Pathophysiology Of The Basal Ganglia And Movement Disorders Gaining New Insights From Modeling And Experimentation To Influence The Clinic

Author : Daniela Andres,Olivier Darbin,Marcelo Merello
Publisher : Frontiers Media SA
Page : 222 pages
File Size : 40,7 Mb
Release : 2017-10-31
Category : Electronic book
ISBN : 9782889453177

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Pathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic by Daniela Andres,Olivier Darbin,Marcelo Merello Pdf

The basal ganglia constitute a group of subcortical structures, highly interconnected among themselves, as well as with the cerebral cortex, thalamus and other brain areas. These nuclei play a central role in the control of voluntary movement, and their specific pathology comprises the group of diseases known as movement disorders, including Parkinson's disease, Huntington's disease, dystonia and Gilles de la Tourette syndrome, among others. Additionally, the presence of a number of circuits within the basal ganglia related to non-motor functions has been acknowledged. Currently, the basal ganglia are thought to participate in cognitive, limbic and learning functions. Moreover, disorders related to the basal ganglia are known to involve a number of complex, non-motor symptoms and syndromes (e.g. compulsive and addictive behavior). In the light of this evidence, it is becoming clear that our knowledge about the basal ganglia needs to be revised, and that new pathophysiological models of movement disorders are needed. In this context, the study of the pathophysiology of the basal ganglia and the treatment of their pathology is becoming increasingly interdisciplinary. Nowadays, an appropriate approach to the study of these problems must necessarily involve the use of complex mathematical modeling, computer simulations, basic research (ranging from biomolecular studies to animal experimentation), and clinical research. This research topic aims to bring together the most recent advances related to the pathophysiology of the basal ganglia and movement disorders.

Author : Adrian C. Michael,George S. Wilson
Publisher : World Scientific
Page : 397 pages
File Size : 41,6 Mb
Release : 2019
Category : Brain
ISBN : 9789811206238

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Compendium of in Vivo Monitoring in Real-time Molecular Neuroscience by Adrian C. Michael,George S. Wilson Pdf

"This book is the third in a series entitled, Compendium of In-Vivo Monitoring in Real-time Molecular Neuroscience. Its purpose is to provide a cross-section of research addressing monitoring in the rodent, and in some cases, the human brain. Detailed understanding of the neurobiology of the brain is demanding and involves increasingly wider scope of talent ranging from physicists, neurobiologists, chemists, molecular biologists and bioengineers. Coming from varied backgrounds, they do not necessarily understand how to formulate functional issues in a mutually understandable way. This aim of this book is to provide information which can serve as a starting point for understanding such a complex topic. The authors provide "tutorial" writing for specialists, as well as material understandable to a wide audience including neuroscientists, those interested in drug discovery, and those using such measurements for diagnosis purposes."-

Author : Malcolm R. Dando
Publisher : Springer Nature
Page : 210 pages
File Size : 48,9 Mb
Release : 2020-08-20
Category : Medical
ISBN : 9783030537906

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Neuroscience and the Problem of Dual Use by Malcolm R. Dando Pdf

This book discusses recent brain research and the potentially dangerous dual-use applications of the findings of these research projects. The book is divided into three sections: Part I examines the rise in dual-use concerns within various state’s chemical and biological non-proliferation regime’s during this century, as well as the rapid technologically driven advances in neuroscience and the associated possible misuse considerations in the same period. Part II reviews the brain research projects in the EU, USA, Japan, China and several other countries with regard to their objectives, achievements and measures to deal with the problem of dual-use. Part III assesses the extent to which the results of this civil neuroscience work, which is intended to be benign, are being, and could be protected against future hostile applications in the development of novel chemical and biological weapons.

Author : Hendrik Jan Groenewegen,Pieter Voorn,Henk W. Berendse,Antonius B. Mulder,Alexander R. Cools
Publisher : Springer Science & Business Media
Page : 601 pages
File Size : 47,6 Mb
Release : 2010-05-03
Category : Medical
ISBN : 9781441903723

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The Basal Ganglia IX by Hendrik Jan Groenewegen,Pieter Voorn,Henk W. Berendse,Antonius B. Mulder,Alexander R. Cools Pdf

The aim of the International Basal Ganglia Society (IBAGS) is to further our understanding of normal basal ganglia function and the pathophysiology of disorders of the basal ganglia, including Parkinson's disease, Huntington's disease, and schizophrenia. Each triennial meeting of IBAGS brings together basic research scientists from all disciplines as well as clinicians who are actively involved in the treatment of basal ganglia disorders, to discuss the most recent advances in the field and to generate new approaches and ideas for the future. This volume comprises the proceedings of the 9th meeting of IBAGS, held in Egmond aan Zee, The Netherlands, September 2nd-6th, 2007.

Author : Richard Nass,Serge Przedborski
Publisher : Elsevier
Page : 686 pages
File Size : 47,7 Mb
Release : 2011-04-28
Category : Psychology
ISBN : 0080559581

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Parkinson's Disease by Richard Nass,Serge Przedborski Pdf

Parkinson’s disease is the second most prevalent neurodegenerative disease and is characterized by the irreversible loss of dopamine neurons. Despite its high prevalence in society and many decades of research, the origin of the pathogenesis and the molecular determinants involved in the disorder has remained elusive. Confounding this issue is the lack of experimental models that completely recapitulate the disease state. The identification of a number of genes thought to play a role in the cell death, and development of both toxin and genetic models to explore the function of the genes both in unaffected and diseased cells are now providing new insights into the molecular basis of the neurodegeneration, as well as therapeutic approaches. In this reference, we will describe the advances and the advantages that various invertebrates, cell culture, rodents, and mammals provide in the identification of the molecular components and mechanisms involved in the cell death, and outline the opportunities that these systems provide in drug discovery. Comprehensive and critical assessment of the utility of various model systems to identify the molecular components and pathways involved in Parkinson’s disease Describes the power of toxin and genetic models to identify novel therapeutic targets and compounds that can be used in PD Current overviews of current status of PD research and discovery from bench-to-bedside Provides novel insights and views on where the future of PD research may lead Provides a powerful teaching tool and template to explore the utility of model systems to identify molecular pathways, molecular targets, and therapeutics that are applicable to a variety of neurological diseases

Author : Ann M. Graybiel,Mahlon R. Delong,Stephen T. Kitai
Publisher : Springer Science & Business Media
Page : 685 pages
File Size : 49,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461501794

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The Basal Ganglia VI by Ann M. Graybiel,Mahlon R. Delong,Stephen T. Kitai Pdf

This volume, the sixth in the IBAGS series, summarizes major contributions in clinical and basic research on the basal ganglia. The sixth meeting of the Society was held on Cape Cod, in the state of Massachusetts, USA, in October, 1998. Altogether 16 countries were represented by 227 participants. This volume contains papers contributed by participants. The focus of the sixth triennial IBAGS meeting, and of this volume, was to bring to gether leaders in basic and clinical science to address two sets of still-persisting questions in the field. The first set focuses on the functions of the basal ganglia in health and disease: What are the core functions of the basal ganglia and cortico-basal ganglia loops? How are these core functions disrupted in disorders affecting the basal ganglia? How do we account for the broad range of behaviors affected by basal ganglia disorders and for the increasing evidence that the basal ganglia influence cognitive as well as motor functions? These issues are addressed in the first five sections of the current volume, which summarize advances in the study of basal ganglia disorders based on studies in humans (Section 1), new results obtained with experimental animal models of basal ganglia disorders (Section 2), results of experiments on information coding in the basal ganglia (Section 3) and new information about functions of the basal ganglia related to learning and adaptive motor control (Section 4).

Author : Malcolm R. McNeil
Publisher : Thieme
Page : 452 pages
File Size : 52,9 Mb
Release : 2011-01-01
Category : Medical
ISBN : 9781588906434

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Clinical Management of Sensorimotor Speech Disorders by Malcolm R. McNeil Pdf

The definitive reference for managing sensorimotor speech disorders Bringing together the expertise of leading research practitioners in the field, the second edition of Clinical Management of Sensorimotor Speech Disorders is an up-to-date reference for the underlying theory and the basic principles of assessment and treatment. This book provides a solid foundation in the conceptual framework essential for classifying and differentiating disorders according to clinical categories. It covers the theory underlying measurement strategies including acoustic, kinematic, aerodynamic, and electromyographic techniques, and guides the reader through treatments for each disorder. New in this edition is a comprehensive section with in-depth coverage of the diseases, syndromes, and pathologic conditions which are accompanied by sensorimotor speech disorders. These chapters provide concise descriptions of the disease and its signs and symptoms, neuropathology, epidemiology, and etiology. Each chapter goes on to present the speech impairment associated with the disorder and its signs and symptoms, etiology, neuropathology, associated cognitive, linguistic, and communicative signs and symptoms, special diagnostic considerations, treatment, and key references. Features: Clear articulation of theoretical issues provides a strong foundation for the clinical management of the dysarthrias, apraxia, and speech problems secondary to hearing loss New chapter on neurogenic fluency disorders Extensive discussion of neuropathologic conditions that cause sensorimotor speech disorders Authoritative and comprehensive, this expanded edition will prove to be the reference of choice for students in speech-language pathology programs as well as clinicians and researchers.

Author : Ann M. Graybiel,Mahlon R. Delong,Stephen T. Kitai
Publisher : Springer
Page : 685 pages
File Size : 49,8 Mb
Release : 2003-03-31
Category : Medical
ISBN : 0306474999

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The Basal Ganglia VI by Ann M. Graybiel,Mahlon R. Delong,Stephen T. Kitai Pdf

This volume, the sixth in the IBAGS series, summarizes major contributions in clinical and basic research on the basal ganglia. The sixth meeting of the Society was held on Cape Cod, in the state of Massachusetts, USA, in October, 1998. Altogether 16 countries were represented by 227 participants. This volume contains papers contributed by participants. The focus of the sixth triennial IBAGS meeting, and of this volume, was to bring to gether leaders in basic and clinical science to address two sets of still-persisting questions in the field. The first set focuses on the functions of the basal ganglia in health and disease: What are the core functions of the basal ganglia and cortico-basal ganglia loops? How are these core functions disrupted in disorders affecting the basal ganglia? How do we account for the broad range of behaviors affected by basal ganglia disorders and for the increasing evidence that the basal ganglia influence cognitive as well as motor functions? These issues are addressed in the first five sections of the current volume, which summarize advances in the study of basal ganglia disorders based on studies in humans (Section 1), new results obtained with experimental animal models of basal ganglia disorders (Section 2), results of experiments on information coding in the basal ganglia (Section 3) and new information about functions of the basal ganglia related to learning and adaptive motor control (Section 4).

Author : Rafael S. Maior,Hisao Nishijo,Fabio Viegas Caixeta
Publisher : Frontiers Media SA
Page : 101 pages
File Size : 50,6 Mb
Release : 2022-01-06
Category : Science
ISBN : 9782889719846

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Non-human Primate Models of Psychiatric Disorders by Rafael S. Maior,Hisao Nishijo,Fabio Viegas Caixeta Pdf

Author : Kristy Kultas-Ilinsky,Igor A. Ilinsky
Publisher : Springer Science & Business Media
Page : 370 pages
File Size : 40,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461512356

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Basal Ganglia and Thalamus in Health and Movement Disorders by Kristy Kultas-Ilinsky,Igor A. Ilinsky Pdf

This volume is comprised of the majority of lecture presentations and a few select posters presented at the International Workshop, "Basal Ganglia and Thalamus in Health and Movement Disorders," held in Moscow, Russia, on May 29-31, 2000. The International Committee responsible for organizing this workshop included Alexander Konovalov, Director, Burdenko Institute of Neurosurgery of the Russian Academy of Medical Sciences, Mahlon DeLong, Chair, Department of Neurology, Emory University, Atlanta, USA, Alim Louis Benabid, Chief, Neurosurgery Service, University of Joseph Fourrier, Grenoble, France, and the two undersigned. The workshop was conceived out of a desire to provide a forum for discussions of both basal ganglia-and motor thalamus-related issues by bringing together basic scientists and clinicians representing different disciplines, research directions, and philosophies. The primary goals were to encourage an exchange of information and ideas in an informal environment, to stimulate integration of the data from different disciplines, and to identifY controversial issues and the most essential questions to be addressed in future research.

Author : Aasef G. Shaikh,Alessandra Rufa
Publisher : Frontiers Media SA
Page : 247 pages
File Size : 42,9 Mb
Release : 2018-08-29
Category : Electronic
ISBN : 9782889455638

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Ocular Motor and Vestibular Function in Neurometabolic, Neurogenetic, and Neurodegenerative Disorders by Aasef G. Shaikh,Alessandra Rufa Pdf

Eye movements provide rich source of information about brain functioning for neurologists and neuroscientists. They provide diagnostic clues, define, and localize motor and cognitive disorders. Objective eye movement assessments associated with clinical observation and genetic testing in neurodegenerative, neurometabolic, and neurogenetic diseases provide insight into their pathophysiology and disease mechanism. Finally the eye movements may be used for testing and following the response to therapies. The concrete value of studying eye movement stems from a number of advantages compared to the study of movements of axial or limb muscles. The eye movements are accessible to clinical inspection, they can be measured precisely, their interpretation is clear and therefore ocular motility examination has high localization value. There are several standardized tasks to study of each subclass of eye movements that are recognized for motor or cognitive behavior. Indeed the studies of eye movement had allowed test of motor and cognitive functions of the brain in a vast range of neurological disease. Both cortical and subcortical dysfunctions may be detected with the analysis of subclasses of eye movements and interpreted in association with other clinical, laboratory and neuroimaging features. The goal of this topic-focused volume of Frontiers in Neurology is to gather seminal studies, from well-known scientists and laboratories from across the world, delineating the features of eye movements and vestibular system in neurogenetic, neurometabolic, and neurodegenerative disorders. Such collection of articles, to our knowledge, is unique and never done in the past. The topics and the compilation will be of interest to broad groups of neuroscientists and neurologists for the reasons as follows: 1) Neurodegenerative diseases represent a large portion of neurological diseases encountered in neurological clinical practice. Eye movement changes may occur early in their course and may be specific, thus orienting the diagnosis. 2) Neurometabolic and neurogenetic conditions, although rare, show specific and characteristic eye movements that represent the hallmark of the disease. Such disorders often represent a pathologic model that helps to understand the normal functioning of specific brain regions and networks.

Author : Anonim
Publisher : ScholarlyEditions
Page : 27 pages
File Size : 47,5 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9781464909955

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Movement Disorders: New Insights for the Healthcare Professional: 2011 Edition by Anonim Pdf

Movement Disorders: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Movement Disorders in a compact format. The editors have built Movement Disorders: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Movement Disorders in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Movement Disorders: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Anonim
Publisher : Academic Press
Page : 4744 pages
File Size : 47,8 Mb
Release : 2014-04-29
Category : Medical
ISBN : 9780123851581

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Encyclopedia of the Neurological Sciences by Anonim Pdf

The Encyclopedia of the Neurological Sciences, Second Edition, Four Volume Set develops from the first edition, covering all areas of neurological sciences through over 1000 entries focused on a wide variety of topics in neurology, neurosurgery, psychiatry and other related areas of neuroscience. The contributing authors represent all aspects of neurology from many viewpoints and disciplines to provide a complete overview of the field. Entries are designed to be understandable without detailed background knowledge in the subject matter, and cross-referencing and suggested further reading lead the reader from a basic knowledge of the subject to more advanced understanding. The easy-to-use 'encyclopedic-dictionary' format of the Encyclopedia of the Neurological Sciences, Second Edition features alphabetic entries, extensive cross-referencing, and a thorough index for quick reference. The wealth of information provided by these four volumes makes this reference work a trusted source of valuable information for a wide range of researchers, from undergraduate students to academic researchers. Provides comprehensive coverage of the field of neurological science in over 1,000 entries in 4 volumes "Encyclopedic-dictionary" format provides for concise, readable entries and easy searching Presents complete, up-to-date information on 32 separate areas of neurology Entries are supplemented with extensive cross-referencing, useful references to primary research articles, and an extensive index

Author : Chihiro Ohye,Minoru Kimura,John S. McKenzie
Publisher : Springer Science & Business Media
Page : 493 pages
File Size : 44,8 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781489901941

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The Basal Ganglia V by Chihiro Ohye,Minoru Kimura,John S. McKenzie Pdf

This volume, The Basal Ganglia V, is derived from proceedings of the fifth Triennial Meeting of the International Basal Ganglia Society (IBAGS). The Meeting was held from 23-26 May, 1995, at Nemuno-Sato, in the Mie Prefecture of central Japan, not far from the traditional birth place of the country. As at previous Meetings, our aim was to hear and discuss new ideas and data on the Basal Ganglia. About one hundred papers were presented, on platform or as posters. We had valuable talks, stimulating discussions, and agreeable social contacts. Although just before this Meeting, there were several unusual accidents in Japan, a big earthquake in the Kobe area, not far from the Meeting place, and toxic gas terrorism in Tokyo, some hundred participants came from Europe, the United States, and elsewhere. All through the Meeting days, we were together in a beautiful environment, surrounded by fresh green vegetation, flowers and blue sea, as has been traditional for IBAGS meetings. We spent happy and pleasant sunny days there, with superb accommodation and cuisine. Also following the traditional policy of our Society, this volume has been edited to include as many papers as possible, without any selection. New ideas and data may sometimes be controversial and still immature, but we accepted all and put them together in this volume. We hope that from these fascinating papers, further new principles of basal ganglia action might emerge in the future.

Author : Ahmed A. Moustafa,Alon Korngreen,Izhar Bar-Gad,Hagai Bergman
Publisher : Frontiers Media SA
Page : 495 pages
File Size : 41,6 Mb
Release : 2015-05-26
Category : Basal ganglia
ISBN : 9782889193882

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Basal ganglia: physiological, behavioral, and computational studies by Ahmed A. Moustafa,Alon Korngreen,Izhar Bar-Gad,Hagai Bergman Pdf

The basal ganglia has received much attention over the last two decades, as it has been implicated in many neurological and psychiatric disorders. Most of this research—in both animals and humans—attempt to understand the neural and biochemical substrates of basic motor and learning processes, and how these are affected in human patients as well as animal models of brain disorders. The current volume contains research articles and reviews describing basic, pre-clinical and clinical neuroscience research of the basal ganglia written by attendees of the 11th Triennial Meeting of the International Basal Ganglia Society (IBAGS) that was held March 3-7th, 2013 at the Princess Hotel, Eilat, Israel and by researchers of the basal ganglia. Specifically, articles in this volume include research reports on the biochemistry, computational theory, anatomy and physiology of single neurons and functional circuitry of the basal ganglia networks as well as the latest data on animal models of basal ganglia dysfunction and clinical studies in human patients.