Predictive Preventive And Personalised Medicine From Bench To Bedside

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Predictive, Preventive, and Personalised Medicine: From Bench to Bedside

Halina Podbielska,Marko Kapalla
Predictive Preventive and Personalised Medicine From Bench to Bedside Book PDF

Author : Halina Podbielska,Marko Kapalla
Publisher : Springer Nature
Page : 352 pages
File Size : 50,7 Mb
Release : 2023-12-01
Category : Medical
ISBN : 9783031348846

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Predictive, Preventive, and Personalised Medicine: From Bench to Bedside by Halina Podbielska,Marko Kapalla Pdf

This volume presents advanced bio/medical sciences with a particular value for translating research achievements into daily medical practice in the framework of Predictive, Preventive and Personalised Medicine (3PM/PPPM). First two decades of the 21st century are characterised by epidemics of non-communicable diseases such as many hundreds of millions of patients diagnosed with cardiovascular diseases and the type 2 diabetes mellitus, breast, lung, liver and prostate malignancies, neurological, sleep, mood and eye disorders, amongst others. Consequent socio-economic burden is tremendous. Unprecedented decrease in age of maladaptive individuals has been reported. The absolute majority of expanding non-communicable disorders carry a chronic character, over a couple of years progressing from reversible suboptimal health conditions to irreversible severe pathologies and cascading collateral complications. The paradigm change from reactive to predictive preventive and personalised medicine is essential to promote population health by application of individualised patient profiling, multi-parametric analysis leading to cost-effective targeted prevention. To this end, inadequate data for risk assessment on speed and urgency of COVID-19, combined with increased globalization of human society, led to the rapid spread of COVID-19. Despite an abundance of digital methods that could be used in slowing or stopping this virus and future pandemics, the world remains unprepared, and lessons have not been learned from previous cases of pandemics. The book presents PPPM strategies which might be of great clinical utility for future pandemics. In a long-term way, a significantly improved healthcare economy is one of the clear benefits of the proposed paradigm shift; a tight collaboration between all stakeholders including scientific community, healthcare providers, patient organisations, policy-makers and educators is analysed for the smooth implementation of the 3PM concepts. Further issues linked to big data management and medical ethics have to be carefully treated in the context of application of artificial intelligence in medicine.

Predictive, Preventive, and Personalised Medicine: From Bench to Bedside

Halina Podbielska,Marko Kapalla
Predictive Preventive and Personalised Medicine From Bench to Bedside Book PDF

Author : Halina Podbielska,Marko Kapalla
Publisher : Springer
Page : 0 pages
File Size : 40,7 Mb
Release : 2023-11-25
Category : Medical
ISBN : 3031348834

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Predictive, Preventive, and Personalised Medicine: From Bench to Bedside by Halina Podbielska,Marko Kapalla Pdf

This volume presents advanced bio/medical sciences with a particular value for translating research achievements into daily medical practice in the framework of Predictive, Preventive and Personalised Medicine (3PM/PPPM). First two decades of the 21st century are characterised by epidemics of non-communicable diseases such as many hundreds of millions of patients diagnosed with cardiovascular diseases and the type 2 diabetes mellitus, breast, lung, liver and prostate malignancies, neurological, sleep, mood and eye disorders, amongst others. Consequent socio-economic burden is tremendous. Unprecedented decrease in age of maladaptive individuals has been reported. The absolute majority of expanding non-communicable disorders carry a chronic character, over a couple of years progressing from reversible suboptimal health conditions to irreversible severe pathologies and cascading collateral complications. The paradigm change from reactive to predictive preventive and personalised medicine is essential to promote population health by application of individualised patient profiling, multi-parametric analysis leading to cost-effective targeted prevention. To this end, inadequate data for risk assessment on speed and urgency of COVID-19, combined with increased globalization of human society, led to the rapid spread of COVID-19. Despite an abundance of digital methods that could be used in slowing or stopping this virus and future pandemics, the world remains unprepared, and lessons have not been learned from previous cases of pandemics. The book presents PPPM strategies which might be of great clinical utility for future pandemics. In a long-term way, a significantly improved healthcare economy is one of the clear benefits of the proposed paradigm shift; a tight collaboration between all stakeholders including scientific community, healthcare providers, patient organisations, policy-makers and educators is analysed for the smooth implementation of the 3PM concepts. Further issues linked to big data management and medical ethics have to be carefully treated in the context of application of artificial intelligence in medicine.

Preventive and Predictive Genetics: Towards Personalised Medicine

Godfrey Grech,Iris Grossman
Preventive and Predictive Genetics Towards Personalised Medicine Book PDF

Author : Godfrey Grech,Iris Grossman
Publisher : Springer
Page : 378 pages
File Size : 42,8 Mb
Release : 2015-06-24
Category : Science
ISBN : 9783319153445

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Preventive and Predictive Genetics: Towards Personalised Medicine by Godfrey Grech,Iris Grossman Pdf

Pharmacogenomics supports personalized medicine by translating genome-based knowledge into clinical practice, offering enhanced benefit for patients and health-care systems at large. Current routine practice for diagnosing and treating patients is conducted by correlating parameters such as age, gender and weight with risks and expected treatment outcomes. In the new era of personalized medicine the healthcare provider is equipped with improved ability to prevent, diagnose, treat and predict outcomes on the basis of complex information sources, including genetic and genomic data. Targeted therapy and reliable prediction of expected outcomes offer patients access to better healthcare management, by way of identifying the therapies effective for the relevant patient group, avoiding prescription of unnecessary treatment and reducing the likelihood of developing adverse drug reactions.

An Information Technology Framework for Predictive, Preventive and Personalised Medicine

Leonard Berliner,Heinz U. Lemke
An Information Technology Framework for Predictive Preventive and Personalised Medicine Book PDF

Author : Leonard Berliner,Heinz U. Lemke
Publisher : Springer
Page : 130 pages
File Size : 46,9 Mb
Release : 2015-03-04
Category : Medical
ISBN : 9783319121666

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An Information Technology Framework for Predictive, Preventive and Personalised Medicine by Leonard Berliner,Heinz U. Lemke Pdf

This book explores how PPPM, clinical practice, and basic research could be best served by information technology (IT). A use-case was developed for hepatocellular carcinoma (HCC). The subject was approached with four interrelated tasks: (1) review of clinical practices relating to HCC; (2) propose an IT system relating to HCC, including clinical decision support and research needs; (3) determine how a clinical liver cancer center can contribute; and, (4) examine the enhancements and impact that the first three tasks will have on the management of HCC. An IT System for Personalized Medicine (ITS-PM) for HCC will provide the means to identify and determine the relative value of the wide number of variables, including clinical assessment of the patient -- functional status, liver function, degree of cirrhosis, and comorbidities; tumor biology, at a molecular, genetic and anatomic level; tumor burden and individual patient response; medical and operative treatments and their outcomes.

Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future

Silvia Mandel
Neurodegenerative Diseases Integrative PPPM Approach as the Medicine of the Future Book PDF

Author : Silvia Mandel
Publisher : Springer Science & Business Media
Page : 402 pages
File Size : 44,8 Mb
Release : 2013-03-12
Category : Medical
ISBN : 9789400758667

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Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future by Silvia Mandel Pdf

This book will compile a collection of chapters dedicated to varied aspects of PPPM in neuropsychiatric and neurodegenerative diseases. Among the topics to be covered are: Recent advances in ALS research News about Clinical aspects and advanced therapy approaches in personalized treatment of ALS Schizophrenia: New treatments and clinical aspects Predictive, Preventive and Personalised Medicine in aging macular degeneration Advances in Multiple Sclerosis Pharmacogenetics, Tailoring Treatment Efficacy, Safety and Regimen Selection Multiple sclerosis related biomarkers: perspectives for clinical application Preventive clinical trials in brain aging: new trends & the need of guidelines MCI_ clinical guidelines in early diagnosis of dementia Alzheimer's disease: diagnostics, prognostics and the road to prevention Biomarkers for early diagnosis of Parkinson's and Alzheimer's diseases Synucleinopathies, tauopathies, TDP-43 proteinopathies and amyloidosis PSP, MSA and other parkinsonisms

Toward Precision Medicine

National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on A Framework for Developing a New Taxonomy of Disease
Toward Precision Medicine Book PDF

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on A Framework for Developing a New Taxonomy of Disease
Publisher : National Academies Press
Page : 142 pages
File Size : 41,6 Mb
Release : 2012-01-16
Category : Medical
ISBN : 9780309222228

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Toward Precision Medicine by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on A Framework for Developing a New Taxonomy of Disease Pdf

Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.

Personalized Medicine in Oncology

Ari VanderWalde
Personalized Medicine in Oncology Book PDF

Author : Ari VanderWalde
Publisher : Mdpi AG
Page : 190 pages
File Size : 48,8 Mb
Release : 2022-01-25
Category : Electronic
ISBN : 3036528210

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Personalized Medicine in Oncology by Ari VanderWalde Pdf

Nowhere is the explosion in comprehensive genomic testing more evident than in oncology. Multiple consensus guidelines now recommend molecular testing as the standard of care for most metastatic tumors. To aid in the advancement of this rapidly changing field, we intend this Special Issue of JPM to focus on technical developments in the genomic profiling of cancer, detail promising somatic alterations that either are, or have a high likelihood of being, relevant in the near future, and to address issues related to the pricing and value of these tests. The last few years have seen the cost of molecular testing decrease by orders of magnitude. In 2018, we saw the first "site-agnostic" drug approvals in cancer (for microsatellite unstable cancer (PD-1 inhibitors) and NTRK-fusions (TRK inhibitors)). Research on targetable mutations, determination of genetic "signatures" that can use multiple individual genes/pathways, development of targeted therapy, and insight into the value of new technology remains at the cutting edge of research in this field. We are soliciting papers that present new technologies to assess predictive biomarkers in cancer, original research (pre-clinical or clinical) that demonstrates promise for particular targeted therapies in cancer, and articles that explore the clinical and financial impacts of this paradigmatic shift in cancer diagnostics and treatment.

Clinical Molecular Diagnostics

Shiyang Pan,Jinhai Tang
Clinical Molecular Diagnostics Book PDF

Author : Shiyang Pan,Jinhai Tang
Publisher : Springer Nature
Page : 889 pages
File Size : 46,7 Mb
Release : 2021-07-08
Category : Medical
ISBN : 9789811610370

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Clinical Molecular Diagnostics by Shiyang Pan,Jinhai Tang Pdf

This book covers the discovery of molecular biomarkers, the development of laboratory testing techniques and their clinical applications, focusing on basic research to clinical practice. It introduces new and crucial knowledge and ethics of clinical molecular diagnosis. This book emphasizes the applications of clinical molecular diagnostic test on health management, especially from different diseased organs. It lets readers to understand and realize precision healthcare.

Anticipation and Medicine

Mihai Nadin
Anticipation and Medicine Book PDF

Author : Mihai Nadin
Publisher : Springer
Page : 363 pages
File Size : 49,7 Mb
Release : 2016-10-22
Category : Technology & Engineering
ISBN : 9783319451428

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Anticipation and Medicine by Mihai Nadin Pdf

In this book, practicing physicians and experts in anticipation present arguments for a new understanding of medicine. Their contributions make it clear that medicine is the decisive test for anticipation. The reader is presented with a provocative hypothesis: If medicine will align itself with the anticipatory condition of life, it can prompt the most important revolution in our time. To this end, all stakeholders—medical practitioners, patients, scientists, and technology developers—will have to engage in the conversation. The book makes the case for the transition from expensive, and only marginally effective, reactive treatment through “spare parts” (joint replacements, organ transplants) and reliance on pharmaceuticals (antibiotics, opiates) to anticipation-informed healthcare. Readers will understand why the current premise of treating various behavioral conditions (attention deficit disorder, hyperactivity, schizophrenia) through drugs has to be re-evaluated from the perspective of anticipation. In the manner practiced today, medicine generates dependence and long-lasting damage to those it is paid to help. As we better understand the nature of the living, the proactive view of healthcare, within which the science and art of healing fuse, becomes a social and political mandate.

Personalized Medicine in Anesthesia, Pain and Perioperative Medicine

Ali Dabbagh
Personalized Medicine in Anesthesia Pain and Perioperative Medicine Book PDF

Author : Ali Dabbagh
Publisher : Springer Nature
Page : 401 pages
File Size : 51,9 Mb
Release : 2020-09-21
Category : Medical
ISBN : 9783030535254

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Personalized Medicine in Anesthesia, Pain and Perioperative Medicine by Ali Dabbagh Pdf

This book discusses the current and future impact of cellular and molecular medicine (CMM) on anesthesiology and perioperative medicine. It covers the topic from a translational perspective and describes the relevance of CMM to daily clinical practice. Taking a bench-to-bedside approach, chapters examine topics including perioperative acute and chronic management, perioperative organ protection, and novel pharmaceuticals. Personalized Medicine in Anesthesia, Pain and Perioperative Medicine is aimed at anesthesiologists and pain physicians, and will also be of interest to pharmacists and those working in cellular and molecular medicine.

Nanoarchitectonics for Brain Drug Delivery

Anurag Kumar Singh,Vivek K. Chaturvedi,Jay Singh
Nanoarchitectonics for Brain Drug Delivery Book PDF

Author : Anurag Kumar Singh,Vivek K. Chaturvedi,Jay Singh
Publisher : CRC Press
Page : 381 pages
File Size : 49,7 Mb
Release : 2024-02-22
Category : Technology & Engineering
ISBN : 9781003851844

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Nanoarchitectonics for Brain Drug Delivery by Anurag Kumar Singh,Vivek K. Chaturvedi,Jay Singh Pdf

This book discusses basics of brain diseases and the role of nanobiotechnology in existing treatment options for neurodegenerative disorders. It begins with an overview of brain diseases and the need for novel drug-delivery approaches. It highlights the current route for the intranasal advanced drug-delivery systems for brain diseases. It also discusses innovative categories of drug-delivery systems, including mesoporous silica nanoparticles, polymeric nanocarriers, and lipid-based nanocarriers through multi-responsive DDSs and their implications in brain disorders. Features: Includes an overview of brain diseases and highlights the need for novel drug-delivery approaches Focuses on theoretical aspects of advanced drug-delivery systems for brain diseases including challenges and progress in nose-to-brain delivery Provides an overview of technological approaches and their implications for neurodegenerative disorders, central nervous system (CNS), and brain drug delivery in brain cancer Discusses key advances in the development of polymer nanoparticles for drug delivery to the CNS Reviews the role of herbal medicines and naturally derived polymeric nanoparticle for the treatment of neurodegenerative disorders This book is aimed at graduate students and researchers in biomedical engineering, biotechnology, drug delivery, and neurology.

Genomic and Personalized Medicine

Anonim
Genomic and Personalized Medicine Book PDF

Author : Anonim
Publisher : Academic Press
Page : 1350 pages
File Size : 48,8 Mb
Release : 2012-10-30
Category : Science
ISBN : 9780123822284

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Genomic and Personalized Medicine by Anonim Pdf

Genomic and Personalized Medicine, Second Edition — winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — is a major discussion of the structure, history, and applications of the field, as it emerges from the campus and lab into clinical action. As with the first edition, leading experts review the development of the new science, the current opportunities for genome-based analysis in healthcare, and the potential of genomic medicine in future healthcare. The inclusion of the latest information on diagnostic testing, population screening, disease susceptability, and pharmacogenomics makes this work an ideal companion for the many stakeholders of genomic and personalized medicine. With advancing knowledge of the genome across and outside protein-coding regions of DNA, new comprehension of genomic variation and frequencies across populations, the elucidation of advanced strategic approaches to genomic study, and above all in the elaboration of next-generation sequencing, genomic medicine has begun to achieve the much-vaunted transformative health outcomes of the Human Genome Project, almost a decade after its official completion in April 2003. Highly Commended 2013 BMA Medical Book Award for Medicine More than 100 chapters, from leading researchers, review the many impacts of genomic discoveries in clinical action, including 63 chapters new to this edition Discusses state-of-the-art genome technologies, including population screening, novel diagnostics, and gene-based therapeutics Wide and inclusive discussion encompasses the formidable ethical, legal, regulatory and social challenges related to the evolving practice of genomic medicine Clearly and beautifully illustrated with 280 color figures, and many thousands of references for further reading and deeper analysis

Comprehensive Biomarker Discovery and Validation for Clinical Application

Péter Horvatovich,Rainer Bischoff
Comprehensive Biomarker Discovery and Validation for Clinical Application Book PDF

Author : Péter Horvatovich,Rainer Bischoff
Publisher : Royal Society of Chemistry
Page : 320 pages
File Size : 50,7 Mb
Release : 2013-06-17
Category : Science
ISBN : 9781849734363

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Comprehensive Biomarker Discovery and Validation for Clinical Application by Péter Horvatovich,Rainer Bischoff Pdf

This book focuses on proteomics biomarker discovery and validation procedures from the clinical perspective. It provides an overview of current technology and the challenges encountered throughout the process. This covers all key stages, from biomarker discovery and validation, through to registration with the European and US regulatory authorities (FDA and EMEA). All the important elements (such as patient selection, sample handling, data processing, and statistical analysis) are described in detail and the reader is introduced to each topic with well-described examples or guidelines for best practice. Case studies are also included to demonstrate clinical applications. Individual chapters explain the best performing techniques for profiling complex body fluids and biomarker discovery. This includes the application of mass spectrometry imaging combined with chromatography in profiling platforms and the use of laser micro dissection and MALDI imaging to study tissues in their natural environment. Future developments needed to improve the success rate of translating biomarker discovery into useful clinical tests are also discussed. Common pitfalls and success stories are described as are the limitations of the various technologies involved. Broad and interdisciplinary in approach, this book provides an excellent source of information for industrial and academic researchers, and those managing biobanks.

Oxford Textbook of Global Public Health

Roger Detels,Martin Gulliford,Quarraisha Abdool Karim,Chorh Chuan Tan
Oxford Textbook of Global Public Health Book PDF

Author : Roger Detels,Martin Gulliford,Quarraisha Abdool Karim,Chorh Chuan Tan
Publisher : Oxford University Press
Page : 1717 pages
File Size : 44,9 Mb
Release : 2017
Category : Medical
ISBN : 9780198810131

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Oxford Textbook of Global Public Health by Roger Detels,Martin Gulliford,Quarraisha Abdool Karim,Chorh Chuan Tan Pdf

Sixth edition of the hugely successful, internationally recognised textbook on global public health and epidemiology, with 3 volumes comprehensively covering the scope, methods, and practice of the discipline

Digital Health in Focus of Predictive, Preventive and Personalised Medicine

Lotfi Chaari
Digital Health in Focus of Predictive Preventive and Personalised Medicine Book PDF

Author : Lotfi Chaari
Publisher : Springer Nature
Page : 164 pages
File Size : 47,8 Mb
Release : 2020-09-30
Category : Medical
ISBN : 9783030498153

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Digital Health in Focus of Predictive, Preventive and Personalised Medicine by Lotfi Chaari Pdf

The edition will cover proceedings of the second International conference on digital health Technologies (ICDHT 2019). The conference will address the topic of P4 medicine from the information technology point of view, and will be focused on the following topics: - Artificial Intelligence for health • Knowledge extraction • Decision-aid systems • Data analysis and risk prediction • Machine learning, deep learning - Health data processing • Data preprocessing, cleaning, management and mining • Computer-aided detection • Big data analysis, prediction and prevention • Cognitive algorithms for healthcare handling dynamic context management • Augmented reality, Motion detection and activity recognition - Devices, infrastructure and communication • Wearable & connected devices • Communication infrastructures, architectures and standards Blockchain for e-Health • Computing/storage infrastructures for e-Health • IoT devices & architectures for Smart Healthcare - Health information systems • Telemedicine, Teleservices • Computing/storage infrastructures for e-Health • Clinical Data Visualisation Standards - Security and privacy for e-health • Health data Analytics for Security and Privacy • E-health Software and Hardware Security • Embedded Security for e-health - Applications in P4 medicine