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Author : Michael Thomas Lotze,Yinan Gong,Jennifer Martinez,Na Dong
Publisher : Frontiers Media SA
Page : 156 pages
File Size : 41,6 Mb
Release : 2022-02-14
Category : Science
ISBN : 9782889743902
Author : Roya Khosravi-Far,Zahra Zakeri,Richard A. Lockshin,Mauro Piacentini
Publisher : Academic Press
Page : 544 pages
File Size : 43,8 Mb
Release : 2008-08-28
Category : Science
ISBN : 0080921647
The 2002 Nobel Prize in Physiology or Medicine was awarded to Sydney Brenner (UK),H. Robert Horvitz (US)and John E. Sulston (UK) "for their discoveries concerning genetic regulation of organ development and programmed cell death." Cell death is a fundamental aspect of embryonic development, normal cellular turnover and maintenance of homeostasis (maintaining a stable, constant environment) on the one hand, and aging and disease on the other. This volume addresses the significant advances with the techniques that are being used to analyze cell death. *Provides the necessary, trusted methods to carry out this research on the latest techniques. Once researchers understand the molecular mechanisms of the apoptotic pathways, they can begin to develop new therapies *Presents key methods on studying tumors and how these cancer cells evade cell death *Eliminates searching through many different sources to avoid pitfalls so the same mistakes are not made over and over
Author : Hala Gali-Muhtasib,Omar Nasser Rahal
Publisher : BoD – Books on Demand
Page : 154 pages
File Size : 48,6 Mb
Release : 2020-01-15
Category : Science
ISBN : 9781789847482
This book incorporates developments in our understanding of cell death mechanisms and highlights recent advances in programmed cell death regulation processes. It provides the reader with the network of pathways targeted by herbal anticancer drugs and discusses the role of endoplasmic reticulum stress in cell death mechanisms in addition to highlighting the mechanisms of autophagy and its role in diseases. This book provides valuable material for researchers and for teaching postgraduate students. Emphasis on recent advances and their clinical applications offers insights to researchers that will likely lead to the development of novel therapeutic approaches.
Author : Gerry Melino,David Vaux
Publisher : John Wiley & Sons
Page : 316 pages
File Size : 44,6 Mb
Release : 2010-02-22
Category : Science
ISBN : 9780470686577
This book on cell death contains 29 self-contained, peer-reviewed articles written by leading scientists in each field. It features overview articles aimed at undergraduates and non-specialists, which present basic information and provide entry into the following advanced articles. These advanced articles are written for postgraduate students and research workers, containing detailed information and key references allowing the reader to investigate a specific area in more depth. The book is an essential resource for educational purposes as well as a reference work for experienced researchers in the field. The articles will also be available electronically as part of the acclaimed Encyclopedia of Life Sciences (ELS). Key features: Provides a comprehensive overview on the research of programmed cell death. Edited by leaders in the field. Clearly written and illustrated articles. Full colour throughout. A spin-on to the acclaimed reference work, the Encyclopedia of Life Science (ELS). Combines introductory information with coverage of the latest discoveries in the field. Features overview level articles for advanced students or people new to a topic and more advanced articles for those requiring more detailed information. Serves as a reference work for advanced students as well as researchers in this field. Ideal library purchase for science, medical, and technology libraries in academia, government, and industry; medical libraries; networks and consortia covering these markets.
Author : Swati Sen Mandi
Publisher : Springer
Page : 204 pages
File Size : 54,6 Mb
Release : 2017-04-20
Category : Science
ISBN : 9788132227670
This book is the first of its kind to highlight the positive impact of natural UV radiation on plants through unique adaptations in various metabolic pathways, and provides an evolutionary sketch of the development of molecular mechanisms for protecting plants from solar UV ever since their migration to terrestrial habitats. Experimental evidence is provided for establishing how plants, through their stationary habit in the open field, survive and flourish by developing suitable UV acclimation strategies through the repair of damaged macromolecules and/or upregulation of screening compounds viz. flavonoids. Presenting an analysis of related literature, it also highlights the importance of outdoor experiments over those in closed chamber under artificial UV light for obtaining realistic data. The book presents a comprehensive account of the stratospheric ozone layer, its formation and seasonal thinning, with particular reference to alarming anthropogenic destruction of the ozone layer since the last quarter of the twentieth century, which has resulted in increased UV fluence on Earth. It discusses variations in the hazardous impact of UV on life at different latitudes through the ages, and examines altitudinal variations in UV effects in case studies demonstrating high antioxidant content and aroma status in Darjeeling tea leaves (at high altitudes) compared with those of the same tea clones in Assam leaves (at low altitudes), with both sites being at the same latitude. It provides evidence which suggests that the UV effects relating to the expression of seed vigour-viability could be epigenetic. Further, it presents recently developed microscopic technologies for demonstrating the penetration of UV into plant cells, and discusses how cellular metabolism can be affected either directly or via signal transduction. Effect of damage in DNA (the key target of UV radiation) has been demonstrated and estimated using precise techniques. The latest “FOX Hunting” technique as a useful means of transcriptome analysis that may be used for developing UV tolerant plants through Marker Assisted Breeding has also been discussed. Using biochemical and biotechnological methods, the experiments presented highlight the gene X environment based upregulation of specific metabolic pathways, allowing i) value addition in plant-derived food, and ii) paving the way for the industrial manufacture of Alternative Medicine products. The book is enriched by a critical review of the available literature and appropriate case studies selected from the author’s own findings, which span nearly four decades of active research.
Author : Roya Khosravi-Far,Eileen White
Publisher : Springer Science & Business Media
Page : 356 pages
File Size : 46,9 Mb
Release : 2007-12-29
Category : Medical
ISBN : 9781402065545
Programmed cell death (PCD) plays pivotal roles in tumor progression, cancer therapeutics and resistance of tumor cells to therapy. This book examines the mechanisms involved in mediating and regulating PCD in cancer. It also provides a detailed indication of the utility of PCD in cancer therapy. The book features chapters on the current and future of RNA interference in therapeutics and Pathways involved in Stem Cell Survival and Death.
Author : Richard A. Lockshin,Zahra Zakeri
Publisher : Wiley-Liss
Page : 578 pages
File Size : 52,7 Mb
Release : 2004
Category : Medical
ISBN : UOM:39015061138270
Offers the most thorough, cutting-edge coverage of the field of cell death since publication of the first edition. Leading international researchers present an up-to-date yet accessible survey ranging from the history of cell death science to its modern methodology. Extensively revised, this new edition features relavant discussions of: the impact of genomics and proteomics; gene therapy and pharmacogenetics; the role of mitochondria; caspase-independent and non-apoptotic cell death; and evolution of mechanisms.
Author : Giancarlo Balercia,Loredana Gandini,Andrea Lenzi,Francesco Lombardo
Publisher : Springer
Page : 79 pages
File Size : 46,8 Mb
Release : 2016-11-26
Category : Medical
ISBN : 9783319417493
This book focuses on the use of various molecules with antioxidant properties in the treatment of major male genital tract disorders, especially male infertility, erectile dysfunction, and accessory gland infection. The coverage also includes discussion of pathophysiology, the molecular basis of male infertility, and the rationale for use of antioxidants, with particular attention to coenzyme Q10 and carnitine. Oxidative stress occurs when the production of reactive oxygen species, including free radicals, exceeds the body’s natural antioxidant defences, leading to cellular damage. Oxidative stress is present in about half of all infertile men, and reactive oxygen species can produce infertility both by damaging the sperm membrane, with consequences for sperm motility, and by altering the sperm DNA. There is consequently a clear rationale for the use of antioxidant treatments within andrology, and various in vitro and in vivo studies have indicated that many antioxidants indeed have beneficial impacts. In providing a detailed and up-to-date overview of the subject, this book will be of interest to both practitioners and researchers in andrology, endocrinology, and urology.
Author : Yusuf Tutar,Lutfi Tutar
Publisher : BoD – Books on Demand
Page : 162 pages
File Size : 43,6 Mb
Release : 2018-08-29
Category : Science
ISBN : 9781789235005
Apoptosis is an essential biochemical process in cell turnover, development, and chemical-induced cell death. Current knowledge and ongoing research of apoptosis highlight our understanding in designing the therapeutic approaches for several diseases. This book covers four main sections: "Apoptosis and Necrosis," "Apoptosis Inducers," "Proteasome and Signaling Pathways in Apoptosis," and "Radiation-Based Apoptosis." The first section implicitly describes the differences between apoptosis and necrosis processes. The following section elaborates the small molecule-induced apoptosis. Then, the third section deals with proteasome and signaling pathways and finally, resistance to chemotherapy and electromagnetic radiation is covered in the last section. Overall, the book deals with pathways for manipulating apoptosis and provides a unique perspective to the scientists.
Author : Anonim
Publisher : Academic Press
Page : 276 pages
File Size : 50,9 Mb
Release : 2001-09-26
Category : Science
ISBN : 0080524869
International Review of Cytology presents current advances and comprehensive reviews in cell biology--both plant and animal. Articles included in this volume address such topics as genetic regulation of preimplantation embryo survival, photoreceptor and second-order cell mosaics in the retina of Xenopus, basement membrane and B-amyloid fibrillogenesis in Alzheimer's disease, regulation of microtubule-associated proteins, and dynein motors of the chlamydomonas flagellum. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
Author : Yufang Shi,John A. Cidlowski,David W. Scott,Jia-Rui Wu,Yun Bo Shi
Publisher : Springer Science & Business Media
Page : 229 pages
File Size : 47,7 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781475758900
The 2002 Nobel Prize in Physiology or Medicine was awarded to Sydney Brenner, H. Robert Horvitz, and John E. Sulston for their seminal discoveries concerning "genetic regulation of organ development and programmed cell death." This clearly marked the prime importance of understanding the molecular mechanisms controlling cell death. The 1 st International Symposium on Programmed Cell Death was held in the Shanghai Science Center of the Chinese Academy of Sciences on September 8-12, 1996. A number of key issues in apoptosis were discussed at the meeting, and progress in major areas of apopto sis research was summarized by expert participants at the meeting and published by Plenum Publishing Corporation as a book entitled Programmed Cell Death. In the last six years, we have witnessed a real explosion in our knowledge on how cells undergo apoptosis, thereby participating in various developmental and pathophysiological processes. At this ever exciting time, we organized the 2nd International Symposium on Programmed Cell Death.
Author : Tobias Ntuli
Publisher : BoD – Books on Demand
Page : 448 pages
File Size : 51,6 Mb
Release : 2015-12-16
Category : Science
ISBN : 9789535122364
This book is a collection of selected and relevant research, concerning the developments within the Cell Death field of study. Each contribution comes as a separate chapter complete in itself but directly related to the books topics and objectives. The target audience comprises scholars and specialists in the field.
Author : Hao Zhou,Rui Guo,Amanda Lochner,Russel J. Reiter,Hsueh-Hsiao Wang
Publisher : Frontiers Media SA
Page : 199 pages
File Size : 43,5 Mb
Release : 2022-11-01
Category : Science
ISBN : 9782832505540
The heart is a strong muscular pump that enables tissue and organ perfusion. Therefore, a continuous supply of fresh blood is vital for cardiac function. In coronary artery disease, plaques or thrombi induce rapid occlusion, which restricts blood flow to the heart. The primary effect of coronary artery disease is substantial cardiomyocyte death, which prevents the heart from effectively pumping blood to vital organs.
Author : M Sluyser
Publisher : CRC Press
Page : 275 pages
File Size : 41,6 Mb
Release : 2002-09-11
Category : Medical
ISBN : 9780203483152
In apoptosis in the mammalian system, cells have a finite life - they develop, are used and then die. Cancer cells escape this programmed routine but, from an understanding of apoptosis, they can be programmed to die. This book addresses the
Author : Hamsa Puthalakath,Christine J. Hawkins
Publisher : Unknown
Page : 291 pages
File Size : 45,5 Mb
Release : 2016
Category : Cell death
ISBN : 149393581X