Pharmacological Effects Of Ethanol On The Nervous System

Author : Richard A. Deitrich,V. Gene Erwin
Publisher : CRC Press
Page : 482 pages
File Size : 49,6 Mb
Release : 1995-12-21
Category : Medical
ISBN : 0849383897

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Pharmacological Effects of Ethanol on the Nervous System by Richard A. Deitrich,V. Gene Erwin Pdf

This book dissects the effects of ethanol on the major neurotransmitter systems affected by ethanol and correlates these actions with the behavioral consequences. The subject is approached first from the perspective of the neurochemical system and the behaviors resulting from ethanol's effects on that system. The behaviors themselves are discussed in later chapters. Some older theories of the effects of ethanol such as the membrane fluidization hypothesis are evaluated in light of new and updated information. Fetal Alcohol Syndrome (FAS) as well as the structural damage in the brain by long term ethanol exposure are also discussed.

Author : Henri Begleiter,Benjamin Kissin
Publisher : Oxford University Press, USA
Page : 544 pages
File Size : 44,6 Mb
Release : 1996
Category : Alcohol
ISBN : 0195100948

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The Pharmacology of Alcohol and Alcohol Dependence by Henri Begleiter,Benjamin Kissin Pdf

This is a comprehensive review of the pharmacological effects of alcohol and the mechanisms underlying the pathogenesis of alcoholism. The book draws on general pharmacology, neuropharmacology, and alcohol studies to explore its theme. The second volume in the ALCOHOL AND ALCOHOLISM series, it focuses on the pharmacologic mechanisms underlying the development of alcoholism. The first section on basic pharmacology is concerned with those aspects that are common to all of alcohol's effects. These include pharmacokinetics, general metabolism, and cross-tolerance. The second section on neuropharmacology describes the effects of alcohol on various brain functions, including circulation and metabolism. The third section provides an in-depth review of the neurobiology of physical dependence, withdrawal, and physiological tolerance. The book as a whole gives a comprehensive and authoritative picture of the complex pharmacologic actions of alcohol, particularly on the nervous system. For clinicians and researchers in the field of alcohol and alcoholism, it will serve as a fundamental reference.

Author : Simone Parvez
Publisher : VSP
Page : 350 pages
File Size : 54,9 Mb
Release : 1985-12
Category : Science
ISBN : 9067640506

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Alcohol, Nutrition And the Nervous System by Simone Parvez Pdf

Author : Edward D. Levin,Jerry J. Buccafusco
Publisher : CRC Press
Page : 395 pages
File Size : 49,8 Mb
Release : 2006-06-22
Category : Medical
ISBN : 9781420004335

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Animal Models of Cognitive Impairment by Edward D. Levin,Jerry J. Buccafusco Pdf

The costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairmen

Author : KOOB,LEWIS,MEYER,PAUL
Publisher : Springer Science & Business Media
Page : 279 pages
File Size : 44,9 Mb
Release : 2013-04-18
Category : Medical
ISBN : 9781475713053

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Neuropharmacology of Ethanol by KOOB,LEWIS,MEYER,PAUL Pdf

Author : Michael W. Miller
Publisher : Wiley-Liss
Page : 424 pages
File Size : 42,9 Mb
Release : 1992
Category : Medical
ISBN : UOM:39015024892856

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Development of the Central Nervous System by Michael W. Miller Pdf

Disseminates information pertaining to the normal and abnormal processes involved during the development of the central nervous system. The toxic effects of alcohol or opiate usage on development are explored by examining the clinical manifestations that appear in the children of substance-abusing mothers. Detailed coverage includes individual ontogenetic and developmental processes such as neural chemical differentiation, cell proliferation and migration.

Author : Edith V. Sullivan,Adolf Pfefferbaum
Publisher : Elsevier
Page : 703 pages
File Size : 49,5 Mb
Release : 2014-10-08
Category : Science
ISBN : 9780444626226

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Alcohol and the Nervous System by Edith V. Sullivan,Adolf Pfefferbaum Pdf

Alcohol is the most widely used drug in the world, yet alcoholism remains a serious addiction affecting nearly 20 million Americans. Our current understanding of alcohol's effect on brain structure and related functional damage is being revolutionized by genetic research, basic neuroscience, brain imaging science, and systematic study of cognitive, sensory, and motor abilities. Volume 125 of the Handbook of Clinical Neurology is a comprehensive, in-depth treatise of studies on alcohol and the brain covering the basic understanding of alcohol's effect on the central nervous system, the diagnosis and treatment of alcoholism, and prospect for recovery. The chapters within will be of interest to clinical neurologists, neuropsychologists, and researchers in all facets and levels of the neuroscience of alcohol and alcoholism. The first focused reference specifically on alcohol and the brain Details our current understanding of how alcohol impacts the central nervous system Covers clinical and social impact of alcohol abuse disorders and the biomedical consequences of alcohol abuse Includes section on neuroimaging of neurochemical markers and brain function

Author : Norman S. Miller
Publisher : Springer Science & Business Media
Page : 359 pages
File Size : 46,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461230441

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The Pharmacology of Alcohol and Drugs of Abuse and Addiction by Norman S. Miller Pdf

This volume is intended for clinicians, researchers, residents, and students. The range is wide and the depth considerable for all the topics covered in the treatment of this timely and relevant subject. This book may serve equally well as a general introduction and a scholarly reference. Ultimately, it is designed to serve those patients suffering from abuse of and addiction to drugs and alcohol. The content and organization of the book flow from general concepts of abuse and addiction to specific details of the pharmacology of alcohol and drugs. Special chapters on topics not found in most other books, such as pharmacology of drug-drug interactions, abstinence, and prevention, are included. This book is written especially for the clinician interested in the pharma cology of alcohol and drugs of abuse and addiction. The pharmacology is integrated into a conceptual approach to diagnosis and treatment of alcohol and drug abuse and addiction. The form and style are didactic, critical as well as straightforward in presentation. Literature references from recent clinical research and basic research provide the foundation for the chapters throughout the book. Be cause the book is written by a clinician-researcher, the information is readily adaptable to clinical problems and research ideas. I would like to express my deep appreciation to Susan Newsom and Darlene Tucci for their invaluable technical assistance. Norman S. Miller vii Contents Preface ....................................................... vii CHAPTER 1 Introduction to the Pharmacological Effects of Alcohol and Drugs and Addiction on the Brain and Behavior .... . . . . . . . . . . . . . . . . . .. . . 1 . . . . . .

Author : Christer Alling,Ivan Diamond,Steven W. Leslie,Grace Y. Sun,W. Gibson Wood
Publisher : Springer Science & Business Media
Page : 320 pages
File Size : 40,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461524700

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Alcohol, Cell Membranes, and Signal Transduction in Brain by Christer Alling,Ivan Diamond,Steven W. Leslie,Grace Y. Sun,W. Gibson Wood Pdf

Alcohol abuse and alcoholism are international problems whose costs economical ly, psychologically and medically have been well documented. Alcohol is a unique drug in that the effects of excessive use can have a deleterious effect on most if not all organs of the body. The brain is one of the organs most affected by excessive alcohol consumption. Effects on the brain can be seen in cognitive function, brain structure and neurochemistry. Over the past few years, there have been significant advances made in understanding how alcohol affects brain neurochemistry. This book examines four major areas, i. e. , membrane lipids, receptors and ion channels, second messengers, and gene expression, where significant advancements have been made. The book is divided into four sections based on the four major areas. In each section, data are examined that cover a range of approaches from in vitro to in vivo studies. The section on membrane lipids includes recent developments in how ethanol affects membrane cholesterol domains, polyunsaturated fatty acids, the cause and consequences of phosphatidylethanol formation, and the modulation of membrane protein function by lipid-protein interaction. The second section comprises chapters on NMDA and 5-HT3 receptors, including new aspects on alcohol neurotoxicity and the molecular heterogeneity that may underlie differences in alcohol sensitivity as well as chapters on GABA-gated chloride flux, and calcium channels.

Author : Kathleen A. Grant,David M. Lovinger
Publisher : Springer
Page : 625 pages
File Size : 45,5 Mb
Release : 2019-03-27
Category : Medical
ISBN : 9783319965239

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The Neuropharmacology of Alcohol by Kathleen A. Grant,David M. Lovinger Pdf

This volume gives an overview of new insights to alcohol pharmacology using DREADDs (Designer Receptors and Unraveling the Neuropharmacology of Alcohol). It examines which pharmacological principles should be applied to understanding DREADDs taking into account some very current research. Additionally, this book covers important topics under the heading of “experimental pharmacology” and alcohol.

Author : Ronald R. Watson
Publisher : CRC Press
Page : 132 pages
File Size : 48,8 Mb
Release : 1992-06-24
Category : Science
ISBN : 0849379350

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Alcohol and Neurobiology by Ronald R. Watson Pdf

The neurological consequences of alcohol abuse need additional research concentrating on prevention and treatment. Public attention and research efforts are being driven by an ever- increasing understanding of the problems and magnitude of alcohol on neurological development. The 10 million alcohol-abusing adults, along with unborn children exposed to alcohol in utero, cost the people of the U.S. more than $100 billion in lost wages, health care, theft, damaged mental functions, and shortened life span. An intimate, detailed knowledge of the effects of alcohol on the biochemical reactions and neurological changes is critical in preventing or treating abuse. We must study the mechanisms of ethanol's effects on the neurological system at a cellular and systematic level to understand its action. These include modifications of hormonal regulation and production with its major functional consequences. Brain development including its cells are a major focus and emphasis of this volume. The progress of research over the past decade is encouraging as we begin to summarize and evaluate in detail advances in understanding changes in the brain's biochemistry and physiology caused by ethanol. This information will assist the researcher, clinician, and student in comprehending the complex changes caused by direct and indirect effects of single drugs at the cellular level.

Author : Antonius M. VanDongen
Publisher : CRC Press
Page : 368 pages
File Size : 42,9 Mb
Release : 2008-10-29
Category : Medical
ISBN : 9781420044157

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Biology of the NMDA Receptor by Antonius M. VanDongen Pdf

The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written

Author : M. Airaksinen
Publisher : Elsevier
Page : 357 pages
File Size : 44,7 Mb
Release : 2013-10-22
Category : Medical
ISBN : 9781483157788

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CNS and Behavioural Pharmacology by M. Airaksinen Pdf

CNS and Behavioural Pharmacology is the third volume of the proceedings of the Sixth International Congress of Pharmacology, organized by the Finnish Pharmacological Society and held in Helsinki, Finland, on July 20-25, 1975. Contributors focus on the findings concerning the central nervous system (CNS) and on the developments in behavioral pharmacology and related areas of research. This volume has 33 chapters divided into five sections. After discussing the application of psychopharmacology to the conservation of wild animals such as ungulates, this book turns its attention to alcohol dependence and the interactions between neurotransmitters and the hypothalamic releasing hormones. The reader is methodically introduced to the pharmacology of emotive behavior, with emphasis on drug effects in mental and emotional disorders as well as the action of psychotropic drugs on emotions, motivations, and social behavior of animals. The final section is devoted to the pharmacological aspects of the cerebrospinal fluid-transport system. This section covers topics such as the metabolism of biogenic amines in the human CNS; the importance of dopamine metabolism for the clinical effects and side effects of neuroleptics; and composite transport systems for organic acids and bases in choroid plexus. This book will be of interest to scientists representing all the major areas of pharmacology, including clinical pharmacology and toxicology, as well as to internists, psychiatrists, neurologists, and anesthesiologists.

Author : Claudio A. Naranjo,Edward M. Sellers
Publisher : Springer Science & Business Media
Page : 378 pages
File Size : 42,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461228783

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Novel Pharmacological Interventions for Alcoholism by Claudio A. Naranjo,Edward M. Sellers Pdf

Novel Pharmacological Interventions for Alcoholism identifies priorities for focusing alcoholism and addiction research efforts during the coming years. A number of important issues concerning methodology, mechanisms, clinical evaluation, and pharmaceutical aspects are discussed. This book is also a plea for a greater degree of collaboration among academics, pharmaceutical physicians and scientists, and drug regulators; it demonstrates that progress in understanding and fighting addiction and alcoholism is possible in the foreseeable future.

Author : John Brick,Carlton K. Erickson
Publisher : Routledge
Page : 234 pages
File Size : 50,9 Mb
Release : 2013
Category : Medical
ISBN : 9780789035271

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Drugs, the Brain, and Behavior by John Brick,Carlton K. Erickson Pdf

Explore the brain and discover the clinical and pharmacological issues surrounding drug abuse and dependence. The authors, research scientists with years of experience in alcohol and drug studies, provide definitions, historic discoveries about the nervous system, and original, eye-catching illustrations to discuss the brain/behavior relationship, basic neuroanatomy, neurophysiology, and the mechanistic actions of mood-altering drugs. You will learn about: * how psychoactive drugs affect cognition, behavior, and emotion * the brain/behavior relationship * the specific effects of major addictive and psychoactive drug groups * new definitions and thinking about abuse and dependence * the medical and forensic consequences of drugs use Drugs, the Brain, and Behavior uses a balance of instruction, illustrations, and tables and formulas that will give you a broad, lasting introduction to this intriguing subject. Whether you're a nurse, chemical dependency counselor, psychologist, or clinician, this book will be a quick reference guide long after the first reading.