Quaternary Stereocenters

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Quaternary Stereocenters

Jens Christoffers,Angelika Baro
Quaternary Stereocenters Book PDF

Author : Jens Christoffers,Angelika Baro
Publisher : John Wiley & Sons
Page : 359 pages
File Size : 49,6 Mb
Release : 2006-05-12
Category : Science
ISBN : 9783527606979

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Quaternary Stereocenters by Jens Christoffers,Angelika Baro Pdf

Filling the gap in the literature, this book presents everything there is to know about this topic. By comprehensively covering the quaternary stereocenters found in a range of important and useful molecules in pharmaceutical and medicinal applications, as well as in thousands of natural products, the book provides the know-how chemists need to synthesize challenging molecules with numerous applications. A must for organic chemists in academia, the pharmaceutical industry and medicine. From the Contents: Important Natural Products Important Pharmaceuticals and Intermediates Aldol Reactions Michael Reactions and Conjugate Additions Cycloaddition Reactions Rearrangement Reactions Alkylation of Ketones and Imines Asymmetric Allylic Alkylation Asymmetric Cross Coupling and Heck Reactions Phase Transfer Catalysis Enzymatic Methods Radical Reactions

Direct construction of d3-methylated all-carbon quaternary stereocenters through carbene-catalyzed desymmetrization

Jingcheng Guo,Ye Zhang,Xiaoxiang Zhang,Zhenqian Fu
Direct construction of d3 methylated all carbon quaternary stereocenters through carbene catalyzed desymmetrization Book PDF

Author : Jingcheng Guo,Ye Zhang,Xiaoxiang Zhang,Zhenqian Fu
Publisher : OAE Publishing Inc.
Page : 11 pages
File Size : 43,6 Mb
Release : 2023-07-19
Category : Science
ISBN : 8210379456XXX

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Direct construction of d3-methylated all-carbon quaternary stereocenters through carbene-catalyzed desymmetrization by Jingcheng Guo,Ye Zhang,Xiaoxiang Zhang,Zhenqian Fu Pdf

The construction of d3-methylated all-carbon quaternary stereocenters has been successfully developed via carbene-catalyzed desymmetrization of prochiral d3-methylated oxindolyl 1,3-diketones. Three new stereogenic centers were efficiently constructed with satisfactory outcomes. Diverse spiro-polycyclic molecules with a d3-methylated all-carbon quaternary stereocenter were generated in good to excellent yields with good to excellent diastereoselectivities and excellent enantioselectivities. This reaction features a broad substrate scope, good functional-group tolerance, and easy scale-up.

Anion-Binding Catalysis

Olga Garcia-Mancheno
Anion Binding Catalysis Book PDF

Author : Olga Garcia-Mancheno
Publisher : John Wiley & Sons
Page : 418 pages
File Size : 48,7 Mb
Release : 2022-03-21
Category : Technology & Engineering
ISBN : 9783527348572

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Anion-Binding Catalysis by Olga Garcia-Mancheno Pdf

Explores the potential of new types of anion-binding catalysts to solve challenging synthetic problems Anion-Binding Catalysis introduces readers to the use of anion-binding processes in catalytic chemical activation, exploring how this approach can contribute to the future design of novel synthetic transformations. Featuring contributions by world-renowned scientists in the field, this authoritative volume describes the structure, properties, and catalytic applications of anions as well as synthetic applications and practical analytical methods. In-depth chapters are organized by type of catalyst rather than reaction type, providing readers with an accessible overview of the existing classes of effective catalysts. The authors discuss the use of halogens as counteranions, the combination of (thio)urea and squaramide-based anion-binding with other types of organocatalysis, anion-binding catalysis by pnictogen and tetrel bonding, nucleophilic co-catalysis, anion-binding catalysis by pnictogen and tetrel bonding, and more. Helping readers appreciate and evaluate the potential of anion-binding catalysis, this timely book: Illustrates the historical development, activation mode, and importance of anion-binding in chemical catalysis Explains the analytic methods used to determine the anion-binding affinity of the catalysts Describes catalytic and synthetic applications of common NH- and OH-based hydrogen-donor catalysts as well as C-H triazole/triazolium catalysts Covers amino-catalysis involving enamine, dienamine, or iminium activation approaches Discusses new trends in the field of anion-binding catalysis, such as the combination of anion-binding with other types of catalysis Presenting the current state of the field as well as the synthetic potential of anion-binding catalysis in future, Anion-Binding Catalysis is essential reading for researchers in both academia and industry involved in organic synthesis, homogeneous catalysis, and pharmaceutical chemistry.

Handbook of Asymmetric Heterogeneous Catalysis

Kuiling Ding,Yasuhiro Uozumi
Handbook of Asymmetric Heterogeneous Catalysis Book PDF

Author : Kuiling Ding,Yasuhiro Uozumi
Publisher : John Wiley & Sons
Page : 467 pages
File Size : 53,8 Mb
Release : 2008-10-20
Category : Science
ISBN : 9783527319138

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Handbook of Asymmetric Heterogeneous Catalysis by Kuiling Ding,Yasuhiro Uozumi Pdf

In this most up-to-date handbook each chapter contains a general introduction, followed by the principles of the immobilization and, finally, applications. In this way, it covers the most important approaches currently employed for the heterogenization of chiral catalysts, including data tables, applications, reaction types and literature citations. For chemists in both academia and industry as well as those working in the fine chemical and pharmaceutical industry.

Strategies and Tactics in Organic Synthesis

Michael Harmata
Strategies and Tactics in Organic Synthesis Book PDF

Author : Michael Harmata
Publisher : Academic Press
Page : 264 pages
File Size : 52,6 Mb
Release : 2017-09-07
Category : Science
ISBN : 9780128117910

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Strategies and Tactics in Organic Synthesis by Michael Harmata Pdf

Strategies and Tactics in Organic Synthesis, Volume 13, provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, this classic provides stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project present the excitement of conception, the frustration of failure and the joy experienced when either rational thought or good fortune gives rise to the successful completion of a project. Readers will be educated, challenged and inspired by these accounts, which portray the idea that triumphs do not come without challenges. This innovative approach also helps illustrate how challenges to further advance the science and art of organic synthesis can be overcome, driving the field forward to meet the demands of society by discovering new reactions, creating new designs and building molecules with atom and step economies that provide functional solutions to create a better world. Presents state-of-the-art developments in organic synthesis Provides insight and offers new perspective to problem-solving Written by leading experts in the field Uses firsthand narrative accounts to vividly illustrate the challenges and joys involved in advancing the science of organic synthesis

Asymmetric Organocatalysis Combined with Metal Catalysis

Bruce A. Arndtsen,Liu-Zhu Gong
Asymmetric Organocatalysis Combined with Metal Catalysis Book PDF

Author : Bruce A. Arndtsen,Liu-Zhu Gong
Publisher : Springer Nature
Page : 211 pages
File Size : 53,6 Mb
Release : 2020-04-24
Category : Science
ISBN : 9783030438517

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Asymmetric Organocatalysis Combined with Metal Catalysis by Bruce A. Arndtsen,Liu-Zhu Gong Pdf

The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience.Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.The chapter "Enamine/Transition Metal Combined Catalysis: Catalytic Transformations Involving Organometallic Electrophilic Intermediates" is available open access under a CC BY 4.0 License via link.springer.com.

Asymmetric Organocatalysis

Benjamin List
Asymmetric Organocatalysis Book PDF

Author : Benjamin List
Publisher : Springer Science & Business Media
Page : 467 pages
File Size : 50,6 Mb
Release : 2010-03-04
Category : Science
ISBN : 9783642028144

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Asymmetric Organocatalysis by Benjamin List Pdf

Annotation Kerstin Etzenbach-Effers, Albrecht Berkessel: Non-Covalent Organocatalysis Based on Hydrogen Bonding: Elucidation of Reaction Paths by Computational Methods.- Petri M. Pihko, Inkeri Majander, and Anniina Erkkilä: Enamine Catalysis.- Jennifer L. Moore, Tomislav Rovis: Lewis Base Catalysts 6: Carbene Catalysts.- Amal Ting, Jennifer M. Goss, Nolan T. McDougal, and Scott E. Schaus: Brønsted Base Catalysts.- O. Andrea Wong, Yian Shi: Chiral Ketone and Iminium Catalysts for Olefin Epoxidation.- Alan C. Spivey, Stellios Arseniyadis: Amine, Alcohol and Phosphine Catalysts for Acyl Transfer Reactions.- John B. Brazier, Nicholas C.O. Tomkinson: Lewis Base Catalysts 2 Secondary and Primary Amine Catalysts for Iminium Catalysis.- Oksana Sereda, Sobia Tabassum, and René Wilhelm: Lewis Acid Organocatalysts.- Daniela Kampen, Corinna M. Reisinger, and Benjamin List: Chiral Bronsted Acids for C Organocatalysis.

Rare Earth Elements

Basudeb Basu,Bubun Banerjee
Rare Earth Elements Book PDF

Author : Basudeb Basu,Bubun Banerjee
Publisher : Walter de Gruyter GmbH & Co KG
Page : 432 pages
File Size : 54,5 Mb
Release : 2023-05-22
Category : Science
ISBN : 9783110788259

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Rare Earth Elements by Basudeb Basu,Bubun Banerjee Pdf

Over the years, the uses and applications of rare earth elements (REEs) diversified in various fields such as catalysis, production of magnets, glasses, alloys, and electronics. This book consists of fifteen chapters, which present recent advances and outlook on REEs and their oxides/salts in catalytic organic transformations, biomedical applications, bioremediation and environmental impacts.

Iron Catalysis

Bernd Plietker
Iron Catalysis Book PDF

Author : Bernd Plietker
Publisher : Springer
Page : 220 pages
File Size : 46,5 Mb
Release : 2011-01-03
Category : Science
ISBN : 9783642146701

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Iron Catalysis by Bernd Plietker Pdf

Juan I. Padrón and Víctor S. Martín: Catalysis by means of Fe-based Lewis acids; Hiroshi Nakazawa*, Masumi Itazaki: Fe–H Complexes in Catalysis; Kristin Schröder, Kathrin Junge, Bianca Bitterlich, and Matthias Beller: Fe-catalyzed Oxidation Reactions of Olefins, Alkanes and Alcohols: Involvement of Oxo- and Peroxo Complexes; Chi-Ming Che, Cong-Ying Zhou, Ella Lai-Ming Wong: Catalysis by Fe=X Complexes (X=NR, CR2); René Peters, Daniel F. Fischer and Sascha Jautze: Ferrocene and Half Sandwich Complexes as Catalysts with Iron Participation; Markus Jegelka, Bernd Plietker: Catalysis by Means of Complex Ferrates.

Strategies and Tactics in Organic Synthesis

Michael F. Greaney,Lei Shi,Naim Nazef
Strategies and Tactics in Organic Synthesis Book PDF

Author : Michael F. Greaney,Lei Shi,Naim Nazef
Publisher : Elsevier Inc. Chapters
Page : 344 pages
File Size : 47,5 Mb
Release : 2013-07-29
Category : Science
ISBN : 9780128056073

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Strategies and Tactics in Organic Synthesis by Michael F. Greaney,Lei Shi,Naim Nazef Pdf

This chapter describes the synthesis of two related sesquiterpenes, anislactone A and merrilactone A. We initially accessed a tetracyclic oxetane in the merrilactone series using a Paternò–Büchi reaction but found the compound to be too underfunctionalized to advance further. We then developed an approach based on reductive epoxide ring opening, whereby a fully elaborated C-ring epoxy-cyclopentane, containing five stereocenters, could undergo reductive epoxide cleavage when treated with Ti(III). The resulting tertiary radical then participates in a 5-exo-dig cyclization onto a pendant alkyne to afford the complete carbon skeleton of both natural products. From this point, orthogonal functionalization routes enabled the synthesis of both anislactone A and merrilactone A. A second-generation merrilactone A synthesis is then described, growing out of discoveries made over the course of the first route in the area of cyclopentannulation. An iodo-aldol method was used to develop an approach to the anislactone skeleton and succeeded in producing the BC bicycle with good stereocontrol and functional group tolerance. Further functionalization, however, did not prove possible due to excessive steric hindrance around the incorporated iodo group preventing any productive transformation. This problem was solved by switching the nucleophile in the tandem-aldol process to cyanide. The resulting domino cyanide-addition aldol cyclization was then successfully employed in the formal synthesis of merrilactone A, using a late-stage [2+2] photocycloaddition to access the D-ring.

Hydrolases in Organic Synthesis

Uwe Theo Bornscheuer,Romas Joseph Kazlauskas
Hydrolases in Organic Synthesis Book PDF

Author : Uwe Theo Bornscheuer,Romas Joseph Kazlauskas
Publisher : John Wiley & Sons
Page : 368 pages
File Size : 50,7 Mb
Release : 2006-05-12
Category : Science
ISBN : 9783527607129

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Hydrolases in Organic Synthesis by Uwe Theo Bornscheuer,Romas Joseph Kazlauskas Pdf

From reviews to the first edtion: "Bornscheuer and Kazlauskas have set out, and succeeded, in producing a definitive manual on hydrolytic enzymes (especially lipases, esterases, and proteases) for organic chemists. This is quite simply the best book of its type and can be unreservedly recommended to organic chemists who have an interest in using hydrolytic enzymes in synthesis." (Nicholas J. Turner, University of Edinburgh) "The book is an indispensable source of information on the use of hydrolases in organic synthesis. The subject matter is very well set out, and the chapters are clearly written and presented from a critical viewpoint. Bornscheuer and Kazlauskas have succeeded admirably in describing the capabilities and limitations of the use of hydrolytic enzymes and in critically evaluating them. No library should be without the book." (Fritz Theil, WITEGA Angewandte Werkstoff-Forschung GmbH, Berlin) The second edition of this extremely successful and well-proven book presents recent developments in the use of hydrolases for organic synthesis, reflecting in particular the enormous progress made in enzyme discovery and optimization with a new chapter on "Protein Sources and Optimization of Biocatalyst Performance". The renowned authors survey the stereoselective reactions of hydrolases, especially lipases, esterases and proteases, giving researchers an overview of what has worked in the past so that they can judge how to solve their own synthetic problems. In total, the book contains over one thousand chemical structures, rounded off by some 1,800 invaluable references.

Issues in Chemistry and General Chemical Research: 2011 Edition

Anonim
Issues in Chemistry and General Chemical Research 2011 Edition Book PDF

Author : Anonim
Publisher : ScholarlyEditions
Page : 10508 pages
File Size : 40,6 Mb
Release : 2012-01-09
Category : Science
ISBN : 9781464963292

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Issues in Chemistry and General Chemical Research: 2011 Edition by Anonim Pdf

Issues in Chemistry and General Chemical Research: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Chemistry and General Chemical Research. The editors have built Issues in Chemistry and General Chemical Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Chemistry and General Chemical Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Chemistry and General Chemical Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Fundamentals of Asymmetric Catalysis

Patrick J. Walsh,Marisa C. Kozlowski
Fundamentals of Asymmetric Catalysis Book PDF

Author : Patrick J. Walsh,Marisa C. Kozlowski
Publisher : University Science Books
Page : 692 pages
File Size : 42,7 Mb
Release : 2009-01-02
Category : Science
ISBN : 1891389548

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Fundamentals of Asymmetric Catalysis by Patrick J. Walsh,Marisa C. Kozlowski Pdf

This work describes the essential aspects of enantioselective catalysis, with chapters organised by concept rather than by reaction type. Each concept is supported by examples to give the reader broad exposure to a wide range of catalysts, reactions and reaction mechanisms.

Comprehensive Chirality

Anonim
Comprehensive Chirality Book PDF

Author : Anonim
Publisher : Newnes
Page : 5635 pages
File Size : 53,5 Mb
Release : 2012-12-31
Category : Science
ISBN : 9780080951683

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Comprehensive Chirality by Anonim Pdf

Although many books exist on the subject of chiral chemistry, they only briefly cover chiral synthesis and analysis as a minor part of a larger work, to date there are none that pull together the background information and latest advances in one comprehensive reference work. Comprehensive Chirality provides a complete overview of the field, and includes chiral research relevant to synthesis, analytic chemistry, catalysis, and pharmaceuticals. The individual chapters in each of the 9 volumes provide an in depth review and collection of references on definition, technology, applications and a guide/links to the related literature. Whether in an Academic or Corporate setting, these chapters will form an invaluable resource for advanced students/researchers new to an area and those who need further background or answers to a particular problem, particularly in the development of drugs. Chirality research today is a central theme in chemistry and biology and is growing in importance across a number of disciplinary boundaries. These studies do not always share a unique identifying factor or subject themselves to clear and concise definitions. This work unites the different areas of research and allows anyone working or researching in chiral chemistry to navigate through the most essential concepts with ease, saving them time and vastly improving their understanding. The field of chirality counts several journals that are directly and indirectly concerned with the field. There is no reference work that encompasses the entire field and unites the different areas of research through deep foundational reviews. Comprehensive Chirality fills this vacuum, and can be considered the definitive work. It will help users apply context to the diverse journal literature offering and aid them in identifying areas for further research and/or for solving problems. Chief Editors, Hisashi Yamamoto (University of Chicago) and Erick Carreira (ETH Zürich) have assembled an impressive, world-class team of Volume Editors and Contributing Authors. Each chapter has been painstakingly reviewed and checked for consistent high quality. The result is an authoritative overview which ties the literature together and provides the user with a reliable background information and citation resource.

Copper(I)-Catalyzed Stereoselective Borylation Reactions

Yu Ozawa
Copper I Catalyzed Stereoselective Borylation Reactions Book PDF

Author : Yu Ozawa
Publisher : Springer Nature
Page : 236 pages
File Size : 46,7 Mb
Release : 2023-05-30
Category : Science
ISBN : 9789819910984

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Copper(I)-Catalyzed Stereoselective Borylation Reactions by Yu Ozawa Pdf

This book focuses on the development of novel functionalized organoboron compounds and those synthetic methods. High degrees of chemo-, regio-, and stereoselectivities of the borylation reactions are attained through catalyst design and optimization. Furthermore, the selectivity-determining mechanisms are analyzed with state-of-the-art DFT and other computational methods. In this book, the author synthesizes some multi-substituted alkenyl and allylic boronates via borylation reactions using a copper(I)/diboron catalyst system. Those compounds contain novel densely substituted and distorted structures, which have not been accessed by other methods. The high stereoselectivities are achieved by the optimization of the catalyst, especially the ligand. Some new ligands are also developed in this book. Furthermore, the derivatization of the borylation products is demonstrated to access the sterically demanding complex molecules. Also, the author performs computational analysis to reveal how the catalyst controls the selectivities. The deep insight into the reaction mechanism provides guides for rational catalyst design for not only copper(I) catalysis but also other transition metal catalysis. Thus, the content should be of interest to academic and industrial scientists in a wide range of areas.