Peroxisome Biology Experimental Models Peroxisomal Disorders And Neurological Diseases

Author : Gérard Lizard
Publisher : Springer Nature
Page : 209 pages
File Size : 47,6 Mb
Release : 2021-01-08
Category : Medical
ISBN : 9783030602048

Get Book

Peroxisome Biology: Experimental Models, Peroxisomal Disorders and Neurological Diseases by Gérard Lizard Pdf

This book provides an overview of the biology and biochemistry of peroxisomes, and discusses the contribution of these organelles to peroxisomal and neurodegenerative diseases. It begins with a detailed introduction to the biogenesis and metabolic functions of peroxisomes, and highlights their role in oxidative stress and in lipid metabolism such as fatty acid oxidation. The following chapters focus on the molecular and clinical aspects of peroxisomal disorders caused by defects in peroxisomal function. In particular, the biological aspects of peroxisomal biogenesis disorders such as Zellweger syndrome and Heimler syndrome are discussed. This includes their underlying genetic causes as well as the biochemical and metabolic defects associated with the disorders. In addition, several chapters cover recent observations suggesting an association between peroxisomal dysfunction and neurodegenerative diseases such as Alzheimer's, Multiple Sclerosis and other degenerative cerebellar pathologies. The final section of the book discusses important cell and animal models for studying the role of peroxisomes in human diseases and presents current therapeutic strategies for their treatment. This book deals with a highly topical subject that is at the heart of current research, and represents a valuable contribution for all students and researchers who want to understand the complex biology of peroxisomes and their role in human diseases.

Author : Tsuneo Imanaka,Nobuyuki Shimozawa
Publisher : Springer Nature
Page : 284 pages
File Size : 53,5 Mb
Release : 2020-01-16
Category : Medical
ISBN : 9789811511691

Get Book

Peroxisomes: Biogenesis, Function, and Role in Human Disease by Tsuneo Imanaka,Nobuyuki Shimozawa Pdf

This book provides readers with a comprehensive overview of peroxisomes and their role in human diseases. It starts by describing the history of peroxisome research and then examines in detail the current understanding of the biogenesis and function of peroxisomes. It then focuses on peroxisomal disorders and the involvement of peroxisomes in cancer and age-related diseases, discussing in detail the use of model organisms to elucidate the pathogenesis of peroxisomal disorders and the physiological importance of peroxisomal proteins. Further, the book examines diagnostic and therapeutic strategies in peroxisomal disorders as well as significant recent advances. Lastly, it addresses various topics in peroxisome research, including the isolation of peroxisomes from mammalian tissues and cells, the structural biology of peroxisomal proteins, the lipidomics of peroxisomal disorders, the value of exome sequencing, and neuropsychological testing in X-linked adrenoleukodystrophy. Given its scope, the book is a valuable resource for postgraduate students and researchers in the life sciences and clinicians in the fields of internal medicine, pediatrics, and neurology.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 50,7 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

Get Book

Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Masanori Honsho,Fabian Dorninger,Johannes Berger
Publisher : Frontiers Media SA
Page : 244 pages
File Size : 45,9 Mb
Release : 2023-02-17
Category : Science
ISBN : 9782832514948

Get Book

Solving the plasmalogen puzzle – from basic science to clinical application by Masanori Honsho,Fabian Dorninger,Johannes Berger Pdf

Author : Juan M. Pascual
Publisher : Cambridge University Press
Page : 507 pages
File Size : 50,6 Mb
Release : 2017-04-20
Category : Medical
ISBN : 9781107042056

Get Book

Progressive Brain Disorders in Childhood by Juan M. Pascual Pdf

A review of childhood neurodegenerative and other progressive but non-degenerative disorders to guide their diagnosis and management.

Author : Uttam Garg,Laurie D. Smith
Publisher : Elsevier
Page : 476 pages
File Size : 44,6 Mb
Release : 2017-06-07
Category : Medical
ISBN : 9780128029183

Get Book

Biomarkers in Inborn Errors of Metabolism by Uttam Garg,Laurie D. Smith Pdf

Biomarkers of Inborn Errors in Metabolism: Clinical Aspects and Laboratory Determination is structured around the new reality that laboratory testing and biomarkers are an integral part in the diagnosis and treatment of inherited metabolic diseases. The book covers currently used biomarkers as well as markers that are in development. Because biomarkers used in the initial diagnosis of disease may be different than the follow-up markers, the book also covers biomarkers used in both the prognosis and treatment of inherited metabolic disorders. With the introduction of expanded new-born screening for inborn metabolic diseases, an increasing numbers of laboratories are involved in follow-up confirmatory testing. The book provides guidance on laboratory test selection and interpreting results in patients with suspected inherited metabolic diseases. The book provides comprehensive guidance on patient diagnosis and follow-up through its illustrative material on metabolic pathways, genetics and pathogenesis, treatment and prognosis of inherited metabolic diseases, along with essential information on clinical presentation. Each chapter is organized with a uniform, easy-to-follow format: a brief description of the disorder and pathway; a description of treatment; biomarkers for diagnosis; biomarkers followed for treatment efficacy; biomarkers followed for disease progression; confounding conditions that can either: affect biomarker expression or mimic IEMs; other biomarkers: less established, future. Provides comprehensive information on the tests/biomarkers selection in newborn screening and follow-up of newborn screens Categorizes biomarkers into diagnostic markers, disease follow-up markers, and prognostic biomarkers Covers confounding factors that can alter biomarkers in the absence of inborn errors of metabolism Offers guidance on how to distinguish acquired causes from inborn errors of metabolism

Author : Frank Roels,Myriam Baes,R. Delanghe
Publisher : Springer
Page : 0 pages
File Size : 50,7 Mb
Release : 2012-10-13
Category : Medical
ISBN : 1461347823

Get Book

Peroxisomal Disorders and Regulation of Genes by Frank Roels,Myriam Baes,R. Delanghe Pdf

In most peroxisomal disorders the nervous system is severely affected which explains the clinical and community burden they represent. This is the first book to focus not only on the mutations causing these inherited illnesses, but also on mechanisms that regulate, suppress or enhance expression of genes and their products (enzymes). Indeed since the success and completion of the Human Genome Project all genes (coding DNA sequences) are known. However, of many, their function, and the role of the gene product has not been determined. An example is X-linked adrenoleukodystrophy, the most frequent peroxisomal disorder. Children are born healthy, but in more than 1 out of 3, demyelination of the brain starts unpredictably and they die in a vegetative state. The gene mutated in most families has been known for 10 years; but the true role of the encoded protein, ALDp, is still speculative; and within the same family, very severe and asymptomatic clinical histories co-exist, unexplained by the mutation.

Author : Michael Schrader
Publisher : Springer Nature
Page : 507 pages
File Size : 51,9 Mb
Release : 2023-03-23
Category : Science
ISBN : 9781071630488

Get Book

Peroxisomes by Michael Schrader Pdf

This fully updated volume assembles a comprehensive collection of methods, techniques, and strategies to investigate the molecular and cellular biology of peroxisomes in different organisms. Peroxisome research is on the rise, as novel functions and proteins of this dynamic organelle are still being discovered through studies in model systems including humans, mice, flies, plants, fungi, and yeast, and this progress is reflected in the chapters included in this collection. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Peroxisomes: Methods and Protocols, Second Edition serves as an ideal guide for researchers working on peroxisome- and organelle-based research questions.

Author : Paul C. Guest
Publisher : Springer
Page : 303 pages
File Size : 48,9 Mb
Release : 2019-03-27
Category : Science
ISBN : 9783030126681

Get Book

Reviews on Biomarker Studies of Metabolic and Metabolism-Related Disorders by Paul C. Guest Pdf

The book recognizes that throughout the scientific, medical, and economic communities, new tests incorporating biomarkers are needed to improve the diagnosis of patients suffering from metabolic disorders. The early identification of those at risk of developing obesity will help to place these individuals on the best treatment course as early as possible for improved treatment outcomes. This will also help to cut costs incurred by the healthcare services. For all of this to occur, new research efforts are needed to identify novel biomarkers that can be used to predict the disease in the presymptomatic stage, for disease monitoring and for prediction of treatment response. It is also possible that new drug targets can be identified using these approaches which, in turn, can lead to the development of new treatment approaches. This volume also includes a series of reviews on biomarker discovery and usage in the study of diseases marked by perturbations in metabolism. It will describe the pros and cons of the various approaches and cover the successes and failures in this important research field.

Author : G. Gordon Gibson,Brian G. Lake
Publisher : CRC Press
Page : 756 pages
File Size : 41,9 Mb
Release : 2013-04-08
Category : Medical
ISBN : 0203481518

Get Book

Peroxisomes by G. Gordon Gibson,Brian G. Lake Pdf

Provides an update on several new aspects of peroxisome biology, including the role of the peroxisome proliferator activated receptor. The book covers morphilogical, biochemical and molecular biological aspects of peroxisomes.

Author : Scott Brady,George Siegel,R. Wayne Albers,Donald Price
Publisher : Academic Press
Page : 1120 pages
File Size : 43,5 Mb
Release : 2011-11-02
Category : Science
ISBN : 9780080959016

Get Book

Basic Neurochemistry by Scott Brady,George Siegel,R. Wayne Albers,Donald Price Pdf

Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology, the outstanding and comprehensive classic text on neurochemistry, is now newly updated and revised in its Eighth Edition. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. It is also an excellent source of current information on basic biochemical and cellular processes in brain function and neurological diseases for continuing medical education and qualifying examinations. This text continues to be the standard reference and textbook for exploring the translational nature of neuroscience, bringing basic and clinical neuroscience together in one authoritative volume. Our book title reflects the expanded attention to these links between neurochemistry and neurologic disease. This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from: Intracellular trafficking; Stem cells, adult neurogenesis, regeneration; Lipid messengers; Expanded coverage of all major neurodegenerative and psychiatric disorders; Neurochemistry of addiction; Neurochemistry of pain; Neurochemistry of hearing and balance; Neurobiology of learning and memory; Sleep; Myelin structure, development, and disease; Autism; and Neuroimmunology. Completely updated text with new authors and material, and many entirely new chapters Over 400 fully revised figures in splendid color 61 chapters covering the range of cellular, molecular and medical neuroscience Translational science boxes emphasizing the connections between basic and clinical neuroscience Companion website at http://elsevierdirect.com/companions/9780123749475

Author : Bruce Spiegelman
Publisher : Springer
Page : 108 pages
File Size : 44,6 Mb
Release : 2018-03-07
Category : Science
ISBN : 9783319727905

Get Book

Hormones, Metabolism and the Benefits of Exercise by Bruce Spiegelman Pdf

The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 47,9 Mb
Release : 2006
Category : Electronic
ISBN : OCLC:757476652

Get Book

Peroxisomes by Anonim Pdf

Author : Jose Antonio Morales-Gonzalez
Publisher : BoD – Books on Demand
Page : 516 pages
File Size : 48,8 Mb
Release : 2013-05-22
Category : Science
ISBN : 9789535111238

Get Book

Oxidative Stress and Chronic Degenerative Diseases by Jose Antonio Morales-Gonzalez Pdf

This work responds to the need to find, in a sole document, the affect of oxidative stress at different levels, as well as treatment with antioxidants to revert and diminish the damage. Oxidative Stress and Chronic Degenerative Diseases - a Role for Antioxidants is written for health professionals by researchers at diverse educative institutions (Mexico, Brazil, USA, Spain, Australia, and Slovenia). I would like to underscore that of the 19 chapters, 14 are by Mexican researchers, which demonstrates the commitment of Mexican institutions to academic life and to the prevention and treatment of chronic degenerative diseases.

Author : Helmut Kindl,Paul B. Lazarow
Publisher : Unknown
Page : 576 pages
File Size : 47,9 Mb
Release : 1982
Category : Science
ISBN : STANFORD:36105037934283

Get Book

Peroxisomes and Glyoxysomes by Helmut Kindl,Paul B. Lazarow Pdf