Pharmacogenomics A Primer For Clinicians

Author : Jerika T. Lam,Mary A Gutierrez
Publisher : McGraw Hill Professional
Page : 186 pages
File Size : 53,6 Mb
Release : 2020-12-22
Category : Medical
ISBN : 9781260457117

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Pharmacogenomics: A Primer for Clinicians by Jerika T. Lam,Mary A Gutierrez Pdf

An invaluable resource to the rapidly emerging field of pharmacogenomics—complete with case studies, clinical pearls, and treatment recommendations The aim of pharmacogenomics is to improve personalized medicine by taking into account how genes affect an individual’s tolerability and response to drugs. Approaching pharmacogenomics from the current clinical, scientific, and implementation perspectives, this guide serves as an invaluable evidence-based resource to the subject. Reflecting the shift from genetics to genomics in the pharmaceutical sphere, the book covers pharmacogenomics fundamentals; genotyping tests and evidence; clinical implementation; ethical, legal, and social issues; and more. You’ll also find illuminating case scenarios, clinical pearls, and evidence-based recommendations for treatments and alternatives based on CPIC, PharmGKB, and FDA guidelines.

Author : Federico Innocenti
Publisher : Springer Science & Business Media
Page : 215 pages
File Size : 45,9 Mb
Release : 2008-02-03
Category : Medical
ISBN : 9781592599578

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Pharmacogenomics by Federico Innocenti Pdf

Expert researchers and physician/clinicians describe in detail the newest and most commonly used technologies today in this rapidly advancing field. The authors provide readily reproducible methods for assessing the functional consequences of a certain polymorphism, evaluate the variety of genotyping platforms currently available, and discuss the management of pharmacogenomic information. Highlights include techniques for making a snapshot of the allele-specific variation in human gene expression, genome wide analysis of allele-specific expression using oligo microarrays, in vivo assays with HaploChIP, SNP genotyping in DNA pools, and PharmGKB, the pharmacogenetics and pharmacogenomics knowledge base. The methodologies for genotyping include denaturing high-performance liquid chromarography, pyrosequencing, kinetic-fluorescence detection, mass spectrometry, and TaqMan assay for insertion/deletions.

Author : Joseph S. Bertino
Publisher : Unknown
Page : 274 pages
File Size : 55,6 Mb
Release : 2013
Category : Pharmacogenomics
ISBN : 6613968668

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Pharmacogenomics by Joseph S. Bertino Pdf

Author : David F. Kisor
Publisher : Jones & Bartlett Publishers
Page : 204 pages
File Size : 43,9 Mb
Release : 2014
Category : Pharmacogenetics
ISBN : 1449633935

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Pharmacogenetics, Kinetics, and Dynamics for Personalized Medicine by David F. Kisor Pdf

Pharmacogenetics, Kinetics, And Dynamics For Personalized Medicine Provides A Primer To Understand Pharmacogenetics (The Study Of Genetic Factors That Influence How A Drug Works) In The Applied Context Of Pharmacokinetics (How The Body Handles A Drug) And Pharmacodynamics (The Effects Of A Drug On The Body). This Valuable Foundation Illuminates How These Principles And Scientific Advances Can Create Optimal Individual Patient Care, That Is, "Personalized Medicine." Through Specific Drug Examples, This Resource Explores How The Genetic Constitution Of An Individual May Lead To The Need For An Altered Dose Or In Some Cases Alternative Drug Therapy. Real-World Cases Highlight The Specific Relationships Between Genetics, Drug Action, And The Body'S Response As Well As Adverse Drug Reactions, Altered Metabolism, And Drug Efficacy. Ethical Issues Concerning Pharmacogenomics And Study Design Are Also Discussed In This Concise Overview.

Author : Thomas G. Schulze,Francis J. McMahon
Publisher : Oxford University Press
Page : 241 pages
File Size : 40,7 Mb
Release : 2018
Category : Medical
ISBN : 9780190221973

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Psychiatric Genetics by Thomas G. Schulze,Francis J. McMahon Pdf

Psychiatrists and other mental health professionals are increasingly confronted with questions about the genetics of psychiatric illness, and the clinical applications of new genetic findings. Psychiatric Genetics: A Primer for Clinical and Basic Scientists addresses these questions through a straightforward introduction to the essentials of psychiatric genetics, complementing more comprehensive textbooks that may seem overwhelming for those new to the field. Written and edited by leaders in the field and the International Society of Psychiatric Genetics (ISPG), the book covers basic epidemiology, recruitment for human studies, phenotyping strategies, formal genetic and molecular genetic studies, statistical genetics, bioinformatics and genomics, pharmacogenetics, the most relevant animal models, and biobanking. Each chapter begins with a list of take home points that summarizes content, followed by a brief overview of current knowledge and suggestions for further reading. This Primer is ideal for medical students, psychiatric residents, psychiatrists, and basic neuroscience researchers who are interested in learning about the key concepts and recent advances in the exciting field of psychiatric genetics.

Author : Showkat Ahmad Ganie,Aarif Ali,Muneeb U. Rehman,Azher Arafah
Publisher : Elsevier
Page : 392 pages
File Size : 44,8 Mb
Release : 2023-06-13
Category : Medical
ISBN : 9780443153372

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Pharmacogenomics by Showkat Ahmad Ganie,Aarif Ali,Muneeb U. Rehman,Azher Arafah Pdf

Pharmacogenomics: From Discovery to Clinical Implementation is a complete reference aimed at building a solid foundation of the key concepts in this fast-moving knowledge area. The editors lined up a group of worldwide experts to contribute to the book. Following a consistent chapter structure, the authors cover the foundational aspects of pharmacogenomics in the first four chapters of the book that include basic concepts, drug metabolism, drug discovery and development, and testing. The second part of the book is dedicated to detailed studies of key health conditions and the potential therapeutic applications of pharmacogenomics. Diseases covered include diabetes, cardiovascular diseases, psychiatric disease, cancer, pulmonary and respiratory diseases, viral diseases, gastroenterology, autoimmune diseases, immunosuppressants, and, finally, an overview of computational resources. Pharmacogenomics: From Discovery to Clinical Implementation is the perfect resource for pharmaceutical science graduate students to learn the key concepts of the area. Researchers and graduate students in the related fields of Genetics, pharmacoepidemiology, molecular biology, and medicinal chemistry will also benefit of the structured approach of the book. Provides an in-depth review of pharmacogenomics and its role in drug discovery/metabolism and its clinical impacts Describes the practice of pharmacogenomics in the treatment of diabetes, cancers, cardiovascular diseases, psychiatric disorders, pulmonary diseases, infectious, gastroenterology, and autoimmune diseases Uses a consistent chapter structure to support understanding of the fundamental concepts in the area

Author : Judy S. Crabtree
Publisher : Academic Press
Page : 114 pages
File Size : 50,9 Mb
Release : 2019-11-15
Category : Medical
ISBN : 9780128204023

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Clinical Precision Medicine by Judy S. Crabtree Pdf

Clinical Precision Medicine: A Primer offers clinicians, researchers and students a practical, up-to-date resource on precision medicine, its evolving technologies, and pathways towards clinical implementation. Early chapters address the fundamentals of molecular biology and gene regulation as they relate to precision medicine, as well as the foundations of heredity and epigenetics. Oncology, an early adopter of precision approaches, is considered with its relationship to genetic variation in drug metabolism, along with tumor immunology and the impact of DNA variation in clinical care. Contributions by Stephanie Kramer, a Clinical Genetic Counselor, also provide current information on prenatal diagnostics and adult genetics that highlight the critical role of genetic counselors in the era of precision medicine. Includes applied discussions of chromosomes and chromosomal abnormalities, molecular genetics, epigenetic regulation, heredity, clinical genetics, pharmacogenomics and immunogenomics Features chapter contributions from leaders in the field Consolidates fundamental concepts and current practices of precision medicine in one convenient resource

Author : Joseph S. Bertino,Angela Kashuba,Joseph D. Ma,Uwe Fuhr,C. Lindsay DeVane
Publisher : McGraw Hill Professional
Page : 289 pages
File Size : 45,7 Mb
Release : 2012-10-12
Category : Medical
ISBN : 9780071813716

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Pharmacogenomics An Introduction and Clinical Perspective by Joseph S. Bertino,Angela Kashuba,Joseph D. Ma,Uwe Fuhr,C. Lindsay DeVane Pdf

A COMPLETE INTRODUCTORY TEXT TO THE FIELD OF PHARMACOGENOMICS The only pharmacogenomics resource to feature a global author team comprised of PharmDs, MDs, PhDs and social scientists, Pharmacogenomics offers an essential, highly accessible survey of this dynamic discipline. You will find thorough coverage of all need-to-know topics, from individual molecules to systemic diseases, plus an examination of the latest technologies that are constantly reshaping the field. Pharmacogenomics is cohesively organized into two sections, the first of which reviews basic aspects of pharmacogenomics, including ethics, regulatory, science, and drug metabolism, along with a "mini" course in molecular genetics and testing. The second section highlights the practical application of pharmacogenomics in cardiovascular medicine, immunology, neurology, and other specialties. FEATURES Important overview of general pharmacogenomics and pharmacogenetics concepts, including genetic variation in signal transduction and targets, plus a review of the genetic concepts of pharmacogenomics Discussion of regulatory considerations in pharmacogenomics Focus on the role of health care professionals along with a review of related privacy issues, as well as broader ethical, legal, and social considerations In-depth chapters on drug metabolism and transporters Practical, step-by-step guidance on public access to pharmacogenomic testing and patient counseling Up-to-date coverage of non-genetic influences on pharmacogenomics Emphasis on gene-drug interactions Numerous tables and figures Chapter-ending references Concise learning objectives at the beginning of each chapter Case studies to familiarize you with the clinical relevance of pharmacogenomics in each specialty

Author : Martin M. Zdanowicz
Publisher : ASHP
Page : 425 pages
File Size : 55,9 Mb
Release : 2010
Category : Medical
ISBN : 9781585282340

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Concepts in Pharmacogenomics by Martin M. Zdanowicz Pdf

The new science of pharmacogenomics aims to understand how an individual's genetic composition affects his/her response to a specific drug or class of drugs. By studying such characteristics as drug metabolizing enzymes, drug transporter activity, and receptor sensitivity, a pharmacist is better able to prescribe the right drug the first time.If you are pharmacist, resident, or student curious about this new field, start withConcepts in Pharmacogenomics. In this practical guide, you will find an overview of the science behind pharmacogenomics, followed by detailed chapters related to its clinical application and implementation.Features include: case studies in each chapter clinical pearls illustrations of key concepts figures, diagrams, and flow charts for visual learners key points summarized.

Author : Shannon C. Miller,Richard N. Rosenthal,Sharon Levy,Andrew J. Saxon,Jeanette M. Tetrault,Sarah E. Wakeman
Publisher : Lippincott Williams & Wilkins
Page : 5147 pages
File Size : 44,7 Mb
Release : 2024-02-15
Category : Medical
ISBN : 9781975201579

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The ASAM Principles of Addiction Medicine by Shannon C. Miller,Richard N. Rosenthal,Sharon Levy,Andrew J. Saxon,Jeanette M. Tetrault,Sarah E. Wakeman Pdf

Principles of Addiction Medicine, 7th ed is a fully reimagined resource, integrating the latest advancements and research in addiction treatment. Prepared for physicians in internal medicine, psychiatry, and nearly every medical specialty, the 7th edition is the most comprehensive publication in addiction medicine. It offers detailed information to help physicians navigate addiction treatment for all patients, not just those seeking treatment for SUDs. Published by the American Society of Addiction Medicine and edited by Shannon C. Miller, MD, Richard N. Rosenthal, MD, Sharon Levy, MD, Andrew J. Saxon, MD, Jeanette M. Tetrault, MD, and Sarah E. Wakeman, MD, this edition is a testament to the collective experience and wisdom of 350 medical, research, and public health experts in the field. The exhaustive content, now in vibrant full color, bridges science and medicine and offers new insights and advancements for evidence-based treatment of SUDs. This foundational textbook for medical students, residents, and addiction medicine/addiction psychiatry fellows, medical libraires and institution, also serves as a comprehensive reference for everyday clinical practice and policymaking. Physicians, mental health practitioners, NP, PAs, or public officials who need reference material to recognize and treat substance use disorders will find this an invaluable addition to their professional libraries.

Author : Russ B. Altman,Russ Altman,David Flockhart,David B. Goldstein
Publisher : Cambridge University Press
Page : 283 pages
File Size : 48,8 Mb
Release : 2012-01-23
Category : Medical
ISBN : 9780521885379

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Principles of Pharmacogenetics and Pharmacogenomics by Russ B. Altman,Russ Altman,David Flockhart,David B. Goldstein Pdf

This textbook presents the latest information on pharmacogenetics and pharmacogenomics for students, professionals and researchers.

Author : José A. G. Agúndez,Elena García-Martín
Publisher : Frontiers Media SA
Page : 124 pages
File Size : 48,7 Mb
Release : 2022-05-05
Category : Science
ISBN : 9782889761036

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Insights in Pharmacogenetics and Pharmacogenomics: 2021 by José A. G. Agúndez,Elena García-Martín Pdf

Author : Kara Sealock,Cydnee Seneviratne,Linda Lane Lilley,Julie S. Snyder
Publisher : Elsevier Health Sciences
Page : 1042 pages
File Size : 47,8 Mb
Release : 2020-10-18
Category : Medical
ISBN : 9780323694810

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Lilley's Pharmacology for Canadian Health Care Practice - E-Book by Kara Sealock,Cydnee Seneviratne,Linda Lane Lilley,Julie S. Snyder Pdf

UPDATED! Thoroughly updated drug content reflects the very latest Health Canada drug approvals, withdrawals, and therapeutic uses, as well as corresponding updated nursing content. NEW! Coverage of current top-of-mind topics includes pharmacology as it pertains to palliative care; the legalization of marihuana for both medical and recreational purposes; issues surrounding the use and misuse of fentanyl and the take-home distribution of naloxone kits used to tackle the growing fentanyl crises; and more. NEW! The latest Canadian statistics, research, legislation, regulations, and clinical practice guidelines have been incorporated throughout the text as well as content reflecting the 2017 CNA Code of Ethics, updated references, and more. NEW! Additional examination review questions help readers more thoroughly prepare for credentialing exams. NEW! Updated case studies better reflect the diverse Canadian population. NEW! Expanded visual program incorporates more diagrams, graphs, charts and photos throughout the text to accompany difficult concepts and theories and help facilitate learning. NEW! Incorporation of the Truth and Reconciliation Commission of Canada’s Calls to Action in chapters 4 and 7 now covers Indigenous health and healing practices, an explanation of the Indigenous medicine wheel, and alternative medicinal interventions.

Author : Dixon Thomas
Publisher : Elsevier
Page : 540 pages
File Size : 45,8 Mb
Release : 2018-11-23
Category : Business & Economics
ISBN : 9780128142776

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Clinical Pharmacy Education, Practice and Research by Dixon Thomas Pdf

Clinical Pharmacy Education, Practice and Research offers readers a solid foundation in clinical pharmacy and related sciences through contributions by 83 leading experts in the field from 25 countries. This book stresses educational approaches that empower pharmacists with patient care and research competencies. The learning objectives and writing style of the book focus on clarifying the concepts comprehensively for a pharmacist, from regular patient counseling to pharmacogenomics practice. It covers all interesting topics a pharmacist should know. This book serves as a basis to standardize and coordinate learning to practice, explaining basics and using self-learning strategies through online resources or other advanced texts. With an educational approach, it guides pharmacy students and pharmacists to learn quickly and apply. Clinical Pharmacy Education, Practice and Research provides an essential foundation for pharmacy students and pharmacists globally. Covers the core information needed for pharmacy practice courses Includes multiple case studies and practical situations with 70% focused on practical clinical pharmacology knowledge Designed for educational settings, but also useful as a refresher for advanced students and researchers

Author : Shaker A. Mousa,Raj Bawa,Gerald F. Audette
Publisher : CRC Press
Page : 669 pages
File Size : 45,6 Mb
Release : 2020-01-17
Category : Medical
ISBN : 9781000021271

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The Road from Nanomedicine to Precision Medicine by Shaker A. Mousa,Raj Bawa,Gerald F. Audette Pdf

The enormous advances in nanomedicine and precision medicine in the past two decades necessitated this comprehensive reference, which can be relied upon by researchers, clinicians, pharmaceutical scientists, regulators, policymakers, and lawyers alike. This standalone, full-color resource broadly surveys innovative technologies and advances pertaining to nanomedicine and precision medicine. In addition, it addresses often-neglected yet crucial areas such as translational medicine, intellectual property law, ethics, policy, FDA regulatory issues, nano-nomenclature, and artificial nano-machines—all accomplished in a user-friendly, broad yet interconnected format. The book is essential reading for the novice and the expert alike in diverse fields such as medicine, law, pharmacy, genomics, biomedical sciences, ethics, and regulatory science. The book’s multidisciplinary approach will attract a global audience and serve as a valuable reference resource for industry, academia, and government.