Peroxisomes

Author : A. Baker,I.A. Graham
Publisher : Springer Science & Business Media
Page : 509 pages
File Size : 52,6 Mb
Release : 2013-03-14
Category : Science
ISBN : 9789401598583

Get Book

Plant Peroxisomes by A. Baker,I.A. Graham Pdf

In the two decades since the last comprehensive work on plant peroxisomes appeared, the scientific approaches employed in the study of plant biology have changed beyond all recognition. The accelerating pace of plant research in the post-genomic era is leading us to appreciate that peroxisomes have many important roles in plant cells, including reserve mobilisation, nitrogen assimilation, defence against stress, and metabolism of plant hormones, which are vital for productivity and normal plant development. Many plant scientists are finding, and will no doubt continue to find, that their own area of research is connected in some way to peroxisomes. Written by the leading experts in the field, this book surveys peroxisomal metabolic pathways, protein targeting and biogenesis of the organelle and prospects for the manipulation of peroxisomal function for biotechnological purposes. It aims to draw together the current state of the art as a convenient starting point for anyone, student or researcher, who wishes to know about plant peroxisomes.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 53,6 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

Get Book

Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Gérard Lizard
Publisher : Springer Nature
Page : 209 pages
File Size : 54,9 Mb
Release : 2021-01-08
Category : Medical
ISBN : 9783030602048

Get Book

Peroxisome Biology: Experimental Models, Peroxisomal Disorders and Neurological Diseases by Gérard Lizard Pdf

This book provides an overview of the biology and biochemistry of peroxisomes, and discusses the contribution of these organelles to peroxisomal and neurodegenerative diseases. It begins with a detailed introduction to the biogenesis and metabolic functions of peroxisomes, and highlights their role in oxidative stress and in lipid metabolism such as fatty acid oxidation. The following chapters focus on the molecular and clinical aspects of peroxisomal disorders caused by defects in peroxisomal function. In particular, the biological aspects of peroxisomal biogenesis disorders such as Zellweger syndrome and Heimler syndrome are discussed. This includes their underlying genetic causes as well as the biochemical and metabolic defects associated with the disorders. In addition, several chapters cover recent observations suggesting an association between peroxisomal dysfunction and neurodegenerative diseases such as Alzheimer's, Multiple Sclerosis and other degenerative cerebellar pathologies. The final section of the book discusses important cell and animal models for studying the role of peroxisomes in human diseases and presents current therapeutic strategies for their treatment. This book deals with a highly topical subject that is at the heart of current research, and represents a valuable contribution for all students and researchers who want to understand the complex biology of peroxisomes and their role in human diseases.

Author : G. Gordon Gibson,Brian G. Lake
Publisher : CRC Press
Page : 756 pages
File Size : 46,5 Mb
Release : 2013-04-08
Category : Medical
ISBN : 0203481518

Get Book

Peroxisomes by G. Gordon Gibson,Brian G. Lake Pdf

Provides an update on several new aspects of peroxisome biology, including the role of the peroxisome proliferator activated receptor. The book covers morphilogical, biochemical and molecular biological aspects of peroxisomes.

Author : Colin Masters,Denis Crane
Publisher : Cambridge University Press
Page : 308 pages
File Size : 45,5 Mb
Release : 1995-07-13
Category : Science
ISBN : 0521482127

Get Book

The Peroxisome by Colin Masters,Denis Crane Pdf

The peroxisome is a cellular organelle which performs a vital role in animals and plants. Many advances have been made in our understanding of the peroxisome in recent years. This book provides a basic introduction to the peroxisome, followed by detailed and comprehensive discussion of its structure and function, and coverage of human peroxisomal diseases. This is an authoritative and readable text, presented in a convenient format with numerous diagrams and chapter summaries, suitable for students and researchers in the biomedical sciences.

Author : Michael Schrader
Publisher : Springer Nature
Page : 507 pages
File Size : 46,9 Mb
Release : 2023-03-23
Category : Science
ISBN : 9781071630488

Get Book

Peroxisomes by Michael Schrader Pdf

This fully updated volume assembles a comprehensive collection of methods, techniques, and strategies to investigate the molecular and cellular biology of peroxisomes in different organisms. Peroxisome research is on the rise, as novel functions and proteins of this dynamic organelle are still being discovered through studies in model systems including humans, mice, flies, plants, fungi, and yeast, and this progress is reflected in the chapters included in this collection. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Peroxisomes: Methods and Protocols, Second Edition serves as an ideal guide for researchers working on peroxisome- and organelle-based research questions.

Author : Anonim
Publisher : World Health Organization
Page : 104 pages
File Size : 53,5 Mb
Release : 1995
Category : Carcinogenesis
ISBN : UCR:31210011167374

Get Book

Peroxisome Proliferation and Its Role in Carcinogenesis by Anonim Pdf

A state-of-the-art consensus report on what is known about peroxisome proliferation, the mechanisms involved, and their relevance to carcinogenesis. Peroxisomes are single, membrane-limited, cytoplasmic organelles that are found in cells of animals, plants, fungi, and protozoa. Peroxisome proliferators include certain hypolipidaemic drugs, phthalate ester plasticizers, industrial solvents, herbicides, food flavours, leukotriene D4 antagonists, and hormones. Numerous studies in rats and mice have demonstrated the hepatocarcinogenic effects of peroxisome proliferators, and these compounds have been unequivocally established as carcinogens. Since humans are exposed to peroxisome proliferators to a significant extent, assessment of the adverse biological effects of this group of compounds, and particularly their potential carcinogenicity, has become an important issue. The report has two parts. The first records the consensus reached by a group of eleven experts, including several of the leading investigators in this field. Questions addressed include the mechanisms by which peroxisome proliferators exert their carcinogenic effects in rodents, the relevance of animal studies to the evaluation of carcinogenic risk in humans, and the potential use of peroxisome proliferation as a biological marker for liver cancer. The report concludes that compounds inducing peroxisome proliferation in rats and mice have little, if any, effect on human liver. The report also issues advice on the interpretation of peroxisome proliferation, demonstrated in animal studies, when evaluating the carcinogenic risk to humans. The second part consists of three background papers presented by members of the working group.

Author : Vladimir I Titorenko, Richard A Rachubinski
Publisher : Frontiers Media SA
Page : 149 pages
File Size : 40,9 Mb
Release : 2015-03-05
Category : Physiology
ISBN : 9782889194643

Get Book

Origin and spatiotemporal dynamics of the peroxisomal endomembrane system by Vladimir I Titorenko, Richard A Rachubinski Pdf

The peroxisome is an organelle with essential roles in lipid metabolism, maintenance of reactive oxygen species homeostasis, and anaplerotic replenishment of tricarboxylic acid cycle intermediates destined for mitochondria. Peroxisomes constitute a dynamic endomembrane system. The homeostatic state of this system is upheld via two pathways for assembling and maintaining the diverse peroxisomal compartments constituting it; the relative contribution of each pathway to preserving such system may vary in different organisms and under various physiological conditions. One pathway begins with the targeting of certain peroxisomal membrane proteins to an endoplasmic reticulum template and their exit from the template via pre-peroxisomal carriers; these carriers mature into metabolically active peroxisomes containing the entire complement of membrane and matrix proteins. Another pathway operates via growth and maturation of pre-existing peroxisomal precursors that do not originate from the endoplasmic reticulum; mature peroxisomes proliferate by undergoing fission. Recent studies have uncovered new roles for the peroxisomal endomembrane system in orchestrating important developmental decisions and defining organismal longevity. This Frontiers Special Topic Issue is focused on the advances in our understanding of how evolutionarily distant organisms coordinate the formation, maturation, proliferation, maintenance, inheritance and quality control of the peroxisomal endomembrane system and how peroxisomal endomembranes communicate with other cellular compartments to orchestrate complex biological processes and various developmental programs from inside the cell.

Author : Maya Schuldiner,Einat Zalckvar,Peter Kijun Kim,Sigrun Reumann,Michael Sattler
Publisher : Frontiers Media SA
Page : 370 pages
File Size : 45,7 Mb
Release : 2021-08-31
Category : Science
ISBN : 9782889712472

Get Book

Peroxisome Biology: Breakthroughs, Challenges and Future Directions by Maya Schuldiner,Einat Zalckvar,Peter Kijun Kim,Sigrun Reumann,Michael Sattler Pdf

Author : Frank Roels,Sylvia De Bie,R.B.H. Schutgens,G.T.N. Besley
Publisher : Springer Science & Business Media
Page : 234 pages
File Size : 41,6 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9789401196352

Get Book

Diagnosis of human peroxisomal disorders by Frank Roels,Sylvia De Bie,R.B.H. Schutgens,G.T.N. Besley Pdf

Peroxisomal disorders constitute a major research front in clinical genetics, paediatrics and cell biology. Since 1983, the metabolic defect in some 20 different peroxisomal disorders has been described. The best known conditions include Zellweger syndrome, rhizomelic chondrodysplasia punctata and X-linked adrenoleukodystrophy and, in the most recent edition of The Metabolic and Molecular Basis Inherited Disease, edited by Scriver and colleagues, more than 100 pages are now devoted to the subject. Progress in our understanding of these conditions, and their diagnosis, results from the application of a variety of laboratory investigations. These include microscopic studies, analysis of metabolites (very long-chain fatty acids, bile acids, and plasmalogens), enzyme studies (peroxisomal beta-oxidation pathway and dihydroxyacetone phosphate acyltransferase), immunodetection of peroxisomal (membrane) proteins and molecular analysis of mutant DNA. In order to encourage a greater awareness in this field and the diagnostic protocols required, an international course was organised in Gent, Belgium, in May 1994, on the clinical and biochemical diagnosis of peroxisomal disorders. A number of international experts in the field who provided intensive hands-on experience over 3.5 days, have now collected their course work and reviews together in this Handbook. The volume is introduced by Sidney Goldfischer, who in 1973 was the first to recognise the absence of peroxisomes in Zellweger syndrome, but whose observations were not fully appreciated for a further decade. This handbook provides the most comprehensive and detailed account of laboratory methods for the diagnosis of peroxisomal disorders. The methods are clearly presented and well illustrated, and should allow laboratories to introduce these methods into their repertoire. Audience: Paediatricians, neurologists, clinical biochemists, pathologists, genetic counsellors, obstetricians, and GPs interested in the recognition, diagnosis and prenatal prevention of peroxisomal disorders.

Author : Cecile Brocard,Andreas Hartig
Publisher : Springer
Page : 540 pages
File Size : 55,7 Mb
Release : 2014-07-23
Category : Science
ISBN : 9783709117880

Get Book

Molecular Machines Involved in Peroxisome Biogenesis and Maintenance by Cecile Brocard,Andreas Hartig Pdf

In eukaryotes, lipid metabolism requires the function of peroxisomes. These multitasking organelles are also part of species-specific pathways such as the glyoxylate cycle in yeast and plants or the synthesis of ether lipid in mammals. Proteins required for the biogenesis of peroxisomes typically assemble in large molecular complexes, which participate in membrane formation, protein transport, peroxisome duplication and - inheritance during cell division. Peroxisomal function is essential for life. Mutations in PEX genes, encoding for biogenesis factors, are often associated with lethal disorders. The association of peroxisomes with other organelles suggests an extensive participation in organellar crosstalk. This book represents a state-of-the-art review in the field of peroxisome research encompassing the cell and molecular biology of peroxisome biogenesis and its diseases, the protein complexes involved in this process and the modern technologies applied to study them. The book is intended for graduate students, researchers and lecturers in biochemistry, molecular and cell biology with a biomedical background.

Author : Luis A. del Río
Publisher : Springer Science & Business Media
Page : 353 pages
File Size : 51,6 Mb
Release : 2013-07-03
Category : Medical
ISBN : 9789400768895

Get Book

Peroxisomes and their Key Role in Cellular Signaling and Metabolism by Luis A. del Río Pdf

Peroxisomes are a class of ubiquitous and dynamic single membrane-bounded cell organelles, devoid of DNA, with an essentially oxidative type of metabolism. In recent years it has become increasingly clear that peroxisomes are involved in a range of important cellular functions in almost all eukaryotic cells. In higher eukaryotes, including humans, peroxisomes catalyze ether phospholipids biosynthesis, fatty acid alpha-oxidation, glyoxylate detoxification, etc, and in humans peroxisomes are associated with several important genetic diseases. In plants, peroxisomes carry out the fatty acid beta-oxidation, photorespiration, metabolism of ROS, RNS and RSS, photomorphogenesis, biosynthesis of phytohormones, senescence, and defence against pathogens and herbivores. In recent years it has been postulated a possible contribution of peroxisomes to cellular signaling. In this volume an updated view of the capacity and function of peroxisomes from human, animal, fungal and plant origin as cell generators of different signal molecules involved in distinct processes of high physiological importance is presented.

Author : Jihan A. Youssef,Mostafa Z. Badr
Publisher : Springer Science & Business Media
Page : 141 pages
File Size : 44,9 Mb
Release : 2013-04-18
Category : Science
ISBN : 9781627034203

Get Book

Peroxisome Proliferator-Activated Receptors by Jihan A. Youssef,Mostafa Z. Badr Pdf

All three peroxisome proliferator-activated receptor (PPAR) subtypes share a high degree of structural homology while exhibiting differences in function, tissue distribution, and ligand specificity. In Peroxisome Proliferator-Activated Receptors: Discovery and Recent Advances, the authors trace the history of PPAR discovery and detail the receptor structure and its posttranslational modifications. Furthermore, endogenous ligands as well as various classes of exogenous ligands, subtype-selective, dual and pan agonists as well as antagonists, are discussed. In addition, the tissue distribution and versatile functions of PPAR subtypes in major organs are described. As PPARs play critical roles as regulators of numerous physiological as well as pathophysiological pathways, Peroxisome Proliferator-Activated Receptors: Discovery and Recent Advances aims to help researchers to develop safer and more effective PPAR modulators as therapeutic agents to treat a myriad of diseases and conditions.

Author : Norbert Latruffe,Maurice Bugaut
Publisher : Springer Science & Business Media
Page : 200 pages
File Size : 47,8 Mb
Release : 2013-04-17
Category : Science
ISBN : 9783642878077

Get Book

Peroxisomes by Norbert Latruffe,Maurice Bugaut Pdf

Discovered and first isolated in 1966 in C. De Duve's laboratory, peroxisomes - organelles which are present in nearly all eukaryotic cells - are still not fully understood. More than 40 peroxisomal enzymes catalyzing a variety of reactions have been characterized. Moreover, peroxisomes can be regarded as toxicological indicators: several compounds, including hypolipemic drugs, plasticizers or pesticides trigger their proliferation. This proliferation may lead to hepatocarcinogenesis in rodents. Interest in peroxisomes stems not only fromtheir biology, but also because there is a deficiency of peroxisomal functions in several genetic diseases. Some genes involved in inborn errors of peroxisomal function have recently been identified. In this manual, based on a FEBS Advanced Course on peroxisomes, protocols on the following topics are described in detail: Isolation and characterization of peroxisomes by ultracentrifugationand immunoblotting; gene regulation studied by mRNA isolation, hybridizationand DNA cell transfection; use of cell lines as peroxisome proliferator targets; transformation with retrovirus; peroxisomes as toxicological markers; cytochrome P450 induction; drug design and computer analysis of ligand/receptor interaction involved in peroxisomal gene expression.

Author : David E. Moody
Publisher : CRC Press
Page : 212 pages
File Size : 46,5 Mb
Release : 1994-07-12
Category : Medical
ISBN : 0849383056

Get Book

Peroxisome Proliferators by David E. Moody Pdf

Induction of drug (xenobiotic)-metabolizing enzymes is a common biological response to xenobiotics, the mechanisms and consequences of which are important in academic, industrial, and regulatory areas of pharmacology and toxicology. This monograph, for the first time, has brought together researchers who deal specifically with drug-metabolizing enzymes and peroxisome proliferators. It contains an up-to-date review of peroxisome proliferation, with detailed tables on the 100 known peroxisome proliferators and studies on their hepatocarcinogic capacity. It provides current material from 12 different laboratories doing cutting-edge research on the effect of peroxisome proliferators on drug-metabolizing enzymes.The book covers the response of cytochrome P450s, UDP-glucuronosyltransferases, epoxide hydrolases, glutathione S-transferase, DT-diaphorase, and other enzymes.