Precision Molecular Pathology Of Glioblastoma

Author : José Javier Otero,Aline Paixao Becker
Publisher : Springer Nature
Page : 266 pages
File Size : 45,8 Mb
Release : 2021-04-30
Category : Medical
ISBN : 9783030691707

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Precision Molecular Pathology of Glioblastoma by José Javier Otero,Aline Paixao Becker Pdf

This volume provides a balanced and realistic review of the current state of glioblastoma, ranging from traditional histological review, molecular pathology of glioma, modern radiomics, neurosurgical focus, and integration of treatment plans by neuro-oncologists. The book reviews basic principles such as epidemiology and etiology, and modern 2016 WHO classification of CNS tumors. Chapters cover a general overview of common molecular techniques used in molecular pathology, molecular pathology in a developing country, key drivers of patient outcomes and predictors of response to radiation and/or chemotherapy treatment, and immunohistochemical surrogates for key molecular pathology. It concludes with reviews on radiomics, animal and stem cell models of glioblastoma, and a chapter on the emerging field of Glioblastoma Neuroscience. Precision Molecular Pathology of Glioblastoma is intended for pathology residents and fellows interested in glioblastoma, general surgical pathologists who need reviews on how to implement modern glioblastoma classification, as well as neuro-radiologists, oncologists, and radiation oncologists needing a holistic perspective to glioblastoma diagnosis and management.

Author : Larissa V. Furtado,Aliya N. Husain
Publisher : Springer
Page : 360 pages
File Size : 41,9 Mb
Release : 2018-08-01
Category : Medical
ISBN : 9783319896267

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Precision Molecular Pathology of Neoplastic Pediatric Diseases by Larissa V. Furtado,Aliya N. Husain Pdf

This book provides a comprehensive, state-of-the art review of pediatric oncology. The text covers relevant concepts in molecular biology and addresses technical principles, applications, challenges, and integration of current and emerging genomic and molecular methods in the diagnosis and personalized management of childhood cancers. The text also discusses a wide array of pediatric neoplasms in the context of molecular pathology in a concise and understandable manner, with focus on their molecular pathogenesis, clinicopathological features, classification, molecular diagnosis, and approaches to personalized care. Written by experts in the field, Precision Molecular Pathology of Neoplastic Pediatric Diseases serves as a valuable resource for pathologists, pediatric oncologists, trainees and researchers with an interest in pediatric and molecular pathology.

Author : Philip T. Cagle,Timothy Craig Allen,Mary Beth Beasley,Lucian R. Chirieac,Sanja Dacic,Alain C. Borczuk,Keith M. Kerr,Lynette M. Sholl,Bryce Portier,Eric H. Bernicker
Publisher : Springer
Page : 296 pages
File Size : 55,9 Mb
Release : 2017-11-10
Category : Medical
ISBN : 9783319629414

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Precision Molecular Pathology of Lung Cancer by Philip T. Cagle,Timothy Craig Allen,Mary Beth Beasley,Lucian R. Chirieac,Sanja Dacic,Alain C. Borczuk,Keith M. Kerr,Lynette M. Sholl,Bryce Portier,Eric H. Bernicker Pdf

This new edition provides the latest information and insights into the molecular basis for lung cancer. Since the publication of the previous edition of this volume, dramatic changes have occurred with the classification of lung cancer, biomarker testing, and molecular therapy. The book covers these changes, providing updates and new insights on the background of lung cancer, testing methods, and the molecular pathology of specific cell types, including adenocarcinoma, squamous cell carcinoma, small cell carcinoma, and precursor and preinvasive lesions. Authored by experts in the field, Precision Molecular Pathology of Lung Cancer, Second Edition remains one of the few books that comprehensively covers the new molecular pathology of lung cancer and is a valuable resource for pathologists, medical oncologists, radiation oncologists, thoracic surgeons, and thoracic radiologists.

Author : Chen Liu
Publisher : Springer
Page : 271 pages
File Size : 45,8 Mb
Release : 2018-01-09
Category : Medical
ISBN : 9783319680828

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Precision Molecular Pathology of Liver Cancer by Chen Liu Pdf

This volume provides the most updated knowledge on the advancement of molecular pathogenesis, molecular diagnosis, and therapy development for hepatocellular carcinoma (HCC). Topics covered include the etiology and pathogenesis of HCC, recent advances in HCC genomics, biomarker discovery and validation in HCC diagnosis, the role of liver biopsy in HCC early diagnosis, and the future prospects of surgical approaches and targeted therapy for HCC. In addition to reviewing the current available knowledge, the book also discusses the future development of a precision and personalized medicine approach for HCC. Written by experts in the field, Precision Molecular Pathology of Liver Cancer is a concise yet comprehensive resource for practitioners who treat patients with hepatocellular carcinoma.

Author : Chung-Che (Jeff) Chang,Robert S. Ohgami
Publisher : Springer
Page : 427 pages
File Size : 50,5 Mb
Release : 2017-09-25
Category : Medical
ISBN : 9783319621463

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Precision Molecular Pathology of Myeloid Neoplasms by Chung-Che (Jeff) Chang,Robert S. Ohgami Pdf

This volume provides a comprehensive, state-of-the art review of myeloid neoplasms. The book presents updated information on epidemiology, clinical presentation, morphologic findings, molecular genomic abnormalities, pathogenesis, and target therapies. The text helps to guide accurate diagnosis, the administration of appropriate ancillary molecular tests, patient management, and investigative efforts. The book also includes over 200 illustrations, photographs, and tables. Written by experts in the field, Precision Molecular Pathology of Myeloid Neoplasms serves as a valuable resource for pathologists, hematologists/oncologists, fellows, and researchers in understanding the molecular pathology of myeloid neoplasms.

Author : Donna E. Hansel,Seth P. Lerner
Publisher : Springer
Page : 243 pages
File Size : 53,6 Mb
Release : 2018-01-05
Category : Medical
ISBN : 9783319647692

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Precision Molecular Pathology of Bladder Cancer by Donna E. Hansel,Seth P. Lerner Pdf

This succinct yet comprehensive volume describes current and emerging concepts in molecular pathology of bladder cancer. Divided into two distinct sections, the first part focuses on the general principles of molecular findings in bladder cancer, while the second part focuses on the molecular changes associated with specific histologic subtypes. The volume also addresses such topics as molecular alterations in non-invasive and invasive disease, including bladder cancer variants as appropriate, emerging molecular classifiers of bladder cancer, and molecular associations to outcome and treatment. Written by experts in the field, Precision Molecular Pathology of Bladder Cancer is a valuable resource for those in the urologic community, including urologic pathologists, urologists, urologic oncologists and radiation oncologists, who treat and manage bladder cancer.

Author : Brian D. Robinson,Juan Miguel Mosquera,Jae Y. Ro,Mukul Divatia
Publisher : Springer
Page : 570 pages
File Size : 54,5 Mb
Release : 2018-02-13
Category : Medical
ISBN : 9783319640969

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Precision Molecular Pathology of Prostate Cancer by Brian D. Robinson,Juan Miguel Mosquera,Jae Y. Ro,Mukul Divatia Pdf

This volume focuses on our current understanding of the molecular underpinnings of prostate cancer and their potential application for precision medicine approaches. The emergence and applications of new technologies has allowed for a rapid expansion of our understanding of the molecular basis of prostate cancer and has revealed a remarkable genetic heterogeneity that may underlie the clinically variable behavior of the disease. The book consists of five sections which provide insight about the following: (1) General principles; (2) Molecular signatures of primary prostate cancer; (3) Molecular signatures of advanced prostate cancer; (4) Key molecular pathways in prostate cancer development and progression; (5) and Precision medicine approach: Diagnosis, treatment, prognosis. Precision Molecular Pathology of Prostate Cancer is an important resource for the practicing oncologist, urologist, and pathologist, and will also be useful for researchers in the prostate cancer community.

Author : Michael T. Deavers,Donna M. Coffey
Publisher : Springer
Page : 286 pages
File Size : 43,8 Mb
Release : 2017-10-28
Category : Medical
ISBN : 9783319579856

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Precision Molecular Pathology of Uterine Cancer by Michael T. Deavers,Donna M. Coffey Pdf

This text provides a comprehensive review for practicing pathologists to understand the molecular biology, diagnostics, and predictive markers and implications for therapy of uterine cancer. While molecular based therapeutic strategies for uterine cancer are not as well developed as for some other organ sites, these are the most common gynecologic malignancies and there have been many important recent developments that are discussed in this volume. Comprehensive chapters address essential information about endometrial carcinoma, uterine mesenchymal tumors, and cervical carcinoma and include the pathogenesis of carcinoma and discuss molecular based classification, biomarkers, therapy, prevention, and hereditary cancers of the uterus. Precision Molecular Pathology of Uterine Cancer is a unique and one of a kind resource for practicing pathologists, pathologists in training and gynecologists.

Author : Thomas James Deeley,Thomas J. Deeley
Publisher : Unknown
Page : 346 pages
File Size : 40,5 Mb
Release : 1974
Category : Medical
ISBN : UOM:39015000297740

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Central Nervous System Tumours by Thomas James Deeley,Thomas J. Deeley Pdf

Author : Ashraf Khan,Ian O. Ellis,Andrew M. Hanby,Ediz F. Cosar,Emad A. Rakha,Dina Kandil
Publisher : Springer
Page : 338 pages
File Size : 41,9 Mb
Release : 2015-08-12
Category : Medical
ISBN : 9781493928866

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Precision Molecular Pathology of Breast Cancer by Ashraf Khan,Ian O. Ellis,Andrew M. Hanby,Ediz F. Cosar,Emad A. Rakha,Dina Kandil Pdf

This volume provides a comprehensive review of the molecular mechanisms involved in precancerous lesions and benign and malignant breast tumors. Given the complex molecular pathways in breast cancer biology, the book simplifies these complex mechanisms and highlights the practical issues important for daily practice. Sections are structured to review breast carcinogenesis and the role of familial predisposition and stem cells in initiation and progression of breast cancer. In-depth chapters present morphologic and molecular correlations in precancerous and malignant breast lesions, while outlining highly practical issues that are in practice today in breast pathology, such as evaluation of estrogen, progesterone receptors, and HER-2. Written by experts in the field, Precision Molecular Pathology of Breast Cancer is a valuable resource that covers the current practice of breast pathology and looks into the future with an emphasis on the molecular basis of breast cancer.

Author : Jahangir Moini,Nicholas Avgeropoulos,Mohtashem Samsam
Publisher : Academic Press
Page : 554 pages
File Size : 44,9 Mb
Release : 2021-04-09
Category : Medical
ISBN : 9780128217559

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Epidemiology of Brain and Spinal Tumors by Jahangir Moini,Nicholas Avgeropoulos,Mohtashem Samsam Pdf

Epidemiology of Brain and Spinal Tumors provides a single volume resource on imaging methods and neuroepidemiology of both brain and spinal tumors. The book covers a variety of imaging techniques, including computed tomography (CT), MRI, positron emission tomography (PET), and other laboratory tests used in diagnosis and treatment. Detailed epidemiology, various imaging methods, and clinical considerations of tumors of the CNS make this an ideal reference for users who will also find diverse information about structures and functions, cytology, epidemiology (including molecular epidemiology), diagnosis and treatment. This book is appropriate for neuroscience researchers, medical professionals and anyone interested in a complete guide to visualizing and understanding CNS tumors. Provides the most up-to-date information surrounding the epidemiology, biology and imaging techniques for brain and spinal tumors, including CT, MRI, PET, and others Includes full color figures, photos, tables, graphs and radioimaging Contains information that will be valuable to anyone interested in the field of neurooncology and the treatment of patients with brain and spinal tumors Serves as a source of background information for basic scientists and pharmaceutical researchers who have an interest in imaging and treatment

Author : Ramasamy Paulmurugan,Tarik F. Massoud
Publisher : Elsevier
Page : 830 pages
File Size : 48,5 Mb
Release : 2021-06-25
Category : Science
ISBN : 9780128215678

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Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies by Ramasamy Paulmurugan,Tarik F. Massoud Pdf

Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies brings current knowledge from an international team of experts on the science and clinical management of glioblastoma chemoresistance. The book discusses topics such as molecular mechanisms of chemoresistance, experimental models to study chemoresistance, chemoresistance to drugs other than Temozolomide, and specific strategies to reverse chemoresistance. Additionally, it encompasses information on how to mitigate chemoresistance by targeted enhancement of p53 function. This book is a valuable resource for cancer researchers, oncologists, neuro-oncologists and other members of the biomedical field. Glioblastoma (GBM) is the most invasive and malignant primary brain tumor in humans with poor survival after diagnosis, therefore it is imperative that molecular and cellular mechanisms behind therapy resistant GBM cells, as well as the therapeutic strategies available to counter the resistance are comprehensively understood. Provides comprehensive, core knowledge related to the entire discipline of glioblastoma chemoresistance, from its many etiological mechanisms, to specific strategies to reverse resistance Presents current information from an international team of experts on the basic science, pre-clinical research, and clinical management of glioblastoma chemoresistance Discusses molecular and cellular mechanisms behind therapy resistant glioblastoma cells, as well as the therapeutic strategies available to counter this resistance

Author : Jahangir Moini,Amparo Gutierrez,Nicholas Avgeropoulos
Publisher : Elsevier
Page : 454 pages
File Size : 51,7 Mb
Release : 2023-05-12
Category : Medical
ISBN : 9780323959025

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Clinical Neuroepidemiology of Acute and Chronic Disorders by Jahangir Moini,Amparo Gutierrez,Nicholas Avgeropoulos Pdf

Clinical Neuroepidemiology of Acute and Chronic Disorders explores the epidemiology of disorders that affect the nervous system, providing comprehensive discussions on incidence, prevalence, and more. With thorough coverage of a variety of disorders, chapters detail etiology, risk factors, pathophysiology, clinical manifestations, diagnosis, global incidence and prevalence, age-specific incidence, global mortality, prevention, treatment and prognosis for each disorder. Chapters uniquely discuss the effects of the COVID-19 coronavirus upon the nervous system and in relation to several diseases, including new discoveries and treatments for Alzheimer’s disease and migraine headaches. Real-world case studies with critical thinking questions and "Focus On" boxes highlight important information. Covers a variety of disorders and their etiology, including risk factors, pathophysiology clinical manifestations diagnosis, incidence of mortality, prevention, treatment and prognosis Features real-world case studies with critical thinking questions and answers Includes Focus On boxes that highlight key information in each chapter Highlights treatments for various disorders, including Alzheimer's disease and migraines Discusses the effects of COVID-19 on the nervous system in relation to several diseases

Author : Kevin M. Haigis, Ph.D.
Publisher : Springer Science & Business Media
Page : 319 pages
File Size : 42,9 Mb
Release : 2013-10-02
Category : Medical
ISBN : 9781461484127

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Molecular Pathogenesis of Colorectal Cancer by Kevin M. Haigis, Ph.D. Pdf

Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for novel therapies to treat the disease.

Author : Pedro Borralho,Fernando Schmitt,Liang Wang,Umberto Malapelle
Publisher : Frontiers Media SA
Page : 279 pages
File Size : 46,5 Mb
Release : 2023-04-05
Category : Science
ISBN : 9782832518373

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Cancer diagnostics in solid tumors - from pathology to precision oncology by Pedro Borralho,Fernando Schmitt,Liang Wang,Umberto Malapelle Pdf