Powder Technology And Pharmaceutical Processes

Author : Dominique Chulia,Michel Deleuil,Yvette Pourcelot
Publisher : Elsevier Science & Technology
Page : 557 pages
File Size : 48,6 Mb
Release : 1994
Category : Science
ISBN : 0444815333

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Powder Technology and Pharmaceutical Processes by Dominique Chulia,Michel Deleuil,Yvette Pourcelot Pdf

Hardbound. This volume offers a multidisciplinary approach to the operations most commonly used in processing solids in the field of pharmacy and also in the fields of fine chemicals, cosmetics, foods, etc. The authors combine the triple standpoint of formulation, physical characterization of materials and process engineering and have selected the basic facts needed to understand the phenomena by which molecules become particles, particles become granules and granules become tablets, extrudates, microcapsules, etc. These operations are then described in very practical terms, including assessment of their effectiveness and limitations, and critical steps are highlighted.About twenty operations carried out on divided solids are described, ranging from crystallization to formulation, in a manner intended to be within the grasp of all involved: it is not a book solely for specialists, but offers a multidisciplinary background and a methodological help to p

Author : Agba D. Salman,Michael Hounslow,Jonathan P.K. Seville
Publisher : Elsevier
Page : 1402 pages
File Size : 45,8 Mb
Release : 2006-11-24
Category : Technology & Engineering
ISBN : 0080467881

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Granulation by Agba D. Salman,Michael Hounslow,Jonathan P.K. Seville Pdf

Granulation provides a complete and comprehensive introduction on the state-of-the-art of granulation and how it can be applied both in an academic context and from an industrial perspective. Coupling science and engineering practices it covers differing length scales from the sub-granule level through behaviour through single granules, to bulk granule behaviour and equipment design. With special focus on a wide range of industrially relevant areas from fertilizer production, through to pharmaceuticals. Experimental data is complemented by mathematical modelling in this emerging field, allowing for a greater understanding of the basis of particle products and this important industry sector. Four themes run through the book: 1. The Macro Scale processing for Granulation – including up to date descriptions of the methods used for granulation and how they come about and how to monitor – on-line these changes. 2. The Applications of granulation from an industrial perspective, with current descriptive roles and how they are undertaken with relevance to industry, and effective properties. 3. Mechanistic descriptions of granulation and the different rate processes occurring within the granulator. This includes methods of modelling the process using Population – Balance Equations, and Multi-level Computational Fluid Dynamics Models. 4. The Micro Scale: Granules and Smaller, looking at single granules and there interactions and modelling, while also considering the structure of granules and their constituent liquid bridges. * Covers a wide range of subjects and industrial applications * Provides an understanding of current issues for industrial and academic environments * Allows the reader an understanding of the science behind engineered granulation processes

Author : Michael Levin
Publisher : CRC Press
Page : 588 pages
File Size : 49,8 Mb
Release : 2001-12-12
Category : Medical
ISBN : 9780824741969

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Pharmaceutical Process Scale-Up by Michael Levin Pdf

Focusing on scientific and practical aspects of process scale-up, this resource details the theory and practice of transferring pharmaceutical processes from laboratory scale to the pilot plant and production scale. It covers parenteral and nonparenterel liquids and semi-solids, products derived from biotechnology, dry blending and powder handling,

Author : M. J. Rhodes
Publisher : John Wiley & Sons
Page : 464 pages
File Size : 47,9 Mb
Release : 1990
Category : Science
ISBN : UOM:39015017992267

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Principles of Powder Technology by M. J. Rhodes Pdf

Powder processing. Characterizing the single particle. Characterization of powder. mixing and segregation in powders. the storage and flow of powders. Gas fluidization. Pneumatic conveying. Solid-gas separation. Size enlargement. Size reduction. Explosion and fire hazards of powders. health risks of fine powders. Flow of liquid-solid suspensions. Solid-liquid separation.

Author : Metin Çelik
Publisher : CRC Press
Page : 360 pages
File Size : 51,6 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781420089189

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Pharmaceutical Powder Compaction Technology by Metin Çelik Pdf

Compaction of powder constituents-both active ingredient and excipients-is examined to ensure consistent and reproducible disintegration and dispersion profiles. Revised to reflect modern pharmaceutical compacting techniques, this second edition of Pharmaceutical Powder Compaction Technology guides pharmaceutical engineers, formulation scientists,

Author : C. E. Capes
Publisher : Elsevier
Page : 205 pages
File Size : 52,6 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483275079

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Particle Size Enlargement by C. E. Capes Pdf

Handbook of Powder Technology, Volume 1: Particle Size Enlargement is the first of a series which will together form a Handbook of Powder Technology, primarily intended for engineers and scientists working in industry. The scope of the Handbook can be defined as being concerned with that part of chemical engineering which deals with processes involving the handling and treatment of material in solid particulate form. This book deals with methods used to create larger entities from fine particles so that the bulk properties of particulates can be improved. These so-called ""size enlargement"" methods evidently concern a broad spectrum of technical disciplines and industries ranging from the relatively small scale requirements of pharmaceutical manufacturers through the tonnage requirements of the fertilizer and minerals processing industries. A primary objective in preparing this book was to present a generalized account of the many size enlargement techniques scattered throughout these diverse industries, with emphasis on similarities and unifying characteristics whenever possible. The book devotes one chapter to each of the principal methods used to bring particles together into agglomerates: agitation methods— tumbling agglomeration, agitation methods—mixer agglomeration, pressure methods, thermal methods, spray and dispersion methods, and agglomeration from liquids.

Author : Anthony J. Hickey,Stefano Giovagnoli
Publisher : Springer
Page : 108 pages
File Size : 42,8 Mb
Release : 2018-08-13
Category : Medical
ISBN : 9783319912202

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Pharmaceutical Powder and Particles by Anthony J. Hickey,Stefano Giovagnoli Pdf

This first monograph in the new AAPS book series concisely reviews important aspects of powder and particle systems and the critical quality attributes that should be used as a guide to future developments intended to maximize the control of product quality and performance. Drs. Hickey and Giovagnoli have written an essential primer for any scientists involved in powder or particle research and manufacturing. It is appropriate for those just entering the field or as a rapid reference for the experienced pharmaceutical scientist. The authors have both academic and industrial experience and the coverage includes solid state chemistry; crystallization; physical processes; particle size and distribution;particle interaction;manufacturing processes;quality by design;and a general discussion of the industry. Pharmaceutical Powder and Particles is intended to concisely review important aspects of powder and particle systems and the critical quality attributes that should be used as a guide to future developments intended to maximize the control of product quality and performance.

Author : Fridrun Podczeck
Publisher : World Scientific
Page : 256 pages
File Size : 48,7 Mb
Release : 1998-07-31
Category : Medical
ISBN : 9781783262311

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Particle-particle Adhesion In Pharmaceutical Powder Handling by Fridrun Podczeck Pdf

This monograph describes the physical principles of adhesion between particles and surfaces. These principles are applied to pharmaceutical processes involved in the manufacture of solid dosage forms such as powders, granules, tablets and dry powder inhalations. To help in the understanding of these systems, physical properties of solid surfaces, and an introduction to the theory of friction is given. Techniques for measuring particle adhesion and fracture mechanical properties of powders are introduced, as far as these are relevant to the processes discussed. The philosophy of the book deviates from that of standard pharmaceutical textbooks, in that it focuses primarily on physical principles involved in the manufacture of dosage forms rather than describing these processes purely by observation.

Author : Hiroaki Masuda,Ko Higashitani,Hideto Yoshida
Publisher : CRC Press
Page : 412 pages
File Size : 40,9 Mb
Release : 2006-11-29
Category : Science
ISBN : 9781420044133

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Powder Technology by Hiroaki Masuda,Ko Higashitani,Hideto Yoshida Pdf

Drawing from the third edition of the bestselling Powder Technology Handbook, this book concentrates on handling methods and unit operations for powder and particle processing techniques. Itexamines the purpose and factors involved in each process-including planning, equipment, measurements, and other necessary considerations. This book c

Author : Ajit S. Narang,Atul Dubey
Publisher : CRC Press
Page : 495 pages
File Size : 52,6 Mb
Release : 2023-03-01
Category : Medical
ISBN : 9781000804478

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Continuous Pharmaceutical Processing and Process Analytical Technology by Ajit S. Narang,Atul Dubey Pdf

Continuous manufacturing of pharmaceuticals, including aspects of modern process development is highlighted in this book with both the ‘why’ and the ‘how’, emphasizing process modeling and process analytical technologies. Presenting specific case studies and drawing upon extensive experience from industry and academic opinion leaders, this book focuses on the practical aspects of continuous manufacturing. It gives the readers the strategic perspective and technical depth needed to adopt and implement these technologies, where appropriate, in order to gain the competitive edge in speed, agility, and reliability. Features: Discusses scientific solutions and process analytical technology to enable continuous manufacturing in the development of new drugs Includes short stories about how some companies have adopted CM and what their drivers were and what benefits were realized Addresses economic and practical considerations, unlike many other technical books Emphasizes the practical aspects to give the reader the strategic imperative and technological depth to adopt and implement these technologies Highlights the "why" and the "how", focusing on the need analysis and process modeling and process analytical technologies

Author : Fernando Muzzio,Sarang Oka
Publisher : Academic Press
Page : 444 pages
File Size : 52,9 Mb
Release : 2022-03-29
Category : Medical
ISBN : 9780128134801

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How to Design and Implement Powder-to-Tablet Continuous Manufacturing Systems by Fernando Muzzio,Sarang Oka Pdf

How to Design and Implement Powder-to-Tablet Continuous Manufacturing Systems provides a comprehensive overview on the considerations necessary for the design of continuous pharmaceutical manufacturing processes. The book covers both the theory and design of continuous processing of associated unit operations, along with their characterization and control. In addition, it discusses practical insights and strategies that the editor and chapter authors have learned. Chapters cover Process Analytical Technology (PAT) tools and the application of PAT data to enable distributed process control. With numerous case studies throughout, this valuable guide is ideal for those engaged in, or learning about, continuous processing in pharmaceutical manufacturing. Discusses the development of strategy blueprints in the design of continuous processes Shows how to create process flowsheet models from individual unit operation models Includes a chapter on characterization methods for materials, the use of statistical methods to analyze material property data, and the use of material databases Covers the evolving regulatory expectations for continuous manufacturing Provides readers with ways to more effectively navigate these expectations

Author : Todd Pugsley,Conrad Winters
Publisher : Unknown
Page : 0 pages
File Size : 47,6 Mb
Release : 2008
Category : Electronic
ISBN : OCLC:254624260

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Particulate Processes in the Pharmaceutical Industry by Todd Pugsley,Conrad Winters Pdf

Author : Ko Higashitani,Hisao Makino,Shuji Matsusaka
Publisher : CRC Press
Page : 681 pages
File Size : 44,7 Mb
Release : 2019-10-16
Category : Science
ISBN : 9781351730594

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Powder Technology Handbook, Fourth Edition by Ko Higashitani,Hisao Makino,Shuji Matsusaka Pdf

The Fourth Edition of Powder Technology Handbook continues to serve as the comprehensive guide to powder technology and the fundamental engineering processes of particulate technology, while incorporating significant advances in the field in the decade since publication of the previous edition. The handbook offers a well-rounded perspective on powder technologies in gas and liquid phases that extends from particles and powders to powder beds and from basic problems to actual applications. This new edition features fully updated and new chapters written by a team of internationally distinguished contributors. All content has been updated and new sections added on. Powder Technology Handbook provides methodologies of powder and particle handling technology essential to scientific researchers and practical industrial engineers. It contains contemporary and comprehensive information on powder and particle handling technology that is extremely useful not only to newcomers but also to experienced engineers and researchers in the field of powder and particle science and technology.

Author : P. J. Cullen,Rodolfo J. Romañach,Nicolas Abatzoglou,Chris D. Rielly
Publisher : John Wiley & Sons
Page : 512 pages
File Size : 53,8 Mb
Release : 2015-05-11
Category : Technology & Engineering
ISBN : 9781118682807

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Pharmaceutical Blending and Mixing by P. J. Cullen,Rodolfo J. Romañach,Nicolas Abatzoglou,Chris D. Rielly Pdf

Written in four parts, this book provides a dedicated and in-depth reference for blending within the pharmaceutical manufacturing industry. It links the science of blending with regulatory requirements associated with pharmaceutical manufacture. The contributors are a combination of leading academic and industrial experts, who provide an informed and industrially relevant perspective of the topic. This is an essential book for the pharmaceutical manufacturing industry, and related academic researchers in pharmaceutical science and chemical and mechanical engineering.

Author : Peter Kleinebudde,Johannes Khinast,Jukka Rantanen
Publisher : John Wiley & Sons
Page : 645 pages
File Size : 48,8 Mb
Release : 2017-09-05
Category : Science
ISBN : 9781119001324

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Continuous Manufacturing of Pharmaceuticals by Peter Kleinebudde,Johannes Khinast,Jukka Rantanen Pdf

A comprehensive look at existing technologies and processes for continuous manufacturing of pharmaceuticals As rising costs outpace new drug development, the pharmaceutical industry has come under intense pressure to improve the efficiency of its manufacturing processes. Continuous process manufacturing provides a proven solution. Among its many benefits are: minimized waste, energy consumption, and raw material use; the accelerated introduction of new drugs; the use of smaller production facilities with lower building and capital costs; the ability to monitor drug quality on a continuous basis; and enhanced process reliability and flexibility. Continuous Manufacturing of Pharmaceuticals prepares professionals to take advantage of that exciting new approach to improving drug manufacturing efficiency. This book covers key aspects of the continuous manufacturing of pharmaceuticals. The first part provides an overview of key chemical engineering principles and the current regulatory environment. The second covers existing technologies for manufacturing both small-molecule-based products and protein/peptide products. The following section is devoted to process analytical tools for continuously operating manufacturing environments. The final two sections treat the integration of several individual parts of processing into fully operating continuous process systems and summarize state-of-art approaches for innovative new manufacturing principles. Brings together the essential know-how for anyone working in drug manufacturing, as well as chemical, food, and pharmaceutical scientists working on continuous processing Covers chemical engineering principles, regulatory aspects, primary and secondary manufacturing, process analytical technology and quality-by-design Contains contributions from researchers in leading pharmaceutical companies, the FDA, and academic institutions Offers an extremely well-informed look at the most promising future approaches to continuous manufacturing of innovative pharmaceutical products Timely, comprehensive, and authoritative, Continuous Manufacturing of Pharmaceuticals is an important professional resource for researchers in industry and academe working in the fields of pharmaceuticals development and manufacturing.