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Author : Frank Clifford Rose
Publisher : Unknown
Page : 207 pages
File Size : 47,9 Mb
Release : 1992
Category : Antiparkinsonian agents
ISBN : 1854630903
Author : Santiago Perez-Lloret
Publisher : Humana
Page : 0 pages
File Size : 48,5 Mb
Release : 2020-08-19
Category : Medical
ISBN : 1071609114
This volume looks at major clinical trials for motor and non-motor symptoms in Parkinson’s Disease (PD) and covers important aspects, including trial design, sample selection, and outcome selection. Chapters in this book discuss topics such as toxin-based rodent or genetic models of PD; clinical trials for motor symptoms, L-DOPA related motor complications, and gait disorders; clinical trials for mood disorders, troubled sleep, autonomic dysfunction; and clinical trials for disease modifying therapies. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory or research center. Cutting-edge and authoritative, Clinical Trials in Parkinson’s Disease is a valuable resource for clinicians and researchers who want to enhance their interpretation of results from clinical trials and to design their own high-quality trials.
Author : Roberto J. Guiloff
Publisher : Springer Science & Business Media
Page : 537 pages
File Size : 40,8 Mb
Release : 2013-03-14
Category : Medical
ISBN : 9781447137870
Clinical Trials in Neurology comprehensively tackles the methodology and design of clinical trials in neurological disease. A general section deals with the ethical aspects, drug development and regulatory requirements, basic trial designs and the statistics used. A diseases section tackles specific aspects of disorders, focusing on the relevant ethical issues, outcome variables and experience with large multicentre trials.
Author : Anonim
Publisher : Unknown
Page : 50 pages
File Size : 52,8 Mb
Release : 2004
Category : Parkinson's disease
ISBN : IND:30000129995183
Author : Juan Segura-Aguilar
Publisher : Academic Press
Page : 306 pages
File Size : 51,7 Mb
Release : 2021-06-12
Category : Medical
ISBN : 9780128221587
More than 50 years have passed since the use of L-dopa in the palliative treatment of Parkinson’s disease, but it remains the most common treatment despite inducing severe side effects such as dyskinesia after 4–6 years of use. Numerous preclinical investigations based on endogenous neurotoxin models have promised various therapies for Parkinson’s disease, but these efforts have failed when attempting to transfer these successful results to preclinical studies. Although several publications have warned of these failures, the scientific community remains mostly unaware, and there is a need to focus their efforts on potential therapeutics that can slow or halt development of the disease. Clinical Studies and Therapies in Parkinson’s Disease: Translations from Preclinical Models analyzes preclinical models based on exogenous neurotoxins and why they have failed. Neuroscientists, neurologists, and neuropharmacologists will benefit greatly from the book’s discussion of these newer models, their benefits, and the need for their implementation. This book also provides the basic concepts of dopamine metabolism for students taking courses in neurochemistry, neuroscience, neuropharmacology, biochemistry, and medicine. Reviews Parkinson's disease classification, pharmacological therapies, and nonmotor and motor symptoms Analyzes preclinical models of Parkinson’s disease therapies based on exogenous neurotoxins and why they have failed Reviews genetic preclinical models based on genetic mutations and endogenous neurotoxins Proposes a more physiological model directly related to the metabolism of dopaminergic neurons Provides the basic concepts and mechanisms of dopamine metabolism
Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation
Publisher : National Academies Press
Page : 127 pages
File Size : 55,5 Mb
Release : 2019-11-16
Category : Medical
ISBN : 9780309494885
Successful drug development relies on accurate and efficient clinical trials to deliver the best and most effective pharmaceuticals and clinical care to patients. However, the current model for clinical trials is outdated, inefficient and costly. Clinical trials are limited by small sample sizes that do not reflect variations among patients in the real world, financial burdens on participants, and slow processes, and these factors contribute to the disconnect between clinical research and clinical practice. On November 28-29, the National Academies of Sciences, Engineering, and Medicine convened a workshop to investigate the current clinical trials system and explore the potential benefits and challenges of implementing virtual clinical trials as an enhanced alternative for the future. This publication summarizes the presentations and discussions from the workshop.
Author : Néstor Gálvez-Jiménez,Hubert H. Fernandez,Alberto J. Espay,Susan H. Fox
Publisher : Cambridge University Press
Page : 385 pages
File Size : 49,7 Mb
Release : 2016-03-24
Category : Medical
ISBN : 9781107053861
This book emphasizes treatment options for Parkinson's disease, providing the necessary clinical and scientific basis for the foundations of solid therapeutics.
Author : Michael O'Kelly,Bohdana Ratitch
Publisher : John Wiley & Sons
Page : 472 pages
File Size : 49,7 Mb
Release : 2014-02-14
Category : Medical
ISBN : 9781118762530
This book provides practical guidance for statisticians, clinicians, and researchers involved in clinical trials in the biopharmaceutical industry, medical and public health organisations. Academics and students needing an introduction to handling missing data will also find this book invaluable. The authors describe how missing data can affect the outcome and credibility of a clinical trial, show by examples how a clinical team can work to prevent missing data, and present the reader with approaches to address missing data effectively. The book is illustrated throughout with realistic case studies and worked examples, and presents clear and concise guidelines to enable good planning for missing data. The authors show how to handle missing data in a way that is transparent and easy to understand for clinicians, regulators and patients. New developments are presented to improve the choice and implementation of primary and sensitivity analyses for missing data. Many SAS code examples are included – the reader is given a toolbox for implementing analyses under a variety of assumptions.
Author : Jonas H. Ellenberg,William C. Koller,James William Langston
Publisher : CRC Press
Page : 600 pages
File Size : 51,5 Mb
Release : 1995-03-01
Category : Medical
ISBN : 0824788230
This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.
Author : Sarat Chandra Yenisetti,Zevelou Koza,Devendra Kumar,Sushil Kumar Singh,Ankit Ganeshpurkar
Publisher : BoD – Books on Demand
Page : 252 pages
File Size : 53,6 Mb
Release : 2023-12-20
Category : Medical
ISBN : 9781803564883
Despite being described about 200 years ago, the pathophysiology of Parkinson’s disease (PD) is not well understood due to its complex etiology and heterogeneity of symptoms and progression. Animal models provide a great opportunity to follow the progression of neurodegeneration and to screen potent therapeutic molecules, knowledge of which can be critical for different levels of clinical trials. Contemporary health technologies are coming in handy to accelerate the pace of developing novel and refined therapeutic strategies for PD. This book, Parkinson’s Disease - Animal Models, Current Therapies and Clinical Trials, provides a comprehensive overview of PD, presenting information on animal models of PD and contemporary therapeutic strategies, health technologies, clinical trials, and their influence on the quality of life of patients with PD.
Author : Cristina Sampaio,Christopher G. Goetz,Anette Schrag
Publisher : Oxford University Press
Page : 328 pages
File Size : 40,6 Mb
Release : 2012-05-01
Category : Medical
ISBN : 9780199783151
For many years, the need to develop valid tools to evaluate signs and symptoms of Parkinson Disease (PD) has been present. However the understanding of all intricacies of rating scales development was not widely available and the first attempts were relatively crude. In 2002, the Movement Disorders Society created a task force to systemize the measurement of Parkinson's Disease. Since then, the Task Force has produced and published several critiques to the available rating scales addressing both motor and non-motor domains of Parkinson Disease. Additionally the task force initiated a project to develop a new version of the UPDRS, the MDS-UPDRS. But none of this was made available in one convenient source. Until now. Rating Scales in Parkinson's Disease: Clinical Practice and Research is written for researchers from the medical and social sciences, and for health professionals wishing to evaluate the progress of their patients suffering from Parkinson's Disease. The book is both exhaustive in the description of the scales and informative on the advantages and limitations of each scale. As such, the text clearly guides readers on how to choose and use the instruments available. Extensive cross-referenced tables and charts closely integrate the parts of the book to facilitate readers in moving from one symptom domain to another.
Author : Cristina Sampaio,Christopher G. Goetz,Anette Schrag
Publisher : Oxford University Press
Page : 342 pages
File Size : 44,5 Mb
Release : 2012-06-28
Category : Medical
ISBN : 9780199783106
For many years, the need to develop valid tools to evaluate signs and symptoms of Parkinson Disease (PD) has been present. However the understanding of all intricacies of rating scales development was not widely available and the first attempts were relatively crude. In 2002, the Movement Disorders Society created a task force to systemize the measurement of Parkinson's Disease. Since then, the Task Force has produced and published several critiques to the available rating scales addressing both motor and non-motor domains of Parkinson Disease. Additionally the task force initiated a project to develop a new version of the UPDRS, the MDS-UPDRS. But none of this was made available in one convenient source. Until now. Rating Scales in Parkinson's Disease is written for researchers from the medical and social sciences, and for health professionals wishing to evaluate the progress of their patients suffering from Parkinson Disease. The book is both exhaustive in the description of the scales and informative on the advantages and limitations of each scale. As such, the text clearly guides readers on how to choose and use the instruments available. Extensive cross-referenced tables and charts closely integrate the parts of the book to facilitate readers in moving from one symptom domain to another.
Author : Frank Clifford Rose,Rose
Publisher : Unknown
Page : 128 pages
File Size : 54,9 Mb
Release : 1991-10-01
Category : Medical
ISBN : 0939957272
Author : Anonim
Publisher : Unknown
Page : 8 pages
File Size : 44,7 Mb
Release : 2003
Category : Electronic
ISBN : RUTGERS:39030032547723
Author : Anonim
Publisher : Academic Press
Page : 580 pages
File Size : 55,8 Mb
Release : 2020-04-02
Category : Psychology
ISBN : 9780444642615
Recent Advances in Parkinson ́s Disease Research, Volume 252, represents a follow-up on two previous volumes presented in the Progress in Brain Research series, Volumes 193 and 193, both published in 2010. It contains a collection of overview articles written by leading researchers in Parkinson's, discussing the most important advances made in basic, translational and clinical research. Topics of note in this new release include What can we learn from iPS cell models of PD, What can we learn from animal models of PD?, Molecular basis of selective neuronal vulnerability in PD, Role of innate and adaptive immunity in Parkinson ́s disease, and much more. Covers all key aspects of current research on Parkinson ́s disease Includes topics that range from basic studies on disease models and pathogenic pathways (e.g., protein misfolding, immune and glial mechanisms) to clinical studies on disease features, microbiome, pathophysiology and therapeutic approaches Presents articles authored by world leaders in their respective fields