Pde Modeling Of Tissue Engineering And Regenerative Medicine

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PDE Modeling of Tissue Engineering and Regenerative Medicine

William E. Schiesser
PDE Modeling of Tissue Engineering and Regenerative Medicine Book PDF

Author : William E. Schiesser
Publisher : Elsevier
Page : 190 pages
File Size : 44,5 Mb
Release : 2022-08-20
Category : Computers
ISBN : 9780443187414

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PDE Modeling of Tissue Engineering and Regenerative Medicine by William E. Schiesser Pdf

PDE Modeling of Tissue Engineering and Regenerative Medicine: Computer Analysis in R presents the formulation and computer implementation of mathematical models for the forefront research areas of tissue engineering and regenerative medicine. The mathematical model discussed in this book consists of a system of eight partial differential equations (PDEs) with dependent variables. The computer-based example models are presented through routines coded in R—a quality, open-source scientific computing system that is readily available from the Internet. Formal mathematics is minimized, e.g., no theorems and proofs. Includes detailed examples that the reader can execute on modest computers. Includes PDE routines based on the method of lines (MOL) for computer-based implementation of PDE models Offers transportable computer source codes for readers in R, with line-by-line code descriptions as it relates to the mathematical model and algorithms Authored by a leading researcher and educator in PDE models

Spatiotemporal Modeling of Stem Cell Differentiation

William E. Schiesser
Spatiotemporal Modeling of Stem Cell Differentiation Book PDF

Author : William E. Schiesser
Publisher : Academic Press
Page : 134 pages
File Size : 53,6 Mb
Release : 2021-09-07
Category : Science
ISBN : 9780323914130

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Spatiotemporal Modeling of Stem Cell Differentiation by William E. Schiesser Pdf

Spatiotemporal Modeling of Stem Cell Differentiation: Partial Differentiation Equation Analysis in R covers topics surrounding how stem cells evolve into specialized cells during tissue formation and in diseased tissue regeneration. As the process of stem cell differentiation occurs in space and time, the mathematical modeling of spatiotemporal development is expressed in this book as systems of partial differential equations (PDEs). In addition, the book explores important feature of six PDE model which can represent, for example, the development of tissue in organs. In addition, the book covers the computer-based implementation of example models through routines coded (programmed) in R. The routines described in the book are available from a download link so that example models can be executed without having to first study numerical methods and computer coding. The routines can then be applied to variations and extensions of the stem differentiation models, such as changes in the PDE parameters (constants) and the form of the model equations. Includes PDE routines based on the method of lines (MOL) for computer-based implementation of PDE models Offers transportable computer source codes for readers in R, with line-by-line code descriptions for mathematical models and algorithms Authored by a leading researcher and educator in PDE models

Biomaterials in Tissue Engineering and Regenerative Medicine

Birru Bhaskar,Parcha Sreenivasa Rao,Naresh Kasoju,Vasagiri Nagarjuna,Rama Raju Baadhe
Biomaterials in Tissue Engineering and Regenerative Medicine Book PDF

Author : Birru Bhaskar,Parcha Sreenivasa Rao,Naresh Kasoju,Vasagiri Nagarjuna,Rama Raju Baadhe
Publisher : Springer Nature
Page : 587 pages
File Size : 55,7 Mb
Release : 2021-04-29
Category : Medical
ISBN : 9789811600029

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Biomaterials in Tissue Engineering and Regenerative Medicine by Birru Bhaskar,Parcha Sreenivasa Rao,Naresh Kasoju,Vasagiri Nagarjuna,Rama Raju Baadhe Pdf

This book comprehensively explores the basic concepts and applications of biomaterials in tissue engineering and regenerative medicine. The book is divided into four sections; the first section deals with the basic concepts and different types of biomaterials used in tissue engineering. The second section discusses the functional requirements and types of materials that are used in developing state-of-the-art of scaffolds for tissue engineering applications. The third section presents the applications of biomaterials for hard and soft tissue engineering, as well as for specialized tissue engineering. The last section addresses the future prospects of nanobiomaterials, intelligent biomaterials, and 3D bioprinting biomaterials in tissue engineering and regenerative medicine. It also discusses various in vitro disease models for tissue bioengineering and regenerative medicine. As such, it offers a valuable resource for students, researchers, scientists, entrepreneurs, and medical/healthcare professionals.

Cells and Materials for Disease Modeling and Regenerative Medicine

Ander Abarrategi,Senentxu Lanceros-Mendez
Cells and Materials for Disease Modeling and Regenerative Medicine Book PDF

Author : Ander Abarrategi,Senentxu Lanceros-Mendez
Publisher : MDPI
Page : 270 pages
File Size : 53,7 Mb
Release : 2021-05-05
Category : Science
ISBN : 9783036502625

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Cells and Materials for Disease Modeling and Regenerative Medicine by Ander Abarrategi,Senentxu Lanceros-Mendez Pdf

Materials science and engineering are strongly developing tools with increasing impact in the biotechnological and biomedical areas. Interestingly, research in molecular and cellular biology is often at the core of the design and development of materials-based approaches, providing biological rationale. Focused on research relying on biology–materials interaction, IJMS launched a Special Issue named “Cells and Materials for Disease Modeling and Regenerative Medicine”. The aim of the Special Issue was to generate a compilation of in vitro and in vivo strategies based on cell–material interactions. This book compiles the papers published in that Special Issue and includes a selection of six original scientific experimental articles and six comprehensive reviews. We are convinced that this collection of articles shows representative examples of the state of the art in the field, unveiling the relevance of materials research in generating new regenerative medicine and disease modeling approaches.

Tissue Engineering in Regenerative Medicine

Harold S. Bernstein
Tissue Engineering in Regenerative Medicine Book PDF

Author : Harold S. Bernstein
Publisher : Springer Science & Business Media
Page : 424 pages
File Size : 53,5 Mb
Release : 2011-08-28
Category : Science
ISBN : 9781617793226

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Tissue Engineering in Regenerative Medicine by Harold S. Bernstein Pdf

Over the past decade, significant advances in the fields of stem cell biology, bioengineering, and animal models have converged on the discipline of regenerative medicine. Significant progress has been made leading from pre-clinical studies through phase 3 clinical trials for some therapies. This volume provides a state-of-the-art report on tissue engineering toward the goals of tissue and organ restoration and regeneration. Examples from different organ systems illustrate progress with growth factors to assist in tissue remodeling; the capacity of stem cells for restoring damaged tissues; novel synthetic biomaterials to facilitate cell therapy; transplantable tissue patches that preserve three-dimensional structure; synthetic organs generated in culture; aspects of the immune response to transplanted cells and materials; and suitable animal models for non-human clinical trials. The chapters of this book are organized into six sections: Stem Cells, Biomaterials and the Extracellular Environment, Engineered Tissue, Synthetic Organs, Immune Response, and Animal Models. Each section is intended to build upon information presented in the previous chapters, and set the stage for subsequent sections. Throughout the chapters, the reader will observe a common theme of basic discovery informing clinical translation, and clinical studies in animals and humans guiding subsequent experiments at the bench.

Innovative Strategies in Tissue Engineering

Mayuri S. Prasad ,Paolo Di Nardo
Innovative Strategies in Tissue Engineering Book PDF

Author : Mayuri S. Prasad ,Paolo Di Nardo
Publisher : River Publishers
Page : 210 pages
File Size : 52,9 Mb
Release : 2015-01-01
Category : Science
ISBN : 9788793237094

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Innovative Strategies in Tissue Engineering by Mayuri S. Prasad ,Paolo Di Nardo Pdf

In spite of intensive investments and investigations carried out in the last decade, many aspects of the stem cell physiology, technology and regulation remain to be fully defined. After the enthusiasm that characterized the first decade of the discovery that when given the right cue, stem cells could repair all the different tissues in the body; it is now time to start a serious and coordinated action to define how to govern the stem cell potential and to exploit it for clinical applications. This can be achieved only with shared research programs involving investigators from all over the world and making the results available to all. The Disputationes Workshop series (http://disputationes.info) is an international initiative aimed at disseminating stem cell related cutting edge knowledge among scientists, healthcare workers, students and policy makers. The present book gathers together some of the ideas discussed during the third and fourth Disputationes Workshops held in Florence (Italy) and Aalborg (Denmark), respectively. The aim of this book is to preserve those ideas in order to contribute to the general discussion on organ repair and to bolster a fundamental scientific and technological leap forwards the treatment of otherwise incurable diseases.

Computational Modeling in Tissue Engineering

Liesbet Geris
Computational Modeling in Tissue Engineering Book PDF

Author : Liesbet Geris
Publisher : Springer Science & Business Media
Page : 438 pages
File Size : 55,8 Mb
Release : 2012-10-30
Category : Technology & Engineering
ISBN : 9783642325632

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Computational Modeling in Tissue Engineering by Liesbet Geris Pdf

One of the major challenges in tissue engineering is the translation of biological knowledge on complex cell and tissue behavior into a predictive and robust engineering process. Mastering this complexity is an essential step towards clinical applications of tissue engineering. This volume discusses computational modeling tools that allow studying the biological complexity in a more quantitative way. More specifically, computational tools can help in: (i) quantifying and optimizing the tissue engineering product, e.g. by adapting scaffold design to optimize micro-environmental signals or by adapting selection criteria to improve homogeneity of the selected cell population; (ii) quantifying and optimizing the tissue engineering process, e.g. by adapting bioreactor design to improve quality and quantity of the final product; and (iii) assessing the influence of the in vivo environment on the behavior of the tissue engineering product, e.g. by investigating vascular ingrowth. The book presents examples of each of the above mentioned areas of computational modeling. The underlying tissue engineering applications will vary from blood vessels over trachea to cartilage and bone. For the chapters describing examples of the first two areas, the main focus is on (the optimization of) mechanical signals, mass transport and fluid flow encountered by the cells in scaffolds and bioreactors as well as on the optimization of the cell population itself. In the chapters describing modeling contributions in the third area, the focus will shift towards the biology, the complex interactions between biology and the micro-environmental signals and the ways in which modeling might be able to assist in investigating and mastering this complexity. The chapters cover issues related to (multiscale/multiphysics) model building, training and validation, but also discuss recent advances in scientific computing techniques that are needed to implement these models as well as new tools that can be used to experimentally validate the computational results.

New Developments in Tissue Engineering and Regeneration

Paulo Rui Fernandes,Paulo Jorge da Silva Bartolo
New Developments in Tissue Engineering and Regeneration Book PDF

Author : Paulo Rui Fernandes,Paulo Jorge da Silva Bartolo
Publisher : Springer
Page : 86 pages
File Size : 53,8 Mb
Release : 2019-03-27
Category : Technology & Engineering
ISBN : 9783030153724

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New Developments in Tissue Engineering and Regeneration by Paulo Rui Fernandes,Paulo Jorge da Silva Bartolo Pdf

This volume presents a new contribution for the field of Tissue Engineering with a focus on the development of mathematical and computational methods that are relevant to understand human tissues, as well to model, design, and fabricate optimized and smart scaffolds. The multidisciplinary character of this field has motivated contributions from different areas with a common objective to replace damaged tissues and organs by healthy ones. This work treats tissue healing approaches, mathematic modelling for scaffold design and bio fabrication methods, giving the reader a broad view of the state of the art in Tissue Engineering. The present book contains contributions from recognized researchers in the field, who were keynote speakers in the Fourth International Conference on Tissue Engineering, held in Lisbon in 2015, and covering different aspects of Tissue Engineering. The book is strongly connected with the conference series of ECCOMAS Thematic Conferences on Tissue Engineering, an event that brings together a considerable number of researchers from all over the world, representing several fields of study related to Tissue Engineering.

Regenerative Medicine Technology

Sean V. Murphy,Anthony Atala
Regenerative Medicine Technology Book PDF

Author : Sean V. Murphy,Anthony Atala
Publisher : CRC Press
Page : 459 pages
File Size : 53,8 Mb
Release : 2016-11-30
Category : Medical
ISBN : 9781498711920

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Regenerative Medicine Technology by Sean V. Murphy,Anthony Atala Pdf

Miniaturization in the fields of chemistry and molecular biology has resulted in the "lab-on-a-chip." Such systems are micro-fabricated devices capable of handling extremely small fluid volumes facilitating the scaling of single or multiple lab processes down to a microchip-sized format. The convergence of lab-on-a-chip technology with the field of cell biology facilitated the development of "organ-on-a-chip" systems. Such systems simulate the function of tissues and organs, having the potential to bypass some cell and animal testing methods. These technologies have generated high interest as applications for disease modeling and drug discovery. This book, edited by Drs. Sean Murphy and Anthony Atala, provides a comprehensive coverage of the technologies that have been used to develop organ-on-a-chip systems. Known leaders cover the basics to the most relevant and novel topics in the field, including micro-fabrication, 3D bio-printing, 3D cell culture techniques, biosensor design and microelectronics, micro-fluidics, data collection, and predictive analysis. The book describes specific tissue types amenable for disease modeling and drug discovery applications. Lung, liver, heart, skin and kidney "on-a-chip" technologies are included as well as a progress report on designing an entire "body-on-a-chip" system. Additionally, the book covers applications of various systems for modeling tissue-specific cancers, metastasis, and tumor microenvironments; and provides an overview of current and potential applications of these systems to disease modeling, toxicity testing, and individualized medicine.

Fundamentals of Tissue Engineering and Regenerative Medicine

Ulrich Meyer,Thomas Meyer,Jörg Handschel,Hans Peter Wiesmann
Fundamentals of Tissue Engineering and Regenerative Medicine Book PDF

Author : Ulrich Meyer,Thomas Meyer,Jörg Handschel,Hans Peter Wiesmann
Publisher : Springer Science & Business Media
Page : 1049 pages
File Size : 46,9 Mb
Release : 2009-02-11
Category : Medical
ISBN : 9783540777557

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Fundamentals of Tissue Engineering and Regenerative Medicine by Ulrich Meyer,Thomas Meyer,Jörg Handschel,Hans Peter Wiesmann Pdf

"Fundamentals of Tissue Engineering and Regenerative Medicine" provides a complete overview of the state of the art in tissue engineering and regenerative medicine. Tissue engineering has grown tremendously during the past decade. Advances in genetic medicine and stem cell technology have significantly improved the potential to influence cell and tissue performance, and have recently expanded the field towards regenerative medicine. In recent years a number of approaches have been used routinely in daily clinical practice, others have been introduced in clinical studies, and multitudes are in the preclinical testing phase. Because of these developments, there is a need to provide comprehensive and detailed information for researchers and clinicians on this rapidly expanding field. This book offers, in a single volume, the prerequisites of a comprehensive understanding of tissue engineering and regenerative medicine. The book is conceptualized according to a didactic approach (general aspects: social, economic, and ethical considerations; basic biological aspects of regenerative medicine: stem cell medicine, biomolecules, genetic engineering; classic methods of tissue engineering: cell, tissue, organ culture; biotechnological issues: scaffolds; bioreactors, laboratory work; and an extended medical discipline oriented approach: review of clinical use in the various medical specialties). The content of the book, written in 68 chapters by the world’s leading research and clinical specialists in their discipline, represents therefore the recent intellect, experience, and state of this bio-medical field.

Deformable Models

Aly Farag
Deformable Models Book PDF

Author : Aly Farag
Publisher : Springer Science & Business Media
Page : 592 pages
File Size : 48,5 Mb
Release : 2007-08-02
Category : Technology & Engineering
ISBN : 9780387312040

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Deformable Models by Aly Farag Pdf

This book covers the complete spectrum of deformable models, its evolution as an imagery field and its use in many biomedical engineering and clinical application disciplines. The book focuses on the core image processing techniques, theory and biomaterials useful to research and industry. Contributors are all pioneers in the field.

Exploring Sources of Variability Related to the Clinical Translation of Regenerative Engineering Products

National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Regenerative Medicine
Exploring Sources of Variability Related to the Clinical Translation of Regenerative Engineering Products Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Regenerative Medicine
Publisher : National Academies Press
Page : 133 pages
File Size : 52,5 Mb
Release : 2019-06-19
Category : Medical
ISBN : 9780309489126

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Exploring Sources of Variability Related to the Clinical Translation of Regenerative Engineering Products by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Regenerative Medicine Pdf

The emerging multidisciplinary field of regenerative engineering is devoted to the repair, regeneration, and replacement of damaged tissues or organs in the body. To accomplish this it uses a combination of principles and technologies from disciplines such as advanced materials science, developmental and stem cell biology, immunology, physics, and clinical translation. The term "regenerative engineering" reflects a new understanding of the use of tissue engineering for regeneration and also the growing number of research and product development efforts that incorporate elements from a variety of fields. Because regenerative engineered therapies rely on live cells and scaffolds, there are inherent challenges in quality control arising from variability in source and final products. Furthermore, each patient recipient, tissue donor, and product application is unique, meaning that the field faces complexities in the development of safe and effective new products and therapies which are not faced by developers of more conventional therapies. Understanding the many sources of variability can help reduce this variability and ensure consistent results. The Forum on Regenerative Medicine hosted a public workshop on October 18, 2018, in Washington, DC, to explore the various factors that must be taken into account in order to develop successful regenerative engineering products. Invited speakers and participants discussed factors and sources of variability in the development and clinical application of regenerative engineering products, characteristics of high-quality products, and how different clinical needs, models, and contexts can inform the development of a product to improve patient outcomes. This publication summarizes the presentation and discussion of the workshop.

Biomaterials and Tissue Engineering

Oguzhan Gunduz,Christophe Egles,Román A. Pérez,Denisa Ficai,Cem Bulent Ustundag
Biomaterials and Tissue Engineering Book PDF

Author : Oguzhan Gunduz,Christophe Egles,Román A. Pérez,Denisa Ficai,Cem Bulent Ustundag
Publisher : Springer Nature
Page : 391 pages
File Size : 43,5 Mb
Release : 2023-08-25
Category : Science
ISBN : 9783031358326

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Biomaterials and Tissue Engineering by Oguzhan Gunduz,Christophe Egles,Román A. Pérez,Denisa Ficai,Cem Bulent Ustundag Pdf

This contributed volume covers all fundamental principles for researchers and professionals interested in the field of Biomaterials and Tissue Engineering, an interdisciplinary field of research with contributions from biomedical scientists, engineers, and physicians. With a strong focus on biomaterials and scaffolds, the book also covers testing and evaluation pathways for in vitro and in vivo studies. This book also presents a broad range of topics including fundamentals of 3D printing and bioprinting, followed by contemporary technology used in tissue engineering applications as well as currently available biomaterials suitable for tissue repair and regeneration. This volume provides information on: (i) why humans need biomaterials, especially in medical applications, (ii) different types of tissue engineering strategies, and (iii) modeling, characterization, and evaluation of outputs of those strategies. This book is a reference material in the field of tissue engineering, and it is very useful for bachelor, M.Sc., and Ph.D. students, researchers, academics, medical, industry, and healthcare professionals from diverse backgrounds.

Deformable Models

Aly Farag
Deformable Models Book PDF

Author : Aly Farag
Publisher : Springer
Page : 1142 pages
File Size : 53,8 Mb
Release : 2007-08-02
Category : Technology & Engineering
ISBN : 0387721495

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Deformable Models by Aly Farag Pdf

This two-volume set on Deformable Models: Biomedical and Clinical Applications & Theory and Biomaterial Applications provides a wide cross-section of the methods and algorithms of variational and PDE methods in biomedical image analysis. The chapters are written by well-known researchers in this field, and the presentation style goes beyond an intricate abstraction of the theory into real application of the methods and description of the algorithms that were implemented. As such these chapters will serve the main goal of the editors of these two volumes in bringing down to earth the latest in variational and PDE methods in modeling of soft tissues. Overall, the thirty-one chapters in the two volumes provide an elegant crosssection of the theory and application of variational and PDE approaches in medical image analysis. Graduate students and researchers at various levels of familiarity with these techniques will find the two volumes very useful for understanding the theory and algorithmic implementations. In addition, the various case studies provided demonstrate the power of these techniques in clinical applications. Researchers at various levels will find these chapters useful to understand the theory, algorithms, and implementation of many of these approaches.

Innovations in Molecular Mechanisms and Tissue Engineering

Jeanne Wilson-Rawls,Kenro Kusumi
Innovations in Molecular Mechanisms and Tissue Engineering Book PDF

Author : Jeanne Wilson-Rawls,Kenro Kusumi
Publisher : Springer
Page : 182 pages
File Size : 52,9 Mb
Release : 2016-12-10
Category : Science
ISBN : 9783319449968

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Innovations in Molecular Mechanisms and Tissue Engineering by Jeanne Wilson-Rawls,Kenro Kusumi Pdf

This book marries stem cell biology, tissue engineering, and regenerative biology into a single, interdisciplinary volume. The chapters also explore embryonic stem cells, induced pluripotent stem cells, cardiovascular regeneration, skeletal development, inflammation, polymeric biomaterials, neural injury, cartilage regeneration, regeneration in ambystoma, models for regeneration using salamander and zebrafish, and more. The volume also discusses recent advances and their potential in developing future therapies. Innovations in Molecular Mechanisms and Tissue Engineering combines perspectives from the biomedical, bioengineering, and medical fields to present a cutting-edge, multifaceted picture of the tissue engineering and regenerative medicine fields. This installment of Springer’s Stem Cell Biology and Regenerative Medicine series is ideal for scientists, clinicians, and researchers in the fields of stem cell biology, regenerative medicine, biomedical engineering, and tissue engineering.