Prions Prions Prions

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Prions Prions Prions

Stanley B. Prusiner
Prions Prions Prions Book PDF

Author : Stanley B. Prusiner
Publisher : Springer
Page : 0 pages
File Size : 41,9 Mb
Release : 2011-09-21
Category : Medical
ISBN : 3642646409

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Prions Prions Prions by Stanley B. Prusiner Pdf

A series of remarkable discoveries in the past three decades have led to the molecular and genetic characterization of the transmissible pathogen causing scrapie in animals and a quartet of human illnesses: kuru, Jakob-Creutzfeld disease, Gerstmann-Sträussler-Scheinker disease, and fatal familial insomnia. To distinguish this pathogen from viruses and viroids, the term "prion" was introduced to emphasize its proteinaceous and infectious nature. Stanley B. Prusiner, editor of this volume, was awarded the 1997 Nobel Prize in Physiology and Medicine for his pioneering discovery of prions. The book reviews advances in studies of prions, which - as considereable evidence indicates - are novel pathogens composed only of protein.

Human Prion Diseases

Anonim
Human Prion Diseases Book PDF

Author : Anonim
Publisher : Elsevier
Page : 512 pages
File Size : 45,6 Mb
Release : 2018-06-07
Category : Medical
ISBN : 9780444639530

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Human Prion Diseases by Anonim Pdf

Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including the pathophysiology of prions and a description of animal and human diseases. This is followed by detailed reports on recent advances in diagnosis strategies for the development of novel anti-prion molecules and possible designs of clinical trials in such a rare disease. An introductory chapter gives an extensive historical background of prion research, with a final chapter highlighting recent progress, and more importantly, unsolved problems. Offers an authoritative overview of prion diseases in humans, detailing the pathogenesis of the disease, clinical investigations, and the diagnosis of both the genetic and acquired forms Provides clarity and context by presenting prion diseases in relation to other neurodegenerative diseases in humans Emphasizes the unique properties of prion diseases and consequent problems they can cause, both clinically and in public health terms

Prion Biology

Stanley B. Prusiner
Prion Biology Book PDF

Author : Stanley B. Prusiner
Publisher : Perspectives Cshl
Page : 0 pages
File Size : 49,5 Mb
Release : 2017
Category : Medical
ISBN : 1621820939

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Prion Biology by Stanley B. Prusiner Pdf

"Prions are infectious proteins responsible for diseases such as Creutzfeldt-Jakob disease and "mad cow" disease. They are misfolded versions of normal proteins that replicate by converting their normal cellular counterparts into abnormal prion proteins that disrupt cell function and can be transmitted to other cells and individuals. This book exam

Prions

Claudio Soto
Prions Book PDF

Author : Claudio Soto
Publisher : CRC Press
Page : 191 pages
File Size : 41,5 Mb
Release : 2005-12-20
Category : Medical
ISBN : 9781420040128

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Prions by Claudio Soto Pdf

Prion-related diseases, known as transmissible spongiform encephalopathies (TSEs), are infectious, fatal neurodegenerative disorders for which there is no cure, treatment, nor even a means for early diagnosis. The horrific advent of Mad Cow Disease -- transmitted to humans through eating meat from steers sickened by bovine spongiform encephalopathy

Prions

Ivo Nikolaev Sirakov
Prions Book PDF

Author : Ivo Nikolaev Sirakov
Publisher : BoD – Books on Demand
Page : 84 pages
File Size : 40,7 Mb
Release : 2019-01-30
Category : Medical
ISBN : 9781789850178

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Prions by Ivo Nikolaev Sirakov Pdf

The cellular prion protein (PrPC) is expressed as a cell surface protein mainly in the central and peripheral nervous system. The discovery that prions are infectious agents changed the concept of protein synthesis in modern biology and built a bridge between the genesis of infectious and genetic diseases. This book discusses the normal function of the PrPC and its modulatory role in synaptic mechanisms. It describes the pathophysiological processes that accompany TSE - neurotoxicity, loss of anti-inflammatory protective function, neuronal death including prion-induced autophagy and apoptosis, and accumulation of PrPSc in the cytoplasm of neurons. Another aspect outlined here is that some prion diseases show strain variations that determine their development, demonstrating their key role in the development and progression of TSE.

Madness and Memory

Stanley B. Prusiner
Madness and Memory Book PDF

Author : Stanley B. Prusiner
Publisher : Yale University Press
Page : 344 pages
File Size : 43,5 Mb
Release : 2014-04-29
Category : Science
ISBN : 9780300191141

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Madness and Memory by Stanley B. Prusiner Pdf

The author, a 1997 recipient of the Noble Prize in medicine, describes the years he spent researching and demonstrating how the infectious proteins known as prions were responsible for brain diseases and how his theory has now become widely accepted in the science establishment.

Neurodegeneration and Prion Disease

David R. Brown
Neurodegeneration and Prion Disease Book PDF

Author : David R. Brown
Publisher : Springer Science & Business Media
Page : 498 pages
File Size : 47,9 Mb
Release : 2005-05-06
Category : Medical
ISBN : 0387239227

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Neurodegeneration and Prion Disease by David R. Brown Pdf

This is the first and only book on the subject of prions to cover the cause of cell death in the disease. It covers the full range of competing theories on the subject, from broad description and basic points up to the final details of the basic science.

Advancing Prion Science

Institute of Medicine,Medical Follow-up Agency,Committee on Transmissible Spongiform Encephalopathies: Assessment of Relevant Science
Advancing Prion Science Book PDF

Author : Institute of Medicine,Medical Follow-up Agency,Committee on Transmissible Spongiform Encephalopathies: Assessment of Relevant Science
Publisher : National Academies Press
Page : 125 pages
File Size : 49,5 Mb
Release : 2003-03-20
Category : Medical
ISBN : 9780309168595

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Advancing Prion Science by Institute of Medicine,Medical Follow-up Agency,Committee on Transmissible Spongiform Encephalopathies: Assessment of Relevant Science Pdf

In Advancing Prion Science, the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science recommends priorities for research and investment to the Department of Defense's National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy (commonly called mad cow disease), chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To develop antemortem diagnostics or therapies for TSEs, the committee concludes that NPRP should invest in basic research specifically to elucidate the structural features of prions, the molecular mechanisms of prion replication, the mechanisms of TSE pathogenesis, and the physiological function of prions' normal cellular isoform. Advancing Prion Science provides the first comprehensive reference on present knowledge about all aspects of TSEs' from basic science to the U.S. research infrastructure, from diagnostics to surveillance, and from prevention to treatment. This report summarizes the progress thus far.

Prions

Akikazu Sakudo,Takashi Onodera
Prions Book PDF

Author : Akikazu Sakudo,Takashi Onodera
Publisher : Unknown
Page : 160 pages
File Size : 51,8 Mb
Release : 2019-03-12
Category : Science
ISBN : 1910190950

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Prions by Akikazu Sakudo,Takashi Onodera Pdf

Essential reading for everyone working with prions from the PhD student to the experienced scientist.

Infectious Diseases from Nature: Mechanisms of Viral Emergence and Persistence

C.J. Peters,Charles H. Calisher
Infectious Diseases from Nature Mechanisms of Viral Emergence and Persistence Book PDF

Author : C.J. Peters,Charles H. Calisher
Publisher : Springer Science & Business Media
Page : 212 pages
File Size : 54,9 Mb
Release : 2006-06-07
Category : Medical
ISBN : 9783211299814

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Infectious Diseases from Nature: Mechanisms of Viral Emergence and Persistence by C.J. Peters,Charles H. Calisher Pdf

Significant zoonotic diseases have appeared with increasing frequency in recent years. At a symposium held in Galveston, Texas, in March 2004, many outstanding virologists and others presented papers under the broad theme of "emergence". The intent was to elucidate the diseases themselves, the mechanisms by which they have emerged, the publication perception and response to the diseases, and the possibility of prevention or prediction. The papers in this book summarize the talks of this meeting. Among the many timely papers are those by Nobel Prize winner Peter Doherty, influenza epidemiologists Robert Webster and Jeffery Taubenberger, and important contributions by Neal Nathanson, Esteban Domingo, Barry Beaty, David Walker, James Hughes, and others of world expertise.

Prion Biology and Diseases

Stanley B. Prusiner
Prion Biology and Diseases Book PDF

Author : Stanley B. Prusiner
Publisher : CSHL Press
Page : 1130 pages
File Size : 51,8 Mb
Release : 2004
Category : Prion diseases
ISBN : 0879696931

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Prion Biology and Diseases by Stanley B. Prusiner Pdf

This volume is a new edition of the most authoritative book on Prion Biology, first published in 1999 and edited by the Nobel Prize-winning founder of the field. This expanded edition has been completely updated, and includes chapters on therapeutics, and diagnostic methods and approaches.

How the Cows Turned Mad

Maxime Schwartz
How the Cows Turned Mad Book PDF

Author : Maxime Schwartz
Publisher : Univ of California Press
Page : 264 pages
File Size : 50,7 Mb
Release : 2004-09-13
Category : Medical
ISBN : 9780520243378

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How the Cows Turned Mad by Maxime Schwartz Pdf

"How the Cows Turned Mad tells the story of a disease that continues to elude on many levels. Yet science has come far in understanding its origins, incubation, and transmission. This book is a case history that illuminates the remarkable progression of science."--BOOK JACKET.

Prions and Diseases

Wen-Quan Zou,Pierluigi Gambetti
Prions and Diseases Book PDF

Author : Wen-Quan Zou,Pierluigi Gambetti
Publisher : Springer Science & Business Media
Page : 322 pages
File Size : 42,7 Mb
Release : 2012-11-08
Category : Medical
ISBN : 9781461453383

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Prions and Diseases by Wen-Quan Zou,Pierluigi Gambetti Pdf

Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases.

Prions and Mad Cow Disease

Brian K. Nunnally,Ira S. Krull
Prions and Mad Cow Disease Book PDF

Author : Brian K. Nunnally,Ira S. Krull
Publisher : CRC Press
Page : 414 pages
File Size : 47,6 Mb
Release : 2003-10-17
Category : Medical
ISBN : 9780824756840

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Prions and Mad Cow Disease by Brian K. Nunnally,Ira S. Krull Pdf

The alarm sounded by Canada's recently confirmed case of bovine spongiform encephalopathy (BSE) has reaffirmed the exigency of establishing improved safeguards and more aggressive surveillance protocols in North America and around the world. Research converging on the probable causative agent-prion proteins-calls for intensive assessment of the headway gained in tracing prions, testing for transmissible neurodegenerative diseases, and developing methods for cornering the epidemic. Administered by an illustrious panel of 36 international contributors, this timely book marshals techniques for prion protein assay and diagnosis of transmissible spongiform encephalopathies (TSEs).

Neuropathology of Neurodegenerative Diseases Book and Online

Gabor G. Kovacs
Neuropathology of Neurodegenerative Diseases Book and Online Book PDF

Author : Gabor G. Kovacs
Publisher : Cambridge University Press
Page : 319 pages
File Size : 41,6 Mb
Release : 2015
Category : Medical
ISBN : 9781107442429

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Neuropathology of Neurodegenerative Diseases Book and Online by Gabor G. Kovacs Pdf

This heavily illustrated, must-have practical guide aids medical specialists and trainees in the diagnosis of neurodegenerative diseases. Includes diagnostic algorithms.