Precision Haematological Cancer Medicine

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Precision Haematological Cancer Medicine

Tariq Mughal

Author : Tariq Mughal
Publisher : CRC Press
Page : 316 pages
File Size : 53,6 Mb
Release : 2018-09-27
Category : Medical
ISBN : 9781498747011

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Precision Haematological Cancer Medicine by Tariq Mughal Pdf

Many experts now consider genetic evaluation to be pivotal for the optimal diagnosis, classification, risk stratification, and therapeutic decision-making for persons diagnosed with blood cancer. This new text specifically focuses on the genetic alterations essential for establishing diagnosis and assesses how they might impact the precision oncology standard of care. Providing an authoritative review of the state of the art, this is essential reading for physicians, hematologists, and oncologists for optimal management of individual patients.

Problem Solving through Precision Oncology

Peter Selby

Author : Peter Selby
Publisher : EBN Health, an imprint of Evidence-based Networks Ltd
Page : 256 pages
File Size : 49,7 Mb
Release : 2016-11-07
Category : Medical
ISBN : 9781846926532

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Problem Solving through Precision Oncology by Peter Selby Pdf

Winner of the BMA Oncology Book of the Year Award. This practical learning and reference handbook provides an overview of the latest progress in the developing field of precision oncology, plus a ground breaking collection of case studies ("Problems") showing precision oncology in practice. The book includes a clear, readable summary of developments, alongside real-life case studies, providing a valuable update for all involved in the oncology community. The editors lead research and clinical teams at four UK centres of excellence in the field.

Precision Medicine in Oncology

Bulent Aydogan,James A. Radosevich

Author : Bulent Aydogan,James A. Radosevich
Publisher : John Wiley & Sons
Page : 288 pages
File Size : 47,7 Mb
Release : 2020-11-02
Category : Medical
ISBN : 9781119432449

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Precision Medicine in Oncology by Bulent Aydogan,James A. Radosevich Pdf

A FRESH EXAMINATION OF PRECISION MEDICINE'S INCREASINGLY PROMINENT ROLE IN THE FIELD OF ONCOLOGY Precision medicine takes into account each patient's specific characteristics and requirements to arrive at treatment plans that are optimized towards the best possible outcome. As the field of oncology continues to advance, this tailored approach is becoming more and more prevalent, channelling data on genomics, proteomics, metabolomics and other areas into new and innovative methods of practice. Precision Medicine in Oncology draws together the essential research driving the field forward, providing oncology clinicians and trainees alike with an illuminating overview of the technology and thinking behind the breakthroughs currently being made. Topics covered include: Biologically-guided radiation therapy Informatics for precision medicine Molecular imaging Biomarkers for treatment assessment Big data Nanoplatforms Casting a spotlight on this emerging knowledge base and its impact upon the management of tumors, Precision Medicine in Oncology opens up new possibilities and ways of working – not only for oncologists, but also for molecular biologists, radiologists, medical geneticists, and others.

Infections in Hematology

Georg Maschmeyer,Kenneth V.I. Rolston

Author : Georg Maschmeyer,Kenneth V.I. Rolston
Publisher : Springer
Page : 335 pages
File Size : 45,7 Mb
Release : 2014-12-13
Category : Medical
ISBN : 9783662440001

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Infections in Hematology by Georg Maschmeyer,Kenneth V.I. Rolston Pdf

Infections are among the most frequent complications in patients with hematological malignancies and in those undergoing high-dose chemotherapy and autologous hematopoietic stem cell transplantation. A profound knowledge on the epidemiology, diagnostic approaches, treatment modalities and prophylactic strategies is essential for the clinical management of these complications in patients who are often severely immunocompromised owing to their underlying diseases and in particular, the intensive myelosuppressive chemo and immunotherapy. This textbook provides a clinically oriented, compact and up-to-date overview on infections in hematology patients and their management. The typical pathogens to be considered in different subgroups of patients are identified and further aspects of the microbiological background are explored. Clinical, imaging, and laboratory-based diagnostic techniques are discussed and therapeutic strategies appropriate to different situations are then presented, with due attention to the pitfalls, toxicities and interactions that can arise during antimicrobial treatment. Strategies to prevent infection are also outlined, encompassing antimicrobial prophylaxis, isolation procedures, hospital hygiene, protective immunization and the use of hematopoietic growth factors.

Oncology in the Precision Medicine Era

Ravi Salgia

Author : Ravi Salgia
Publisher : Springer Nature
Page : 352 pages
File Size : 51,6 Mb
Release : 2019-12-17
Category : Medical
ISBN : 9783030314712

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Oncology in the Precision Medicine Era by Ravi Salgia Pdf

This volume comprehensively reviews oncology in the precision medicine era of personalized care, latest developments in the field, and indications and clinical trials for the treatment of cancer with targeted therapies, immunotherapy, and epigenetic modulators. It thoroughly addresses concerns of various types of cancers including cancers of the head and neck, lung, colon, esophagus, bladder, pancreas, and breast; melanoma; multiple myeloma; hepatocellular carcinoma; renal cell carcinoma; and sarcomas. It is organized and written in a format that is easy to follow for both clinicians and non-clinical scientists interested in personalized medicine. Chapters cover the identification of the clinical problem and summary of recent findings, tumor biology and heterogeneity, genomics, examples of simple and complex cases, biological pathways, future clinical trials, and financial considerations. Oncology in the Precision Medicine Era: Value-Based Medicine will serve as a useful resource for medical oncologists and healthcare providers tailoring medicine to the needs of the individual patient, from prevention and diagnosis to treatment and follow up.

Small Molecules in Hematology

Uwe M. Martens

Author : Uwe M. Martens
Publisher : Springer
Page : 304 pages
File Size : 42,9 Mb
Release : 2019-08-30
Category : Electronic
ISBN : 3030082563

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Small Molecules in Hematology by Uwe M. Martens Pdf

This book, written by respected experts, discusses in detail the latest developments in targeted therapy for hematologic malignancies using small molecules. It covers a wide range of small molecules including tyrosine kinase inhibitors, immunomodulatory drugs, the IDH-2 inhibitor enasidenib, the BCL-2 inhibitor venetoclax, and the proteasome inhibitor carfilzomib. For each molecule, aspects such as the chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed. Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of precision cancer therapy is now growing rapidly, and the advances being made will mean significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. An accompanying volume addresses the use of small molecules in oncology, and the two volumes together represent the third edition of the book originally published under the same title.

Precision Cancer Medicine

Sameek Roychowdhury,Eliezer M. Van Allen

Author : Sameek Roychowdhury,Eliezer M. Van Allen
Publisher : Springer Nature
Page : 196 pages
File Size : 40,7 Mb
Release : 2020-01-02
Category : Medical
ISBN : 9783030236373

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Precision Cancer Medicine by Sameek Roychowdhury,Eliezer M. Van Allen Pdf

Genomic sequencing technologies have augmented the classification of cancer beyond tissue of origin and towards a molecular taxonomy of cancer. This has created opportunities to guide treatment decisions for individual patients with cancer based on their cancer’s unique molecular characteristics, also known as precision cancer medicine. The purpose of this text will be to describe the contribution and need for multiple disciplines working together to deliver precision cancer medicine. This entails a multi-disciplinary approach across fields including molecular pathology, computational biology, clinical oncology, cancer biology, drug development, genetics, immunology, and bioethics. Thus, we have outlined a current text on each of these fields as they work together to overcome various challenges and create opportunities to deliver precision cancer medicine. As trainees and junior faculty enter their respective fields, this text will provide a framework for understanding the role and responsibility for each specialist to contribute to this team science approach.

Personalized Medicine in Oncology

Ari VanderWalde

Author : Ari VanderWalde
Publisher : Mdpi AG
Page : 190 pages
File Size : 41,8 Mb
Release : 2022-01-25
Category : Electronic
ISBN : 3036528210

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Personalized Medicine in Oncology by Ari VanderWalde Pdf

Nowhere is the explosion in comprehensive genomic testing more evident than in oncology. Multiple consensus guidelines now recommend molecular testing as the standard of care for most metastatic tumors. To aid in the advancement of this rapidly changing field, we intend this Special Issue of JPM to focus on technical developments in the genomic profiling of cancer, detail promising somatic alterations that either are, or have a high likelihood of being, relevant in the near future, and to address issues related to the pricing and value of these tests. The last few years have seen the cost of molecular testing decrease by orders of magnitude. In 2018, we saw the first "site-agnostic" drug approvals in cancer (for microsatellite unstable cancer (PD-1 inhibitors) and NTRK-fusions (TRK inhibitors)). Research on targetable mutations, determination of genetic "signatures" that can use multiple individual genes/pathways, development of targeted therapy, and insight into the value of new technology remains at the cutting edge of research in this field. We are soliciting papers that present new technologies to assess predictive biomarkers in cancer, original research (pre-clinical or clinical) that demonstrates promise for particular targeted therapies in cancer, and articles that explore the clinical and financial impacts of this paradigmatic shift in cancer diagnostics and treatment.

Lung Cancer and Personalized Medicine

Aamir Ahmad,Shirish Gadgeel

Author : Aamir Ahmad,Shirish Gadgeel
Publisher : Springer
Page : 228 pages
File Size : 49,5 Mb
Release : 2015-12-14
Category : Medical
ISBN : 9783319242231

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Lung Cancer and Personalized Medicine by Aamir Ahmad,Shirish Gadgeel Pdf

This, the first of two volumes on personalized medicine in lung cancer, touches on the core issues related to the understanding of lung cancer—statistics and epidemiology of lung cancer—along with the incidence of lung cancer in non-smokers. A major focus of this volume is the state of current therapies against lung cancer—immune, targeted therapies against EGFR TKIs, KRAS, ALK, angiogenesis; the associated challenges, especially resistance mechanisms; and recent progress in targeted drug development based on metal chemistry. Chapters are written by some of the leading experts in the field, who provide a better understanding of lung cancer, the factors that make it lethal, and current research focused on developing personalized treatment plans. With a unique mix of topics, this volume summarizes the current state-of-knowledge on lung cancer and the available therapies.

Precision Medicine in Cancer Therapy

Daniel D. Von Hoff,Haiyong Han

Author : Daniel D. Von Hoff,Haiyong Han
Publisher : Springer
Page : 283 pages
File Size : 41,6 Mb
Release : 2019-06-17
Category : Medical
ISBN : 9783030163914

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Precision Medicine in Cancer Therapy by Daniel D. Von Hoff,Haiyong Han Pdf

This book presents the latest advances in precision medicine in some of the most common cancer types, including hematological, lung and breast malignancies. It also discusses emerging technologies that are making a significant impact on precision medicine in cancer therapy. In addition to describing specific approaches that have already entered clinical practice, the book explores new concepts and tools that are being developed. Precision medicine aims to deliver personalized healthcare tailored to a patient’s genetics, lifestyle and environment, and cancer therapy is one of the areas in which it has flourished in recent years. Documenting the latest advances, this book is of interest to physicians and clinical fellows in the front line of the war on cancer, as well as to basic scientists working in the fields of cancer biology, drug development, biomarker discovery, and biomedical engineering. The contributing authors include translational physicians with first-hand experience in precision patient care.

Policy Issues in the Clinical Development and Use of Immunotherapy for Cancer Treatment

National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,National Cancer Policy Forum

Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,National Cancer Policy Forum
Publisher : National Academies Press
Page : 135 pages
File Size : 49,8 Mb
Release : 2016-12-10
Category : Medical
ISBN : 9780309442329

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Policy Issues in the Clinical Development and Use of Immunotherapy for Cancer Treatment by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,National Cancer Policy Forum Pdf

Immunotherapy is a form of cancer therapy that harnesses the body's immune system to destroy cancer cells. In recent years, immunotherapies have been developed for several cancers, including advanced melanoma, lung cancer, and kidney cancer. In some patients with metastatic cancers who have not responded well to other treatments, immunotherapy treatment has resulted in complete and durable responses. Given these promising findings, it is hoped that continued immunotherapy research and development will produce better cancer treatments that improve patient outcomes. With this promise, however, there is also recognition that the clinical and biological landscape for immunotherapies is novel and not yet well understood. For example, adverse events with immunotherapy treatment are quite different from those experienced with other types of cancer therapy. Similarly, immunotherapy dosing, therapeutic responses, and response time lines are also markedly different from other cancer therapies. To examine these challenges and explore strategies to overcome them, the National Academies of Sciences, Engineering, and Medicine held a workshop in February and March of 2016. This report summarizes the presentations and discussions from the workshop.

Therapy Response Imaging in Oncology

Mizuki Nishino

Author : Mizuki Nishino
Publisher : Springer Nature
Page : 266 pages
File Size : 53,5 Mb
Release : 2020-01-07
Category : Medical
ISBN : 9783030311711

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Therapy Response Imaging in Oncology by Mizuki Nishino Pdf

This book is a detailed guide to therapy response imaging in cancer patients that fully takes into account the revolutionary progress and paradigm shift in treatment approaches for advanced disease. The opening chapters describe the role of imaging as a “common language” for tumor response evaluation in oncology and address challenges and strategies in the era of precision cancer therapy and cancer immunotherapy. Practical pitfalls are discussed, with emphasis on the importance of approaching cancer as a systemic disease and the need for increased awareness of drug toxicity due to novel therapies. Therapy response imaging in a wide range of cancer types is then comprehensively described and illustrated, using a disease-specific approach. A concluding section focuses on emerging approaches and future directions, including radiomics/radiogenomics, co-clinical imaging, and molecular and functional imaging. Therapy Response Imaging in Oncology will be of high value for radiologists, nuclear medicine physicians, and oncologists. It will also be of interest to cancer care providers and oncology trial investigators.

'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine

Nosheen Masood,Saima Shakil Malik

Author : Nosheen Masood,Saima Shakil Malik
Publisher : Springer Nature
Page : 499 pages
File Size : 46,8 Mb
Release : 2020-03-20
Category : Medical
ISBN : 9789811510670

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'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine by Nosheen Masood,Saima Shakil Malik Pdf

This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.

Pathology of Laboratory Animals

Kurt Benirschke,F.M. Garner,T.C. Jones

Author : Kurt Benirschke,F.M. Garner,T.C. Jones
Publisher : Springer Science & Business Media
Page : 1050 pages
File Size : 50,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461299424

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Pathology of Laboratory Animals by Kurt Benirschke,F.M. Garner,T.C. Jones Pdf

Laboratory Animal Medicine has made enor We deeply appreciate the efforts of each of the mous strides in the 47 years since R. Jaffe published authors and co-authors of the 23 chapters in this his "Anatomy and Pathology of Spontaneous Dis two volume work. In some instances the reader will eases of Small Laboratory Animals" in 1931. So note what appears to be repetition in certain chap ters. This repetition was allowed to stand in some much new information had accumulated that in a cases because different approaches seemed useful, new edition in 1958, Jaffe, aided by Cohrs and Meessen, needed the assistance of 46 colleagues to although efforts were made to delete most of the do the subject justice. Like its predecessor, this two redundancy which inevitably arises in a venture of volume comprehensive treatise on "Pathologie der this kind. We will be grateful if our colleagues point out errors and send us specific and general Laboratoriumstiere" was written in German and criticism of this work to allow corrections in the thus not readily available to the widening circle of event of reprinting or a next edition. veterinarians and pathologists who now are inter One objective has been to assemble current in ested in laboratory animals. Aside from the need to have a comprehensive formation in the pathologic aspects of diseases of review of laboratory animal pathology in English, laboratory animals.

Economic Evaluation in Genomic Medicine

Vasilios Fragoulakis,Christina Mitropoulou,Marc Williams,George P. Patrinos

Author : Vasilios Fragoulakis,Christina Mitropoulou,Marc Williams,George P. Patrinos
Publisher : Academic Press
Page : 174 pages
File Size : 45,7 Mb
Release : 2015-03-20
Category : Science
ISBN : 9780128016114

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Economic Evaluation in Genomic Medicine by Vasilios Fragoulakis,Christina Mitropoulou,Marc Williams,George P. Patrinos Pdf

Economic Evaluation in Genomic Medicine introduces health economics and economic evaluation to genomic clinicians and researchers, while also introducing the topic to health economists. Each chapter includes an executive summary, questions, and case studies, along with supplementary online materials, including process guides, maps, flow charts, diagrams, and economic evaluation spreadsheets to enhance the learning process. The text can easily be used as course material for related graduate and undergraduate courses, providing a succinct overview of the existing, state-of-the-art application of economic evaluation to genomic healthcare and precision medicine. Interrelates economic evaluation and genomic medicine Instructs healthcare professionals and bioscientists about economic evaluation in genomic medicine Teaches health economists about application of economic evaluation in genomic medicine Introduces health economics and economic evaluation to clinicians and researchers involved in genomics Includes process guides, maps, flow charts and diagrams

Precision Haematological Cancer Medicine

Precision Haematological Cancer Medicine by Tariq Mughal Pdf

Problem Solving through Precision Oncology by Peter Selby Pdf

Precision Medicine in Oncology by Bulent Aydogan,James A. Radosevich Pdf

Infections in Hematology by Georg Maschmeyer,Kenneth V.I. Rolston Pdf

Oncology in the Precision Medicine Era by Ravi Salgia Pdf

Small Molecules in Hematology by Uwe M. Martens Pdf

Precision Cancer Medicine by Sameek Roychowdhury,Eliezer M. Van Allen Pdf

Personalized Medicine in Oncology by Ari VanderWalde Pdf

Lung Cancer and Personalized Medicine by Aamir Ahmad,Shirish Gadgeel Pdf

Precision Medicine in Cancer Therapy by Daniel D. Von Hoff,Haiyong Han Pdf

Policy Issues in the Clinical Development and Use of Immunotherapy for Cancer Treatment by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Care Services,National Cancer Policy Forum Pdf

Therapy Response Imaging in Oncology by Mizuki Nishino Pdf

'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine by Nosheen Masood,Saima Shakil Malik Pdf

Pathology of Laboratory Animals by Kurt Benirschke,F.M. Garner,T.C. Jones Pdf

Economic Evaluation in Genomic Medicine by Vasilios Fragoulakis,Christina Mitropoulou,Marc Williams,George P. Patrinos Pdf

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