Practical Toxicology

Author : David Woolley,Adam Woolley
Publisher : CRC Press
Page : 528 pages
File Size : 40,6 Mb
Release : 2017-03-16
Category : Medical
ISBN : 9781498709309

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Practical Toxicology by David Woolley,Adam Woolley Pdf

Practical Toxicology: Evaluation, Prediction, and Risk, Third Edition shows how to conduct a program of safety evaluation and testing and then to interpret and apply the resulting data and information in the real world, beginning with the basic concepts in toxicology and progressing to the interpretation of the resulting data. Revised and updated chapters on risk assessment guide the reader to setting the foundations necessary for submission to regulatory authorities. In addition, a new chapter in the book reviews the errors in toxicology, mistakes, misuse, mismanagement, and misunderstanding with a view to avoiding these in the future. New Chapters in the Third Edition: Toxicology in silico Errors in Toxicology Safety Assessment of Extractables and Leachables. This new edition follows a practical sequence from introducing the basics of toxicology (including the vital concept of normality in controls) to describing a test program and then interpreting the data and translating that to risk assessment that can be used in a number of real world situations where safety and secure risk assessment are essential. Although written primarily from the perspective of pharmaceutical development, the test designs and toxicological problems encountered in that field are entirely relevant to those with other classes of chemicals, the only difference being the regulatory context. Toxicology is an international discipline and the book has been written to take into account some of the differences in regulatory nuance between the main regions of the world. Completely revised and written in an easily accessible style, the text address several audiences—from students and post-graduates coming to the subject for the first time to established professionals who find themselves needing to learn about toxicology, toxicity testing, interpretation of the results, and risk assessment. It is intended primarily as a textbook, with case studies and information on where to go to ask questions, but can also be used as a practical reference book. It covers all the basics of toxicology and the main aspects of safety evaluation testing and risk assessment while reviewing critically the current state of the discipline. It also provides a foundation for those seeking registration or certification.

Author : David Woolley,Adam Woolley
Publisher : CRC Press
Page : 472 pages
File Size : 42,7 Mb
Release : 2008-09-22
Category : Medical
ISBN : 9781420043150

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A Guide to Practical Toxicology by David Woolley,Adam Woolley Pdf

This practical, user-friendly, and informative text surveys basic principles of toxicology. It is an invaluable guide to evaluating toxicity and related data, approaching toxicity testing and interpretation, and understanding the concepts of hazard prediction and risk assessment and management. A Guide to Practical Toxicology: examines how to evaluate various groups of chemicals—pharmaceuticals, cosmetics, and agrochemicals provides insights on toxicity determination, normality and naturality, prediction, and regulation Two all-new chapters cover: safety pharmacology evaluation of different chemical classes

Author : Elsa Nielsen,Grete Ostergaard,John Christian Larsen
Publisher : CRC Press
Page : 450 pages
File Size : 40,6 Mb
Release : 2008-02-21
Category : Medical
ISBN : 9781420006940

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Toxicological Risk Assessment of Chemicals by Elsa Nielsen,Grete Ostergaard,John Christian Larsen Pdf

Unlike many existing books on toxicology that cover either toxicity of a particular substance or toxicity of chemicals on particular organ systems, Toxicological Risk Assessment of Chemicals: A Practical Guide lays out the principle activities of conducting a toxicological risk assessment, including international approaches and methods for the risk

Author : Ronald D. Hood,Ronald D Hood
Publisher : CRC Press
Page : 1164 pages
File Size : 41,9 Mb
Release : 2005-08-30
Category : Medical
ISBN : 9781420040548

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Developmental and Reproductive Toxicology by Ronald D. Hood,Ronald D Hood Pdf

Completely revised and updated, Developmental and Reproductive Toxicology: A Practical Approach, Second Edition draws together valuable information typically scattered throughout the literature, plus some not previously published, into one complete resource. In addition to the traditional aspects of developmental toxicity testing, the book covers e

Author : Laura Robinson
Publisher : John Wiley & Sons
Page : 400 pages
File Size : 54,7 Mb
Release : 2018-11-05
Category : Science
ISBN : 9781118881903

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A Practical Guide to Toxicology and Human Health Risk Assessment by Laura Robinson Pdf

Toxicology – the study of the adverse effects of chemicals on living organisms is the cornerstone to all aspects of chemical safety and knowledge of the subject is needed in a wide spectrum of fields from the chemical industry to medicine, emergency services, forensics, and regulatory science. Toxicology involves the study of symptoms, mechanisms, treatments and detection of poisoning ... especially the poisoning of people. The many problems arising from a poor understanding of toxicology and its applications in hazard communication and chemical safety motivated the author’s training courses and webinars, leading to this valuable book. Providing a practical and accessible guide, A Practical Guide to Toxicology and Human Health Risk Assessment enables readers to quickly build up knowledge and understanding of toxicology and its use in hazard identification, which is a fundamental part of chemical risk assessment. The book also covers current toxicological testing strategies and the use of physicochemical test data in hazard identification and exposure assessment. Examples are provided throughout the book to highlight important issues along with a summary of the key points that have been covered in each of the respective chapters. The book concludes with a listing of online resources on toxicology and risk assessment.

Author : David Woolley,Adam Woolley
Publisher : CRC Press
Page : 336 pages
File Size : 45,8 Mb
Release : 2003-02-20
Category : Medical
ISBN : 0748409238

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A Guide to Practical Toxicology by David Woolley,Adam Woolley Pdf

Toxicology is a means to an important end: safety. The effective toxicologist begins with this in mind, and uses a clear understanding of safety as a relative concept, together with a rational view of the current safety evaluation paradigm to direct their work. Too often this approach is ignored or discouraged by traditional practice. This lucid, readable book encourages both experienced toxicologists and those in training to place toxicological investigation in such a framework. It looks at the importance of toxicological normality, reviews toxicity testing methods, and explores new and 'alternative' methods of safety evaluation. The interpretation of toxicity findings in individual studies and data packages and the prediction of human-relevant hazards are reviewed, followed by an introduction to risk and how we perceive and assess risk in the light of known hazards and the probability of their occurrence. The final stage of the toxicological process, risk assessment and management, is reviewed with particular reference to the work-place. A Guide to Practical Toxicology uses text boxes to give background information on specific subjects or to act as simple guides to toxicological method or process; this is supported by tables and case-studies intended to illustrate method, study design and interpretation. These features mean the book works at different levels, suitable for professional and student toxicologists as well as those from outside the field who require some knowledge of toxicological method and interpretation, for instance in occupational hygiene or medicine and veterinary surgery.

Author : Rudolf Kobert
Publisher : Unknown
Page : 228 pages
File Size : 43,8 Mb
Release : 1897
Category : Poisoning
ISBN : OSU:32435016974644

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Practical Toxicology by Rudolf Kobert Pdf

Author : Shankar M Bakkannavar
Publisher : Elsevier India
Page : 262 pages
File Size : 49,5 Mb
Release : 2017-12-30
Category : Forensic toxicology
ISBN : 9788131250471

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Forensic Medicine and Toxicology Practical Manual, 1st Edition - E-Book by Shankar M Bakkannavar Pdf

This Practical manual is designed to address the need of the undergraduate medical students to help them to face the practical examination with ease. This prepares the students adequately in practical aspects. Salient features: Contains both practical and viva sections Practical section contains exercises as well as Objective Structured Practical Examination questions Each practical is supported by specific objectives, inference and opinions Each practical is followed by practice exercise Helps the students to learn practicals by themselves Each practical contains a video link which students can download and get a classroom experience while preparing Viva section contains most frequently asked must know and nice to know questions during practical examinations Contains both practical and viva sections Practical section contains exercises as well as Objective Structured Practical Examination questions Each practical is supported by specific objectives, inference and opinions Each practical is followed by practice exercise Helps the students to learn practicals by themselves Each practical contains a video link which students can download and get a classroom experience while preparing

Author : Rudolf Kobert,Ludwig Heinrich Friedburg
Publisher : Unknown
Page : 220 pages
File Size : 55,9 Mb
Release : 2019-01-03
Category : Electronic
ISBN : 3337715370

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Practical Toxicology by Rudolf Kobert,Ludwig Heinrich Friedburg Pdf

Author : Rudolf Kobert
Publisher : Unknown
Page : 128 pages
File Size : 44,5 Mb
Release : 1898
Category : Electronic
ISBN : OCLC:265430584

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Practical Toxicology for Physicians and Students by Rudolf Kobert Pdf

Author : Alan Poole,George B. Leslie
Publisher : Cambridge University Press
Page : 216 pages
File Size : 52,7 Mb
Release : 1989-12-14
Category : Medical
ISBN : 0521341183

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A Practical Approach to Toxicological Investigations by Alan Poole,George B. Leslie Pdf

First published in 1989, this book acknowledges that new drugs, food additives and other compounds need to be carefully screened for toxic side-effects. The bulk of this study is devoted to the practical questions of 'what toxicological studies should we perform?' and 'how should we perform them?' Compounds which undergo toxicity testing may be conveniently categorised as those which are intended for administration to man and those which are not. The former include pharmaceuticals to be used medicinally or prophylactically and chemicals which are added to our food, drinks or medicine to improve their stability, appearance or palatability. Since it is on pharmaceuticals that the most comprehensive toxicological evaluations are generally performed, this book has been directed primarily towards to toxicological evaluation of potential new drugs. The principles and methodology of toxicological evaluation of other types of compounds are essentially similar.

Author : David Woolley,Adam Woolley
Publisher : CRC Press
Page : 778 pages
File Size : 54,7 Mb
Release : 2017-03-16
Category : Medical
ISBN : 9781498709323

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Practical Toxicology by David Woolley,Adam Woolley Pdf

Practical Toxicology: Evaluation, Prediction, and Risk, Third Edition shows how to conduct a program of safety evaluation and testing and then to interpret and apply the resulting data and information in the real world, beginning with the basic concepts in toxicology and progressing to the interpretation of the resulting data. Revised and updated chapters on risk assessment guide the reader to setting the foundations necessary for submission to regulatory authorities. In addition, a new chapter in the book reviews the errors in toxicology, mistakes, misuse, mismanagement, and misunderstanding with a view to avoiding these in the future. New Chapters in the Third Edition: Toxicology in silico Errors in Toxicology Safety Assessment of Extractables and Leachables. This new edition follows a practical sequence from introducing the basics of toxicology (including the vital concept of normality in controls) to describing a test program and then interpreting the data and translating that to risk assessment that can be used in a number of real world situations where safety and secure risk assessment are essential. Although written primarily from the perspective of pharmaceutical development, the test designs and toxicological problems encountered in that field are entirely relevant to those with other classes of chemicals, the only difference being the regulatory context. Toxicology is an international discipline and the book has been written to take into account some of the differences in regulatory nuance between the main regions of the world. Completely revised and written in an easily accessible style, the text address several audiences—from students and post-graduates coming to the subject for the first time to established professionals who find themselves needing to learn about toxicology, toxicity testing, interpretation of the results, and risk assessment. It is intended primarily as a textbook, with case studies and information on where to go to ask questions, but can also be used as a practical reference book. It covers all the basics of toxicology and the main aspects of safety evaluation testing and risk assessment while reviewing critically the current state of the discipline. It also provides a foundation for those seeking registration or certification.

Author : D. K. Molina, M.D.,Veronica Hargrove
Publisher : CRC Press
Page : 180 pages
File Size : 41,8 Mb
Release : 2018-10-03
Category : Medical
ISBN : 9781351260589

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Handbook of Forensic Toxicology for Medical Examiners by D. K. Molina, M.D.,Veronica Hargrove Pdf

Forensic professionals, particularly medical examiners—often working through heavy caseloads—require quick and easy access to reliable sources of information to help interpret toxicology results. While several in-depth resources are available, they are often large, cumbersome, and contain more information than is often needed. The Handbook of Forensic Toxicology for Medical Examiners is a concise handbook referencing the most common toxic substances and their reported non-toxic, toxic, and lethal concentrations, making it an ideal text for quick reference in the lab or autopsy room. Features of the Second Edition: Explains the principles of postmortem toxicology and the factors which must be considered Provides tables of toxicologic data for over 200 commonly encountered substances, including drugs of abuse, poisons, prescription drugs, and over-the-counter medications Includes discussion and description of the novel psychoactive drugs—including synthetic opioids, cannabinoids, stimulants and hallucinogens Supplemental appendices provide additional information regarding specimen types and selection, testing methodologies, normal laboratory values, and conversion charts The busy forensic professional needs a concise handbook that provides critical information quickly and accurately. This heavily referenced text offers an easy-to-use format allowing for rapid access for both routine daily use and preparation for courtroom testimony.

Author : Ali S. Faqi
Publisher : Elsevier
Page : 1074 pages
File Size : 43,5 Mb
Release : 2024-02-11
Category : Medical
ISBN : 9780323984621

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A Comprehensive Guide to Toxicology in Nonclinical Drug Development by Ali S. Faqi Pdf

A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Third Edition is a valuable reference providing a complete understanding of all aspects of nonclinical toxicology in pharmaceutical research. This updated edition has been expanded and re-developed covering a wide-range of toxicological issues in small molecules and biologics. Topics include ADME in drug discovery, pharmacokinetics, toxicokinetics, formulations, and genetic toxicology testing. The book has been thoroughly updated throughout to reflect the latest scientific advances and includes new information on antiviral drugs, anti-diabetic drugs, immunotherapy, and a discussion on post-pandemic drug development challenges and opportunities. This is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings. Provides updated, unique content not covered in one comprehensive resource, including chapters on stem cells, antiviral drugs, anti-diabetic drugs, and immunotherapy Includes the latest international guidelines for nonclinical toxicology in both small and large molecules Incorporates practical examples in order to illustrate day-to-day activities and expectations associated with working in nonclinical toxicology

Author : G.O. Evans
Publisher : CRC Press
Page : 230 pages
File Size : 54,9 Mb
Release : 1996-04-29
Category : Medical
ISBN : 9780748403509

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Animal Clinical Chemistry by G.O. Evans Pdf

By presenting background information on the selection and application of biochemical tests in safety assessment studies, this text seeks to provide a basis for improving the knowledge required to interpret data from toxicological studies. In addition to chapters which discuss the assessment of specific organ toxicity (such as the liver, kidney and thyroid), the book also covers pre-analytical variables, regulatory requirements and statistical approaches, and highlights some of the major differences between man and different laboratory animals. The editor and contributor are all members of the Animal Clinical Chemistry Association, a group formed to advance the science of animal clinical chemistry in safety evaluation, toxicology and veterinary science.