Prions And Brain Diseases In Animals And Humans

Author : Douglas R.O. Morrison
Publisher : Springer Science & Business Media
Page : 349 pages
File Size : 40,8 Mb
Release : 2013-06-29
Category : Science
ISBN : 9781489918963

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Prions and Brain Diseases in Animals and Humans by Douglas R.O. Morrison Pdf

Most of the world's experts on prions met for a workshop in Erice in August 1996. The aim of the workshop was to discuss the fundamentals of the science ofprions. It was for tunate that so many could be present given the pressure that they were under because of the data presented in March 1996, indicating that Bovine Spongiform Encephalopathy, BSE or Mad Cow Disease, had penetrated the species barrier and was beginning to cause a new dis ease in humans--the new variant ofCreutzfeldt-Jakob Disease, nvCJD. This important and urgent subject became an additional major topic at the workshop. This is a book containing most of the talks plus the abstracts of those unable to find time to write up their talks. Almost all papers were written in the spring and summer of 1997 and contain material added after the workshop; thus Bob Will's paper on the new variant of cm contains data up to July 1997 and four contributions arrived in October 1997. In addition to the talks given at our workshop, there was a special joint session with the Planetary Emergencies Workshop where many distinguished scientists, including three Nobel laureates, discussed major issues affecting our planet. Six talks were given by us to this other workshop, five about prions, BSE, and nvCJD, and one on the broader issue of new epi demics by Luc Montagnier. Although most of the talks concerned research issues, there were a few special talks.

Author : Wen-Quan Zou,Pierluigi Gambetti
Publisher : Springer Science & Business Media
Page : 322 pages
File Size : 48,6 Mb
Release : 2012-11-08
Category : Medical
ISBN : 9781461453383

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Prions and Diseases by Wen-Quan Zou,Pierluigi Gambetti Pdf

Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases.

Author : Anonim
Publisher : Elsevier
Page : 512 pages
File Size : 43,6 Mb
Release : 2018-06-07
Category : Medical
ISBN : 9780444639530

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Human Prion Diseases by Anonim Pdf

Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including the pathophysiology of prions and a description of animal and human diseases. This is followed by detailed reports on recent advances in diagnosis strategies for the development of novel anti-prion molecules and possible designs of clinical trials in such a rare disease. An introductory chapter gives an extensive historical background of prion research, with a final chapter highlighting recent progress, and more importantly, unsolved problems. Offers an authoritative overview of prion diseases in humans, detailing the pathogenesis of the disease, clinical investigations, and the diagnosis of both the genetic and acquired forms Provides clarity and context by presenting prion diseases in relation to other neurodegenerative diseases in humans Emphasizes the unique properties of prion diseases and consequent problems they can cause, both clinically and in public health terms

Author : Beat Hörnlimann,Detlev Riesner,Hans A. Kretzschmar
Publisher : Walter de Gruyter
Page : 743 pages
File Size : 43,5 Mb
Release : 2009-05-08
Category : Medical
ISBN : 9783110200171

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Prions in Humans and Animals by Beat Hörnlimann,Detlev Riesner,Hans A. Kretzschmar Pdf

This comprehensive work, aimed at both students and researchers alike, systematically covers all aspects of prion diseases (transmissible spongiform encephalopathies), from their history, microbiology and pathology to their transmissibility and prevention. The book describes diseases such as Creutzfeldt-Jakob disease, kuru, mad cow disease (BSE), chronic wasting disease and scrapie, highlighting their biochemical, molecular biological, genetic, and clinical aspects. A detailed presentation of the impact of prion diseases in fields such as pharmaceutics, blood products, disinfection, surgical instruments and epidemiology concludes with a discussion of preventive measures. A renowned editorial team, representing the fields of medicine, veterinary medicine and molecular biology, brought together 80 internationally respected authors for this translation and new edition of the successful German publication, not only from relevant research fields, but also from industry and public health institutions. The book includes chapters by, among many other notable scientists, William J. Hadlow, who discovered the relationship between the human and animal forms of prion diseases and Michael P. Alpers, with 45 years of experience in Papua New Guinea investigating the first known human epidemic form, kuru, transmitted by endocannibalism. Further contributions from Gerald A. H. Wells, a veterinary pathologist who described BSE and recognised its similarity to scrapie, thus recording the first cases in 1986 of the most important animal epidemic of modern times, and Robert G. Will, a medical neurologist and epidemiologist who discovered the emergence of the variant form of Creutzfeldt-Jakob disease in 1996, underscore the strength of this author team. Carefully edited with numerous illustrations, this work offers a systematic approach committed to a clear presentation of the current knowledge of prion diseases. It aims to inspire and stimulate interdisciplinary cooperation, innovative research ideas and effective prevention.

Author : Stanley B. Prusiner
Publisher : Prentice Hall
Page : 628 pages
File Size : 53,6 Mb
Release : 1992
Category : Bovine spongiform encephalopathy
ISBN : UOM:39015009127419

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Prion Diseases of Humans and Animals by Stanley B. Prusiner Pdf

Author : Wen-Quan Zou,Pierluigi Gambetti
Publisher : Springer Nature
Page : 773 pages
File Size : 47,5 Mb
Release : 2023-01-01
Category : Medical
ISBN : 9783031205651

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Prions and Diseases by Wen-Quan Zou,Pierluigi Gambetti Pdf

Transmissible spongiform encephalopathies (TSE), known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. Modern studies, including the protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In the second edition of Prions and Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date discussion of these unique infectious pathogens and their associated diseases. The book provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the full range of animal and human prion diseases. As a result, the book contains by far the most authoritative views about the past, present, and future of prions and prion diseases. The new second edition covers such important emerging topics such as inherited human prion disease, stem-cell models in prion research, human prion disease surveillance, and gene therapy strategies.

Author : Jorg Tatzelt
Publisher : Unknown
Page : 80 pages
File Size : 52,7 Mb
Release : 2010
Category : Prions
ISBN : 0954333527

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The Prion Protein by Jorg Tatzelt Pdf

A conformational transition of the cellular prion protein (PrPC) into an aberrantly folded isoform designated scrapie prion protein (PrPSc) is the hallmark of a variety of neurodegenerative disorders collectively called prion diseases. They include Creutzfeldt-Jakob disease and Gerstmann-Stäussler-Scheinker syndrome in humans, scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle and chronic wasting disease (CWD) in free-ranging deer. In contrast to the deadly properties of misfolded PrP, PrPC seems to possess a neuroprotective activity. More-over, animal models indicated that the stress-protective activity of PrPC and the neurotoxic effects of PrPSc are somehow interconnected. In this timely book, leading scientists in the field have come together to highlight the apparently incongruous activities of different PrP conformers. The articles outline current research on celluar pathways implicated in the formation and signaling of neurotoxic and physiological PrP isoforms and delineate future research direction. Topics covered include the physiologcial activity of PrPC and its possible role as a neurotrophic factor, the finding that aberrant PrP conformers can cause neurodegeneration in the absence of infectious prion propagation, the requirement of the GPI anchor of PrPC for the neurotoxic effects of scrapie prions, the pathways implicated in the formation and neurotoxic properties of cytosolically localized PrP, the impact of metal ions on the processing of PrP, and the role of autophagy in the propagation and clearance of PrPSc. The book is fully illustrated and chapters include comprehensive reference sections. Essential reading for scientists involved in prion research.

Author : Institute of Medicine,Medical Follow-up Agency,Committee on Transmissible Spongiform Encephalopathies: Assessment of Relevant Science
Publisher : National Academies Press
Page : 125 pages
File Size : 41,6 Mb
Release : 2003-03-20
Category : Medical
ISBN : 9780309168595

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Advancing Prion Science by Institute of Medicine,Medical Follow-up Agency,Committee on Transmissible Spongiform Encephalopathies: Assessment of Relevant Science Pdf

In Advancing Prion Science, the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science recommends priorities for research and investment to the Department of Defense's National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy (commonly called mad cow disease), chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To develop antemortem diagnostics or therapies for TSEs, the committee concludes that NPRP should invest in basic research specifically to elucidate the structural features of prions, the molecular mechanisms of prion replication, the mechanisms of TSE pathogenesis, and the physiological function of prions' normal cellular isoform. Advancing Prion Science provides the first comprehensive reference on present knowledge about all aspects of TSEs' from basic science to the U.S. research infrastructure, from diagnostics to surveillance, and from prevention to treatment. This report summarizes the progress thus far.

Author : Gabor G. Kovacs
Publisher : Cambridge University Press
Page : 319 pages
File Size : 45,7 Mb
Release : 2014-12-04
Category : Medical
ISBN : 9781107442429

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Neuropathology of Neurodegenerative Diseases Book and Online by Gabor G. Kovacs Pdf

This heavily illustrated, must-have practical guide aids medical specialists and trainees in the diagnosis of neurodegenerative diseases. Includes diagnostic algorithms.

Author : Wen-Quan Zou,Pierluigi Gambetti
Publisher : Springer Science & Business Media
Page : 246 pages
File Size : 44,6 Mb
Release : 2012-11-27
Category : Medical
ISBN : 9781461453055

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Prions and Diseases by Wen-Quan Zou,Pierluigi Gambetti Pdf

Volume I highlights the association of the cellular prion protein (PrPC) with copper and zinc, the potential roles of PrPC in Alzheimer’s disease and cancers, insoluble PrPC, PMCA, molecular and cellular mechanisms of PrPSc formation and clearance, possible co-factors involved in the conversion of PrPC into PrPSc, infectious and pathogenic forms of PrP, cell biology of prions, prion strains and their interference, as well as yeast prions and their inheritable and structural traits. This unique volume will take you through the fascinating chronicle of prions in mammals, yeast, and fungi.

Author : Marc Vandevelde,Robert Higgins,Anna Oevermann
Publisher : John Wiley & Sons
Page : 228 pages
File Size : 43,9 Mb
Release : 2012-08-24
Category : Medical
ISBN : 9781118349496

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Veterinary Neuropathology by Marc Vandevelde,Robert Higgins,Anna Oevermann Pdf

Introducing the theoretical and practical basics of veterinary neuropathology, this concise and well illustrated book is an essential basic diagnostic guide for pathologists, neurologists and diagnostic imaging specialists. It presents readers with strategies to deal with neuropathological problems, showing how to interpret gross and histological lesions using a systematic approach based on pattern recognition. It starts with an overview of the general principles of neuroanatomy, neuropathological techniques, basic tissue reaction patterns, and recognition of major lesion patterns. The book goes on to cover vascular diseases, inflammatory diseases, trauma, congenital malformations, metabolic-toxic diseases, neoplasia and degenerative diseases mainly of the central nervous system. In the respective chapters pathologists can quickly find information to support their daily diagnostic workup for both small and large domestic species. Based on the authors’ extensive diagnostic and post graduate teaching experience as well as the inclusion of MRI as it relates to neuropathology, this book also offers a comprehensive but basic analysis of veterinary neuropathology that neurologists and other MRI users will find very useful. An essential manual for daily diagnostic work Richly illustrated with high quality colour gross, histological and MRI images Includes a section on the function and use of MRI (by Johann Lang, DECVDI) Accompanied by a website presenting MRI sequences for interpretation and correlation with neuropathological findings edited by Johann Lang (University of Bern, Switzerland) and Eric Wiesner (University of California, Davis, USA) www.wiley.com/go/vandevelde/veterinaryneuropathology

Author : C.J. Peters,Charles H. Calisher
Publisher : Springer Science & Business Media
Page : 212 pages
File Size : 44,5 Mb
Release : 2006-06-07
Category : Medical
ISBN : 9783211299814

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Infectious Diseases from Nature: Mechanisms of Viral Emergence and Persistence by C.J. Peters,Charles H. Calisher Pdf

Significant zoonotic diseases have appeared with increasing frequency in recent years. At a symposium held in Galveston, Texas, in March 2004, many outstanding virologists and others presented papers under the broad theme of "emergence". The intent was to elucidate the diseases themselves, the mechanisms by which they have emerged, the publication perception and response to the diseases, and the possibility of prevention or prediction. The papers in this book summarize the talks of this meeting. Among the many timely papers are those by Nobel Prize winner Peter Doherty, influenza epidemiologists Robert Webster and Jeffery Taubenberger, and important contributions by Neal Nathanson, Esteban Domingo, Barry Beaty, David Walker, James Hughes, and others of world expertise.

Author : Martin H. Groschup,Hans Kretzschmar
Publisher : Springer Science & Business Media
Page : 284 pages
File Size : 49,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783709163085

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Prion Diseases by Martin H. Groschup,Hans Kretzschmar Pdf

The overwhelming interest and the participation of more than 500 scientists from 26 countries made this symposium the largest meeting ever held in the field. In this book twenty-six invited speakers comprehensively present their data on the pathogenesis of prion diseases in humans and animals, on molecular mechanisms involved in the transmissibility across species barriers, on animal and in-vitro models currently available for the detection and quantification of infectivity and on the characterization of prion strains.

Author : Anonim
Publisher : Elsevier
Page : 480 pages
File Size : 52,6 Mb
Release : 2018-01-09
Category : Medical
ISBN : 9780444640772

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Neurogenetics by Anonim Pdf

Neurogenetics, Part II, Volume 148, the latest release in the Handbook of Clinical Neurology, provides the latest information on the genetic methodologies that are having a significant impact on the study of neurological and psychiatric disorders. Using genetic science, researchers have identified over 200 genes that cause or contribute to neurological disorders. Still an evolving field of study, defining the relationship between genes and neurological and psychiatric disorders is expected to dramatically grow in scope. Part II builds on the foundation of Part I, expanding the coverage to dementias, paroxysmal disorders, neuromuscular disorders, white matter and demyelination diseases, cerebrovascular diseases, adult psychiatric disorders and cancer and phacomatoses. Contains comprehensive coverage of neurogenetics Details the latest science and its impact on our understanding of neurological, psychiatric disorders Presents a focused reference for clinical practitioners and the neuroscience/neurogenetics research community

Author : Stanley B. Prusiner
Publisher : Unknown
Page : 30 pages
File Size : 52,8 Mb
Release : 1994-03-01
Category : Creutzfeldt-Jakob disease
ISBN : 1873240694

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Prion Diseases of Humans and Animals by Stanley B. Prusiner Pdf