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Principles of Evolutionary Medicine by Peter D. Gluckman,Alan Beedle,Tatjana Buklijas,Felicia Low,Mark A. Hanson Pdf
This is the first integrated and comprehensive textbook to explain the principles of evolutionary biology from a medical perspective and to focus on how medicine and public health might utilise evolutionary biology.
Principles of Evolutionary Medicine by Peter D. Gluckman,Alan Beedle,Tatjana Buklijas,Felicia Low,Mark Hanson Pdf
This is the first integrated and comprehensive textbook to explain the principles of evolutionary biology from a medical perspective and to focus on how medicine and public health might utilise evolutionary biology.
The Oxford Handbook of Evolutionary Medicine by Martin Brüne,Wulf Schiefenhövel Pdf
Medicine is grounded in the natural sciences, among which biology stands out with regard to the understanding of human physiology and conditions that cause dysfunction. Ironically though, evolutionary biology is a relatively disregarded field. One reason for this omission is that evolution is deemed a slow process. Indeed, macroanatomical features of our species have changed very little in the last 300,000 years. A more detailed look, however, reveals that novel ecological contingencies, partly in relation to cultural evolution, have brought about subtle changes pertaining to metabolism and immunology, including adaptations to dietary innovations, as well as adaptations to the exposure to novel pathogens. Rapid pathogen evolution and evolution of cancer cells cause major problems for the immune system to find adequate responses. In addition, many adaptations to past ecologies have turned into risk factors for somatic disease and psychological disorder in our modern worlds (i.e. mismatch), among which epidemics of autoimmune diseases, cardiovascular diseases, diabetes and obesity, as well as several forms of cancer stand out. In addition, depression, anxiety and other psychiatric conditions add to the list. The Oxford Handbook of Evolutionary Medicine is a compilation of cutting edge insights into the evolutionary history of ourselves as a species, and how and why our evolved design may convey vulnerability to disease. Written in a classic textbook style emphasising physiology and pathophysiology of all major organ systems, the Oxford Handbook of Evolutionary Medicine will be valuable for students as well as scholars in the fields of medicine, biology, anthropology and psychology.
Evolution and Medicine provides an accessible introduction to the new field of evolutionary medicine. Evolutionary concepts help explain why we remain vulnerable to disease, how pathogens and cancer cells evolve, and how the diseases that affected our evolutionary ancestors have shaped our biology. The book interweaves the presentation of evolutionary principles with examples that illustrate how an evolutionary perspective enhances our understanding of disease. It discusses the theory of evolution by natural selection, the genetic basis of evolutionary change, evolutionary life history theory, and host-pathogen coevolution, and uses these concepts to provide new insights into diseases such as cystic fibrosis, cancer, sexually transmitted diseases, and malaria, incorporating the latest research in rapidly developing fields such as epigenetics and the study of the human microbiome. The book concludes with a discussion of the ways in which recent, culturally constructed changes in the human environment are increasing the prevalence of man-made diseases such as diabetes and cardiovascular diseases, and are exacerbating socioeconomic disparities in health. Just as evolutionary biology is concerned with populations and with changes in populations over time, evolutionary medicine is concerned with the health of populations. Evolution and Medicine emphasizes the role of demographic processes in evolution and disease, and stresses the importance of improving population health as a strategy for improving the health of individuals. This accessible text is written primarily for physicians, biomedical scientists, and both premedical and medical students, and will appeal to all readers with a background or interest in medicine.
A Primer of Evolutionary Medicine by Stephen Stearns Pdf
Evolutionary Medicine is a textbook intended for use in undergraduate, graduate, medical school, and continuing medical education (CME) courses. Its professional illustrations and summaries of chapters and sections make its messages readily accessible.
Edward P Bass Professor of Ecology and Evolutionary Biology Stephen C Stearns,Stephen C Stearns,David W Wallace Professor of Immunobiology Ruslan Medzhitov,Ruslan Medzhitov
Author : Edward P Bass Professor of Ecology and Evolutionary Biology Stephen C Stearns,Stephen C Stearns,David W Wallace Professor of Immunobiology Ruslan Medzhitov,Ruslan Medzhitov Publisher : Unknown Page : 0 pages File Size : 43,6 Mb Release : 2024-07 Category : Medical ISBN : 0192871986
Evolutionary Medicine by Edward P Bass Professor of Ecology and Evolutionary Biology Stephen C Stearns,Stephen C Stearns,David W Wallace Professor of Immunobiology Ruslan Medzhitov,Ruslan Medzhitov Pdf
With recent updates, the second edition of Evolutionary Medicine presents general principles of evolutionary biology and organismal design, then applies them to medical issues where these principles bring useful insights.
John S. Torday,Neil W. Blackstone,Virender K. Rehan
Author : John S. Torday,Neil W. Blackstone,Virender K. Rehan Publisher : John Wiley & Sons Page : 248 pages File Size : 55,8 Mb Release : 2018-05-03 Category : Science ISBN : 9781118838334
Evidence-Based Evolutionary Medicine by John S. Torday,Neil W. Blackstone,Virender K. Rehan Pdf
A groundbreaking, evidence-based text to the growing field of evolutionary medicine Evidence-Based Evolutionary Medicine offers a comprehensive review of the burgeoning field of evolutionary medicine and explores vital topics such as evolution, ecology, and aging as they relate to mainstream medicine. The text integrates Darwinian principles and evidence-based medicine in order to offer a clear picture of the underlying principles that reflect how and why organisms have evolved on a cellular level. The authors—noted authorities in their respective fields—address evolutionary medicine from a developmental cell-molecular perspective. They explore the first principles of physiology that explain the generation of existing tissues, organs, and organ systems. The text offers an understanding of the overall biology as a vertically integrated whole, from unicellular to multicellular organisms. In addition, it addresses clinical diagnostic and therapeutic approaches, both traditional and cell-homeostatic. This groundbreaking text: • Offers a much-needed, logical, and fundamental approach to biology and medicine • Provides a clear explanation of complex physiology and pathophysiology • Integrates topics like evolution, ecology and aging into mainstream medicine, making them more relevant • Contains the first evidence-based text on evolutionary medicine Written for medical and graduate students in biology, physiology, anatomy, endocrinology, reproductive biology, medicine, pathology, systems biology, this vital resource offers a unique text of both biology as an integrated whole with universal properties; and of medicine seeing the individual as a whole, not an inventory of parts and diseases.
Why We Get Sick by Randolph M. Nesse, MD,George C. Williams Pdf
The next time you get sick, consider this before picking up the aspirin: your body may be doing exactly what it's supposed to. In this ground-breaking book, two pioneers of the science of Darwinian medicine argue that illness as well as the factors that predispose us toward it are subject to the same laws of natural selection that otherwise make our bodies such miracles of design. Among the concerns they raise: When may a fever be beneficial? Why do pregnant women get morning sickness? How do certain viruses "manipulate" their hosts into infecting others? What evolutionary factors may be responsible for depression and panic disorder? Deftly summarizing research on disorders ranging from allergies to Alzheimer's, and form cancer to Huntington's chorea, Why We Get Sick, answers these questions and more. The result is a book that will revolutionize our attitudes toward illness and will intrigue and instruct lay person and medical practitioners alike.
Evolutionary Thinking in Medicine by Alexandra Alvergne,Crispin Jenkinson,Charlotte Faurie Pdf
The aim of this edited book is to provide health professionals, across a wide variety of specialisms, with a targeted access to evolutionary medicine. Throughout the book, the views of both medical and evolutionary scientists on the latest relevant research is presented with a focus on practical implications. The inclusion of boxes explaining the theoretical background as well as both a glossary for technical terms and a lay summary for non- specialists enable medical researchers, public health professionals, policy makers, physicians, students, scholars and the public alike to quickly and easily access appropriate information. This edited volume is thus relevant to anyone keen on finding out how evolutionary medicine can improve the health and well-being of people.
Sequence — Evolution — Function by Eugene V. Koonin,Michael Galperin Pdf
Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the peculiarities of the emerging field of Genome Biology and to learn how to benefit from the enormous amount of sequence data available in the public databases. The book is non-technical with respect to the computer methods for genome analysis and discusses these methods from the user's viewpoint, without addressing mathematical and algorithmic details. Prior practical familiarity with the basic methods for sequence analysis is a major advantage, but a reader without such experience will be able to use the book as an introduction to these methods. This book is perfect for introductory level courses in computational methods for comparative and functional genomics.
In the wake of the rapid advance of a number of diseases including epidemic drug-resistant bacteria and viruses, tuberculosis, malaria, cancer, and AIDS, Lappe puts forth that the real cause of our current plight is rooted in an historical blindness to the natural forces that have shaped disease organisms and a continued ignorance of the interplay between our massive destruction of the natural order and our own well being. Annotation copyright by Book News, Inc., Portland, OR
Textbook of Evolutionary Psychiatry and Psychosomatic Medicine by Martin Brüne Pdf
Psychiatry and Psychosomatic Medicine are concerned with medical conditions affecting brain, mind and behaviour in manifold ways. Traditional approaches have focused on a restricted array of potential causes of psychiatric and psychosomatic conditions - including adverse experiences such as trauma, neglect or abuse, genetic vulnerability and epigenetic regulation of gene expression. Whilst essential for the understanding of mental disorders, these approaches have disregarded important questions such as why the human mind is vulnerable to dysfunction at all. The Textbook of Evolutionary Psychiatry and Psychosomatic Medicine updates and expands on the original Textbook of Evolutionary Psychiatry (OUP, 2008) to provide answers to these questions by emphasising an evolutionary perspective on psychiatric and psychosomatic conditions. It explains how the human brain/mind has been shaped by natural and sexual selection; why adaptations to environmental conditions in our evolutionary past may nowadays work in suboptimal ways; and how human cognition, emotions, and behaviour can be scientifically framed to improve our understanding of how people try to attain important biosocial goals pertaining to one's status in society, mating, eliciting and providing care, and maintaining rewarding relationships. The evolutionary topics relevant to the understanding of psychiatric and psychosomatic conditions include the concepts of genetic plasticity, life history theory, stress regulation and immunological aspects. In addition, it is argued that an evolutionary framework is also necessary to understand how psychotherapy and psychopharmacology work to improve the lives of patients with psychiatric and psychosomatic disorders. The Textbook of Evolutionary Psychiatry and Psychosomatic Medicine is a valuable text for all students of Psychology, Medicine, and Psychotherapy who seek an understanding of the evolutionary issues surrounding health and disease.
Every day, 1500 Americans die of cancer, and yet for most of us this deadly disease remains mysterious. Why is it so common? Why are there so many different causes? Why does treatment so often fail? What, ultimately, is cancer? In this fascinating new book, a leading cancer researcher offers general readers clear and convincing answers to these and many other questions. Mel Greaves places cancer in its evolutionary context, arguing that we can best answer the big questions about cancer by looking through a Darwinian lens. Drawing on both ancient and more modern evolutionary legacies, he shows how human development has changed the rules of evolutionary games, trapping us in a nature-nurture mismatch. Compelling examples, from the King of Naples intestinal tumor in the 15th century, through the epidemic of scrotal skin cancer in 18th-century chimney sweeps, to the current surge of cases of prostate cancer illustrate his thesis. He also shows why the old paradigms of infectious diseases or genetic disorders have proved fruitless when trying to explain this complex and elusive disease. And finally, he looks at the implications for research, prevention, and treatment of cancer that an evolutionary perspective provides. Drawing on the most recent research, this is the first book to put cancer in its evolutionary framework. At a time when Darwinian perspectives on everything from language acquisition to economics are providing new breakthroughs in understanding, medicine seems to have much to gain from the insights provided by evolutionary biology. Written in an exceptionally lucid and entertaining style, this book will be of broad interest to all those who wish to know more about this dread disease.
We have built a world that no longer fits our bodies. Our genes - selected through our evolution - and the many processes by which our development is tuned within the womb, limit our capacity to adapt to the modern urban lifestyle. There is a mismatch. We are seeing the impact of this mismatch in the explosion of diabetes, heart disease and obesity. But it also has consequences in earlier puberty and old age. Bringing together the latest scientific research in evolutionary biology, development, medicine, anthropology and ecology, Peter Gluckman and Mark Hanson, both leading medical scientists, argue that many of our problems as modern-day humans can be understood in terms of this fundamental and growing mismatch. It is an insight that we ignore at our peril.