Clinical Trials In Parkinson S Disease

Author : Santiago Perez-Lloret
Publisher : Humana
Page : 0 pages
File Size : 51,8 Mb
Release : 2020-08-19
Category : Medical
ISBN : 1071609114

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Clinical Trials In Parkinson's Disease by Santiago Perez-Lloret Pdf

This volume looks at major clinical trials for motor and non-motor symptoms in Parkinson’s Disease (PD) and covers important aspects, including trial design, sample selection, and outcome selection. Chapters in this book discuss topics such as toxin-based rodent or genetic models of PD; clinical trials for motor symptoms, L-DOPA related motor complications, and gait disorders; clinical trials for mood disorders, troubled sleep, autonomic dysfunction; and clinical trials for disease modifying therapies. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory or research center. Cutting-edge and authoritative, Clinical Trials in Parkinson’s Disease is a valuable resource for clinicians and researchers who want to enhance their interpretation of results from clinical trials and to design their own high-quality trials.

Author : Frank Clifford Rose
Publisher : Unknown
Page : 207 pages
File Size : 55,5 Mb
Release : 1992
Category : Antiparkinsonian agents
ISBN : 1854630903

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Parkinson's Disease and the Problems of Clinical Trials by Frank Clifford Rose Pdf

Author : Néstor Gálvez-Jiménez,Hubert H. Fernandez,Alberto J. Espay,Susan H. Fox
Publisher : Cambridge University Press
Page : 385 pages
File Size : 55,5 Mb
Release : 2016-03-24
Category : Medical
ISBN : 9781107053861

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Parkinson's Disease: Current and Future Therapeutics and Clinical Trials by Néstor Gálvez-Jiménez,Hubert H. Fernandez,Alberto J. Espay,Susan H. Fox Pdf

This book emphasizes treatment options for Parkinson's disease, providing the necessary clinical and scientific basis for the foundations of solid therapeutics.

Author : J. Eric Ahlskog, PhD, MD
Publisher : Oxford University Press
Page : 544 pages
File Size : 43,7 Mb
Release : 2015-08-03
Category : Health & Fitness
ISBN : 9780190231880

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The New Parkinson's Disease Treatment Book by J. Eric Ahlskog, PhD, MD Pdf

The fundamental guide to the most effective treatments for Parkinson's Disease, from a Mayo Clinic doctor with thirty years of clinical and research experience. In this second edition follow-up to the extremely successful first edition, Dr. Ahlskog draws on thirty years of clinical experience to present the definitive guide to dealing with all aspects of Parkinson's Disease, from treatment options and side effects to the impact of the disease on caregivers and family. Dr. Ahlskog's goal is to educate patients so that they can better team up with their doctors to do battle with the disease, streamlining the decision-making process and enhancing their treatment. To do this, Dr. Ahlskog offers a gold mine of information, distilled from his years of experience treating people with Parkinson's at the Mayo Clinic. In addition to providing a comprehensive account of Parkinson's medications, this book also examines additional aspects of treatment, such as the role of nutrition, exercise, and physical therapy. Although many commendable texts have been written on the subject of Parkinson's Disease, their discussions of treatment have not been in depth. Dr. Ahlskog sifts through aspects of the disease in order to give the reader a comprehensive sense of Parkinson's and the best available treatment options. With a broader understanding of the disease and the available options, patients are able to make more informed choices, and doctors are able to provide more tailored care. This book delivers hopeful, helpful, and extensive information to all parties concerned: patients, caregivers, and doctors. The ultimate guide to symptoms and treatment, this thoroughly updated second edition is the first place patients should turn for reliable, easy-to-grasp information on Parkinson's Disease.

Author : Sarat Chandra Yenisetti,Zevelou Koza,Devendra Kumar,Sushil Kumar Singh,Ankit Ganeshpurkar
Publisher : BoD – Books on Demand
Page : 252 pages
File Size : 55,9 Mb
Release : 2023-12-20
Category : Medical
ISBN : 9781803564883

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Parkinson’s Disease - Animal Models, Current Therapies and Clinical Trials by Sarat Chandra Yenisetti,Zevelou Koza,Devendra Kumar,Sushil Kumar Singh,Ankit Ganeshpurkar Pdf

Despite being described about 200 years ago, the pathophysiology of Parkinson’s disease (PD) is not well understood due to its complex etiology and heterogeneity of symptoms and progression. Animal models provide a great opportunity to follow the progression of neurodegeneration and to screen potent therapeutic molecules, knowledge of which can be critical for different levels of clinical trials. Contemporary health technologies are coming in handy to accelerate the pace of developing novel and refined therapeutic strategies for PD. This book, Parkinson’s Disease - Animal Models, Current Therapies and Clinical Trials, provides a comprehensive overview of PD, presenting information on animal models of PD and contemporary therapeutic strategies, health technologies, clinical trials, and their influence on the quality of life of patients with PD.

Author : Frank Clifford Rose,Rose
Publisher : Unknown
Page : 128 pages
File Size : 48,6 Mb
Release : 1991-10-01
Category : Medical
ISBN : 0939957272

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Parkinson's Disease by Frank Clifford Rose,Rose Pdf

Author : Cristina Sampaio,Christopher G. Goetz,Anette Schrag
Publisher : Oxford University Press
Page : 328 pages
File Size : 55,7 Mb
Release : 2012-05-01
Category : Medical
ISBN : 9780199783151

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Rating Scales in Parkinson's Disease by Cristina Sampaio,Christopher G. Goetz,Anette Schrag Pdf

For many years, the need to develop valid tools to evaluate signs and symptoms of Parkinson Disease (PD) has been present. However the understanding of all intricacies of rating scales development was not widely available and the first attempts were relatively crude. In 2002, the Movement Disorders Society created a task force to systemize the measurement of Parkinson's Disease. Since then, the Task Force has produced and published several critiques to the available rating scales addressing both motor and non-motor domains of Parkinson Disease. Additionally the task force initiated a project to develop a new version of the UPDRS, the MDS-UPDRS. But none of this was made available in one convenient source. Until now. Rating Scales in Parkinson's Disease: Clinical Practice and Research is written for researchers from the medical and social sciences, and for health professionals wishing to evaluate the progress of their patients suffering from Parkinson's Disease. The book is both exhaustive in the description of the scales and informative on the advantages and limitations of each scale. As such, the text clearly guides readers on how to choose and use the instruments available. Extensive cross-referenced tables and charts closely integrate the parts of the book to facilitate readers in moving from one symptom domain to another.

Author : Jonas H. Ellenberg,William C. Koller,James William Langston
Publisher : CRC Press
Page : 600 pages
File Size : 41,9 Mb
Release : 1995-03-01
Category : Medical
ISBN : 0824788230

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Etiology of Parkinson's Disease by Jonas H. Ellenberg,William C. Koller,James William Langston Pdf

This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.

Author : Roberto J. Guiloff
Publisher : Springer Science & Business Media
Page : 537 pages
File Size : 49,8 Mb
Release : 2013-03-14
Category : Medical
ISBN : 9781447137870

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Clinical Trials in Neurology by Roberto J. Guiloff Pdf

Clinical Trials in Neurology comprehensively tackles the methodology and design of clinical trials in neurological disease. A general section deals with the ethical aspects, drug development and regulatory requirements, basic trial designs and the statistics used. A diseases section tackles specific aspects of disorders, focusing on the relevant ethical issues, outcome variables and experience with large multicentre trials.

Author : Anonim
Publisher : Elsevier
Page : 578 pages
File Size : 45,5 Mb
Release : 2020-04-16
Category : Science
ISBN : 9780444642608

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Recent Advances in Parkinson's Disease by Anonim Pdf

Recent Advances in Parkinson ́s Disease Research, Volume 252, represents a follow-up on two previous volumes presented in the Progress in Brain Research series, Volumes 193 and 193, both published in 2010. It contains a collection of overview articles written by leading researchers in Parkinson's, discussing the most important advances made in basic, translational and clinical research. Topics of note in this new release include What can we learn from iPS cell models of PD, What can we learn from animal models of PD?, Molecular basis of selective neuronal vulnerability in PD, Role of innate and adaptive immunity in Parkinson ́s disease, and much more. Covers all key aspects of current research on Parkinson ́s disease Includes topics that range from basic studies on disease models and pathogenic pathways (e.g., protein misfolding, immune and glial mechanisms) to clinical studies on disease features, microbiome, pathophysiology and therapeutic approaches Presents articles authored by world leaders in their respective fields

Author : Ray Dorsey,Todd Sherer,Michael S. Okun,Bastiaan R. Bloem
Publisher : PublicAffairs
Page : 271 pages
File Size : 53,9 Mb
Release : 2020-03-17
Category : Health & Fitness
ISBN : 9781541724495

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Ending Parkinson's Disease by Ray Dorsey,Todd Sherer,Michael S. Okun,Bastiaan R. Bloem Pdf

In this "must-read" guide (Lonnie Ali), four leading doctors and advocates offer a bold action plan to prevent, care for, and treat Parkinson's disease-one of the great health challenges of our time. Brain diseases are now the world's leading source of disability. The fastest growing of these is Parkinson's: the number of impacted patients has doubled to more than six million over the last twenty-five years and is projected to double again by 2040. Harmful pesticides that increase the risk of Parkinson's continue to proliferate, many people remain undiagnosed and untreated, research funding stagnates, and the most effective treatment is now a half century old. In Ending Parkinson's Disease, four top experts provide a plan to help prevent Parkinson's, improve care and treatment, and end the silence associated with this devastating disease.

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation
Publisher : National Academies Press
Page : 127 pages
File Size : 55,8 Mb
Release : 2019-11-16
Category : Medical
ISBN : 9780309494885

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Virtual Clinical Trials by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation Pdf

Successful drug development relies on accurate and efficient clinical trials to deliver the best and most effective pharmaceuticals and clinical care to patients. However, the current model for clinical trials is outdated, inefficient and costly. Clinical trials are limited by small sample sizes that do not reflect variations among patients in the real world, financial burdens on participants, and slow processes, and these factors contribute to the disconnect between clinical research and clinical practice. On November 28-29, the National Academies of Sciences, Engineering, and Medicine convened a workshop to investigate the current clinical trials system and explore the potential benefits and challenges of implementing virtual clinical trials as an enhanced alternative for the future. This publication summarizes the presentations and discussions from the workshop.

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Page : 111 pages
File Size : 55,8 Mb
Release : 2016-11-07
Category : Medical
ISBN : 9780309442589

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Neuroscience Trials of the Future by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders Pdf

On March 3-4, 2016, the National Academies of Sciences, Engineering, and Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop in Washington, DC, bringing together key stakeholders to discuss opportunities for improving the integrity, efficiency, and validity of clinical trials for nervous system disorders. Participants in the workshop represented a range of diverse perspectives, including individuals not normally associated with traditional clinical trials. The purpose of this workshop was to generate discussion about not only what is feasible now, but what may be possible with the implementation of cutting-edge technologies in the future.

Author : Patrik Brundin,C. Warren Olanow
Publisher : Springer Science & Business Media
Page : 397 pages
File Size : 54,6 Mb
Release : 2006-08-31
Category : Medical
ISBN : 9780387328232

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Restorative Therapies in Parkinson's Disease by Patrik Brundin,C. Warren Olanow Pdf

In this exciting and timely book new approaches to repairing the parkinsonian brain are described by leading experts. Never in history has there been greater hope that novel experimental therapies can support significant restoration of brain function. This book gives an overview of the current state-of-the-art research for brain repair, what the challenges are and an indication of what research can provide for the next generation of people with Parkinson’s disease. The comprehensive chapters are geared to an audience of neuroscientists, neurologists, neurosurgeons and anyone interested in how findings in the research laboratory can effectively be transferred to the clinic.

Author : Nutan Sharma,Elaine Richman
Publisher : Harvard University Press
Page : 233 pages
File Size : 55,8 Mb
Release : 2009-06-30
Category : Health & Fitness
ISBN : 9780674043473

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Parkinson's Disease and the Family by Nutan Sharma,Elaine Richman Pdf

Too often, with Parkinson's disease, a loved one serves as medical interpreter, patient advocate, and caregiver. Sharma and Richman draw on the latest research and clinical practice techniques to offer valuable suggestions for managing patient care and, perhaps more important, for healing the family unit.