Lung Cancer And Personalized Medicine

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Lung Cancer and Personalized Medicine

Aamir Ahmad,Shirish Gadgeel
Lung Cancer and Personalized Medicine Book PDF

Author : Aamir Ahmad,Shirish Gadgeel
Publisher : Springer
Page : 228 pages
File Size : 40,6 Mb
Release : 2015-12-14
Category : Medical
ISBN : 9783319242231

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Lung Cancer and Personalized Medicine by Aamir Ahmad,Shirish Gadgeel Pdf

This, the first of two volumes on personalized medicine in lung cancer, touches on the core issues related to the understanding of lung cancer—statistics and epidemiology of lung cancer—along with the incidence of lung cancer in non-smokers. A major focus of this volume is the state of current therapies against lung cancer—immune, targeted therapies against EGFR TKIs, KRAS, ALK, angiogenesis; the associated challenges, especially resistance mechanisms; and recent progress in targeted drug development based on metal chemistry. Chapters are written by some of the leading experts in the field, who provide a better understanding of lung cancer, the factors that make it lethal, and current research focused on developing personalized treatment plans. With a unique mix of topics, this volume summarizes the current state-of-knowledge on lung cancer and the available therapies.

Lung Cancer and Personalized Medicine: Novel Therapies and Clinical Management

Aamir Ahmad,Shirish M. Gadgeel
Lung Cancer and Personalized Medicine Novel Therapies and Clinical Management Book PDF

Author : Aamir Ahmad,Shirish M. Gadgeel
Publisher : Springer
Page : 231 pages
File Size : 46,5 Mb
Release : 2015-12-24
Category : Medical
ISBN : 9783319249322

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Lung Cancer and Personalized Medicine: Novel Therapies and Clinical Management by Aamir Ahmad,Shirish M. Gadgeel Pdf

This, the second of two volumes on personalized medicine in lung cancer, touches upon the recent progress in targeted drug development based on genomics; emerging biomarkers and therapeutic targets such as EMT, cancer stem cells, and the tumor microenvironment; current personalized clinical management and radiation therapy for lung cancers; and the promise of epigenetics and next-generation sequencing for the advancements towards personalized therapy of lung cancer patients. With chapters on state-of-the-art therapies and technologies written by leading experts working to develop novel companion diagnosis tools for the personalized treatment of lung cancer patients, this volume brings readers up-to-date by presenting the current knowledge on the efforts to make personalized management of lung cancer patients a reality.

Lung Cancer and Personalized Medicine

Anonim
Lung Cancer and Personalized Medicine Book PDF

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 47,9 Mb
Release : 2016
Category : Lungs
ISBN : 3319249339

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Lung Cancer and Personalized Medicine by Anonim Pdf

This, the second of two volumes on personalized medicine in lung cancer, touches upon the recent progress in targeted drug development based on genomics; emerging biomarkers and therapeutic targets such as EMT, cancer stem cells, and the tumor microenvironment; current personalized clinical management and radiation therapy for lung cancers; and the promise of epigenetics and next-generation sequencing for the advancements towards personalized therapy of lung cancer patients. With chapters on state-of-the-art therapies and technologies written by leading experts working to develop novel companion diagnosis tools for the personalized treatment of lung cancer patients, this volume brings readers up-to-date by presenting the current knowledge on the efforts to make personalized management of lung cancer patients a reality.

Update on the Treatment of Metastatic Non-small Cell Lung Cancer (NSCLC) in New Era of Personalised Medicine

Vera Hirsh,Barbara Melosky
Update on the Treatment of Metastatic Non small Cell Lung Cancer NSCLC in New Era of Personalised Medicine Book PDF

Author : Vera Hirsh,Barbara Melosky
Publisher : Frontiers Media SA
Page : 95 pages
File Size : 47,8 Mb
Release : 2018-01-24
Category : Electronic
ISBN : 9782889453979

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Update on the Treatment of Metastatic Non-small Cell Lung Cancer (NSCLC) in New Era of Personalised Medicine by Vera Hirsh,Barbara Melosky Pdf

Lung cancer remains a major cause of death in of both women and men in our society. Lung cancer treatment paradigms have changed enormously as we’ve started to understand the genetic complexity and the multiple driver mutations influencing the disease. Therapeutics directed towards, or to inhibit signaling pathways has resulted in increased life spans for our patients. Over the last two decades, we have gone from simple chemotherapy used to treat all, to a personalized medicine approach for the majority. For non-small cell lung cancer patients without driver mutations, the world of immune oncology has arrived. These improved long-term outcomes mean that now our lung cancer patients can live with their cancers, but without progression. The aim of this book is to catalogue the current state of knowledge for the many facets of advanced lung cancer. It describes current treatment approaches for driver mutations, rare mutations, and rare thoracic malignancies such as neuroendocrine tumors. Most importantly, this book addresses the topics of palliative treatment and care which allow our patients to enjoy longer survival with the highest quality of life. We hope you enjoy this e-book. The future is brighter for lung cancer patients and as lung cancer specialists; we finally feel sense optimism about treatment options for our patients.

Molecular Pathology of Lung Cancer

Philip T. Cagle,Timothy Craig Allen,Mary Beth Beasley,Lucian R. Chirieac,Sanja Dacic,Alain C. Borczuk,Keith M. Kerr
Molecular Pathology of Lung Cancer Book PDF

Author : Philip T. Cagle,Timothy Craig Allen,Mary Beth Beasley,Lucian R. Chirieac,Sanja Dacic,Alain C. Borczuk,Keith M. Kerr
Publisher : Springer Science & Business Media
Page : 216 pages
File Size : 52,8 Mb
Release : 2012-06-14
Category : Medical
ISBN : 9781461431978

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Molecular Pathology of Lung Cancer by Philip T. Cagle,Timothy Craig Allen,Mary Beth Beasley,Lucian R. Chirieac,Sanja Dacic,Alain C. Borczuk,Keith M. Kerr Pdf

As with other books in the Molecular Pathology Library Series, Molecular Pathology of Lung Cancer bridges the gap between the molecular specialist and the clinical practitioner, including the surgical pathologist who now has a key role in decisions regarding molecular targeted therapy for lung cancer. Molecular Pathology of Lung Cancer provides the latest information and current insights into the molecular basis for lung cancer, including precursor and preinvasive lesions, molecular diagnosis, molecular targeted therapy, molecular prognosis, molecular radiology and related fields for lung cancer generally and for the specific cell types. As many fundamental concepts about lung cancer have undergone revision in only the past few years, this book will likely be the first to comprehensively cover the new molecular pathology of lung cancer. It provides a foundation in this field for pathologists, medical oncologists, radiation oncologists, thoracic surgeons, thoracic radiologists and their trainees, physician assistants, and nursing staff.

Update on the Treatment of Metastatic Non-small Cell Lung Cancer (NSCLC) in New Era of Personalised Medicine

Anonim
Update on the Treatment of Metastatic Non small Cell Lung Cancer NSCLC in New Era of Personalised Medicine Book PDF

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 51,7 Mb
Release : 2018
Category : Electronic
ISBN : OCLC:1368434024

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Update on the Treatment of Metastatic Non-small Cell Lung Cancer (NSCLC) in New Era of Personalised Medicine by Anonim Pdf

Lung Cancer remains a major cause of death in of both women and men in our society. Lung cancer treatment paradigms have changed enormously as we've started to understand the genetic complexity and the multiple driver mutations influencing the disease. Therapeutics directed towards, or to inhibit signaling pathways has resulted in increased life spans for our patients. Over the last two decades, we have gone from simple chemotherapy used to treat all, to a personalized medicine approach for the majority. For non-small cell lung cancer patients without driver mutations, the world of immune oncology has arrived. These improved long-term outcomes mean that now our lung cancer patients can live with their cancers, but without progression. The aim of this book is to catalogue the current state of knowledge for the many facets of advanced lung cancer. It describes current treatment approaches for driver mutations, rare mutations, and rare thoracic malignancies such as neuroendocrine tumors. Most importantly, this book addresses the topics of palliative treatment and care which allow our patients to enjoy longer survival with the highest quality of life. We hope you enjoy this e-book. The future is brighter for lung cancer patients and as lung cancer specialists; we finally feel sense optimism about treatment options for our patients.

The Treatment of Metastatic Non-small Cell Lung Cancer (NSCLC) in New Era of Personalised Medicine

Vera Hirsh,Barbara Melosky
The Treatment of Metastatic Non small Cell Lung Cancer NSCLC in New Era of Personalised Medicine Book PDF

Author : Vera Hirsh,Barbara Melosky
Publisher : Frontiers Media SA
Page : 142 pages
File Size : 44,8 Mb
Release : 2015-10-20
Category : Medicine (General)
ISBN : 9782889195435

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The Treatment of Metastatic Non-small Cell Lung Cancer (NSCLC) in New Era of Personalised Medicine by Vera Hirsh,Barbara Melosky Pdf

Lung cancer is the leading cause of cancer related mortality in Canada and USA. Majority of the patients present in advanced stage of the disease and of these only about 2% will be alive at 5 years. NSCLC is the most common form of lung cancer, accounting for approximately 87% of cases. Systemic chemotherapies have been used to treat metastatic NSCLC for decades, but the improvements of outcomes have reached a plateau. Recent advances in understanding signalling pathways for malignant cells, their interconections,the importance of various receptors and biomarkers and the interplay between various oncogenes have led to the development of targeted treatments that are improving both efficacy and safety of the treatments. Knowledge about the advantages of treatments with the targeted agents in metastatic NSCLC is growing rapidly. Combining various targeted agents or sequencing them properly will be important in the era of personalised medicine and overcoming development of the resistence to various targeted agents will be challenging. The importance of a team work,from the diagnosis through various treatments, to supportive care, from the interventional radiologists, pneumologists or surgeons, who have to obtain a satisfactory tumor tissue specimen, to pathologists, radiation and medical oncologists, to supportive care specialists, will be described in our publications. We will cover completely present and future approaches to personalised medicine in this rapidly evolving field of metastatic NSCLC.

Precision Medicine in Cancer Therapy

Daniel D. Von Hoff,Haiyong Han
Precision Medicine in Cancer Therapy Book PDF

Author : Daniel D. Von Hoff,Haiyong Han
Publisher : Springer
Page : 283 pages
File Size : 51,7 Mb
Release : 2019-06-17
Category : Medical
ISBN : 9783030163914

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Precision Medicine in Cancer Therapy by Daniel D. Von Hoff,Haiyong Han Pdf

This book presents the latest advances in precision medicine in some of the most common cancer types, including hematological, lung and breast malignancies. It also discusses emerging technologies that are making a significant impact on precision medicine in cancer therapy. In addition to describing specific approaches that have already entered clinical practice, the book explores new concepts and tools that are being developed. Precision medicine aims to deliver personalized healthcare tailored to a patient’s genetics, lifestyle and environment, and cancer therapy is one of the areas in which it has flourished in recent years. Documenting the latest advances, this book is of interest to physicians and clinical fellows in the front line of the war on cancer, as well as to basic scientists working in the fields of cancer biology, drug development, biomarker discovery, and biomedical engineering. The contributing authors include translational physicians with first-hand experience in precision patient care.

Cancer Genetics and Genomics for Personalized Medicine

Il-Jin Kim
Cancer Genetics and Genomics for Personalized Medicine Book PDF

Author : Il-Jin Kim
Publisher : CRC Press
Page : 230 pages
File Size : 52,9 Mb
Release : 2017-04-11
Category : Medical
ISBN : 9781315341101

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Cancer Genetics and Genomics for Personalized Medicine by Il-Jin Kim Pdf

This book covers almost all fields of cancer genetics and genomics for personalized medicine. Targeted therapy, or precision medicine, or personalized medicine is becoming a standard treatment for many diseases, including cancer. However, how much do we know about the personalized medicine approach? This lucid book helps undergraduate and graduate students, professional researchers, and clinicians to better understand the key concept of personalized medicine. The most up-to-date topics on personalized medicine in this book cover the recent trends in and updates on lung, gastric, liver, breast, and other types of cancers. Circulating tumor cell, cell-free circulating DNA, and microRNAs are discussed as new diagnostic and prognostic markers for cancer. The avatar mouse model is also discussed for maximizing treatment efficacy and prognosis prediction, and so is microenvironment as a drug resistance mechanism. With classical and new pathological approaches, the book provides a systemic overview of personalized immunotherapies and hyperthermic intraperitoneal chemotherapy, followed by new emerging fields of hereditary cancer, thereby equipping readers to eventually contribute in developing more advanced tools and therapies for curing cancer.

Lung Cancer

Henry S. Park
Lung Cancer Book PDF

Author : Henry S. Park
Publisher : BoD – Books on Demand
Page : 226 pages
File Size : 41,7 Mb
Release : 2021-06-02
Category : Medical
ISBN : 9781789855753

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Lung Cancer by Henry S. Park Pdf

Lung cancer continues to be the leading cause of cancer mortality worldwide among both men and women. Recent advances in prevention, screening and management in the past decade have led to significant improvements in survival and quality of life. Local treatments like minimally invasive surgery, radiotherapy, and image-guided ablation have contributed to improving the effectiveness and tolerability of potentially curative treatments in early-stage, locally advanced, and oligometastatic/oligoprogressive disease. Chemotherapy, targeted therapy, immunotherapy, and palliative local therapy options have expanded rapidly, with new regimens showing improved outcomes even for those with widely metastatic disease. This book comprehensively reviews the evidence that has driven personalized medicine, based on a variety of multidisciplinary perspectives by international lung cancer experts.

Lung Cancer Unveiled: From Research to Personalized Care

Dr. Spineanu Eugenia
Lung Cancer Unveiled From Research to Personalized Care Book PDF

Author : Dr. Spineanu Eugenia
Publisher : Dr. Spineanu Eugenia
Page : 227 pages
File Size : 49,6 Mb
Release : 2024-03-03
Category : Medical
ISBN : 8210379456XXX

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Lung Cancer Unveiled: From Research to Personalized Care by Dr. Spineanu Eugenia Pdf

Unlock the secrets of lung cancer in "Lung Cancer Unveiled: From Research to Personalized Care." Delve into the world of cutting-edge research, revolutionary treatments, and the global efforts that are reshaping the landscape of lung cancer care. In this comprehensive treatise, you'll embark on a journey through the intricate web of lung cancer, exploring its multifaceted nature and the global collaborations that are driving progress. Discover how epidemiology and risk factors play a pivotal role in shaping the incidence of lung cancer and how early detection technologies are transforming the odds for patients. With a focus on personalized treatment approaches, this treatise unveils the power of precision medicine in lung cancer care. Explore genetic profiling, molecular biomarkers, and immunotherapy innovations that are redefining how we combat this deadly disease. Learn how personalized treatment strategies are offering patients not just hope, but real outcomes that extend survival and enhance quality of life. But "Lung Cancer Unveiled" goes beyond the science. It delves into the global efforts, advocacy, and healthcare policies that are shaping the future of lung cancer care. Gain insights into the collaborative initiatives, research advancements, and challenges that researchers, clinicians, and organizations worldwide are tackling head-on. If you seek knowledge, hope, and actionable insights into lung cancer, this treatise is your comprehensive guide. With its SEO-optimized content, it's designed not just to inform but also to reach those who need it most. Join us on this journey through the world of lung cancer research, and discover how we're unveiling a brighter future for patients and their families.

Targeted Therapies in Lung Cancer: Management Strategies for Nurses and Practitioners

Marianne Davies,Beth Eaby-Sandy
Targeted Therapies in Lung Cancer Management Strategies for Nurses and Practitioners Book PDF

Author : Marianne Davies,Beth Eaby-Sandy
Publisher : Springer
Page : 120 pages
File Size : 45,6 Mb
Release : 2019-07-16
Category : Medical
ISBN : 9783030165505

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Targeted Therapies in Lung Cancer: Management Strategies for Nurses and Practitioners by Marianne Davies,Beth Eaby-Sandy Pdf

This book aims to educate nurses and advanced practice providers (APP’s) about known mutations, availability of targeted therapy and the management of patients with non-small cell lung cancer (NSCLC). It will educate nurses and practitioners about the scope of therapy to assure safe and effective lung cancer treatment. In this era of personalized medicine, nurses and APP’s are responsible for guiding patients from diagnosis through treatment. This starts with the identification of patients that can benefit from these therapies, the key role of biopsy acquisition (ie. what to test, when and how often) and treatment selection based on the mutation identified. Readers will learn about the mechanisms of action, administration, potential adverse side effects and unique management strategies for these targeted agents. Lung cancer continues to be the leading cause of cancer death in the United States and worldwide. Recent advances in the identification of specific oncogenic mutations that drive cancer development, growth and metastasis have led to major paradigm shifts in lung cancer treatment. Sophisticated methods are required to identify specific mutations at the time of diagnosis. This book explains how molecularly targeted therapies have been developed that target these drivers. To date, several tyrosine kinase inhibitors have been approved to target the epidermal growth factor receptor (EGFR), EML4-ALK ,ROS1 and BRAF. Most recently, immune checkpoint inhibitors have been approved with some indication that efficacy may be enhanced for patients who overexpress PD-L1. While some driver mutations have been identified, there is ongoing investigation into additional mutations. In the case of driver mutations, lung cancers will develop resistance to therapy. This book provides nurses and APP’s with the mechanisms of resistance that have been identified such as T790 mutation and many others in the EGFR mutation, and shows how the next level of drug development is focused on identifying mechanisms of resistance and development of new agents that overcome these mutations. With this book in hand, nurses and practitioners will be able to navigate patients through this ever expanding field of lung cancer treatment.

Oncology in the Precision Medicine Era

Ravi Salgia
Oncology in the Precision Medicine Era Book PDF

Author : Ravi Salgia
Publisher : Springer Nature
Page : 352 pages
File Size : 48,7 Mb
Release : 2019-12-17
Category : Medical
ISBN : 9783030314712

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Oncology in the Precision Medicine Era by Ravi Salgia Pdf

This volume comprehensively reviews oncology in the precision medicine era of personalized care, latest developments in the field, and indications and clinical trials for the treatment of cancer with targeted therapies, immunotherapy, and epigenetic modulators. It thoroughly addresses concerns of various types of cancers including cancers of the head and neck, lung, colon, esophagus, bladder, pancreas, and breast; melanoma; multiple myeloma; hepatocellular carcinoma; renal cell carcinoma; and sarcomas. It is organized and written in a format that is easy to follow for both clinicians and non-clinical scientists interested in personalized medicine. Chapters cover the identification of the clinical problem and summary of recent findings, tumor biology and heterogeneity, genomics, examples of simple and complex cases, biological pathways, future clinical trials, and financial considerations. Oncology in the Precision Medicine Era: Value-Based Medicine will serve as a useful resource for medical oncologists and healthcare providers tailoring medicine to the needs of the individual patient, from prevention and diagnosis to treatment and follow up.

Precision Medicine in Oncology

Bulent Aydogan,James A. Radosevich
Precision Medicine in Oncology Book PDF

Author : Bulent Aydogan,James A. Radosevich
Publisher : John Wiley & Sons
Page : 288 pages
File Size : 45,8 Mb
Release : 2020-11-02
Category : Medical
ISBN : 9781119432449

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Precision Medicine in Oncology by Bulent Aydogan,James A. Radosevich Pdf

A FRESH EXAMINATION OF PRECISION MEDICINE'S INCREASINGLY PROMINENT ROLE IN THE FIELD OF ONCOLOGY Precision medicine takes into account each patient's specific characteristics and requirements to arrive at treatment plans that are optimized towards the best possible outcome. As the field of oncology continues to advance, this tailored approach is becoming more and more prevalent, channelling data on genomics, proteomics, metabolomics and other areas into new and innovative methods of practice. Precision Medicine in Oncology draws together the essential research driving the field forward, providing oncology clinicians and trainees alike with an illuminating overview of the technology and thinking behind the breakthroughs currently being made. Topics covered include: Biologically-guided radiation therapy Informatics for precision medicine Molecular imaging Biomarkers for treatment assessment Big data Nanoplatforms Casting a spotlight on this emerging knowledge base and its impact upon the management of tumors, Precision Medicine in Oncology opens up new possibilities and ways of working – not only for oncologists, but also for molecular biologists, radiologists, medical geneticists, and others.

Targeted Therapies for Lung Cancer

Ravi Salgia
Targeted Therapies for Lung Cancer Book PDF

Author : Ravi Salgia
Publisher : Springer
Page : 238 pages
File Size : 47,8 Mb
Release : 2019-06-26
Category : Medical
ISBN : 9783030178321

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Targeted Therapies for Lung Cancer by Ravi Salgia Pdf

This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient’s genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.