Prions And Diseases

Author : Anonim
Publisher : Elsevier
Page : 512 pages
File Size : 43,6 Mb
Release : 2018-06-07
Category : Medical
ISBN : 9780444639530

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Human Prion Diseases by Anonim Pdf

Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including the pathophysiology of prions and a description of animal and human diseases. This is followed by detailed reports on recent advances in diagnosis strategies for the development of novel anti-prion molecules and possible designs of clinical trials in such a rare disease. An introductory chapter gives an extensive historical background of prion research, with a final chapter highlighting recent progress, and more importantly, unsolved problems. Offers an authoritative overview of prion diseases in humans, detailing the pathogenesis of the disease, clinical investigations, and the diagnosis of both the genetic and acquired forms Provides clarity and context by presenting prion diseases in relation to other neurodegenerative diseases in humans Emphasizes the unique properties of prion diseases and consequent problems they can cause, both clinically and in public health terms

Author : Stanley B. Prusiner
Publisher : Springer
Page : 0 pages
File Size : 55,9 Mb
Release : 2011-09-21
Category : Medical
ISBN : 3642646409

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Prions Prions Prions by Stanley B. Prusiner Pdf

A series of remarkable discoveries in the past three decades have led to the molecular and genetic characterization of the transmissible pathogen causing scrapie in animals and a quartet of human illnesses: kuru, Jakob-Creutzfeld disease, Gerstmann-Sträussler-Scheinker disease, and fatal familial insomnia. To distinguish this pathogen from viruses and viroids, the term "prion" was introduced to emphasize its proteinaceous and infectious nature. Stanley B. Prusiner, editor of this volume, was awarded the 1997 Nobel Prize in Physiology and Medicine for his pioneering discovery of prions. The book reviews advances in studies of prions, which - as considereable evidence indicates - are novel pathogens composed only of protein.

Author : Wen-Quan Zou,Pierluigi Gambetti
Publisher : Springer Nature
Page : 773 pages
File Size : 43,8 Mb
Release : 2023-01-01
Category : Medical
ISBN : 9783031205651

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Prions and Diseases by Wen-Quan Zou,Pierluigi Gambetti Pdf

Transmissible spongiform encephalopathies (TSE), known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. Modern studies, including the protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In the second edition of Prions and Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date discussion of these unique infectious pathogens and their associated diseases. The book provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the full range of animal and human prion diseases. As a result, the book contains by far the most authoritative views about the past, present, and future of prions and prion diseases. The new second edition covers such important emerging topics such as inherited human prion disease, stem-cell models in prion research, human prion disease surveillance, and gene therapy strategies.

Author : David R. Brown
Publisher : Springer Science & Business Media
Page : 498 pages
File Size : 49,6 Mb
Release : 2005-05-06
Category : Medical
ISBN : 0387239227

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Neurodegeneration and Prion Disease by David R. Brown Pdf

This is the first and only book on the subject of prions to cover the cause of cell death in the disease. It covers the full range of competing theories on the subject, from broad description and basic points up to the final details of the basic science.

Author : Wen-Quan Zou,Pierluigi Gambetti
Publisher : Springer Science & Business Media
Page : 322 pages
File Size : 52,8 Mb
Release : 2012-11-08
Category : Medical
ISBN : 9781461453383

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Prions and Diseases by Wen-Quan Zou,Pierluigi Gambetti Pdf

Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases.

Author : Claudio Soto
Publisher : CRC Press
Page : 191 pages
File Size : 42,5 Mb
Release : 2005-12-20
Category : Medical
ISBN : 9781420040128

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Prions by Claudio Soto Pdf

Prion-related diseases, known as transmissible spongiform encephalopathies (TSEs), are infectious, fatal neurodegenerative disorders for which there is no cure, treatment, nor even a means for early diagnosis. The horrific advent of Mad Cow Disease -- transmitted to humans through eating meat from steers sickened by bovine spongiform encephalopathy

Author : C.J. Peters,Charles H. Calisher
Publisher : Springer Science & Business Media
Page : 212 pages
File Size : 50,6 Mb
Release : 2006-06-07
Category : Medical
ISBN : 9783211299814

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Infectious Diseases from Nature: Mechanisms of Viral Emergence and Persistence by C.J. Peters,Charles H. Calisher Pdf

Significant zoonotic diseases have appeared with increasing frequency in recent years. At a symposium held in Galveston, Texas, in March 2004, many outstanding virologists and others presented papers under the broad theme of "emergence". The intent was to elucidate the diseases themselves, the mechanisms by which they have emerged, the publication perception and response to the diseases, and the possibility of prevention or prediction. The papers in this book summarize the talks of this meeting. Among the many timely papers are those by Nobel Prize winner Peter Doherty, influenza epidemiologists Robert Webster and Jeffery Taubenberger, and important contributions by Neal Nathanson, Esteban Domingo, Barry Beaty, David Walker, James Hughes, and others of world expertise.

Author : Institute of Medicine,Medical Follow-up Agency,Committee on Transmissible Spongiform Encephalopathies: Assessment of Relevant Science
Publisher : National Academies Press
Page : 125 pages
File Size : 42,5 Mb
Release : 2003-03-20
Category : Medical
ISBN : 9780309168595

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Advancing Prion Science by Institute of Medicine,Medical Follow-up Agency,Committee on Transmissible Spongiform Encephalopathies: Assessment of Relevant Science Pdf

In Advancing Prion Science, the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science recommends priorities for research and investment to the Department of Defense's National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy (commonly called mad cow disease), chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To develop antemortem diagnostics or therapies for TSEs, the committee concludes that NPRP should invest in basic research specifically to elucidate the structural features of prions, the molecular mechanisms of prion replication, the mechanisms of TSE pathogenesis, and the physiological function of prions' normal cellular isoform. Advancing Prion Science provides the first comprehensive reference on present knowledge about all aspects of TSEs' from basic science to the U.S. research infrastructure, from diagnostics to surveillance, and from prevention to treatment. This report summarizes the progress thus far.

Author : Rosalind M. Ridley,Harry F. Baker
Publisher : Unknown
Page : 272 pages
File Size : 55,5 Mb
Release : 1998
Category : Medical
ISBN : STANFORD:36105020164120

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Fatal Protein by Rosalind M. Ridley,Harry F. Baker Pdf

This book presents a clear and authoritative account of the prion diseases for the non-specialist. It deals with the history of scrapie in sheep, the spread of kuru through cannibalism in Papua New Guinea, BSE, which has killed 170,000 cattle in the UK, and the question of whether the newvariant form of Creutzfeld-Jakob disease (CJD) results from eating BSE-infected meat. All aspects of the diseases are covered, including genetics, clinical aspects, laboratory research, epidemiology, and field studies. Accessibly written by authors who are leading researchers in the field, it is thefirst book to provide a scientifically accurate yet readable account of these topical diseases.

Author : Martin H. Groschup,Hans Kretzschmar
Publisher : Springer Science & Business Media
Page : 284 pages
File Size : 54,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783709163085

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Prion Diseases by Martin H. Groschup,Hans Kretzschmar Pdf

The overwhelming interest and the participation of more than 500 scientists from 26 countries made this symposium the largest meeting ever held in the field. In this book twenty-six invited speakers comprehensively present their data on the pathogenesis of prion diseases in humans and animals, on molecular mechanisms involved in the transmissibility across species barriers, on animal and in-vitro models currently available for the detection and quantification of infectivity and on the characterization of prion strains.

Author : Wen-Quan Zou,Pierluigi Gambetti
Publisher : Springer Science & Business Media
Page : 246 pages
File Size : 43,5 Mb
Release : 2012-11-27
Category : Medical
ISBN : 9781461453055

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Prions and Diseases by Wen-Quan Zou,Pierluigi Gambetti Pdf

Volume I highlights the association of the cellular prion protein (PrPC) with copper and zinc, the potential roles of PrPC in Alzheimer’s disease and cancers, insoluble PrPC, PMCA, molecular and cellular mechanisms of PrPSc formation and clearance, possible co-factors involved in the conversion of PrPC into PrPSc, infectious and pathogenic forms of PrP, cell biology of prions, prion strains and their interference, as well as yeast prions and their inheritable and structural traits. This unique volume will take you through the fascinating chronicle of prions in mammals, yeast, and fungi.

Author : Stanley B. Prusiner
Publisher : Yale University Press
Page : 344 pages
File Size : 48,6 Mb
Release : 2014-04-29
Category : Science
ISBN : 9780300191141

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Madness and Memory by Stanley B. Prusiner Pdf

The author, a 1997 recipient of the Noble Prize in medicine, describes the years he spent researching and demonstrating how the infectious proteins known as prions were responsible for brain diseases and how his theory has now become widely accepted in the science establishment.

Author : Stanley B. Prusiner
Publisher : Prentice Hall
Page : 628 pages
File Size : 54,9 Mb
Release : 1992
Category : Medical
ISBN : UOM:39015009127419

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Prion Diseases of Humans and Animals by Stanley B. Prusiner Pdf

Author : Ivo Nikolaev Sirakov
Publisher : BoD – Books on Demand
Page : 84 pages
File Size : 45,7 Mb
Release : 2019-01-30
Category : Medical
ISBN : 9781789850178

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Prions by Ivo Nikolaev Sirakov Pdf

The cellular prion protein (PrPC) is expressed as a cell surface protein mainly in the central and peripheral nervous system. The discovery that prions are infectious agents changed the concept of protein synthesis in modern biology and built a bridge between the genesis of infectious and genetic diseases. This book discusses the normal function of the PrPC and its modulatory role in synaptic mechanisms. It describes the pathophysiological processes that accompany TSE - neurotoxicity, loss of anti-inflammatory protective function, neuronal death including prion-induced autophagy and apoptosis, and accumulation of PrPSc in the cytoplasm of neurons. Another aspect outlined here is that some prion diseases show strain variations that determine their development, demonstrating their key role in the development and progression of TSE.

Author : Gabor G. Kovacs
Publisher : Cambridge University Press
Page : 319 pages
File Size : 44,6 Mb
Release : 2015
Category : Medical
ISBN : 9781107442429

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Neuropathology of Neurodegenerative Diseases Book and Online by Gabor G. Kovacs Pdf

This heavily illustrated, must-have practical guide aids medical specialists and trainees in the diagnosis of neurodegenerative diseases. Includes diagnostic algorithms.