Practical Oncologic Molecular Pathology

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Practical Oncologic Molecular Pathology

Yi Ding,Linsheng Zhang
Practical Oncologic Molecular Pathology Book PDF

Author : Yi Ding,Linsheng Zhang
Publisher : Springer Nature
Page : 449 pages
File Size : 45,9 Mb
Release : 2021-07-10
Category : Medical
ISBN : 9783030732271

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Practical Oncologic Molecular Pathology by Yi Ding,Linsheng Zhang Pdf

This book is a review and high-yield reference on the clinical molecular diagnostics of malignant neoplasms. It aims to address the practical questions frequently encountered in the molecular oncology practice, as well as key points and pitfalls in the clinical interpretation of molecular tests in guiding precision cancer management. The text uses a Q&A format and case presentations, with emphasis on understanding the molecular test methods, diagnosis, classification, risk assessment and clinical correlation. Starting with an update on the molecular biology of cancer, the book focuses on the topics related to molecular diagnostics and genetics-based precision oncology. Separate chapters are dedicated to discussion of the bioinformatics for the analysis of genetic/genomic data generated from molecular assays, and quality control (QC)/quality assurance (QA) programs in the clinical laboratories; both are critical in producing high quality results for clinical care of cancer patients. These are followed by organ system-based reviews and discussions on the molecular genetic abnormalities and related tests covering diverse types of common to rare malignant neoplasms. This book also provides up-to-date knowledge related to malignant neoplasms, discusses the established as well as evolving requirements for pathologic diagnosis of these malignancies. It also discusses the cost effective utilization of molecular tests in clinical oncology. Written by experts in the field, Practical Oncologic Molecular Pathology serves as a valuable reference for practicing pathologists, fellows, residents and other health care professionals.

Molecular Pathology in Clinical Practice

Debra G.B. Leonard
Molecular Pathology in Clinical Practice Book PDF

Author : Debra G.B. Leonard
Publisher : Springer
Page : 1001 pages
File Size : 50,7 Mb
Release : 2016-02-02
Category : Medical
ISBN : 9783319196749

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Molecular Pathology in Clinical Practice by Debra G.B. Leonard Pdf

This authoritative textbook offers in-depth coverage of all aspects of molecular pathology practice and embodies the current standard in molecular testing. Since the successful first edition, new sections have been added on pharmacogenetics and genomics, while other sections have been revised and updated to reflect the rapid advances in the field. The result is a superb reference that encompasses molecular biology basics, genetics, inherited cancers, solid tumors, neoplastic hematopathology, infectious diseases, identity testing, HLA typing, laboratory management, genomics and proteomics. Throughout the text, emphasis is placed on the molecular variations being detected, the clinical usefulness of the tests and important clinical and laboratory issues. The second edition of Molecular Pathology in Clinical Practice will be an invaluable source of information for all practicing molecular pathologists and will also be of utility for other pathologists, clinical colleagues and trainees.

Molecular Pathology in Clinical Practice: Oncology

Debra G.B. Leonard
Molecular Pathology in Clinical Practice Oncology Book PDF

Author : Debra G.B. Leonard
Publisher : Springer
Page : 0 pages
File Size : 46,9 Mb
Release : 2008-12-12
Category : Medical
ISBN : 0387873643

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Molecular Pathology in Clinical Practice: Oncology by Debra G.B. Leonard Pdf

Molecular Pathology in Clinical Practice: Oncology is an authoritative and comprehensive guide that provides the general pathologist in clinical practice, as well as residents and fellows during their training, with the current standard in molecular oncology testing. It addresses all areas of molecular oncology testing including: molecular biology basics, inherited cancers, solid tumors, neoplastic hematopathology, identity testing and laboratory management. The book integrates the latest advancements in the field with the basic principles and practical applications.

Diagnostic Molecular Pathology in Practice

Iris Schrijver
Diagnostic Molecular Pathology in Practice Book PDF

Author : Iris Schrijver
Publisher : Springer Science & Business Media
Page : 329 pages
File Size : 49,7 Mb
Release : 2011-09-09
Category : Medical
ISBN : 9783642196775

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Diagnostic Molecular Pathology in Practice by Iris Schrijver Pdf

This entirely case-based book covers a broad cross-section of the practical issues frequently encountered in the day-to-day activities of a molecular genetic pathologist. The book is divided into four sections on the principal areas addressed in molecular genetic pathology (MGP): inherited diseases, hematopathology, solid tumors, and infectious diseases. The topics covered by the cases in each section include test selection, qualitative and quantitative laboratory techniques, test interpretation, prognostic and therapeutic considerations, ethical considerations, technical troubleshooting, and result reporting. This book will be ideal for trainees in MGP and clinical molecular genetics who require a practice-based preparation for board examinations. It will also be very useful for residents and fellows in medical specialties to which MGP is pertinent, and for practicing pathologists who want to learn more about the current practice of molecular diagnostics.

Molecular Pathology and Diagnostics of Cancer

Domenico Coppola
Molecular Pathology and Diagnostics of Cancer Book PDF

Author : Domenico Coppola
Publisher : Springer Science & Business Media
Page : 599 pages
File Size : 50,8 Mb
Release : 2013-11-29
Category : Medical
ISBN : 9789400771925

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Molecular Pathology and Diagnostics of Cancer by Domenico Coppola Pdf

Molecular pathology is based on the emergence of new techniques that greatly enhance the diagnostic accuracy when facing with challenging differential diagnoses. In addition, new molecular techniques are entering the clinical arena for their value in predicting therapy response and tumor prognosis. This book provides a guide for the practicing pathologist and for both pathology residents and fellows during the daily sign-out of challenging cases. The book is organized by anatomical systems and provides a detailed description of molecular tests that may help in the diagnosis. Furthermore, a description of the current molecular tests required to identify patients for treatment is offered. The application of molecular pathology techniques to the clinical practice has already shown its usefulness and the number of such tests is growing exponentially as more molecular targets are discovered. Molecular Pathology and Diagnostics of Cancer will give practicing and training pathologists an up-to date resource to guide the correct management of pathology cases requiring molecular testing.

Diagnostic Pathology: Molecular Oncology E-Book

Mohammad A Vasef,Aaron Auerbach
Diagnostic Pathology Molecular Oncology E Book Book PDF

Author : Mohammad A Vasef,Aaron Auerbach
Publisher : Elsevier Health Sciences
Page : 1000 pages
File Size : 55,7 Mb
Release : 2019-08-08
Category : Medical
ISBN : 9780323611459

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Diagnostic Pathology: Molecular Oncology E-Book by Mohammad A Vasef,Aaron Auerbach Pdf

Covering all aspects of molecular pathology as it relates to the transformation and pathogenesis of cancer, this award-winning volume in the Diagnostic Pathology series is an expert resource for pathologists at all levels of experience and training, both as a quick reference and as an efficient review to improve knowledge and skills. This easily accessible, point-of-care reference features templated, bulleted content that is generously illustrated with charts, graphs, tables, and color photomicrographs of histology with special stains. It offers a practical, clinical approach to examining how molecular mutations affect common medical diseases and identifies the relevant and appropriate molecular tests to perform for a complete work-up in the era of molecular-targeted therapies. Provides updated information on molecular mutations in different tumors, including solid tumors and hematopoietic neoplasms, and new targeted therapies geared toward these molecular alterations Discusses now widely used immunotherapy treatments, including how immunotherapy has revolutionized the treatment of many neoplasms such as breast and lung carcinomas and lymphoma Features more than 2,000 annotated images throughout, including H&E stains, immunostains, and FISH images Covers timely topics such as: Recent advances in cancer immunotherapy, specifically in the molecular basis of immunotherapy Newly discovered targeted therapies, including multiple lung carcinoma therapies now considered for patients based on existing mutations to specific genes (KRAS, ALK, BRAF, and ROS) The need for integration of myeloid and lymphoid gene panels due to increased knowledge from next generation sequencing studies of new mutations and the resulting newly developed molecular targets Increased usage of next generation sequencing techniques Changes to hematopoietic tumor details based on revised WHO guidelines Recipient of a 2016 BMA Award: Highly Commended, Pathology (previous edition)

Molecular Pathology

John M. S. Bartlett,Abeer Shaaban,Fernando Schmitt
Molecular Pathology Book PDF

Author : John M. S. Bartlett,Abeer Shaaban,Fernando Schmitt
Publisher : Cambridge University Press
Page : 417 pages
File Size : 46,8 Mb
Release : 2015-11-05
Category : Medical
ISBN : 9781107443464

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Molecular Pathology by John M. S. Bartlett,Abeer Shaaban,Fernando Schmitt Pdf

Practical overview of current molecular techniques and their applications in each organ system, for practising and trainee pathologists.

Molecular Pathology in Clinical Practice: Infectious Diseases

Debra G.B. Leonard
Molecular Pathology in Clinical Practice Infectious Diseases Book PDF

Author : Debra G.B. Leonard
Publisher : Springer
Page : 0 pages
File Size : 43,9 Mb
Release : 2008-12-12
Category : Medical
ISBN : 0387873678

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Molecular Pathology in Clinical Practice: Infectious Diseases by Debra G.B. Leonard Pdf

Molecular Pathology in Clinical Practice: Infectious Diseases is an authoritative and comprehensive guide that provides the general pathologist in clinical practice, as well as residents and fellows during their training, with the current standard in molecular infectious disease testing. The book integrates the latest advancements in the field with the basic principles and practical applications.

Molecular Surgical Pathology

Liang Cheng,John N. Eble
Molecular Surgical Pathology Book PDF

Author : Liang Cheng,John N. Eble
Publisher : Springer Science & Business Media
Page : 442 pages
File Size : 46,6 Mb
Release : 2012-11-15
Category : Medical
ISBN : 9781461449003

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Molecular Surgical Pathology by Liang Cheng,John N. Eble Pdf

Molecular Surgical Pathology provides a concise review of recent advancement of molecular pathology in each organ system. The text is intended as a “first knowledge base” in the rapidly evolving field of molecular pathology and is organized in a user friendly outline format. Each chapter is organ-based and covers important aspects of molecular pathology and its impact on our daily practice of surgical pathology. The topics presented herein constitute the fundamentals and core base of knowledge required for the daily practice of surgical pathology. This book focuses on the practical utilities of molecular techniques and molecular biomarkers in daily practice of surgical pathology. The emphasis is on the impact of molecular pathology for tumor classification, diagnosis and differential diagnosis as well as its implications for patient management and personalized care. Numerous tables, diagrams and color illustrations are included throughout. Molecular Surgical Pathology will prove a very useful resource for pathologists in training who are preparing for the Board and in-service examination. It will also be a unique and invaluable resource for medical oncologists, physicians, other medical professionals and basic research scientists with interest in molecular pathology of human cancers.

Diagnostic Pathology - Molecular Oncology

Mohammad A. Vasef,Aaron Auerbach
Diagnostic Pathology Molecular Oncology Book PDF

Author : Mohammad A. Vasef,Aaron Auerbach
Publisher : Elsevier
Page : 1016 pages
File Size : 42,7 Mb
Release : 2019-08-05
Category : Electronic
ISBN : 0323611443

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Diagnostic Pathology - Molecular Oncology by Mohammad A. Vasef,Aaron Auerbach Pdf

Covering all aspects of molecular pathology as it relates to the transformation and pathogenesis of cancer, this award-winning volume in the Diagnostic Pathology?series is an expert resource for pathologists at all levels of experience and training, both as a quick reference and as an efficient review to improve knowledge and skills. This easily accessible, point-of-care reference features templated, bulleted content that is generously illustrated with charts, graphs, tables, and color photomicrographs of histology with special stains. It offers a practical, clinical approach to examining how molecular mutations affect common medical diseases and identifies the relevant and appropriate molecular tests to perform for a complete work-up in the era of molecular-targeted therapies. Provides updated information on molecular mutations in different tumors, including solid tumors and hematopoietic neoplasms, and new targeted therapies geared toward these molecular alterations Discusses now widely used immunotherapy treatments, including how immunotherapy has revolutionized the treatment of many neoplasms such as breast and lung carcinomas and lymphoma Features more than 2,000 annotated images throughout, including H&E stains, immunostains, and FISH images Covers timely topics such as: Recent advances in cancer immunotherapy, specifically in the molecular basis of immunotherapy Newly discovered targeted therapies, including multiple lung carcinoma therapies now considered for patients based on existing mutations to specific genes (KRAS, ALK, BRAF, and ROS) The need for integration of myeloid and lymphoid gene panels due to increased knowledge from next generation sequencing studies of new mutations and the resulting newly developed molecular targets Increased usage of next generation sequencing techniques Changes to hematopoietic tumor details based on revised WHO guidelines Recipient of a 2016 BMA Award: Highly Commended, Pathology (previous edition) Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices

Diagnostic Molecular Pathology

William B. Coleman,Gregory J. Tsongalis
Diagnostic Molecular Pathology Book PDF

Author : William B. Coleman,Gregory J. Tsongalis
Publisher : Academic Press
Page : 846 pages
File Size : 54,9 Mb
Release : 2023-10-27
Category : Science
ISBN : 9780128229934

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Diagnostic Molecular Pathology by William B. Coleman,Gregory J. Tsongalis Pdf

Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing, Second Edition assembles a group of experts to discuss the molecular basis and mechanisms of major human diseases and disease processes and how the molecular features of disease can be harnessed to develop practical molecular tests for disease detection, diagnosis and prognosis. The book explains how molecular tests are utilized in the treatment of patients in personalized medicine, highlights new technologies and approaches of applied molecular pathology, and discusses how this discovery-based research yields new and useful biomarkers and tests. As it is essential to stay up-to-date on new molecular diagnostics in this changing field, this book covers critically important areas in the practice of personalized medicine and reflects our understanding of the pathology, pathogenesis and pathophysiology of human disease. Includes new material on mass spectrometry for infectious diseases, microbiome, homology-directed repair for PARPi, whole genome sequencing for constitutional testing, and much more Provides insights on the value of the molecular test in comparison to traditional methods, which include speed, precision, sensitivity and clinical impacts for the patient Focuses on the menu of molecular diagnostic tests available in modern molecular pathology or clinical laboratories that can be applied to disease detection, diagnosis and classification in the clinical workup of a patient Explains how molecular tests are utilized to guide the treatment of patients in personalized medicine (guided therapies) and for the prognostication of disease

Molecular Pathology in Clinical Practice: Genetics

Debra G.B. Leonard
Molecular Pathology in Clinical Practice Genetics Book PDF

Author : Debra G.B. Leonard
Publisher : Springer
Page : 0 pages
File Size : 53,6 Mb
Release : 2008-12-12
Category : Medical
ISBN : 0387873732

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Molecular Pathology in Clinical Practice: Genetics by Debra G.B. Leonard Pdf

Molecular Pathology Testing in Clinical Practice: Genetics is an authoritative and comprehensive guide that provides the general pathologist in clinical practice, as well as residents and fellows during their training, with the current standard in molecular genetic testing. The book integrates the latest advancements in the field with the basic principles and practical applications.

Molecular Oncology Testing for Solid Tumors

Michael Ola Idowu,Catherine Isabelle Dumur,Carleton Theodore Garrett
Molecular Oncology Testing for Solid Tumors Book PDF

Author : Michael Ola Idowu,Catherine Isabelle Dumur,Carleton Theodore Garrett
Publisher : Springer
Page : 742 pages
File Size : 49,5 Mb
Release : 2015-08-18
Category : Medical
ISBN : 9783319163048

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Molecular Oncology Testing for Solid Tumors by Michael Ola Idowu,Catherine Isabelle Dumur,Carleton Theodore Garrett Pdf

Familiarity with and understanding molecular testing is becoming imperative for practicing physicians, especially pathologists and oncologists given the current explosion of molecular tests for diagnostic, prognostic and predictive indications. Molecular Oncology Testing for Solid Tumors is designed to present an up to date practical approach to molecular testing in a easy to understand format. Emphasis is placed on quality assurance (pre-analytic, analytic and post-analytic) and test interpretation, including but not limited to: the important role of pathologists in ensuring specimen adequacy for molecular testing; factors to consider in choosing platforms for molecular assays; advantages and limitations inherent to common assays/platforms that pathologists need to communicate effectively with clinicians; the importance of required quality assurance measures to ensure accurate / reproducible results; pitfalls in test interpretation (including different types of artifacts that may lead to False Positive or False Negative interpretations); test reporting using standard nomenclature; review of the current and future potential utility of next-generation sequencing in oncology. All chapters are written by pathologists and clinicians experienced in practical applications of molecular tests for solid tumors. The uniqueness of this textbook is the use of a standardized template for each of the molecular tests being discussed followed by a discussion of relevant quality assurance issues to ensure focused and efficient presentation of information. This will enable readers to easily understand the Order, Report and Evaluate (ORE) process of molecular tests. Lastly, summary tables of all the molecular assays and mutations discussed in the text are provided as an appendix for quick reference. For readers interested in more detailed information, a link to websites where additional information can be obtained is provided.

Molecular Diagnostics in Cytopathology

Sinchita Roy-Chowdhuri,Paul A. VanderLaan,John M. Stewart,Gilda da Cunha Santos
Molecular Diagnostics in Cytopathology Book PDF

Author : Sinchita Roy-Chowdhuri,Paul A. VanderLaan,John M. Stewart,Gilda da Cunha Santos
Publisher : Springer
Page : 534 pages
File Size : 52,9 Mb
Release : 2018-11-21
Category : Medical
ISBN : 9783319973975

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Molecular Diagnostics in Cytopathology by Sinchita Roy-Chowdhuri,Paul A. VanderLaan,John M. Stewart,Gilda da Cunha Santos Pdf

Molecular diagnostics are increasingly used to help guide targeted therapy in solid organ tumors and hematologic malignancies. A large proportion of molecular testing is performed on limited-volume samples obtained via minimally invasive techniques, such as fine needle aspiration. Increasingly, cytopathologists play an essential role in this process, both in the triage of specimens during rapid on-site evaluation and in the evaluation of archival samples to determine suitability for ancillary testing. Therefore, it is imperative that practicing cytopathologists stay abreast of up-to-date diagnostic, prognostic, and predictive ancillary tests that can be used on limited cytologic material. This is a challenge since the landscape of known genomic alterations is constantly evolving and the subsequent set of testing options is ever expanding. The proposed text will provide a user-friendly quick-reference handbook to serve as a useful resource for practicing pathologists and laboratory personnel dealing with, and interested in, this evolving field of molecular cytopathology. Essential components to be presented include: 1) pre-analytic factors that affect sample selection and evaluation; 2) specimen preparation to maximize confidence in results; 3) interpretation of results; 4) potential limitations; and 5) workflow algorithms. In addition, specific disease specific molecular testing details will be outlined to provide the reader with resources for quick reference. All chapters will be written by experts in their fields and will include the most up-to-date scientific and clinical information. Molecular Diagnostics in Cytopathology will be of value to Cytopathologists, Cytotechnologists, Cytotechnology students, Cytopathology fellows, Surgical pathologists, Pathology residents and fellows, Molecular Pathologists, Molecular pathology fellows, Molecular technologists, as well as Translational researchers with an interest in molecular cytopathology.

Advances in Molecular Pathology

Gregory J. Tsongalis
Advances in Molecular Pathology Book PDF

Author : Gregory J. Tsongalis
Publisher : Elsevier Health Sciences
Page : 177 pages
File Size : 48,9 Mb
Release : 2022-11-01
Category : Medical
ISBN : 9780323940405

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Advances in Molecular Pathology by Gregory J. Tsongalis Pdf

Advances in Molecular Pathology reviews the year’s most important findings and updates within the field in order to provide molecular pathologists with the current clinical information they need to improve patient outcomes. A distinguished editorial board, led by Dr. Gregory Tsongalis, identifies key areas of major progress and controversy and invites preeminent specialists to contribute original articles devoted to these topics. These insightful overviews in molecular pathology inform and enhance clinical practice by bringing concepts to a clinical level and exploring their everyday impact on patient care. Provides in-depth, clinical reviews in molecular pathology, providing actionable insights for clinical practice. Presents the latest information in the field under the leadership of an experienced editorial team. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.