addressed and applied directly to diabetes medicine. Provides comprehensive and cutting-edge knowledge of whole pancreas and islet transplantation Addresses imaging, treatment, scaffold technology, the use of stem cells to generate insulin, 3D printing, and more Offers an update on the progress of regenerative medicine research aimed at beta cell replacement for the treatment of diabetes

Author : Lanza
Publisher : CRC-Press
Page : 204 pages
File Size : 54,5 Mb
Release : 1994
Category : Medical
ISBN : 1570591342

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Immunomodulation of Pancreatic Islets by Lanza Pdf

Author : Rainer W.G. Gruessner,David E.R. Sutherland
Publisher : Springer Science & Business Media
Page : 736 pages
File Size : 43,7 Mb
Release : 2004-04-27
Category : Medical
ISBN : 0387005897

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Transplantation of the Pancreas by Rainer W.G. Gruessner,David E.R. Sutherland Pdf

Although pancreas transplants have been performed for more than 30 years, the last few years have witnessed significant growth in the options available for pancreas transplantation as well as subtantial improvements in outcome. It is therefore appropriate that a new text summarize the recent advances and put forth the standard of future care. Transplantation of the Pancreas, edited by Drs. Gruessner and Sutherland fulfills this mission by providing a state-of-the-art, definitive reference work on pancreas transplantation for transplant surgeons and physicians as well as for endocrinologists, diabetologists, nephrologists, and neurologist. The editors, from the renowned University of Minnesota Transplant Division and the Diabetes Institute, have assembled a group of renowned experts to provide an all inclusive overview of pancreas transplantation. The text features insights on the pathophysiology of diabetes mellitus and the limitations of nontransplant treatments, highlights experimental research and clinical history of pancreas transplantation, and compares and contrasts different surgical procedures. The discussions detail the broad spectrum of posttransplant complications and their treatments, which frequently require skills in general, vascular, and laparoscopic surgery, interventional radiology, critical care, and infectious disease. Chapters on immunosuppression, immunology, pathology, long-term outcome, quality of life, and cost-effectiveness focus on issues unique to pancreas recipients. Evolving areas, such as pretransplant evaluation of pancreas transplant candidates, living donation, and the current status of islet transplantation are discussed. Augmented by more than 280 illustrations, including full color line drawings created exclusively for the text, this book is the standard reference for all transplant professionals as well as all physicians caring for diabetic patients.

Author : Charles M. Peterson,Lois Jovanovic-Peterson,Bent Formby
Publisher : Springer Science & Business Media
Page : 223 pages
File Size : 41,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461237662

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Fetal Islet Transplantation by Charles M. Peterson,Lois Jovanovic-Peterson,Bent Formby Pdf

The breadth of research efforts represented by the many excellent papers in these proceedings is an eloquent testimonial to the idea of one man Dr. Josiah Brown-to whose memory this volume is dedicated. His tragic and unexpected loss in a swimming accident in August 1985 brought to an abrupt close a long and distinguished career as a physician and scientist. The possibility of using fetal pancreas tissue for transplantation into insulin-deficient diabetic recipients had intrigued Dr. Brown for several years prior to 1972, when he began in earnest to assemble a research team to explore this idea in detail. He felt that improvements in the formulation and administration of insulin (even the later recombinant human insulin) had taken us about as far as we could go in treating diabetes, and that methods for achieving complete cures must be explored. Numerous advantages of the fetal pancreas quickly became apparent, and were explored scientifically by Dr. Brown and his group. Transplanted pancreas tissue from a fetal donor of the appropriate developmental stage engrafts quickly, and can reverse diabetes very efficiently (1-3). By shunting the venous'drainage of the graft into the hepatic portal vein, a single pancreatic rudiment can, in time, provide enough insulin to restore normoglycemia and urine volume in a diabetic adult recipient (4). As with fetal pancreas rudiments in culture, transplanted fetal pancreas tissue loses its exocrine character, while continuing to develop and maintain endocrine function.

Author : Ashesh Piyush Shah,Cataldo Doria
Publisher : Unknown
Page : 128 pages
File Size : 48,9 Mb
Release : 2024-06-15
Category : Intestine, Small
ISBN : 331905547X

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Contemporary Small Bowel Transplantation by Ashesh Piyush Shah,Cataldo Doria Pdf

"Intestinal transplantation remains on the cutting edge of solid organ transplantation. Each potential recipient provides a unique case of intestinal failure with individual intricacies requiring the combined efforts of a complex multidisciplinary team in order to achieve success. Contemporary Small Bowel Transplantation covers all aspects of intestinal transplantation in a manner accessible to all providers and provides specific guidance for those that may come in contact with this field and these patients. The text provides an understanding of the critical pre-operative evaluation, thorough descriptions of each surgical procedure and postoperative management. Areas such as infectious disease, nutrition and graft versus host disease will be addressed in detail. Key controversies and administrative issues unique to intestinal transplantation are covered. Contemporary Small Bowel Transplantation provides critical guidance for the new transplant surgeon, gastroenterologist or administrator as they navigate the challenging field of intestinal transplantation."--Publisher's website.

Author : A. M. James Shapiro,James A. M. Shaw
Publisher : CRC Press
Page : 368 pages
File Size : 54,8 Mb
Release : 2007-07-25
Category : Medical
ISBN : 9781420016512

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Islet Transplantation and Beta Cell Replacement Therapy by A. M. James Shapiro,James A. M. Shaw Pdf

Beta cell replacement through transplantation remains the only treatment option for Type 1 diabetes enabling restoration of near-physiological glucose levels without significant hypoglycemia. Outlining the most recent advances and research breakthroughs, this practical guide and reference work explores the impact of islet cell transplantation and b

Author : Shahidul Islam
Publisher : Unknown
Page : 128 pages
File Size : 49,9 Mb
Release : 2024-06-15
Category : Bioorganic chemistry
ISBN : 9400768842

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Islets of Langerhans, 2. Ed by Shahidul Islam Pdf

Author : Rainer W. G. Gruessner,Angelika C. Gruessner
Publisher : Springer Nature
Page : 1267 pages
File Size : 44,9 Mb
Release : 2023-10-23
Category : Medical
ISBN : 9783031209994

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Transplantation of the Pancreas by Rainer W. G. Gruessner,Angelika C. Gruessner Pdf

Now in its fully revised and expanded second edition, this textbook remains the definitive resource on pancreas transplantation. Enlarged, updated and improved, it consists of 93 chapters over 11 sections, with chapter authors who are recognized international leaders in their fields and represent institutions from five continents. Since the publication of the original edition in 2004, substantial progress has been made in the field of pancreas transplantation, specifically in regard to standardization of operative techniques and immunosuppression; significant improvements in patient and graft survival rates; and improved diagnosis and therapy of graft rejection and recurrence of disease. Pancreas transplants are no longer primarily performed in the USA and Europe for Type 1 diabetes mellitus; over the past 15 years, they have been performed with increasing frequency worldwide and also for Type 2 diabetes mellitus. The new edition of this textbook covers all aspects of pancreas transplantation: indications, recipient categories, surgical donor and recipient techniques, living donor transplantation, postoperative management and follow-up, post-transplant complications and malignancies, immunosuppression, treatment and diagnosis of rejection, impact on endocrine function and secondary complications of diabetes, recurrence of disease, quality of life, economic issues and overall outcome results. In addition, state-of-the art chapters focus on the classification, epidemiology and pathogenesis of Type 1 and 2 diabetes mellitus as well as on other beta-cell replacement therapies including islet auto- and allo-transplantation. This textbook is the primary reference on pancreas transplantation for transplant surgeons (established and in-training), pancreas and HPB surgeons, diabetologists, endocrinologists, gastroenterologists, pancreatologists and other health professionals with a focus on transplantation and diabetes (cardiologists, neurologists, urologists, ophthalmologists).

Author : Georgios Tsoulfas
Publisher : BoD – Books on Demand
Page : 454 pages
File Size : 41,7 Mb
Release : 2018-07-25
Category : Medical
ISBN : 9781789233407

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Organ Donation and Transplantation by Georgios Tsoulfas Pdf

One of the most interesting and at the same time most challenging fields of medicine and surgery has been that of organ donation and transplantation. It is a field that has made tremendous strides during the last few decades through the combined input and efforts of scientists from various specialties. What started as a dream of pioneers has become a reality for the thousands of our patients whose lives can now be saved and improved. However, at the same time, the challenges remain significant and so do the expectations. This book will be a collection of chapters describing these same challenges involved including the ethical, legal, and medical issues in organ donation and the technical and immunological problems the experts are facing involved in the care of these patients.The authors of this book represent a team of true global experts on the topic. In addition to the knowledge shared, the authors provide their personal clinical experience on a variety of different aspects of organ donation and transplantation.

Author : David B. Adams,Peter B. Cotton,Nicholas J. Zyromski,John A. Windsor
Publisher : John Wiley & Sons
Page : 336 pages
File Size : 50,8 Mb
Release : 2017-02-02
Category : Medical
ISBN : 9781118924921

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Pancreatitis by David B. Adams,Peter B. Cotton,Nicholas J. Zyromski,John A. Windsor Pdf

Pancreatitis: medical and surgical management provides gastroenterologists and GI surgeons, both fully qualified and in training, with a focused, evidence-based approach to the most exciting developments in the diagnosis and clinical management of pancreatitis. Focusing mainly on the rapidly changing and innovative medical and surgical strategies to manage the disease, new surgical procedures such as endoscopic biliary intervention and minimally invasive necrosectomy to exciting new medical therapies like Antiprotease, Lexipafant, probiotics and enzyme treatment are all discussed. Full colour throughout, with over 250 colour illustrations and with reference to the latest clinical guidelines from the AGA, ACG and UEGW at all times, it is an essential consultation tool for all those managing patients with this increasingly common condition.