Antimicrobial Resistance And Virulence Common Mechanisms

Author : Etienne Giraud,Ivan Rychlik,Axel Cloeckaert
Publisher : Frontiers Media SA
Page : 140 pages
File Size : 54,7 Mb
Release : 2017-06-01
Category : Electronic book
ISBN : 9782889451814

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Antimicrobial Resistance and Virulence Common Mechanisms by Etienne Giraud,Ivan Rychlik,Axel Cloeckaert Pdf

Multiple relationships exist between antimicrobial resistance and bacterial virulence, and the spread of clones combining multiple antibiotic resistance and a high virulence level is an increasing problem. It was previously described how mutation-driven or horizontally acquired resistance mechanisms can also have effects on virulence. It was also reported that mobile genetic elements often carry both resistance determinants and virulence-modulating genes, which favors the co-selection of both traits. In the present volume, we present a collection of articles which document additional aspects of the interactions between antimicrobial resistance and virulence in bacteria, and describe their potential therapeutic consequences.

Author : Jun Lin,Kunihiko Nishino,Marilyn C. Roberts,Marcelo Tolmasky,Rustam I. Aminov,Lixin Zhang
Publisher : Frontiers Media SA
Page : 226 pages
File Size : 48,5 Mb
Release : 2015-06-01
Category : Antibiotics
ISBN : 9782889195268

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Mechanisms of antibiotic resistance by Jun Lin,Kunihiko Nishino,Marilyn C. Roberts,Marcelo Tolmasky,Rustam I. Aminov,Lixin Zhang Pdf

Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse.gov/sites/default/files/docs/carb_national_strategy.pdf). Understanding the mechanisms by which bacteria successfully defend themselves against the antibiotic assault represent the main theme of this eBook published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy. The articles in the eBook update the reader on various aspects and mechanisms of antibiotic resistance. A better understanding of these mechanisms should facilitate the development of means to potentiate the efficacy and increase the lifespan of antibiotics while minimizing the emergence of antibiotic resistance among pathogens.

Author : Manuela Oliveira
Publisher : Mdpi AG
Page : 232 pages
File Size : 47,7 Mb
Release : 2022-04-15
Category : Science
ISBN : 3036539069

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Antimicrobial Resistance and Virulence Mechanisms by Manuela Oliveira Pdf

The worldwide emergence of antimicrobial-resistant bacteria, specially those resistant to last-resource antibiotics, is now a common problem being defined as one of three priorities for the safeguarding of One Health by the Tripartite Alliance, which includes the World Health Organization (WHO), the Food and Agriculture Organization (FAO) and the Office International des Epizooties (OIE). Bacteria resistance profiles, together with the expression of specific virulence markers, have a major influence on the outcomes of infectious diseases. These bacterial traits are interconnected, since not only the presence of antibiotics may influence bacterial virulence gene expression and consequently infection pathogenesis, but some virulence factors may also contribute to an increased bacterial resistance ability, as observed in biofilm-producing strains. The surveillance of important resistant and virulent clones and associated mobile genetic elements is essential for decision making in terms of mitigation measures to be applied for the prevention of such infections in both human and veterinary medicine. However, the role of natural environments as important components of the dissemination cycle of these strains has not been consider until recently. This Special Issue aims to publish manuscripts that contribute to the understanding of the impact of bacterial antimicrobial resistance and virulence in the three areas of the One Health triad-i.e., animal, human and environmental health.

Author : Indira T. Kudva,Nancy A. Cornick,Paul J. Plummer,Qijing Zhang,Tracy L. Nicholson,John P. Bannantine,Bryan H. Bellaire
Publisher : John Wiley & Sons
Page : 871 pages
File Size : 51,5 Mb
Release : 2020-07-10
Category : Medical
ISBN : 9781555819286

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Virulence Mechanisms of Bacterial Pathogens by Indira T. Kudva,Nancy A. Cornick,Paul J. Plummer,Qijing Zhang,Tracy L. Nicholson,John P. Bannantine,Bryan H. Bellaire Pdf

Ground-breaking overview of an enduring topic Despite the use of antibiotics, bacterial diseases continue to be a critical issue in public health, and bacterial pathogenesis remains a tantalizing problem for research microbiologists. This new edition of Virulence Mechanisms of Bacterial Pathogens broadly covers the knowledge base surrounding this topic and presents recently unraveled bacterial virulence strategies and cutting-edge therapies. A team of editors, led by USDA scientist Indira Kudva, compiled perspectives from experts to explain the wide variety of mechanisms through which bacterial pathogens cause disease: the host interface, host cell enslavement, and bacterial communication, secretion, defenses, and persistence. A collection of reviews on targeted therapies rounds out the seven sections of this unique book. The new edition provides insights into some of the most recent advances in the area of bacterial pathogenesis, including how metabolism shapes the host-pathogen interface interactions across species and genera mechanisms of the secretion systems evasion, survival, and persistence mechanisms new therapies targeting various adaptive and virulence mechanisms of bacterial pathogens Written to promote discussion, extrapolation, exploration, and multidimensional thinking, Virulence Mechanisms of Bacterial Pathogens serves as a textbook for graduate courses on bacterial pathogenesis and a resource for specialists in bacterial pathogenicity, such as molecular biologists, physician scientists, infectious disease clinicians, dental scientists, veterinarians, molecular biologists, industry researchers, and technicians.

Author : Manuela Oliveira
Publisher : Unknown
Page : 0 pages
File Size : 44,5 Mb
Release : 2022
Category : Electronic
ISBN : 3036539050

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Antimicrobial Resistance and Virulence Mechanisms by Manuela Oliveira Pdf

The worldwide emergence of antimicrobial-resistant bacteria, specially those resistant to last-resource antibiotics, is now a common problem being defined as one of three priorities for the safeguarding of One Health by the Tripartite Alliance, which includes the World Health Organization (WHO), the Food and Agriculture Organization (FAO) and the Office International des Epizooties (OIE). Bacteria resistance profiles, together with the expression of specific virulence markers, have a major influence on the outcomes of infectious diseases. These bacterial traits are interconnected, since not only the presence of antibiotics may influence bacterial virulence gene expression and consequently infection pathogenesis, but some virulence factors may also contribute to an increased bacterial resistance ability, as observed in biofilm-producing strains. The surveillance of important resistant and virulent clones and associated mobile genetic elements is essential for decision making in terms of mitigation measures to be applied for the prevention of such infections in both human and veterinary medicine. However, the role of natural environments as important components of the dissemination cycle of these strains has not been consider until recently. This Special Issue aims to publish manuscripts that contribute to the understanding of the impact of bacterial antimicrobial resistance and virulence in the three areas of the One Health triad-i.e., animal, human and environmental health.

Author : National Research Council,Division on Earth and Life Studies,Division of Medical Sciences,Commission on Life Sciences,Committee to Study the Human Health Effects of Subtherapeutic Antibiotic Use in Animal Feeds
Publisher : National Academies Press
Page : 393 pages
File Size : 52,8 Mb
Release : 1980-02-01
Category : Medical
ISBN : 9780309030441

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The Effects on Human Health of Subtherapeutic Use of Antimicrobials in Animal Feeds by National Research Council,Division on Earth and Life Studies,Division of Medical Sciences,Commission on Life Sciences,Committee to Study the Human Health Effects of Subtherapeutic Antibiotic Use in Animal Feeds Pdf

Author : Anonim
Publisher : Academic Press
Page : 620 pages
File Size : 46,5 Mb
Release : 1998-07-01
Category : Science
ISBN : 0080860567

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Bacterial Pathogenesis by Anonim Pdf

Established almost 30 years ago, Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Now totally revamped, revitalized, with a new format and expanded scope, Methods in Microbiology will continue to provide you with tried and tested, cutting-edge protocols to directly benefit your research. Focuses on the methods most useful for the microbiologist interested in the way in which bacteria cause disease Includes section devoted to 'Approaches to characterising pathogenic mechanisms' by Stanley Falkow Covers safety aspects, detection, identification and speciation Includes techniques for the study of host interactions and reactions in animals and plants Describes biochemical and molecular genetic approaches Essential methods for gene expression and analysis Covers strategies and problems for disease control

Author : World Health Organization
Publisher : Unknown
Page : 232 pages
File Size : 52,8 Mb
Release : 2014
Category : Medical
ISBN : 9241564741

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Antimicrobial Resistance by World Health Organization Pdf

Summary report published as technical document with reference number: WHO/HSE/PED/AIP/2014.2.

Author : Steeve Giguère,John F. Prescott,Patricia Dowling
Publisher : John Wiley & Sons
Page : 49 pages
File Size : 42,6 Mb
Release : 2013-07-25
Category : Medical
ISBN : 9781118675076

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Antimicrobial Therapy in Veterinary Medicine by Steeve Giguère,John F. Prescott,Patricia Dowling Pdf

The Fifth Edition of Antimicrobial Therapy in Veterinary Medicine, the most comprehensive reference available on veterinary antimicrobial drug use, has been thoroughly revised and updated to reflect the rapid advancements in the field of antimicrobial therapy. Encompassing all aspects of antimicrobial drug use in animals, the book provides detailed coverage of virtually all types of antimicrobials relevant to animal health. Now with a new chapter on antimicrobial therapy in zoo animals, Antimicrobial Therapy in Veterinary Medicine offers a wealth of invaluable information for appropriately prescribing antimicrobial therapies and shaping public policy. Divided into four sections covering general principles of antimicrobial therapy, classes of antimicrobial agents, special considerations, and antimicrobial drug use in multiple animal species, the text is enhanced by tables, diagrams, and photos. Antimicrobial Therapy in Veterinary Medicine is an essential resource for anyone concerned with the appropriate use of antimicrobial drugs, including veterinary practitioners, students, public health veterinarians, and industry and research scientists.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 41,9 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : National Academies Of Sciences Engineeri,National Academies of Sciences Engineering and Medicine,Health And Medicine Division,Board On Population Health And Public He,Board on Population Health and Public Health Practice,Committee on the Long-Term Health and Economic Effects of Antimicrobial Resistance in the United States
Publisher : National Academies Press
Page : 128 pages
File Size : 52,6 Mb
Release : 2022-07-20
Category : Medical
ISBN : 0309269458

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Combating Antimicrobial Resistance and Protecting the Miracle of Modern Medicine by National Academies Of Sciences Engineeri,National Academies of Sciences Engineering and Medicine,Health And Medicine Division,Board On Population Health And Public He,Board on Population Health and Public Health Practice,Committee on the Long-Term Health and Economic Effects of Antimicrobial Resistance in the United States Pdf

The National Strategy for Combating Antibiotic Resistant Bacteria, published in 2014, sets out a plan for government work to mitigate the emergence and spread of resistant bacteria. Direction on the implementation of this strategy is provided in five-year national action plans, the first covering 2015 to 2020, and the second covering 2020 to 2025. Combating Antimicrobial Resistance and Protecting the Miracle of Modern Medicine evaluates progress made against the national strategy. This report discusses ways to improve detection of resistant infections and estimate the risk to human health from environmental sources of resistance. In addition, the report considers the effect of agricultural practices on human and animal health and animal welfare and ways these practices could be improved, and advises on key drugs and diseases for which animal-specific test breakpoints are needed.

Author : William Shafer
Publisher : Springer Science & Business Media
Page : 274 pages
File Size : 45,9 Mb
Release : 2006-10-05
Category : Medical
ISBN : 9783540299165

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Antimicrobial Peptides and Human Disease by William Shafer Pdf

Microbes are in our midst soon after birth. Thankfully, the number of harmless (and often beneficial) microbes far outnumber those that would do us harm. Our ability to ward-off pathogens in our environment, including those that can colonize our exterior and/or interior surfaces, depends on the integrative action of the innate and adaptive immunity systems. This volume of CTMI, entitled Antimicrobial Peptides and Human Disease, is dedicated to the role of antimicrobial peptides (AMPs) in the innate host defense system of homo sapiens.

Author : M. Donald McGavin
Publisher : Mosby
Page : 0 pages
File Size : 43,7 Mb
Release : 2007
Category : Medical
ISBN : 0323028705

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Pathologic Basis of Veterinary Disease by M. Donald McGavin Pdf

The 4th edition of this textbook, now in full color, presents both general pathology and special pathology in one comprehensive resource. Coverage includes a brief review of basic principles related to anatomy, structure and function, followed by congenital and functional abnormalities and discussions of viral, bacterial, and parasitic infections and neoplasia. Logically organized chapters discuss normal functions of the body system, followed by pathologic conditions found in domestic and companion animals. While focusing primarily on diseases in North America, the text also includes pathologic conditions found in other parts of the world, as well as those being brought into this country, such as West Nile virus, through the importation of cattle, sheep, and other animals. Contributors are recognized in their area of expertise and are well known in research and education. Now in full color throughout with vivid new illustrations that clarify difficult concepts. Includes six new chapters covering general pathology that discuss topics such as cellular and tissue responses to injury, vascular disorders, inflammation, and tumor biology. All chapters emphasize mechanisms of disease (organ, tissue, cell, and molecular injury). Features sequential presentations of disease processes (portal of entry * target cells * cellular injury * visual appearance of injury * resolution of injury * clinical outcomes). Emphasizes portals of entry for microbes and injurious agents. Focuses on defense mechanisms against microbes and injurious agents.

Author : Aníbal de J. Sosa,Denis K. Byarugaba,Carlos F. Amábile-Cuevas,Po-Ren Hsueh,Samuel Kariuki,Iruka N. Okeke
Publisher : Springer Science & Business Media
Page : 554 pages
File Size : 53,5 Mb
Release : 2009-10-08
Category : Science
ISBN : 9780387893709

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Antimicrobial Resistance in Developing Countries by Aníbal de J. Sosa,Denis K. Byarugaba,Carlos F. Amábile-Cuevas,Po-Ren Hsueh,Samuel Kariuki,Iruka N. Okeke Pdf

Avoiding infection has always been expensive. Some human populations escaped tropical infections by migrating into cold climates but then had to procure fuel, warm clothing, durable housing, and crops from a short growing season. Waterborne infections were averted by owning your own well or supporting a community reservoir. Everyone got vaccines in rich countries, while people in others got them later if at all. Antimicrobial agents seemed at first to be an exception. They did not need to be delivered through a cold chain and to everyone, as vaccines did. They had to be given only to infected patients and often then as relatively cheap injectables or pills off a shelf for only a few days to get astonishing cures. Antimicrobials not only were better than most other innovations but also reached more of the world’s people sooner. The problem appeared later. After each new antimicrobial became widely used, genes expressing resistance to it began to emerge and spread through bacterial populations. Patients infected with bacteria expressing such resistance genes then failed treatment and remained infected or died. Growing resistance to antimicrobial agents began to take away more and more of the cures that the agents had brought.

Author : P. J. Quinn,Peter J. Quinn
Publisher : Mosby
Page : 648 pages
File Size : 44,9 Mb
Release : 1994
Category : Medical
ISBN : 0723417113

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Clinical Veterinary Microbiology by P. J. Quinn,Peter J. Quinn Pdf