Principles Of Human Organs On Chips

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Principles of Human Organs-on-Chips

Masoud Mozafari
Principles of Human Organs on Chips Book PDF

Author : Masoud Mozafari
Publisher : Woodhead Publishing
Page : 492 pages
File Size : 50,8 Mb
Release : 2023-01-17
Category : Medical
ISBN : 9780128236109

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Principles of Human Organs-on-Chips by Masoud Mozafari Pdf

Principles of Human Organs-on-Chips covers all aspects of microfluidic organ-on-a-chip systems, from fabrication to application and commercialization. Organ-on-a-chip models are created to mimic the structural, microenvironmental and physiological functions of human organs, providing the potential to bypass some cell and animal testing methods. This is a useful platform with widespread applications, frequently in drug screening and pathological studies. This book offers a comprehensive and authoritative reference on microfluidic organs-on-chips, spanning all key aspects from fabrication methods, cell culture systems and cell-based analysis, to dedicated chapters on specific tissue types and their associated organ-on-a-chip models, as well as their use as disease models, drug screening platforms and more. Principles of Human Organs-on-Chips helps materials scientists and biomedical engineers to better understand the specific requirements and challenges in the design and fabrication of organ-on-a-chip devices. This book also bridges the knowledge gap between medical device design and subsequent clinical applications, allowing medical professionals to easily learn about related engineering concepts and techniques. Describes various microfluidic systems and fabrication methods Covers models and applications for a broad range of tissue types, including liver, eye, immune, gut, and more Offers an interdisciplinary approach, combining engineering techniques and clinical applications of organs-on-chips

Lab-on-a-Chip Fabrication and Application

Margarita Stoytcheva,Roumen Zlatev
Lab on a Chip Fabrication and Application Book PDF

Author : Margarita Stoytcheva,Roumen Zlatev
Publisher : BoD – Books on Demand
Page : 210 pages
File Size : 43,6 Mb
Release : 2016-06-29
Category : Science
ISBN : 9789535124573

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Lab-on-a-Chip Fabrication and Application by Margarita Stoytcheva,Roumen Zlatev Pdf

The necessity of on-site, fast, sensitive, and cheap complex laboratory analysis, associated with the advances in the microfabrication technologies and the microfluidics, made it possible for the creation of the innovative device lab-on-a-chip (LOC), by which we would be able to scale a single or multiple laboratory processes down to a chip format. The present book is dedicated to the LOC devices from two points of view: LOC fabrication and LOC application.

Microfluidic Cell Culture Systems

Christopher Bettinger,Jeffrey T Borenstein,Sarah L Tao
Microfluidic Cell Culture Systems Book PDF

Author : Christopher Bettinger,Jeffrey T Borenstein,Sarah L Tao
Publisher : William Andrew
Page : 452 pages
File Size : 42,5 Mb
Release : 2012-12-31
Category : Science
ISBN : 9781437734607

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Microfluidic Cell Culture Systems by Christopher Bettinger,Jeffrey T Borenstein,Sarah L Tao Pdf

The fields of microfluidics and BioMEMS are significantly impacting cell biology research and applications through the application of engineering solutions to human disease and health problems. The dimensions of microfluidic channels are well suited to the physical scale of biological cells, and the many advantages of microfluidics make it an attractive platform for new techniques in biology. This new professional reference applies the techniques of microsystems to cell culture applications. The authors provide a thoroughly practical guide to the principles of microfluidic device design and operation and their application to cell culture techniques. The resulting book is crammed with strategies and techniques that can be immediately deployed in the lab. Equally, the insights into cell culture applications will provide those involved in traditional microfluidics and BioMEMS with an understanding of the specific demands and opportunities presented by biological applications. The goal is to guide new and interested researchers and technology developers to the important areas and state-of-the-practice strategies that will enhance the efficiency and value of their technologies, devices and biomedical products. Provides insights into the design and development of microfluidic systems with a specific focus on cell culture applications Focuses on strategies and techniques for the design and fabrication of microfluidic systems and devices for cell culture Provides balanced coverage of microsystems engineering and bioengineering

Current Trends in Biomedical Engineering

Christiane Bertachini Lombello,Patricia Aparecida da Ana
Current Trends in Biomedical Engineering Book PDF

Author : Christiane Bertachini Lombello,Patricia Aparecida da Ana
Publisher : Springer Nature
Page : 294 pages
File Size : 40,6 Mb
Release : 2023-10-30
Category : Technology & Engineering
ISBN : 9783031387432

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Current Trends in Biomedical Engineering by Christiane Bertachini Lombello,Patricia Aparecida da Ana Pdf

This book brings together the latest updates from various subareas of biomedical engineering, providing readers with a broad overview of the current state of the art and the technological trends to be refined in the coming years with the goal of improving human health. It shows the important advances in each subfield, rehabilitation technology, computational systems applied to health, and medical devices, with practical examples. It includes topics not covered in other books in the area, such as digital health, bioprinting, organs-on-a-chip, the open data paradigm, and electrical impedance tomography. It is a short and easy-to-read book, and provides bibliographic references for the reader to go deeper into their areas of interest. This book is aimed at a very broad group of professionals and students in biomedical engineering and related areas, seeking to contextualize and understand the latest scientific advances in each subfield of biomedical engineering, including neuroengineering, regenerative medicine, additive manufacturing orthosis, postural analysis of Parkinson's patients, modelling and simulation using biomechanical open data, regenerative medicine, advanced drug delivery systems, bioprinting, biophotonic and electrical impedance tomography.

Basic Concepts on 3D Cell Culture

Cornelia Kasper,Dominik Egger,Antonina Lavrentieva
Basic Concepts on 3D Cell Culture Book PDF

Author : Cornelia Kasper,Dominik Egger,Antonina Lavrentieva
Publisher : Springer Nature
Page : 252 pages
File Size : 41,6 Mb
Release : 2021-06-09
Category : Medical
ISBN : 9783030667498

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Basic Concepts on 3D Cell Culture by Cornelia Kasper,Dominik Egger,Antonina Lavrentieva Pdf

This textbook shall introduce the students to 3D cell culture approaches and applications. An overview on existing techniques and equipment is provided and insight into various aspects and challenges that researchers need to consider and face during culture of 3D cells is given. The reader will learn the importance of physiological cell, tissue and organ models and gains important knowledge on 3D analytics. This textbook deepens selected aspects of the textbook “Cell Culture Technology”, which also is published in this series, while offering extended insight into 3D cell culture. The concept of the textbook encompasses various lectures ranging from basics in cell cultivation, tissue engineering, biomaterials and biocompatibility, in vitro test systems and regenerative medicine. The textbook addresses Master- and PhD students interested and/or working in the field of modern cell culture applications and will support the understanding of the essential strategies in 3D cell culture and waken awareness for the potentials and challenges of this application.

Biochip Technology

Jing Cheng,Larry J. Kricka
Biochip Technology Book PDF

Author : Jing Cheng,Larry J. Kricka
Publisher : CRC Press
Page : 453 pages
File Size : 47,7 Mb
Release : 2003-09-02
Category : Science
ISBN : 9780203305041

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Biochip Technology by Jing Cheng,Larry J. Kricka Pdf

Biochip technology has experienced explosive growth in recent years and Biochip technology describes the basic manufacturing and fabrication processes and the current range of applications of these chips. Top scientists from the biochip industry and related areas explain the diverse applications of biochips in gene sequencing, expression monitoring, disease diagnosis, tumor examination, ligand assay and drug discovery.

Discovering the Brain

National Academy of Sciences,Institute of Medicine,Sandra Ackerman
Discovering the Brain Book PDF

Author : National Academy of Sciences,Institute of Medicine,Sandra Ackerman
Publisher : National Academies Press
Page : 195 pages
File Size : 47,8 Mb
Release : 1992-01-01
Category : Medical
ISBN : 9780309045292

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Discovering the Brain by National Academy of Sciences,Institute of Medicine,Sandra Ackerman Pdf

The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."

Principles of Tissue Engineering

Robert Lanza,Robert Langer,Joseph P. Vacanti
Principles of Tissue Engineering Book PDF

Author : Robert Lanza,Robert Langer,Joseph P. Vacanti
Publisher : Academic Press
Page : 1936 pages
File Size : 49,9 Mb
Release : 2013-10-17
Category : Technology & Engineering
ISBN : 9780123983701

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Principles of Tissue Engineering by Robert Lanza,Robert Langer,Joseph P. Vacanti Pdf

Now in its fourth edition, Principles of Tissue Engineering has been the definite resource in the field of tissue engineering for more than a decade. The fourth edition provides an update on this rapidly progressing field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation by the world’s experts of what is currently known about each specific organ system. As in previous editions, this book creates a comprehensive work that strikes a balance among the diversity of subjects that are related to tissue engineering, including biology, chemistry, material science, and engineering, among others, while also emphasizing those research areas that are likely to be of clinical value in the future. This edition includes greatly expanded focus on stem cells, including induced pluripotent stem (iPS) cells, stem cell niches, and blood components from stem cells. This research has already produced applications in disease modeling, toxicity testing, drug development, and clinical therapies. This up-to-date coverage of stem cell biology and other emerging technologies –such as brain-machine interfaces for controlling bionics and neuroprostheses– is complemented by a series of new and updated chapters on recent clinical experience in applying tissue engineering, as well as a new section on the application of tissue-engineering techniques for food production. The result is a comprehensive textbook that will be useful to students and experts alike. Includes new chapters on biomaterial-protein interactions, nanocomposite and three-dimensional scaffolds, skin substitutes, spinal cord, vision enhancement, and heart valves Offers expanded coverage of adult and embryonic stem cells of the cardiovascular, hematopoietic, musculoskeletal, nervous, and other organ systems Full-color presentation throughout

Hidden in Plain Sight

Albert Folch
Hidden in Plain Sight Book PDF

Author : Albert Folch
Publisher : MIT Press
Page : 353 pages
File Size : 54,9 Mb
Release : 2022-04-26
Category : Technology & Engineering
ISBN : 9780262046893

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Hidden in Plain Sight by Albert Folch Pdf

Stories behind essential microfluidic devices, from the inkjet printer to DNA sequencing chip. Hidden from view, microfluidics underlies a variety of devices that are essential to our lives, from inkjet printers to glucometers for the monitoring of diabetes. Microfluidics—which refers to the technology of miniature fluidic devices and the study of fluids at submillimeter levels—is invisible to most of us because it is hidden beneath ingenious user interfaces. In this book, Albert Folch, a leading researcher in microfluidics, describes the development and use of key microfluidic devices. He explains not only the technology but also the efforts, teams, places, and circumstances that enabled these inventions. Folch reports, for example, that the inkjet printer was one of the first microfluidic devices invented, and traces its roots back to nineteenth-century discoveries in the behavior of fluid jets. He also describes how rapid speed microfluidic DNA sequencers have enabled the sequencing of animal, plant, and microbial species genomes; organs on chips facilitate direct tests of drugs on human tissue, leapfrogging over the usual stage of animal testing; at-home pregnancy tests are based on clever microfluidic principles; microfluidics can be used to detect cancer cells in the early stages of metastasis; and the same technology that shoots droplets of ink on paper in inkjet printers enables 3D printers to dispense layers of polymers. Folch tells the stories behind these devices in an engaging style, accessible to nonspecialists. More than 100 color illustrations show readers amazing images of microfluids under the microscope.

Biomedical Applications of Microfluidic Devices

Michael R. Hamblin,Mahdi Karimi
Biomedical Applications of Microfluidic Devices Book PDF

Author : Michael R. Hamblin,Mahdi Karimi
Publisher : Academic Press
Page : 352 pages
File Size : 40,6 Mb
Release : 2020-11-12
Category : Technology & Engineering
ISBN : 9780128187920

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Biomedical Applications of Microfluidic Devices by Michael R. Hamblin,Mahdi Karimi Pdf

Biomedical Applications of Microfluidic Devices introduces the subject of microfluidics and covers the basic principles of design and synthesis of actual microchannels. The book then explores how the devices are coupled to signal read-outs and calibrated, including applications of microfluidics in areas such as tissue engineering, organ-on-a-chip devices, pathogen identification, and drug/gene delivery. This book covers high-impact fields (microarrays, organ-on-a-chip, pathogen detection, cancer research, drug delivery systems, gene delivery, and tissue engineering) and shows how microfluidics is playing a key role in these areas, which are big drivers in biomedical engineering research. This book addresses the fundamental concepts and fabrication methods of microfluidic systems for those who want to start working in the area or who want to learn about the latest advances being made. The subjects covered are also an asset to companies working in this field that need to understand the current state-of-the-art. The book is ideal for courses on microfluidics, biosensors, drug targeting, and BioMEMs, and as a reference for PhD students. The book covers the emerging and most promising areas of biomedical applications of microfluidic devices in a single place and offers a vision of the future. Covers basic principles and design of microfluidics devices Explores biomedical applications to areas such as tissue engineering, organ-on-a-chip, pathogen identification, and drug and gene delivery Includes chemical applications in organic and inorganic chemistry Serves as an ideal text for courses on microfluidics, biosensors, drug targeting, and BioMEMs, as well as a reference for PhD students

Organ-on-a-chip

Julia Hoeng,David Bovard,Manuel Peitsch
Organ on a chip Book PDF

Author : Julia Hoeng,David Bovard,Manuel Peitsch
Publisher : Academic Press
Page : 546 pages
File Size : 46,7 Mb
Release : 2019-11-09
Category : Technology & Engineering
ISBN : 9780128172032

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Organ-on-a-chip by Julia Hoeng,David Bovard,Manuel Peitsch Pdf

Organ-on-a-Chip: Engineered Microenvironments for Safety and Efficacy Testing contains chapters from world-leading researchers in the field of organ on a chip development and applications, with perspectives from life sciences, medicine, physiology and engineering. The book contains an overview of the field, with sections covering the major organ systems and currently available technologies, platforms and methods. As readers may also be interested in creating biochips, materials and engineering best practice, these topics are also described. Users will learn about the limitations of 2D in-vitro models and the available 3D in-vitro models (what benefits they offer and some examples). Finally, the MOC section shows how the organ on a chip technology can be adapted to improve the physiology of in-vitro models. Includes case studies of other organs on a chip that have been developed and successfully used Provides insights into functional microphysiological organ on a chip platforms for toxicity and efficacy testing, along with opportunities for translational medicine Presented fields (PK/PD, physiology, medicine, safety) are given a definition followed by the challenges and potential of organs on a chip

Microfluidic Cell Culture Systems

Jeffrey T Borenstein,Vishal Tandon,Sarah L Tao,Joseph L. Charest
Microfluidic Cell Culture Systems Book PDF

Author : Jeffrey T Borenstein,Vishal Tandon,Sarah L Tao,Joseph L. Charest
Publisher : Elsevier
Page : 396 pages
File Size : 51,7 Mb
Release : 2018-09-12
Category : Science
ISBN : 9780128136720

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Microfluidic Cell Culture Systems by Jeffrey T Borenstein,Vishal Tandon,Sarah L Tao,Joseph L. Charest Pdf

Techniques for microfabricating intricate microfluidic structures that mimic the microenvironment of tissues and organs, combined with the development of biomaterials with carefully engineered surface properties, have enabled new paradigms in and cell culture-based models for human diseases. The dimensions of surface features and fluidic channels made accessible by these techniques are well-suited to the size scale of biological cells. Microfluidic Cell Culture Systems applies design and experimental techniques used in in microfluidics, and cell culture technologies to organ-on-chip systems. This book is intended to serve as a professional reference, providing a practical guide to design and fabrication of microfluidic systems and biomaterials for use in cell culture systems and human organ models. The book covers topics ranging from academic first principles of microfluidic design, to clinical translation strategies for cell culture protocols. The goal is to help professionals coming from an engineering background to adapt their expertise for use in cell culture and organ models applications, and likewise to help biologists to design and employ microfluidic technologies in their cell culture systems. This 2nd edition contains new material that strengthens the focus on in vitro models useful for drug discovery and development. One new chapter reviews liver organ models from an industry perspective, while others cover new technologies for scaling these models and for multi-organ systems. Other new chapters highlight the development of organ models and systems for specific applications in disease modeling and drug safety. Previous chapters have been revised to reflect the latest advances. Provides design and operation methodology for microfluidic and microfabricated materials and devices for organ-on-chip disease and safety models. This is a rapidly expanding field that will continue to grow along with advances in cell biology and microfluidics technologies. Comprehensively covers strategies and techniques ranging from academic first principles to industrial scale-up approaches. Readers will gain insight into cell-material interactions, microfluidic flow, and design principles. Offers three fundamental types of information: 1) design principles, 2) operation techniques, and 3) background information/perspectives. The book is carefully designed to strike a balance between these three areas, so it will be of use to a broad range of readers with different technical interests and educational levels.

Principles of Regenerative Medicine

Anthony Atala,Robert Lanza,James A. Thomson,Robert Nerem
Principles of Regenerative Medicine Book PDF

Author : Anthony Atala,Robert Lanza,James A. Thomson,Robert Nerem
Publisher : Academic Press
Page : 1202 pages
File Size : 44,7 Mb
Release : 2010-12-16
Category : Science
ISBN : 0123814235

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Principles of Regenerative Medicine by Anthony Atala,Robert Lanza,James A. Thomson,Robert Nerem Pdf

Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine New discoveries from leading researchers on restoration of diseased tissues and organs

Microfluidics and Multi Organs on Chip

P. V. Mohanan
Microfluidics and Multi Organs on Chip Book PDF

Author : P. V. Mohanan
Publisher : Springer Nature
Page : 712 pages
File Size : 43,7 Mb
Release : 2022-07-11
Category : Medical
ISBN : 9789811913792

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Microfluidics and Multi Organs on Chip by P. V. Mohanan Pdf

This book highlights the application of microfluidics in cell biology research, chemical biology, and drug discovery. It covers the recent breakthroughs and prospects of organ-on-a-chip, human-on-a-chip, multi-organ-on-a-chip for personalized medicine. The book presents the preclinical studies of organs-on-a-chip, concepts of multiple vascularized organ-on-chips, application of organ-on-a-chip in blood-brain barrier model, culture and co-culture of cells on multi-organ-on-chip and parameter measurements in microfluidic devices. It underscores the advantage of microfluidic devices for developing efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Further, it entails human-on-a-chip for measuring the systemic response as well as immediate effects of an organ reaction on other organs. In summary, this book reviews the development of a microfluidic-based organ-on-a-chip device for the preclinical evaluation, ADME studies of drugs, chemicals, and medical devices. This book is a valuable source for pharma companies, product developers, students, researchers, academicians, and practitioners.

Bioinspired Structures and Design

Wole Soboyejo,Leo Daniel
Bioinspired Structures and Design Book PDF

Author : Wole Soboyejo,Leo Daniel
Publisher : Cambridge University Press
Page : 373 pages
File Size : 44,7 Mb
Release : 2020-09-17
Category : Science
ISBN : 9781107015586

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Bioinspired Structures and Design by Wole Soboyejo,Leo Daniel Pdf

Human cortical bone as a structural material : Hierarchical design and biological degradation / Robert Ritchie and Elizabeth A. Zimmermann -- Bio-inspiration from nacre / Nima Rahbar and Sina Askarinejad -- Bio-inspiration from bamboo / Ting Tan and Wole Soboyejo.