Phase Transfer Catalysis In Organic Synthesis

Author : William P. Weber,George W. Gokel
Publisher : Springer Science & Business Media
Page : 295 pages
File Size : 52,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642463570

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Phase Transfer Catalysis in Organic Synthesis by William P. Weber,George W. Gokel Pdf

The field of phase transfer catalysis is a tribute to the chemists involved in process development research. Phase transfer catalysis is a solution to numerous cost and yield problems encountered regularly in industrial laboratories. In fact, much of the early work in this area was conducted by industrial chemists although the work was not labelled phase transfer catalysis at the time. We certainly do not intend to minimize the contributions of academic chemists to this field, but it is an unalterable fact that much of the early understanding and many of the early advances came from industrial laboratories. A special tribute is due to Dr. Charles Starks of the Continental Oil Company. By the mid sixties, Starks had formulated the principles of phase transfer catalysis and had applied for patents on many reactions that others were later to examine in somewhat greater detail. His mechanistic model of phase transfer catalysis still stands up well today and is a model for much of the thinking in this area. It is fitting that Starks suggested the name "phase transfer catalysis" by which the whole field is now known. We wish to thank a number of people who have aided us in many ways in the preparation of this volume. We very much appreciate the helpful discussions and insights provided by Drs. Henry Stevens and Andrew Kaman of PPG Industries in Barberton, Ohio. We also thank Dr. L. A.

Author : C.M. Starks,M. Halper
Publisher : Springer Science & Business Media
Page : 682 pages
File Size : 50,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789401106870

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Phase-Transfer Catalysis by C.M. Starks,M. Halper Pdf

Since 1971 when useful working concepts for the technique of phase-transfer catalysis (PTC) were introduced, the understanding, development, and applica tions of this method for conducting organic reactions has expanded exponentially. PTC has brought vast new dimensions and options to chemists and chemical engineers. From its use in less than ten commercial processes in 1975, PTC use has increased so that in the early 1990s it is involved in more than 600 industrial applications to manufacture products valued at between 10 and 20 billion U.S. dollars. PTC is widely used for simple organic reactions, steps in synthesis of pharmaceuticals, agricultural chemicals, perfumes, ftavorants, and dyes; for specialty polymerization reactions, polymer modifications, and monomer synthe sis; for pollution and environmental control processes; for analysis oftrace organic and inorganic compounds; and for many other applications. Often, PTC offers the best (and sometimes only) practical technique to obtain certain products. The authors experience in teaching a short course on phase-transfer catalysis has shown to us that a newcomer to PTC can easily be frustrated and confused by the large amount of information available in the literature and in patents. The purpose of this book, therefore, was to bring this information together in a logical and user-friendly way, without sacrificing matters of scholarly and fundamental importance.

Author : Y. Sasson,Ronny Neumann
Publisher : Springer Science & Business Media
Page : 579 pages
File Size : 54,8 Mb
Release : 2012-12-06
Category : Technology & Engineering
ISBN : 9789400900233

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Handbook of Phase Transfer Catalysis by Y. Sasson,Ronny Neumann Pdf

Phase transfer catalysis is a sophisticated chemical technique which can be used to perform a variety of chemical reactions under mild conditions and with improved control. Since the concept was developed, both the theoretical and practical synthetic applications have seen considerable development, to the point where the technique can be applied to many areas of chemistry. Thus, phase transfer methods are now utilized in many applications, from research chemistry to full-scale production, where the benefits of faster, cleaner and more selective reactions are required. In this new book, the editors have brought together a range of contributors, each of whom is working at the forefront of the technology, to provide a clear, concise and ahtoritative review of this important area of chemistry. Industrial and academic chemists working on the synthesis, scale-up, production or analysis of a wide range of chemical products will find this book an essential reference on phase transfer technology.

Author : William P Weber,George W Gokel
Publisher : Unknown
Page : 304 pages
File Size : 45,6 Mb
Release : 1986-12-01
Category : Electronic
ISBN : 3642463584

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Phase Transfer Catalysis in Organic Synthesis by William P Weber,George W Gokel Pdf

Author : Charles Liotta
Publisher : Elsevier
Page : 379 pages
File Size : 43,5 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323153300

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Phase Transfer Catalysis by Charles Liotta Pdf

Phase Transfer Catalysis: Principles and Techniques outlines the theory, mechanism, and kinetics of the phase transfer catalysis (PTC) process. This book surveys the principal reaction types that have employed the PTC, including the typical experimental procedures for preparing catalysts and conducting representative types of chemical reactions. This compilation discusses the transfer of anions from aqueous to organic phases, macrocyclic ethers as phase transfer catalysts, halide displacement reactions, and Darzen’s reaction with chloroacetonitrile. The dihalocarbene insertion reactions into C-H bonds, Wittig reaction with aqueous sodium hydroxide, and phase transfer catalyzed oxidation and reduction reactions are also elaborated. This text likewise covers the deuterium exchange of active hydrogens and thiolation with organic thiocyanates. This publication is beneficial to chemists and students studying the principles and techniques related to PTC.

Author : Keiji Maruoka
Publisher : John Wiley & Sons
Page : 236 pages
File Size : 44,8 Mb
Release : 2008-03-31
Category : Science
ISBN : 3527318429

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Asymmetric Phase Transfer Catalysis by Keiji Maruoka Pdf

Edited by the leading expert on the topic, this is the first book to present the latest developments in this exciting field. Alongside the theoretical aspects, the top contributors provide practical protocols to give readers additional important information otherwise unavailable. A must for every synthetic chemist in academia and industry.

Author : Eckehard Volker Dehmlow,Sigrid Sonja Dehmlow
Publisher : Wiley-VCH
Page : 524 pages
File Size : 43,8 Mb
Release : 1993-05-13
Category : Science
ISBN : UOM:39015026951056

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Phase Transfer Catalysis by Eckehard Volker Dehmlow,Sigrid Sonja Dehmlow Pdf

E. V. Dehmlow, S. S. Dehmlow Phase Transfer Catalysis Third, Revised and Enlarged Edition Phase Transfer Catalysis has matured, and so has this book. Certain PTC-variants have become standard techniques in the lab, and PTC may be on the brink of large-scale use. The new edition describes important new developments in PTC. Furthermore, it has been extensively updated and offers a comprehensive list of very recent references. New material has been added on solid/liquid PTC enantioselective reactions metal-organic reactions reduction and oxidation reactions elimination and substitution reactions

Author : Laurence R. Weatherley
Publisher : Cambridge University Press
Page : 379 pages
File Size : 50,9 Mb
Release : 2020-04-16
Category : Mathematics
ISBN : 9781108421010

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Intensification of Liquid–Liquid Processes by Laurence R. Weatherley Pdf

Explore and review novel techniques for intensifying transport and reaction in liquid-liquid and related systems with this essential toolkit. Topics include discussion of the principles of process intensification, the nexus between process intensification and sustainable engineering, and the fundamentals of liquid-liquid contacting, from an expert with over forty-five years' experience in the field. Providing promising directions for investment and for new research in process intensification, in addition to a unique review of the fundamentals of the topic, this book is the perfect guide for senior undergraduate students, graduate students, developers, and research staff in chemical engineering and biochemical engineering.

Author : Eckehard V. Dehmlow,Sigrid S. Dehmlow
Publisher : Unknown
Page : 408 pages
File Size : 40,8 Mb
Release : 1983
Category : Catalysis
ISBN : STANFORD:36105032804804

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Phase Transfer Catalysis by Eckehard V. Dehmlow,Sigrid S. Dehmlow Pdf

Author : R. Alan Jones
Publisher : Elsevier
Page : 565 pages
File Size : 53,8 Mb
Release : 2000-11-14
Category : Science
ISBN : 0080540155

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Quaternary Ammonium Salts by R. Alan Jones Pdf

This text provides experimental methods for a wide range of organic reactions, systematically arranged according to reaction type, and describes the advantages and limitations of the procedures. Traditional methods to speed up organic reactions involve energy-consuming processes and costly and environmentally "unfriendly" solvents. Additionally, isolation of the product requires energy and time-consuming purification processes. A simple solution, especially for reactions involving anionic reactants, is the use of phase-transfer catalysis. Quaternary ammonium cations have the ability to transfer the anionic reactants as non-solvated ion-pairs from aqueous media into organic media. The resultant effect is to increase the rate of the organic reaction by enhancing the reactivity of the anionic species and increasing the encounter rate with the organic substrate. Side reactions are frequently eliminated so that the overall yield of the desired product is increased. Quaternary Ammonium Salts presents procedures for reducing reaction times and the need for extreme conditions, which are frequently encountered under standard reaction procedures. This is the only book to be published on quaternary ammonium salts. Best Synthetic Methods volumes allow the practicing synthetic chemist to choose between all the alternatives and assess their real advantages and limitations. Each volume of the series deals with a particular topic from a practical point of view, giving detailed examples and precise experimental directions and hints. With the emphasis on laboratory use, these volumes represent a comprehensive and practical guide to modern synthetic organic chemistry.

Author : Jens Christoffers,Angelika Baro
Publisher : John Wiley & Sons
Page : 359 pages
File Size : 53,8 Mb
Release : 2006-05-12
Category : Science
ISBN : 9783527606979

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Quaternary Stereocenters by Jens Christoffers,Angelika Baro Pdf

Filling the gap in the literature, this book presents everything there is to know about this topic. By comprehensively covering the quaternary stereocenters found in a range of important and useful molecules in pharmaceutical and medicinal applications, as well as in thousands of natural products, the book provides the know-how chemists need to synthesize challenging molecules with numerous applications. A must for organic chemists in academia, the pharmaceutical industry and medicine. From the Contents: Important Natural Products Important Pharmaceuticals and Intermediates Aldol Reactions Michael Reactions and Conjugate Additions Cycloaddition Reactions Rearrangement Reactions Alkylation of Ketones and Imines Asymmetric Allylic Alkylation Asymmetric Cross Coupling and Heck Reactions Phase Transfer Catalysis Enzymatic Methods Radical Reactions

Author : Keiji Maruoka
Publisher : John Wiley & Sons
Page : 228 pages
File Size : 53,8 Mb
Release : 2008-09-08
Category : Science
ISBN : 9783527622634

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Asymmetric Phase Transfer Catalysis by Keiji Maruoka Pdf

Edited by the leading expert on the topic, this is the first book to present the latest developments in this exciting field. Alongside the theoretical aspects, the top contributors provide practical protocols to give readers additional important information otherwise unavailable. A must for every synthetic chemist in academia and industry.

Author : V.K. Ahluwalia,M. Kidwai
Publisher : Springer Science & Business Media
Page : 279 pages
File Size : 40,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781402031755

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New Trends in Green Chemistry by V.K. Ahluwalia,M. Kidwai Pdf

Organic chemistry has played a vital role in the development of diverse molecules which are used in medicines, agrochemicals and polymers. Most ofthe chemicals are produced on an industrial scale. The industrial houses adopt a synthesis for a particular molecule which should be cost-effective. No attention is paid to avoid the release of harmful chemicals in the atmosphere, land and sea. During the past decade special emphasis has been made towards green synthesis which circumvents the above problems. Prof. V. K. Ahluwalia and Dr. M. Kidwai have made a sincere effort in this direction. This book discusses the basic principles of green chemistry incorporating the use of green reagents, green catalysts, phase transfer catalysis, green synthesis using microwaves, ultrasound and biocatalysis in detail. Special emphasis is given to liquid phase reactions and organic synthesis in the solid phase. I must congratulate both the authors for their pioneering efforts to write this book. Careful selection of various topics in the book will serve the rightful purpose for the chemistry community and the industrial houses at all levels. PROF. JAVED IQBAL, PhD, FNA Distinguished Research Scientist & Head Discovery Research Dr. Reddy's Laboratories Ltd.

Author : L. K. Doraiswamy
Publisher : Oxford University Press
Page : 942 pages
File Size : 45,7 Mb
Release : 2001-02-15
Category : Technology & Engineering
ISBN : 0198025696

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Organic Synthesis Engineering by L. K. Doraiswamy Pdf

This book will formally launch "organic synthesis engineering" as a distinctive field in the armory of the reaction engineer. Its main theme revolves around two developments: catalysis and the role of process intensification in enhancing overall productivity. Each of these two subjects are becoming increasingly useful in organic synthesis engineering, especially in the production of medium and small volume chemicals and enhancing reaction rates by extending laboratory techniques, such as ultrasound, phase transfer catalysts, membrane reactor, and microwaves, to industrial scale production. This volume describes the applications of catalysis in organic synthesis and outlines different techniques of reaction rate and/or selectivity enhancement against a background of reaction engineering principles for both homogeneous and heterogeneous systems.

Author : Kazuaki Ishihara,Kilian Muniz
Publisher : John Wiley & Sons
Page : 452 pages
File Size : 55,9 Mb
Release : 2022-05-16
Category : Technology & Engineering
ISBN : 9783527348299

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Iodine Catalysis in Organic Synthesis by Kazuaki Ishihara,Kilian Muniz Pdf

Iodine Catalysis in Organic Synthesis The first book of its kind to highlight iodine as a sustainable alternative to conventional transition metal catalysis Iodine Catalysis in Organic Synthesis provides detailed coverage of recent advances in iodine chemistry and catalysis, focusing on the utilization of various iodine-containing compounds as oxidative catalysts. Featuring contributions by an international panel of leading research chemists, this authoritative volume explores the development of environmentally benign organic reactions and summarizes catalytic transformations of molecular iodine and iodine compounds such as hypervalent organoiodine and inorganic iodine salts. Readers are first introduced to the history of iodine chemistry, the conceptual background of homogeneous catalysis, and the benefits of iodine catalysis in comparison with transition metals. Next, chapters organized by reaction type examine enantioselective transformations, catalytic reactions involving iodine, catalyst states, oxidation in iodine and iodine catalyses, and catalytic reactions based on halogen bonding. Practical case studies and real-world examples of different applications in organic synthesis and industry are incorporated throughout the text. An invaluable guide for synthetic chemists in both academic and industrial laboratories, Iodine Catalysis in Organic Synthesis: Provides a thorough overview of typical iodine-catalyzed reactions, catalyst systems, structures, and reactivity Explores promising industrial applications of iodine-based reagents for organic synthesis Highlights the advantages iodine catalysis has over classical metal-catalyzed reactions Discusses sustainable and eco-friendly methods in hypervalent iodine chemistry Edited by two world authorities on the catalytic applications of organoiodine compounds, Iodine Catalysis in Organic Synthesis is required reading for catalytic, organic, and organometallic chemists, medicinal and pharmaceutical chemists, industrial chemists, and academic researchers and advanced students in relevant fields.