Principles And Applications Of Molecular Diagnostics

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Principles and Applications of Molecular Diagnostics

Nader Rifai,A. Rita Horvath,Carl T. Wittwer,Jason Park
Principles and Applications of Molecular Diagnostics Book PDF

Author : Nader Rifai,A. Rita Horvath,Carl T. Wittwer,Jason Park
Publisher : Elsevier
Page : 422 pages
File Size : 45,7 Mb
Release : 2018-06-13
Category : Science
ISBN : 9780128160626

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Principles and Applications of Molecular Diagnostics by Nader Rifai,A. Rita Horvath,Carl T. Wittwer,Jason Park Pdf

Principles and Applications of Molecular Diagnostics serves as a comprehensive guide for clinical laboratory professionals applying molecular technology to clinical diagnosis. The first half of the book covers principles and analytical concepts in molecular diagnostics such as genomes and variants, nucleic acids isolation and amplification methods, and measurement techniques, circulating tumor cells, and plasma DNA; the second half presents clinical applications of molecular diagnostics in genetic disease, infectious disease, hematopoietic malignancies, solid tumors, prenatal diagnosis, pharmacogenetics, and identity testing. A thorough yet succinct guide to using molecular testing technology, Principles and Applications of Molecular Diagnostics is an essential resource for laboratory professionals, biologists, chemists, pharmaceutical and biotech researchers, and manufacturers of molecular diagnostics kits and instruments. Explains the principles and tools of molecular biology Describes standard and state-of-the-art molecular techniques for obtaining qualitative and quantitative results Provides a detailed description of current molecular applications used to solve diagnostics tasks

Diagnostic Molecular Microbiology

David H. Persing
Diagnostic Molecular Microbiology Book PDF

Author : David H. Persing
Publisher : ASM Press
Page : 668 pages
File Size : 50,9 Mb
Release : 1993
Category : Medical
ISBN : 155581056X

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Diagnostic Molecular Microbiology by David H. Persing Pdf

Diagnostic Molecular Microbiology is the first major text to provide complete coverage of both the principles and applications of molecular diagnostic methods as they pertain to infectious diseases. Written and edited by leading international experts, this text provides both the theoretical and practical framework for understanding the powerful uses of nucleic acid amplification technologies and for applying these techniques to the rapid detection and characterisation of microbial pathogens (bacterial, viral, fungal, parasitic) in the clinical laboratory. The nine chapters in part 1: Principles summarise the basic theory underlying the emerging discipline of molecular diagnostics. The sixty–six protocols in part 2: Applications, offer proven applications of molecular diagnostic techniques for the diagnosis of infectious diseases. Written in the tradition of ASM′s other classic manuals, this book provides a valuable reference and teaching tool for any clinical microbiology laboratory.

Principles and Applications of Molecular Diagnostics

Nader Rifai,A. Rita Horvath,Carl T. Wittwer,Jason Park
Principles and Applications of Molecular Diagnostics Book PDF

Author : Nader Rifai,A. Rita Horvath,Carl T. Wittwer,Jason Park
Publisher : Elsevier
Page : 0 pages
File Size : 51,5 Mb
Release : 2018-06-18
Category : Science
ISBN : 0128160616

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Principles and Applications of Molecular Diagnostics by Nader Rifai,A. Rita Horvath,Carl T. Wittwer,Jason Park Pdf

Principles and Applications of Molecular Diagnostics serves as a comprehensive guide for clinical laboratory professionals applying molecular technology to clinical diagnosis. The first half of the book covers principles and analytical concepts in molecular diagnostics such as genomes and variants, nucleic acids isolation and amplification methods, and measurement techniques, circulating tumor cells, and plasma DNA; the second half presents clinical applications of molecular diagnostics in genetic disease, infectious disease, hematopoietic malignancies, solid tumors, prenatal diagnosis, pharmacogenetics, and identity testing. A thorough yet succinct guide to using molecular testing technology, Principles and Applications of Molecular Diagnostics is an essential resource for laboratory professionals, biologists, chemists, pharmaceutical and biotech researchers, and manufacturers of molecular diagnostics kits and instruments.

Fundamentals of Molecular Diagnostics

David E. Bruns,Edward R. Ashwood,Carl A. Burtis
Fundamentals of Molecular Diagnostics Book PDF

Author : David E. Bruns,Edward R. Ashwood,Carl A. Burtis
Publisher : Elsevier Health Sciences
Page : 298 pages
File Size : 48,7 Mb
Release : 2007-05-25
Category : Medical
ISBN : 9781416037378

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Fundamentals of Molecular Diagnostics by David E. Bruns,Edward R. Ashwood,Carl A. Burtis Pdf

This book offers an introduction to the newest, fastest-growing field in laboratory science. Explaining and clarifying the molecular techniques used in diagnostic testing, this text provides both entry-level and advanced information. It covers the principles of molecular biology along with genomes and nucleic acid alterations, techniques and instrumentation, and applications of molecular diagnostics. Written by leading experts, including Patrick Bossuyt, Angela Caliendo, Rossa W.K. Chiu, Kojo S.J. Elenitoba-Johnson, Andrea Ferreira-Gonzalez, Amy Groszbach, Sultan Habeebu, Doris Haverstick, Malek Kamoun, Anthony Killeen, Noriko Kusukawa, Y.M. Dennis Lo, Elaine Lyon, Gwendolyn McMillin, Christopher Price, James Versalovic, Cindy Vnencak-Jones, Victor Weedn, Peter Wilding, Thomas Williams, and Carl Wittwer, this book includes illustrations, tables, and a colorful design to make information easy to find and easy to use. A full-color, 4-page insert shows realistic images of the output for many molecular tests. Learning Objectives open each chapter with an overview of what you should achieve. Key Words are listed and defined at the beginning of each chapter, and are bolded in the text. Review Questions at the end of every chapter let you measure your comprehension. Advanced Concepts are included, but set apart from the rest of the text, for students who want a higher level of learning. Ethics boxes address ethical issues, allowing you to apply your knowledge to real-life scenarios. A glossary of all key words may be easily accessed in the back of the book.

Diagnostic Molecular Microbiology

David H. Persing
Diagnostic Molecular Microbiology Book PDF

Author : David H. Persing
Publisher : ASM Press
Page : 668 pages
File Size : 42,5 Mb
Release : 1993
Category : Communicable diseases
ISBN : UOM:39015038159748

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Diagnostic Molecular Microbiology by David H. Persing Pdf

Diagnostic Molecular Microbiology is the first major text to provide complete coverage of both the principles and applications of molecular diagnostic methods as they pertain to infectious diseases. Written and edited by leading international experts, this text provides both the theoretical and practical framework for understanding the powerful uses of nucleic acid amplification technologies and for applying these techniques to the rapid detection and characterisation of microbial pathogens (bacterial, viral, fungal, parasitic) in the clinical laboratory. The nine chapters in part 1: Principles summarise the basic theory underlying the emerging discipline of molecular diagnostics. The sixty–six protocols in part 2: Applications, offer proven applications of molecular diagnostic techniques for the diagnosis of infectious diseases. Written in the tradition of ASM′s other classic manuals, this book provides a valuable reference and teaching tool for any clinical microbiology laboratory.

Molecular Diagnostics: Promises and Possibilities

Mousumi Debnath,Godavarthi B.K.S. Prasad,Prakash S. Bisen
Molecular Diagnostics Promises and Possibilities Book PDF

Author : Mousumi Debnath,Godavarthi B.K.S. Prasad,Prakash S. Bisen
Publisher : Springer Science & Business Media
Page : 520 pages
File Size : 46,8 Mb
Release : 2010-01-29
Category : Medical
ISBN : 9789048132614

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Molecular Diagnostics: Promises and Possibilities by Mousumi Debnath,Godavarthi B.K.S. Prasad,Prakash S. Bisen Pdf

A rapid development in diverse areas of molecular biology and genetic engineering resulted in emergence of variety of tools. These tools are not only applicable to basic researches being carried out world over, but also exploited for precise detection of abnormal conditions in plants, animals and human body. Although a basic researcher is well versed with few techniques used by him/her in the laboratory, they may not be well acquainted with methodologies, which can be used to work out some of their own research problems. The picture is more blurred when the molecular diagnostic tools are to be used by physicians, scientists and technicians working in diagnostic laboratories in hospitals, industry and academic institutions. Since many of them are not trained in basics of these methods, they come across several gray areas in understanding of these tools. The accurate application of molecular diagnostic tools demands in depth understanding of the methodology for precise detection of the abnormal condition of living body. To meet the requirements of a good book on molecular diagnostics of students, physicians, scientists working in agricultural, veterinary, medical and pharmaceutical sciences, it needs to expose the reader lucidly to: Give basic science behind commonly used tools in diagnostics Expose the readers to detailed applications of these tools and Make them aware the availability of such diagnostic tools The book will attract additional audience of pathologists, medical microbiologists, pharmaceutical sciences, agricultural scientists and veterinary doctors if the following topics are incorporated at appropriate places in Unit II or separately as a part of Unit-III in the book. Molecular diagnosis of diseases in agricultural crops Molecular diagnosis of veterinary diseases. Molecular epidemiology, which helps to differentiate various epidemic strains and sources of disease outbreaks. Even in different units of the same hospital, the infections could be by different strains of the same species and the information becomes valuable for infection control strategies. Drug resistance is a growing problem for bacterial, fungal and parasitic microbes and the molecular biology tools can help to detect the drug resistance genes without the cultivation and in vitro sensitivity testing. Molecular diagnostics offers faster help in the selection of the proper antibiotic for the treatment of tuberculosis, which is a major problem of the in the developing world. The conventional culture and drug sensitivity testing of tuberculosis bacilli is laborious and time consuming, whereas molecular diagnosis offers rapid drug resistant gene detection even from direct clinical samples. The same approach for HIV, malaria and many more diseases needs to be considered. Molecular diagnostics in the detection of diseases during foetal life is an upcoming area in the foetal medicine in case of genetic abnormalities and infectious like TORCH complex etc. The book will be equally useful to students, scientists and professionals working in the field of molecular diagnostics.

Molecular Microbiology

David H. Persing,Fred C. Tenover,Randall T. Hayden,Margareta Ieven,Melissa B. Miller,Frederick S. Nolte,Yi-Wei Tang,Alex van Belkum
Molecular Microbiology Book PDF

Author : David H. Persing,Fred C. Tenover,Randall T. Hayden,Margareta Ieven,Melissa B. Miller,Frederick S. Nolte,Yi-Wei Tang,Alex van Belkum
Publisher : John Wiley & Sons
Page : 835 pages
File Size : 40,5 Mb
Release : 2020-07-24
Category : Science
ISBN : 9781555819071

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Molecular Microbiology by David H. Persing,Fred C. Tenover,Randall T. Hayden,Margareta Ieven,Melissa B. Miller,Frederick S. Nolte,Yi-Wei Tang,Alex van Belkum Pdf

Presenting the latest molecular diagnostic techniques in one comprehensive volume The molecular diagnostics landscape has changed dramatically since the last edition of Molecular Microbiology: Diagnostic Principles and Practice in 2011. With the spread of molecular testing and the development of new technologies and their opportunities, laboratory professionals and physicians more than ever need a resource to help them navigate this rapidly evolving field. Editors David Persing and Fred Tenover have brought together a team of experienced researchers and diagnosticians to update this third edition comprehensively, to present the latest developments in molecular diagnostics in the support of clinical care and of basic and clinical research, including next-generation sequencing and whole-genome analysis. These updates are provided in an easy-to-read format and supported by a broad range of practical advice, such as determining the appropriate type and quantity of a specimen, releasing and concentrating the targets, and eliminating inhibitors. Molecular Microbiology: Diagnostic Principles and Practice Presents the latest basic scientific theory underlying molecular diagnostics Offers tested and proven applications of molecular diagnostics for the diagnosis of infectious diseases, including point-of-care testing Illustrates and summarizes key concepts and techniques with detailed figures and tables Discusses emerging technologies, including the use of molecular typing methods for real-time tracking of infectious outbreaks and antibiotic resistance Advises on the latest quality control and quality assurance measures Explores the increasing opportunities and capabilities of information technology Molecular Microbiology: Diagnostic Principles and Practice is a textbook for molecular diagnostics courses that can also be used by anyone involved with diagnostic test selection and interpretation. It is also a useful reference for laboratories and as a continuing education resource for physicians.

Diagnostic Molecular Biology

Chang-Hui Shen
Diagnostic Molecular Biology Book PDF

Author : Chang-Hui Shen
Publisher : Elsevier
Page : 590 pages
File Size : 41,9 Mb
Release : 2023-06-29
Category : Science
ISBN : 9780323986090

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Diagnostic Molecular Biology by Chang-Hui Shen Pdf

Diagnostic Molecular Biology, Second Edition describes the fundamentals of molecular biology in a clear, concise manner with each technique explained within its conceptual framework and current applications of clinical laboratory techniques comprehensively covered. This targeted approach covers the principles of molecular biology, including basic knowledge of nucleic acids, proteins and chromosomes; the basic techniques and instrumentations commonly used in the field of molecular biology, including detailed procedures and explanations; and the applications of the principles and techniques currently employed in the clinical laboratory. Topics such as whole exome sequencing, whole genome sequencing, RNA-seq, and ChIP-seq round out the discussion. Fully updated, this new edition adds recent advances in the detection of respiratory virus infections in humans, like influenza, RSV, hAdV, hRV but also corona. This book expands the discussion on NGS application and its role in future precision medicine. Provides explanations on how techniques are used to diagnosis at the molecular level Explains how to use information technology to communicate and assess results in the lab Enhances our understanding of fundamental molecular biology and places techniques in context Places protocols into context with practical applications Includes extra chapters on respiratory viruses (Corona)

Clinical Molecular Diagnostics

Shiyang Pan,Jinhai Tang
Clinical Molecular Diagnostics Book PDF

Author : Shiyang Pan,Jinhai Tang
Publisher : Springer Nature
Page : 889 pages
File Size : 52,8 Mb
Release : 2021-07-08
Category : Medical
ISBN : 9789811610370

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Clinical Molecular Diagnostics by Shiyang Pan,Jinhai Tang Pdf

This book covers the discovery of molecular biomarkers, the development of laboratory testing techniques and their clinical applications, focusing on basic research to clinical practice. It introduces new and crucial knowledge and ethics of clinical molecular diagnosis. This book emphasizes the applications of clinical molecular diagnostic test on health management, especially from different diseased organs. It lets readers to understand and realize precision healthcare.

Molecular Diagnostics

George P. Patrinos,Wilhelm Ansorge,Phillip B. Danielson
Molecular Diagnostics Book PDF

Author : George P. Patrinos,Wilhelm Ansorge,Phillip B. Danielson
Publisher : Academic Press
Page : 520 pages
File Size : 52,9 Mb
Release : 2016-10-27
Category : Medical
ISBN : 9780128029886

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Molecular Diagnostics by George P. Patrinos,Wilhelm Ansorge,Phillip B. Danielson Pdf

Molecular Diagnostics, Third Edition, focuses on the technologies and applications that professionals need to work in, develop, and manage a clinical diagnostic laboratory. Each chapter contains an expert introduction to each subject that is next to technical details and many applications for molecular genetic testing that can be found in comprehensive reference lists at the end of each chapter. Contents are divided into three parts, technologies, application of those technologies, and related issues. The first part is dedicated to the battery of the most widely used molecular pathology techniques. New chapters have been added, including the various new technologies involved in next-generation sequencing (mutation detection, gene expression, etc.), mass spectrometry, and protein-specific methodologies. All revised chapters have been completely updated, to include not only technology innovations, but also novel diagnostic applications. As with previous editions, each of the chapters in this section includes a brief description of the technique followed by examples from the area of expertise from the selected contributor. The second part of the book attempts to integrate previously analyzed technologies into the different aspects of molecular diagnostics, such as identification of genetically modified organisms, stem cells, pharmacogenomics, modern forensic science, molecular microbiology, and genetic diagnosis. Part three focuses on various everyday issues in a diagnostic laboratory, from genetic counseling and related ethical and psychological issues, to safety and quality management. Presents a comprehensive account of all new technologies and applications used in clinical diagnostic laboratories Explores a wide range of molecular-based tests that are available to assess DNA variation and changes in gene expression Offers clear translational presentations by the top molecular pathologists, clinical chemists, and molecular geneticists in the field

Molecular Diagnostics

Lela Buckingham
Molecular Diagnostics Book PDF

Author : Lela Buckingham
Publisher : F.A. Davis
Page : 576 pages
File Size : 53,7 Mb
Release : 2019-02-22
Category : Medical
ISBN : 9780803699540

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Molecular Diagnostics by Lela Buckingham Pdf

Meet the challenges of this rapidly expanding field with a solid understanding of the fundamentals of nucleic acid biochemistry as well as the advanced concepts integral to practice in today’s laboratories. With a focus on the application of molecular concepts to the diagnosis of disease, the 3rd Edition of this popular resource encompasses microbiology, virology, genetics, oncology, and human identification.

Molecular Diagnostics

Lela Buckingham
Molecular Diagnostics Book PDF

Author : Lela Buckingham
Publisher : F. A. Davis Company
Page : 0 pages
File Size : 48,5 Mb
Release : 2012
Category : Medical
ISBN : 0803626770

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Molecular Diagnostics by Lela Buckingham Pdf

The first text on molecular diagnostics specifically designed for clinical laboratory science programs is back! This exceptional resource introduces the fundamentals of nucleic acid, as well as more advanced concepts. With a focus on the application of molecular concepts in the clinical laboratory to diagnosis diseases, the 2nd Edition includes important updates and improvements to keep up with the rapidly developing field. Inside youll find in-depth explanations of the principles of molecular-based assays as well as reference material, trouble-shooting tips for the laboratory, and discussions that emphasize the continuing emergence of new diagnostic technologies.

Principles of Molecular Pathology

Anthony Killeen
Principles of Molecular Pathology Book PDF

Author : Anthony Killeen
Publisher : Springer Science & Business Media
Page : 347 pages
File Size : 44,9 Mb
Release : 2003-11-07
Category : Medical
ISBN : 9781592594313

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Principles of Molecular Pathology by Anthony Killeen Pdf

Anthony Killeen, MD, PhD, offers a comprehensive yet concise introduction to molecular pathology that encompasses both applied and theoretical knowledge. Writing in a very readable style, the author reviews the basic concepts of human molecular biology, explains the principles of the most commonly used analytical methods, and discusses the molecular principles that underlie both inherited diseases and acquired genetic abnormalities that lead to cancer. Using common viral infections as examples, the book applies these molecular methods to the detection of microbial pathogens. The growing importance of pharmacogenetics and identity testing in the clinical laboratory is also highlighted.

Principles of Molecular Diagnostics and Personalized Cancer Medicine

Dongfeng Tan,Henry T. Lynch
Principles of Molecular Diagnostics and Personalized Cancer Medicine Book PDF

Author : Dongfeng Tan,Henry T. Lynch
Publisher : Lippincott Williams & Wilkins
Page : 2177 pages
File Size : 51,8 Mb
Release : 2012-12-07
Category : Medical
ISBN : 9781469820644

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Principles of Molecular Diagnostics and Personalized Cancer Medicine by Dongfeng Tan,Henry T. Lynch Pdf

The role of molecular genetics in the treatment of malignancy continues to grow at an astonishing rate. Today’s subspecialized multidisciplinary approach to oncology has incorporated advances in targeted molecular therapy, prognosis, risk assessment, and prevention—all based at least in part on molecular diagnostics and imaging. Inside this cutting-edge resource, readers will explore broad, comprehensive perspectives on the current trends in molecular diagnosis of cancer and personalized cancer medicine. Authoritative discussions share insights from noted experts in cancer research, clinical trials, molecular diagnostics, personalized therapy, bioinformatics, and federal regulations. From the basic mechanisms of carcinogenesis to the most advanced molecular screening, staging, and treatment technologies, readers will discover clear and straightforward discussions directly relevant to patient diagnosis and care.

Molecular Methods in Plant Disease Diagnostics

Neil Boonham,Jenny Tomlinson,Rick Mumford
Molecular Methods in Plant Disease Diagnostics Book PDF

Author : Neil Boonham,Jenny Tomlinson,Rick Mumford
Publisher : CABI
Page : 212 pages
File Size : 53,7 Mb
Release : 2016-04-19
Category : Science
ISBN : 9781780641478

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Molecular Methods in Plant Disease Diagnostics by Neil Boonham,Jenny Tomlinson,Rick Mumford Pdf

Using molecular methods for plant disease diagnosis provides diagnosticians with a number of advantages over more traditional methods. They can allow the identification of morphologically similar species, for example, or the detection of infection prior to symptom formation. Not only can molecular tools help by increasing the efficacy, accuracy and speed of diagnosis; their common technological basis provides further benefits, especially where resources are limited and traditional skills are hard to sustain. This book provides protocols for nucleic acid-based methods currently applied to plant pathogen detection and identification. It takes the practitioner through the full range of molecular diagnostic and detection methods and, as these generic techniques are appropriate for use on any target with minimal modification, also provides a useful resource for students of plant pathology and plant pathologists. Beginning with the background and future directions of the science, it then addresses DNA barcoding, microarrays, polymerase chain reactions (PCR), quality assurance and more, forming a complete reference on the subject.