Polymeric Gene Delivery Systems

Author : Yiyun Cheng
Publisher : Springer
Page : 358 pages
File Size : 40,7 Mb
Release : 2018-09-04
Category : Technology & Engineering
ISBN : 9783319778662

Get Book

Polymeric Gene Delivery Systems by Yiyun Cheng Pdf

​The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. The chapter "Polymeric Nanoparticle-Mediated Gene Delivery for Lung Cancer Treatment" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Author : Mansoor M. Amiji
Publisher : CRC Press
Page : 707 pages
File Size : 53,9 Mb
Release : 2004-09-29
Category : Medical
ISBN : 9780203500477

Get Book

Polymeric Gene Delivery by Mansoor M. Amiji Pdf

To treat disease or correct genetic disorders using gene therapy, the most suitable vehicle must be able to deliver genes to the appropriate tissues and cells in the body in a specific as well as safe and effective manner. While viruses are the most popular vehicles to date, their disadvantages include toxicity, limited size of genes they can carry

Author : Glen S. Kwon
Publisher : CRC Press
Page : 680 pages
File Size : 49,7 Mb
Release : 2005-04-12
Category : Medical
ISBN : 0824725328

Get Book

Polymeric Drug Delivery Systems by Glen S. Kwon Pdf

Emphasizing four major classes of polymers for drug delivery-water-soluble polymers, hydrogels, biodegradable polymers, and polymer assemblies-this reference surveys efforts to adapt, modify, and tailor polymers for challenging molecules such as poorly water-soluble compounds, peptides/proteins, and plasmid DNA.

Author : Ravin Narain
Publisher : Woodhead Publishing
Page : 302 pages
File Size : 41,8 Mb
Release : 2016-01-09
Category : Science
ISBN : 9780081005217

Get Book

Polymers and Nanomaterials for Gene Therapy by Ravin Narain Pdf

Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy. The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy. This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy. Explores current challenges in the research of genetic diseases Discusses polymers for gene therapy and their function in designing advanced materials Provides examples of organic and inorganic nanomaterials for gene therapy Includes labeling, targeting, and assays Looks at characterization, physico-(bio)chemical properties, and applications

Author : Dan Luo,W. Mark Saltzman
Publisher : Springer Science & Business Media
Page : 160 pages
File Size : 45,8 Mb
Release : 2003-09-30
Category : Science
ISBN : 0306477017

Get Book

Synthetic DNA Delivery Systems by Dan Luo,W. Mark Saltzman Pdf

DNA delivery into cells is a rapidly developing area in gene therapy and biotechnology. Moreover, it is a powerful research tool to determine gene structure, regulation, and function. Viral methods of DNA delivery are well-characterized and efficient, but little is known about the toxicity and immunogenecity of viral vectors. As a result, non-viral, transfection methods of DNA delivery are of increasing interest. Synthetic DNA Delivery Systems is a comprehensive and current resource on DNA transfection. The use of histidine-rich peptides and polypeptides as DNA delivery systems and self-assembled delivery systems based on cationic lipids and polymers are discussed. Targeted delivery to organelles, tumor cells and dendritic cells comprise an important topic.

Author : Zhongwei Gu
Publisher : John Wiley & Sons
Page : 360 pages
File Size : 44,5 Mb
Release : 2014-12-04
Category : Medical
ISBN : 9783527672721

Get Book

Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery by Zhongwei Gu Pdf

Here, front-line researchers in the booming field of nanobiotechnology describe the most promising approaches for bioinspired drug delivery, encompassing small molecule delivery, delivery of therapeutic proteins and gene delivery. The carriers surveyed include polymeric, proteinaceous and lipid systems on the nanoscale, with a focus on their adaptability for different cargoes and target tissues. Thanks to the broad coverage of carriers as well as cargoes discussed, every researcher in the field will find valuable information here.

Author : Ijeoma F. Uchegbu,Andreas G. Schatzlein
Publisher : CRC Press
Page : 426 pages
File Size : 47,9 Mb
Release : 2006-05-19
Category : Medical
ISBN : 9781000611243

Get Book

Polymers in Drug Delivery by Ijeoma F. Uchegbu,Andreas G. Schatzlein Pdf

Together, the nano explosion and the genomic revolution are ushering in a new frontier in drug delivery. In recent years we've seen how polymers can play a crucial role in controlling the rate of drug release, enhancing solubility and uptake, and limiting degradation and toxicity. In the very near future, they may well be used to deliver gene thera

Author : Prashant Kesharwani,Kishore M. Paknikar,Virendra Gajbhiye
Publisher : Academic Press
Page : 434 pages
File Size : 54,8 Mb
Release : 2019-06-25
Category : Medical
ISBN : 9780128173312

Get Book

Polymeric Nanoparticles as a Promising Tool for Anti-cancer Therapeutics by Prashant Kesharwani,Kishore M. Paknikar,Virendra Gajbhiye Pdf

Polymeric Nanoparticles as Promising Tool for Anti-cancer Therapeutics provides an understanding of polymeric compounds and their use in cancer therapies. The book begins by giving an overview of the current status, future challenges and potential utilization of polymeric nanoparticles. It then covers specific polymeric nanoparticles through contributions from world-renowned experts and researchers. Chapters examine specific polymeric nanoparticles, their development as potential targeted delivery systems, and cancer characteristics that can be targeted for therapy development. The book synthesizes current research trends in the field, thus enhancing existing knowledge of nanomedicine, drug delivery and therapeutic intervention strategies in human cancers. Users will find this to be an ideal reference for research scientists and those in the pharmaceutical and medical fields who are working to develop novel cancer therapies using nanoparticle-based delivery systems. Explores the development of polymeric nanoparticle systems for the purpose of cancer therapy Presents thoroughly analyzed data and results regarding the usage of polymeric nanoparticles-based platforms for the diagnosis and treatment of cancer Highlights various cancer characteristics that can be targeted for therapeutic development using polymeric nanoparticles

Author : Ambikanandan Misra
Publisher : Elsevier
Page : 686 pages
File Size : 51,9 Mb
Release : 2010-09-09
Category : Science
ISBN : 9780123849656

Get Book

Challenges in Delivery of Therapeutic Genomics and Proteomics by Ambikanandan Misra Pdf

Delivery of therapeutic proteomics and genomics represent an important area of drug delivery research. Genomics and proteomics approaches could be used to direct drug development processes by unearthing pathways involved in disease pathogenesis where intervention may be most successful. This book describes the basics of genomics and proteomics and highlights the various chemical, physical and biological approaches to protein and gene delivery. Covers a diverse array of topics from basic sciences to therapeutic applications of proteomics and genomics delivery Of interest to researchers in both academia and industry Highlights what’s currently known and where further research is needed

Author : Vivek Dave,Nikita Gupta,Srija Sur
Publisher : John Wiley & Sons
Page : 467 pages
File Size : 47,9 Mb
Release : 2020-12-29
Category : Computers
ISBN : 9781119711681

Get Book

Nanopharmaceutical Advanced Delivery Systems by Vivek Dave,Nikita Gupta,Srija Sur Pdf

The book provides a single volume covering detailed descriptions about various delivery systems, their principles and how these are put in use for the treatment of multiple diseases. It is divided into four sections where the first section deals with the introduction and importance of novel drug delivery system. The second section deals with the most advanced drug delivery systems like microbubbles, dendrimers, lipid-based nanoparticles, nanofibers, microemulsions etc., describing the major principles and techniques of the preparations of the drug delivery systems. The third section elaborates on the treatments of diverse diseases like cancer, topical diseases, tuberculosis etc. The fourth and final section provides a brief informative description about the regulatory aspects of novel drug delivery system that is followed in various countries.

Author : Associate Professor in the Chemistry Department Tomoko Fujiwara,Tomoko Fujiwara,Director of CMC and Pharmaceutical Development X Michael Liu,X. Michael Liu,Professor in the Department of Chemistry and Materials Engineering Yuichi Ohya,Yuichi Ohya,Professor in the Chemistry Department Yongmei Wang
Publisher : American Chemical Society
Page : 118 pages
File Size : 47,5 Mb
Release : 2021-04-30
Category : Medical
ISBN : 0841238146

Get Book

Polymers in Therapeutic Delivery by Associate Professor in the Chemistry Department Tomoko Fujiwara,Tomoko Fujiwara,Director of CMC and Pharmaceutical Development X Michael Liu,X. Michael Liu,Professor in the Department of Chemistry and Materials Engineering Yuichi Ohya,Yuichi Ohya,Professor in the Chemistry Department Yongmei Wang Pdf

Polymer-based systems hold great promise for the delivery of genes and drugs, as polymers can be designed and modified to meet new challenges.

Author : Yakai Feng,Abraham Jacob Domb,Bin He,Wenzhong Li
Publisher : Frontiers Media SA
Page : 143 pages
File Size : 52,8 Mb
Release : 2022-05-30
Category : Science
ISBN : 9782889762743

Get Book

Multifunctional Polymeric Materials for Drug and Gene Delivery by Yakai Feng,Abraham Jacob Domb,Bin He,Wenzhong Li Pdf

Author : Ronit Satchi-Fainaro,Ruth Duncan
Publisher : Springer Science & Business Media
Page : 224 pages
File Size : 50,9 Mb
Release : 2006-02-10
Category : Technology & Engineering
ISBN : 3540292101

Get Book

Polymer Therapeutics I by Ronit Satchi-Fainaro,Ruth Duncan Pdf

Author : Dennis M. Brown
Publisher : Springer Science & Business Media
Page : 438 pages
File Size : 51,9 Mb
Release : 2003-09-08
Category : Medical
ISBN : 9781592594276

Get Book

Drug Delivery Systems in Cancer Therapy by Dennis M. Brown Pdf

Leading experts survey the currently available technologies designed to improve the delivery of today's cancer chemotherapeutic agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development. In their outline and discussion of the use of novel formulation technologies-including synthetic polymers and biomaterials for prolonged or sustained drug release to achieve potentially greater therapeutic effect-they profile those technologies that have resulted in a number of approved and late-stage clinical products.

Author : Saurabh Bhatia
Publisher : Springer
Page : 225 pages
File Size : 47,9 Mb
Release : 2016-09-23
Category : Technology & Engineering
ISBN : 9783319411293

Get Book

Natural Polymer Drug Delivery Systems by Saurabh Bhatia Pdf

This book describes 200 bio-polymers, including the most recent and advanced nanotechnology applications. The applications of various bio-medical and other future potential uses are covered and examined in depth. Systematic discussion of current leading natural polymers is also included.