Personalized Precision Medicine Role Of Epigenetic Biomarkers

Author : Tommy Royal
Publisher : American Medical Publishers
Page : 0 pages
File Size : 41,7 Mb
Release : 2023-09-19
Category : Medical
ISBN : 9798887403717

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Personalized Precision Medicine: Role of Epigenetic Biomarkers by Tommy Royal Pdf

Epigenetics is the study of heritable phenotype changes that do not entail changes in the DNA sequence. Epigenetic abnormalities have emerged as the most promising biomarkers for diagnosis and prognosis in the early stage of illnesses, such as cancer, autoimmune diseases and psychological disorders. A medical model in which people are divided into groups with medical decisions, practices, interventions and products being tailored to the individual patient based on their predicted response or risk of disease is referred as personalized medicine. The terms precision medicine and personalized medicine are utilized interchangeably for describing the concept. Diagnostic testing is used often in personalized medicine to determine suitable and optimal therapies based on a patient's genetic content, or other molecular or cellular analysis. Certain aspects of personalized medicine utilize genetic information, such as pharmacogenomics. With the help of genomics, proteomics and imaging techniques, molecular scale data of the patients is obtained easily. These molecular biomarkers are then used in determining the prognosis of diseases such as cancer. The readers would gain knowledge that would broaden their perspective about personalized precision medicine through this book. Also included herein is a detailed explanation of the role of epigenetic biomarkers. This book will help the readers in keeping pace with the rapid changes in this field of study.

Author : Jiucun Wang,Dongyi He,Momiao Xiong,Yun Liu
Publisher : Frontiers Media SA
Page : 485 pages
File Size : 52,5 Mb
Release : 2020-12-21
Category : Science
ISBN : 9782889661848

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Epigenetic Biomarker and Personalized Precision Medicine by Jiucun Wang,Dongyi He,Momiao Xiong,Yun Liu Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Jose Luis Garcia-Gimenez
Publisher : Elsevier
Page : 616 pages
File Size : 42,7 Mb
Release : 2021-11-12
Category : Medical
ISBN : 9780323858052

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Epigenetics in Precision Medicine by Jose Luis Garcia-Gimenez Pdf

In recent years, knowledge of epigenetic mechanisms underlying disease onset and progression has proven crucial for the development of novel early diagnosis and prognosis biomarkers for patient stratification and precision medicine. Epigenetics in Precision Medicine, a new volume in the Translational Epigenetics series, provides a thorough discussion and overview of current developments in clinical epigenetics with special emphasis on epigenetic biomarkers that can be used for clinical diagnosis, prognosis, patient stratification, and treatment monitoring. Disease types discussed include cancer, metabolic disorders, neurodegenerative diseases, bone disease, and immune-related disorders. The book examines the challenges of advancing epigenetics research and translating findings to the clinic and drug discovery in each of these areas, as well as current solutions; chapter authors discuss how to leverage epigenomic technologies, applications, and tools, such as next-generation sequencing, to discover new epigenetic biomarkers in disease and drug studies. Epigenetics in Precision Medicine focuses on complex epigenetic mechanisms in several pathologies, and explores how epigenetics can power the advance of precision medicine, not only by improving in vitro diagnostic and prognostic tools, but by providing new therapeutic approaches to treat human disease. Provides a thorough grounding in epigenetics-driven precision medicine, with emphasis on developing and implementing early diagnosis and prognosis biomarkers, and supporting patient stratification Empowers researchers and clinicians to incorporate epigenetics in new disease research, drug discovery, and clinical practice Features chapter contributions from international leaders in the field

Author : Claudio Carini,Sandeep M Menon,Mark Chang
Publisher : CRC Press
Page : 368 pages
File Size : 53,6 Mb
Release : 2014-03-27
Category : Mathematics
ISBN : 9781466593879

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Clinical and Statistical Considerations in Personalized Medicine by Claudio Carini,Sandeep M Menon,Mark Chang Pdf

Clinical and Statistical Considerations in Personalized Medicine explores recent advances related to biomarkers and their translation into clinical development. Leading clinicians, biostatisticians, regulators, commercial professionals, and researchers address the opportunities and challenges in successfully applying biomarkers in drug discovery and preclinical and clinical development. Robust Biomarkers for Drug Development and Disease Treatment The first four chapters discuss biomarker development from a clinical perspective. Coverage ranges from an introduction to biomarkers to advances in RNAi screens, epigenetics, and rare diseases as targets for personalized medicine approaches. Subsequent chapters examine the statistical considerations in applying a personalized medicine approach, including multiplicity in pharmacogenomics. The last chapter assesses the regulatory issues involved in using biomarkers. Improve Patient Care and Reduce Costs and Side Effects Despite the vast amount of literature on biomarkers, there is no comprehensive book that integrates the clinical and statistical components. This book is one of the first to incorporate both the clinical and statistical aspects of biomarkers in the personalized medicine paradigm. Covering a wide spectrum of personalized medicine-related topics, it presents state-of-the-art techniques for advancing the application of biomarkers in drug discovery and development.

Author : José Luis García-Giménez
Publisher : Academic Press
Page : 696 pages
File Size : 52,9 Mb
Release : 2015-12-07
Category : Science
ISBN : 9780128019214

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Epigenetic Biomarkers and Diagnostics by José Luis García-Giménez Pdf

Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease. Focuses on recent progress in several areas of epigenetics, general concepts regarding epigenetics, and the future prospects of this discipline in clinical diagnostics and prognostics Describes the importance of the quality of samples and clinical associated data, and also the ethical issues for epigenetic diagnostics Discusses the advances in epigenomics technologies, including next-generation sequencing based tools and applications Expounds on the utility of epigenetic biomarkers for diagnosis and prognosis of several diseases, highlighting the study of these biomarkers in cancer, cardiovascular and metabolic diseases, infertility, and infectious diseases Includes a special section that discusses the relevance of biobanks in the maintenance of high quality biosamples and clinical-associated data, and the relevance of the ethical aspects in epigenetic studies

Author : Mukesh Verma,Debmalya Barh
Publisher : Academic Press
Page : 344 pages
File Size : 40,8 Mb
Release : 2016-12-22
Category : Medical
ISBN : 9780128095027

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Progress and Challenges in Precision Medicine by Mukesh Verma,Debmalya Barh Pdf

Progress and Challenges in Precision Medicine presents an insightful overview to the myriad factors of personalized and precision medicine. The availability of the human genome, large amounts of data on individual genetic variations, environmental interactions, influence of lifestyle, and cutting-edge tools and technologies for big-data analysis have led to the age of personalized and precision medicine. Bringing together a global range of experts on precision medicine, this book collects previously scattered information into one concise volume which covers the most important developments so far in precision medicine and also suggests the most likely avenues for future development. The book includes clinical information, informatics, public policy implications, and information on case studies. It is a useful reference and background work for students, researchers, and clinicians working in the biomedical and medical fields, as well as policymakers in the health sciences. Provides an overview of the growing field of precision medicine Contains chapters from geographically diverse experts in their field Explores important aspects of precision medicine, including applications, ethics, and development

Author : Anonim
Publisher : Academic Press
Page : 442 pages
File Size : 41,5 Mb
Release : 2019-11-01
Category : Medical
ISBN : 9780128142608

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Prognostic Epigenetics by Anonim Pdf

This volume provides comprehensive information on how mapping an individual’s epigenome can be medically relevant and holds the potential to improve preventive medicine and precision therapeutics at an early-stage (prior to disease onset). In order to advance clinical adoption of the recently developed epigenetic approaches, it is necessary for translational scientists, clinicians, and students to gain a better understanding about epigenetic mechanisms that are associated with a particular disorder; and to be able to effectively identify biomarkers that can be applied in drug development and for better diagnosis and prognosis of diseases. Prognostic Epigenetics is the most-inclusive volume to-date specifically dedicated to epigenetic markers that have been developed for prognosis of diseases, recent advances in this field, the clinical implementation of this research, and the future outlook. Compiles all known information on prognostic epigenetics and its role in preventive medicine and drug discovery Covers the basic functionality of epigenetic mechanisms involved in early disease prognosis and diagnosis, and provides tools for the identification and development of these biomarkers for a wide range of diseases Enables clinicians, researchers, and pharmacologists to improve preventive medicine and precision therapeutics throughout a person’s lifetime Features chapter contributions from leading international researchers

Author : Fouad Sabry
Publisher : One Billion Knowledgeable
Page : 370 pages
File Size : 54,5 Mb
Release : 2022-10-05
Category : Medical
ISBN : PKEY:6610000394012

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Personalized Medicine by Fouad Sabry Pdf

What Is Personalized Medicine A medical model known as personalized medicine, which is also known as precision medicine, categorizes patients into distinct groups, and then tailors medical decisions, practices, interventions, and/or products to each individual patient based on how they are expected to react to treatment or their likelihood of developing a disease. Personalized medicine is also known as precision medicine. Although the terms personalized medicine, precision medicine, stratified medicine, and P4 medicine are often used interchangeably to describe this concept, some authors and organizations use these expressions separately to indicate particular nuances. Personalized medicine refers to the practice of tailoring medical treatment to each individual patient. Precision medicine refers to the practice of treating patients based How You Will Benefit (I) Insights, and validations about the following topics: Chapter 1: Personalized medicine Chapter 2: Pharmacogenomics Chapter 3: MammaPrint Chapter 4: Medical genetics Chapter 5: Biomarker (medicine) Chapter 6: Biomarker (cell) Chapter 7: Predictive medicine Chapter 8: Public health genomics Chapter 9: Cancer Genome Project Chapter 10: Personal genomics Chapter 11: Cancer biomarker Chapter 12: Icahn Genomics Institute Chapter 13: Molecular pathological epidemiology Chapter 14: Molecular diagnostics Chapter 15: Precision medicine Chapter 16: Toxgnostics Chapter 17: Predictive genomics Chapter 18: Clinicogenomics Chapter 19: Elective genetic and genomic testing Chapter 20: Personalized onco-genomics Chapter 21: Cancer pharmacogenomics (II) Answering the public top questions about personalized medicine. (III) Real world examples for the usage of personalized medicine in many fields. (IV) 17 appendices to explain, briefly, 266 emerging technologies in each industry to have 360-degree full understanding of personalized medicine' technologies. Who This Book Is For Professionals, undergraduate and graduate students, enthusiasts, hobbyists, and those who want to go beyond basic knowledge or information for any kind of personalized medicine.

Author : Richard H. Carmona,Mark Liponis
Publisher : Oxford University Press
Page : 585 pages
File Size : 42,7 Mb
Release : 2017-12-12
Category : Medical
ISBN : 9780190241254

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Integrative Preventive Medicine by Richard H. Carmona,Mark Liponis Pdf

For most clinicians, the science and evidence for many integrative therapies is largely unknown or considered suspect. Most physicians don't have time to learn integrative approaches and aren't sure what to recommend or which approaches have merit or improved outcomes. Here, clinicians have easy access to the best practices in integrative medicine and expectations for outcomes

Author : Ramona G. Dumitrescu,Mukesh Verma
Publisher : Humana
Page : 298 pages
File Size : 51,5 Mb
Release : 2019-09-17
Category : Medical
ISBN : 1493993836

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Cancer Epigenetics for Precision Medicine by Ramona G. Dumitrescu,Mukesh Verma Pdf

This volume discusses certain epigenetic changes recognized in early carcinogenic lesions and different tumors, as well as factors that alter the epigenome and epigenetic profile such as diet, alcohol, immunity, circadian rhythm, and more. The chapters in this book further delve into this field and cover topics such as epigenome-based precision medicine in lung cancer; interplay between genetic and epigenetic changes in breast cancer subtypes; genetic regulation of PDCD1 gene in cancer immunology; and pyrosequencing methylation analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Cancer Epigenetics for Precision Medicine: Methods and Protocols is a valuable resource to help researchers and scientists identify these specific biomarkers and work towards the prevention, diagnosis, and prognosis of different cancers in the future.

Author : Debmalya Barh,Dipali Dhawan,Nirmal Kumar Ganguly
Publisher : Springer Science & Business Media
Page : 832 pages
File Size : 44,6 Mb
Release : 2013-10-14
Category : Medical
ISBN : 9788132211846

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Omics for Personalized Medicine by Debmalya Barh,Dipali Dhawan,Nirmal Kumar Ganguly Pdf

“Omics for Personalized Medicine” will give to its prospective readers the insight of both the current developments and the future potential of personalized medicine. The book brings into light how the pharmacogenomics and omics technologies are bringing a revolution in transforming the medicine and the health care sector for the better. Students of biomedical research and medicine along with medical professionals will benefit tremendously from the book by gaining from the diverse fields of knowledge of new age personalized medicine presented in the highly detailed chapters of the book. The book chapters are divided into two sections for convenient reading with the first section covering the general aspects of pharmaocogenomic technology that includes latest research and development in omics technologies. The first section also highlights the role of omics in modern clinical trials and even discusses the ethical consideration in pharmocogenomics. The second section is focusing on the development of personalized medicine in several areas of human health. The topics covered range from metabolic and neurological disorders to non-communicable as well as infectious diseases, and even explores the role of pharmacogenomics in cell therapy and transplantation technology. Thirty-four chapters of the book cover several aspects of pharmacogenomics and personalized medicine and have taken into consideration the varied interest of the readers from different fields of biomedical research and medicine. Advent of pharmacogenomics is the future of modern medicine, which has resulted from culmination of decades of research and now is showing the way forward. The book is an honest endeavour of researchers from all over the world to disseminate the latest knowledge and knowhow in personalized medicine to the community health researchers in particular and the educated public in general.

Author : Gabriella Pravettoni,Stefano Triberti
Publisher : Springer Nature
Page : 191 pages
File Size : 43,6 Mb
Release : 2019-11-29
Category : Psychology
ISBN : 9783030279943

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P5 eHealth: An Agenda for the Health Technologies of the Future by Gabriella Pravettoni,Stefano Triberti Pdf

This open access volume focuses on the development of a P5 eHealth, or better, a methodological resource for developing the health technologies of the future, based on patients’ personal characteristics and needs as the fundamental guidelines for design. It provides practical guidelines and evidence based examples on how to design, implement, use and elevate new technologies for healthcare to support the management of incurable, chronic conditions. The volume further discusses the criticalities of eHealth, why it is difficult to employ eHealth from an organizational point of view or why patients do not always accept the technology, and how eHealth interventions can be improved in the future. By dealing with the state-of-the-art in eHealth technologies, this volume is of great interest to researchers in the field of physical and mental healthcare, psychologists, stakeholders and policymakers as well as technology developers working in the healthcare sector.

Author : Ioana Agache,Peter Hellings
Publisher : Academic Press
Page : 228 pages
File Size : 51,8 Mb
Release : 2018-09-19
Category : Medical
ISBN : 9780128134726

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Implementing Precision Medicine in Best Practices of Chronic Airway Diseases by Ioana Agache,Peter Hellings Pdf

Implementing Precision Medicine in Best Practices of Chronic Airway Diseases provides a comprehensive overview of the application of precision medicine in airway diseases with a goal of promoting optimal control of disease, higher patient satisfaction and disease prevention. As medical research continues to fund this area, the book highlights the need for implementation of the principles of precision medicine into the bedside management of chronic airway diseases. It is clear that chronic airway diseases are heterogeneous and that a personalized approach is warranted whereby treatment is tailored to the level of the individual patient. Written for basic researchers, medical doctors and other healthcare practitioners this book provides guidance on the implementation of the principles of precision medicine into further research and daily clinical practice. Bridges the gap between precision medicine research and the implementation of the principles into daily clinical practice Includes contributions from key opinion leaders in the field of airway disease giving a worldwide perspective Discusses precision medicine in terms of personalized and stratified medicine, biomarkers, prediction of success, participation of the patient and prevention of disease

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on A Framework for Developing a New Taxonomy of Disease
Publisher : National Academies Press
Page : 142 pages
File Size : 55,6 Mb
Release : 2012-01-16
Category : Medical
ISBN : 9780309222228

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Toward Precision Medicine by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on A Framework for Developing a New Taxonomy of Disease Pdf

Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.

Author : Robinson Ramírez-Vélez,Mikel Izquierdo
Publisher : Frontiers Media SA
Page : 130 pages
File Size : 44,6 Mb
Release : 2019-10-09
Category : Electronic
ISBN : 9782889630639

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Precision Physical Activity and Exercise Prescriptions for Disease Prevention: The Effect of Interindividual Variability Under Different Training Approaches by Robinson Ramírez-Vélez,Mikel Izquierdo Pdf