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Primer on Cerebrovascular Diseases by K. Michael Welch Pdf
Primer on Cerebrovascular Diseases is a handy reference source for scientists, students, and physicians needing reliable, up-to-date information on basic mechanisms, physiology, pathophysiology, and medical issues related to brain vasculature. The book consists of short, specific chapters written by international experts on cerebral vasculature, and presents the information in a comprehensive and easily accessible manner. The book also contains valuable information on practical applications of basic research. Presents topics in a comprehensive and accessible format Written by international authorities on cerebral vasculature Provides practical applications for researchers
Primer on Cerebrovascular Diseases by Louis R. Caplan,José Biller,Megan C. Leary,Eng H. Lo,Ajith J Thomas,Midori Yenari,John H. Zhang Pdf
Primer on Cerebrovascular Diseases, Second Edition, is a handy reference source for scientists, students, and physicians needing reliable, up-to-date information on basic mechanisms, physiology, pathophysiology, and medical issues related to brain vasculature. The book consists of short, specific chapters written by international experts on cerebral vasculature, presenting the information in a comprehensive and easily accessible manner. Numerous changes have occurred in the field since the publication of the first edition in 1997, particularly our understanding of the genetic aspects of cerebrovascular disease. This updated edition reflects the advances made over the last two decades, not only demonstrating the promise for therapy, but also for a molecular understanding of cerebrovascular diseases. The new edition includes new and expanded topics, including carotid stenting, Iatrogenic causes of stroke, axonal transport and injury, RNAIs, proteomics, and more. Provides concise chapters on topics in cerebral blood flow and metabolism, pathogenesis of cerebrovascular disorders, diagnostic testing, and management in a comprehensive and accessible format Written by international leading authorities on cerebral vasculature Provides up-to-date information on practical applications of basic research and the main clinical issues facing the community, such as axonal transport and proteomics
Author : Larry B. Goldstein Publisher : John Wiley & Sons Page : 349 pages File Size : 48,9 Mb Release : 2011-09-13 Category : Medical ISBN : 9781444359879
A Primer on Stroke Prevention and Treatment by Larry B. Goldstein Pdf
Society-sanctioned guidelines are valuable tools, but accessing key information can be a daunting task. This book illuminates a clear path to successful application of the American Heart Association/American Stroke Association guidelines. Organized for fast reference, this new volume helps practitioners improve patient care.
Prevention, diagnosis and treatment are the watchwords in stroke research, for basic neuroscientists and clinicians alike. This 2002 book, from the 22nd Princeton Conference on Cerebrovascular Disease, contains contributions from outstanding investigators on numerous topics in stroke research. The contents cover the status and future directions of stroke pathophysiology, diagnosis and treatment, with special emphasis on the molecular and cellular mechanisms of ischaemic cell death and repair, and clinical issues including imaging, risk factors and therapeutic strategies in stroke. Available in both print and online formats, this survey of the basic and clinical science of stroke is an essential resource for all involved in advancing knowledge of cerebrovascular disease.
Molecular and Cellular Biology of Neuroprotection in the CNS by Christian Alzheimer Pdf
Univ. of Kiel, Germany. Text provides an overview of the recent developments in neuroprotective signaling and experimental neuroprotection. Also offers a detailed look at many of the highly intertwined processes that determine the fate of CNS neurons in the face of acute or chronic insults.
Updated and revised, this new edition of Caplan’s Stroke continues to provide a concise and pragmatic approach to the evaluation, diagnosis, and management of adult and pediatric stroke patients. Dr. Caplan—a highly esteemed stroke authority— shares with you his vast experience and wisdom as a stroke clinician, including his time-tested strategies and unique clinical pearls that you can implement into your own practice. Expanded coverage of imaging and laboratory diagnosis and treatment as well as extensive revisions throughout, brings you the latest advances on prevention, complications, and rehabilitation. The use of case studies illustrates the types of clinical scenarios you may experience in practice. And, its conversational, easy-to-read format make Caplan’s Stroke an ideal resource for general neurologists, non-neurologists, and stroke specialists alike. Discusses all cerebrovascular diseases to help you differentiate among all types of stroke so you can treat each patient appropriately. Takes a distinctly personal and individual approach to general principles, pathophysiology, diagnosis, treatment, and rehabilitation, offering practical, clinical guidance on stroke and stroke related issues. Provides detailed discussions on stroke syndromes in children and adults, including large artery occlusive disease of the anterior circulation, brain embolism, spinal cord stroke, and many, many more, to help you better manage every condition you see. Uses case studies to highlight and emphasize clinical points. Includes expanded coverage of imaging and laboratory diagnosis and treatment to help you make better informed evaluation and management decisions. Presents meticulous revisions and updates throughout, particularly to the chapters on stroke prevention and rehabilitation to keep you current on today’s best practices. Features a new two-color design with updated artwork and more images that elucidates key points and enhances visual guidance.
Current Review of Cerebrovascular Disease by Marc Fisher,Julien Bogousslavsky Pdf
New, exciting, and innovative advances in the field of cerebrovascular medicine continue to occur at a rapid pace. The fourth edition of Current Review of Cerebrovascular Disease provides an update on these rapidly evolving topics and a gives the reader insight into the thought-provoking issues in stroke neurology that have undergone tremendous changes during the past two years. The volume covers four main sections: basic science, diagnostics, clinical aspects, and treatment.
Risk Factors for Cerebrovascular Disease and Stroke by Sudha Seshadri,St?phanie Debette Pdf
Risk Factors for Cerebrovascular Disease and Stroke address the relationship of a wide variety of vascular risk factors in the spectrum of cerebrovascular diseases. An international group of professionals the forefront of research and education, provide their expertise about environmental and genetic determinants for cerebrovascular disease and stroke. The authors aim to provide information on developments of genetic, environmental and lifestyle-related risk factors of various subtypes of stroke, and MRI-markers of cerebrovascular disease. One in two men, and one in three women after the age of 40, will develop a stroke in their lifetime. The burden of cerebrovascular disease extends far beyond that of acute clinical events such as stroke, with "covert" vascular injury on brain MRI being highly prevalent in older community-dwelling persons. Therefore, improving our understanding of the risk factors for stroke and cerebrovascular disease is of paramount importance for improving prevention strategies. Secular trends in stroke epidemiology, risk factors, and intermediate markers (including carotid ultrasound, brain MRI and circulating biomarkers) are presented. Cutting edge information on genetic, environmental and lifestyle-related risk factors of various subtypes of stroke and MRI-markers of cerebrovascular diseases are displayed. This important book is an essential reference to physicians interested in more effective primary prevention of stroke.
Oxford Textbook of Stroke and Cerebrovascular Disease by Bo Norrving Pdf
Stroke is a major health concern worldwide, and the epidemiological data is staggering. One in six people will have a stroke during the course of their life; it is the second most common cause of death; and stroke also ranks second among causes contributing to the global burden of disability. However, the burden of stroke can be alleviated: it is potentially preventable, treatable, and possible to manage long term. Despite continuing advances in our knowledge about this disease, there is currently still a large evidence-to-clinical practice gap in all regions. The Oxford Textbook of Stroke and Cerebrovascular Disease is a comprehensive textbook on clinical stroke, covering all major aspects of cerebrovascular disease including epidemiology, risk factors, primary prevention, pathophysiology, diagnostics, clinical features, acute therapies, secondary prevention, prognosis, and rehabilitation. It makes use of current pedagogic principles, and includes not only aspects on management in the acute hospital phase of stroke, but also public health issues, prevention, long-term management, and silent vascular disease (which is becoming increasingly epidemic in the general population). Topical aspects also include advice to improve clinical skills in examination, diagnosing, and treating stroke. The text also covers the fields of silent cerebrovascular disease (silent brain infarcts, microbleeds, white matter ischemic abnormalities) that more recently have been recognized to be highly prevalent in the general population, and that carry important risks on vascular events and cognitive decline/dementia. Chapters are written by a most distinguished group of international experts in the field of stroke from around the world, and have been carefully edited to ensure consistency in style and clarity of contents. The concurrent online version allows access to the full content of the textbook, contains links from the references to primary research journal articles, allows full text searches, and provides access to figures and tables that can be downloaded to PowerPoint®. Practical, easy to use, yet detailed with respect to pathophysiology, diagnostics, and management, this text provides a source of reference for the detection and management of all stroke and less common cerebrovascular diseases for practising and trainee neurologists, geriatricians, and all stroke physicians and clinicians.
Cerebral Vasospasm by R. Loch Macdonald,Bruce Weir Pdf
Bryce Weir is a high-profile, respected neurologist. Dr. Macdonald is a colleague of Dr. Weir's and is a "rising star" in the field of neurology. This book is the first to cover all aspects of cerebral vasospasm in depth. It takes the reader from the first descriptions of this puzzling and deadly phenomenon to the latest laboratory evidence explaining its pathophysiology. Packed with clinical pearls, it is a must for neurosurgeons, interventional radiologists, neurologists, and neuropathologists. Key Features * Examines the current understanding of vascular smooth muscle physiology * Provides in-depth overviews of symptoms and treatments * Written by acknowledged experts on the subject * Vividly illustrated with beautiful photographs and diagrams * Cites over 4,000 key papers on vasospasms * Presents key data in an easy-to-use format
Neuropsychology of Cardiovascular Disease by Shari R. Waldstein,Merrill F. Elias Pdf
Cardiovascular disease, the leading cause of morbidity and mortality in the United States and many other countries, confers substantial risk for cerebrovascular events, such as stroke and vascular dementia. The neuropsychological sequelae of such conditions are well documented and can have a devastating impact on individuals' quality of life. However, prior to the development of overt cerebrovascular complications, persons with cardiovascular disease or its risk factors may display mild to severe neuropsychological difficulties. Medical and surgical treatments for cardiovascular disease have also been found to affect neuropsychological function. This landmark volume offers the first comprehensive overview of the neuropsychological consequences of cardiovascular disease, tracking its natural history, epidemiology, and treatments. It encourages researchers and clinicians to consider all relevant facets of vascular disease processes in their evaluation, study, and treatment of affected patients and indicates a need for primary and secondary prevention efforts. Neuropsychology of Cardiovascular Disease will be welcomed as an invaluable resource by neuropsychologists, specialists in behavioral medicine, neurologists, cardiologists, epidemiologists, gerontologists, and many other health professionals whose work brings them into contact with these challenging patients.
Sarah T. Pendlebury,Matthew F. Giles,Peter M. Rothwell
Author : Sarah T. Pendlebury,Matthew F. Giles,Peter M. Rothwell Publisher : Cambridge University Press Page : 407 pages File Size : 55,7 Mb Release : 2009-02-19 Category : Medical ISBN : 9780521735124
Oxidative Stress Revisited - Major Role in Vascular Diseases by Cristina M. Sena,Raquel Seiça,George Perry Pdf
Oxidative stress is an underlying factor in health and disease. Reactive oxygen species are produced as a result of normal cellular metabolism. The subsequent altered redox state between the formation and the neutralization of pro-oxidants results in their increased levels and therefore leads to cellular damage. Different research disciplines have increased our knowledge of the importance of this cell redox status and the recognition of oxidative stress as a process with implications for many pathophysiological states. Genetic and environmental factors, nutrition and lifestyle may indicate a pro-oxidative and pro-inflammatory state, linked to alterations in cellular structure and function. Oxidative stress emerges as a common, unifying factor in several conditions including diabetes and cardiovascular diseases. This eBook aims to provide novel data regarding the role played by oxidative stress and inflammation in the development of chronic diseases and the different classes of therapeutics from the bench to the clinic, stressing the awareness of these concepts for the treatment of disease. In addition, articles addressing an overview of the role of oxidative stress in vascular diseases reviewing some current concepts indicating that oxidative stress and inflammation are key mechanisms linking vascular diseases and current state-of-the-art approaches to monitor, prevent and inhibit oxidative stress will be highlighted. There is a close relation between oxidative stress, inflammation and cardiovascular diseases. Despite the great amount of investigation carried out in the field, there are still uncertainties about the mechanisms by which free radicals can modify tissues such as perivascular adipose tissue that ultimately will reflect on vascular function. This eBook will focus on articles that can explore and identify these mechanisms. Concurrent with this understanding of oxidative stress milieu, it is necessary to recognize the need for new pharmacological tools effective in restoring oxidative balance. The abundance of new information and the paradigm shift in our understanding of how antioxidants and other redox-active drugs work in a wide variety of vascular diseases will be specifically highlighted. This eBook will provide a comprehensive, up-to-date source of information on the design and mechanistic, pharmacological, and medicinal aspects of redox-active therapeutics. Finally, a unique feature of the eBook is to provide a way to foster an enthralling discussion revisiting old paradigms and finding new solutions for the treatment of vascular diseases. The topic will include original research articles, hypotheses, perspectives and (mini)reviews from experts in the field. The next decade shows promise for the translation of this body of knowledge to novel human therapeutics and this eBook will enable to increment our knowledge in this field.
The Cerebral Circulation by Marilyn J. Cipolla Pdf
This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.
The 3 volumes of which this reference work is comprised cover the development and philosophy behind public health, its ways of dealing with health problems, and the applications of public health science at national and international levels.