Pathogenicity And Drug Resistance Of Human Pathogens

Author : Saif Hameed,Zeeshan Fatima
Publisher : Springer Nature
Page : 411 pages
File Size : 42,6 Mb
Release : 2020-01-23
Category : Medical
ISBN : 9789813294493

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Pathogenicity and Drug Resistance of Human Pathogens by Saif Hameed,Zeeshan Fatima Pdf

The book comprehensively discusses the mechanisms of pathogenesis and drug resistance; current diagnostics landscape of four key human pathogens; bacterial, fungal, protozoans and viral which are the causes of major infectious diseases. It also assesses the emerging technologies for the detection and quantification of these pathogens. Further, it discusses the novel opportunities to fight against these infectious diseases and to identify pertinent drug targets with novel methodologies. It also reviews the current and future insights into the control, elimination, and eradication of these infectious diseases. Importantly, the book discusses the epidemiological characteristics and various challenges in combating Ebola and Influenza diseases. Finally, the book highlights the growing role of nanotechnology and bioinformatics resources for combating the infectious diseases. In summary, the book provides the mechanistic insight of the pathogenicity, drug-resistance, therapeutic strategies and identification of the novel drug targets of Mycobacterium tuberculosis, Plasmodium, Candida, Hepatitis C and emerging viral infections.

Author : Saif Hameed,Zeeshan Fatima
Publisher : Unknown
Page : 404 pages
File Size : 40,7 Mb
Release : 2019
Category : Bioinformatics
ISBN : 9813294507

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Pathogenicity and Drug Resistance of Human Pathogens by Saif Hameed,Zeeshan Fatima Pdf

The book comprehensively discusses the mechanisms of pathogenesis and drug resistance; current diagnostics landscape of four key human pathogens; bacterial, fungal, protozoans and viral which are the causes of major infectious diseases. It also assesses the emerging technologies for the detection and quantification of these pathogens. Further, it discusses the novel opportunities to fight against these infectious diseases and to identify pertinent drug targets with novel methodologies. It also reviews the current and future insights into the control, elimination, and eradication of these infectious diseases. Importantly, the book discusses the epidemiological characteristics and various challenges in combating Ebola and Influenza diseases. Finally, the book highlights the growing role of nanotechnology and bioinformatics resources for combating the infectious diseases. In summary, the book provides the mechanistic insight of the pathogenicity, drug-resistance, therapeutic strategies and identification of the novel drug targets of Mycobacterium tuberculosis, Plasmodium, Candida, Hepatitis C and emerging viral infections.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 45,5 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Fangkun Wang,Dongyan Niu,Zhang Wan Jiang
Publisher : Frontiers Media SA
Page : 160 pages
File Size : 49,5 Mb
Release : 2021-11-25
Category : Science
ISBN : 9782889716975

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Foodborne Enterobacteriaceae of Animal Origin: Epidemic Characteristics of Drug Resistance, Pathogenic Mechanisms, and Novel Control Measures by Fangkun Wang,Dongyan Niu,Zhang Wan Jiang Pdf

Author : Etienne Giraud,Ivan Rychlik,Axel Cloeckaert
Publisher : Frontiers Media SA
Page : 140 pages
File Size : 55,6 Mb
Release : 2017-06-01
Category : Electronic book
ISBN : 9782889451814

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Antimicrobial Resistance and Virulence Common Mechanisms by Etienne Giraud,Ivan Rychlik,Axel Cloeckaert Pdf

Multiple relationships exist between antimicrobial resistance and bacterial virulence, and the spread of clones combining multiple antibiotic resistance and a high virulence level is an increasing problem. It was previously described how mutation-driven or horizontally acquired resistance mechanisms can also have effects on virulence. It was also reported that mobile genetic elements often carry both resistance determinants and virulence-modulating genes, which favors the co-selection of both traits. In the present volume, we present a collection of articles which document additional aspects of the interactions between antimicrobial resistance and virulence in bacteria, and describe their potential therapeutic consequences.

Author : Sahra Kırmusaoğlu,Sonia Bhonchal Bhardwaj
Publisher : BoD – Books on Demand
Page : 248 pages
File Size : 45,9 Mb
Release : 2020-12-09
Category : Science
ISBN : 9781789859874

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Pathogenic Bacteria by Sahra Kırmusaoğlu,Sonia Bhonchal Bhardwaj Pdf

Pathogenic bacteria are the main problem in hospital- and community-acquired infections. As bacteria continue to develop more resistance to antibiotics, it is imperative to develop antibacterial treatment strategies. Written by experts from all over the world, this book examines pathogenic bacteria and their link to multidrug resistance. Over thirteen chapters, it presents examples of pathogenesis, virulence factors, and treatment strategies.

Author : Anonim
Publisher : Academic Press
Page : 620 pages
File Size : 44,7 Mb
Release : 1998-07-01
Category : Science
ISBN : 0080860567

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Bacterial Pathogenesis by Anonim Pdf

Established almost 30 years ago, Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Now totally revamped, revitalized, with a new format and expanded scope, Methods in Microbiology will continue to provide you with tried and tested, cutting-edge protocols to directly benefit your research. Focuses on the methods most useful for the microbiologist interested in the way in which bacteria cause disease Includes section devoted to 'Approaches to characterising pathogenic mechanisms' by Stanley Falkow Covers safety aspects, detection, identification and speciation Includes techniques for the study of host interactions and reactions in animals and plants Describes biochemical and molecular genetic approaches Essential methods for gene expression and analysis Covers strategies and problems for disease control

Author : Maurizio Fraziano,Roberto Nisini,Gian Maria Rossolini,Marco Rinaldo Oggioni
Publisher : Frontiers Media SA
Page : 170 pages
File Size : 53,5 Mb
Release : 2020-12-30
Category : Science
ISBN : 9782889663071

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Exploiting Novel Combined Host- and Pathogen-Directed Therapies for Combating Bacterial Multidrug Resistance by Maurizio Fraziano,Roberto Nisini,Gian Maria Rossolini,Marco Rinaldo Oggioni Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Anthony R.M. Coates
Publisher : Springer Science & Business Media
Page : 194 pages
File Size : 53,6 Mb
Release : 2012-10-22
Category : Medical
ISBN : 9783642289514

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Antibiotic Resistance by Anthony R.M. Coates Pdf

This book describes antibiotic resistance amongst pathogenic bacteria. It starts with an overview of the erosion of the efficacy of antibiotics by resistance and the decrease in the rate of replacement of redundant compounds. The origins of antibiotic resistance are then described. It is proposed that there is a large bacterial resistome which is a collection of all resistance genes and their precursors in both pathogenic and non-pathogenic bacteria. Ongoing resistance surveillance programs are also discussed, together with the perspective of a clinical microbiologist. The book then turns to specific themes such as the most serious area of resistance in pathogens, namely in Gram-negative organisms. The role of combinations of antibiotics in combating resistance emergence is discussed, particularly in the tuberculosis field, and then the importance of non-multiplying and persistent bacteria which are phenotypically resistant to antibiotics and prolong the duration of therapy of antibiotics which leads to poor compliance and resistance emergence. The role of anti-microbial compounds in textiles is covered, with its potential to exacerbate the spread of resistance. Then, efflux pumps are discussed. The final chapter describes the compounds which are in late stage clinical development, illustrating the paucity of the antibiotic pipeline, especially for Gram-negative bacteria.

Author : National Research Council,Division on Earth and Life Studies,Division of Medical Sciences,Commission on Life Sciences,Committee to Study the Human Health Effects of Subtherapeutic Antibiotic Use in Animal Feeds
Publisher : National Academies Press
Page : 393 pages
File Size : 46,6 Mb
Release : 1980-02-01
Category : Medical
ISBN : 9780309030441

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The Effects on Human Health of Subtherapeutic Use of Antimicrobials in Animal Feeds by National Research Council,Division on Earth and Life Studies,Division of Medical Sciences,Commission on Life Sciences,Committee to Study the Human Health Effects of Subtherapeutic Antibiotic Use in Animal Feeds Pdf

Author : Gottfried Unden,Eckhard Thines,Anja Schuffler
Publisher : John Wiley & Sons
Page : 240 pages
File Size : 50,7 Mb
Release : 2016-03-11
Category : Science
ISBN : 9783527682416

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Host - Pathogen Interaction by Gottfried Unden,Eckhard Thines,Anja Schuffler Pdf

In light of the rapidity increasing incidence rate of bacterial and fungal infections with multi-resistant pathogens, the metabolic changes associated with host-pathogen interactions offer one of the most promising starting points for developing novel antibiotics. . Part one of this comprehensive guide describes the metabolic adaptation of pathogenic microbes in humans, while part two points to routes for the development of novel antibiotics. This is volume six of the book series on drug discovery in infectious diseases by Paul Selzer.

Author : Vincent A. Fischetti,Richard P. Novick,Joseph J. Ferretti,Daniel A. Portnoy,Mirian Braunstein,Julian I. Rood
Publisher : ASM Press
Page : 0 pages
File Size : 45,5 Mb
Release : 2019-12-17
Category : Science
ISBN : 1683670124

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Gram-Positive Pathogens by Vincent A. Fischetti,Richard P. Novick,Joseph J. Ferretti,Daniel A. Portnoy,Mirian Braunstein,Julian I. Rood Pdf

Gram-positive bacteria, lacking an outer membrane and related secretory systems and having a thick peptidoglycan, have developed novel approaches to pathogenesis by acquiring (among others) a unique family of surface proteins, toxins, enzymes, and prophages. For the new edition, the editors have enhanced this fully researched compendium of Gram-positive bacterial pathogens by including new data generated using genomic sequencing as well as the latest knowledge on Gram-positive structure and mechanisms of antibiotic resistance and theories on the mechanisms of Gram-positive bacterial pathogenicity. This edition emphasizes streptococci, staphylococci, listeria, and spore-forming pathogens, with chapters written by many of the leading researchers in these areas. The chapters systematically dissect these organisms biologically, genetically, and immunologically, in an attempt to understand the strategies used by these bacteria to cause human disease. “This textbook comprises a superb collection of scientific knowledge making it a must-read for any graduate student, medical doctor, or investigator studying these gram-positive bacteria and inspiring future imaginations of biological knowledge.” - William R. Jacobs, Jr., PhD, Professor Microbiology & Immunology, Albert Einstein College of Medicine

Author : Institute of Medicine,Board on Global Health,Forum on Microbial Threats
Publisher : National Academies Press
Page : 330 pages
File Size : 45,6 Mb
Release : 2009-05-10
Category : Science
ISBN : 9780309131216

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Microbial Evolution and Co-Adaptation by Institute of Medicine,Board on Global Health,Forum on Microbial Threats Pdf

Dr. Joshua Lederberg - scientist, Nobel laureate, visionary thinker, and friend of the Forum on Microbial Threats - died on February 2, 2008. It was in his honor that the Institute of Medicine's Forum on Microbial Threats convened a public workshop on May 20-21, 2008, to examine Dr. Lederberg's scientific and policy contributions to the marketplace of ideas in the life sciences, medicine, and public policy. The resulting workshop summary, Microbial Evolution and Co-Adaptation, demonstrates the extent to which conceptual and technological developments have, within a few short years, advanced our collective understanding of the microbiome, microbial genetics, microbial communities, and microbe-host-environment interactions.

Author : Jean Pieters,John D. McKinney
Publisher : Springer Science & Business Media
Page : 248 pages
File Size : 40,6 Mb
Release : 2013-12-09
Category : Medical
ISBN : 9783642402326

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Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism by Jean Pieters,John D. McKinney Pdf

Mycobacterium tuberculosis is one of the most notorious pathogens on earth, causing the death of approximately 1.5 million people annually. A major problem in the fight against tuberculosis is the emergence of strains that have acquired resistance to all available antibiotics. One key to the success of M. tuberculosis as a pathogen is its ability to circumvent host immune responses at different levels. This is not only a result of the special makeup of M. tuberculosis in terms of genetic diversity and DNA metabolism and its possession of specialized secretion systems, but also of its ability to hijack the host’s innate immune defence mechanisms. In this volume, researchers from different disciplines provide a topical overview of the diverse mechanisms that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic and molecular makeup, as well as the complex strategies these bacteria utilize to escape immune destruction within infected hosts.

Author : Busi Siddhardha,Madhu Dyavaiah,Asad Syed
Publisher : Springer Nature
Page : 685 pages
File Size : 40,9 Mb
Release : 2020-03-28
Category : Science
ISBN : 9789811516955

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Model Organisms for Microbial Pathogenesis, Biofilm Formation and Antimicrobial Drug Discovery by Busi Siddhardha,Madhu Dyavaiah,Asad Syed Pdf

This book provides essential insights into microbial pathogenesis, host-pathogen interactions, and the anti-microbial drug resistance of various human pathogens on the basis of various model organisms. The initial sections of the book introduce readers to the mechanisms of microbial pathogenesis, host-pathogen interactions, anti-microbial drug resistance, and the dynamics of biofilm formation. Due to the emergence of various microbial resistant strains, it is especially important to understand the prognosis for microbial infections, disease progression profiles, and mechanisms of resistance to antibiotic therapy in order to develop novel therapeutic strategies. In turn, the second part of the book presents a comparative analysis of various animal models to help readers understand microbial pathogenesis, host-pathogen interactions, anti-microbial drug discovery, anti-biofilm therapeutics, and treatment regimes. Given its scope, the book represents a valuable asset for microbiologists, biotechnologists, medical professionals, drug development researchers, and pharmacologists alike.