Proteases Ii

Author : Alan J. Barrett,J. Fred Woessner,Neil D. Rawlings
Publisher : Elsevier
Page : 1182 pages
File Size : 41,9 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780080984155

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Handbook of Proteolytic Enzymes, Volume 1 by Alan J. Barrett,J. Fred Woessner,Neil D. Rawlings Pdf

Handbook of Proteolytic Enzymes, Second Edition, Volume 1: Aspartic and Metallo Peptidases is a compilation of numerous progressive research studies on proteolytic enzymes. This edition is organized into two main sections encompassing 328 chapters. This handbook is organized around a system for the classification of peptidases, which is a hierarchical one built on the concepts of catalytic type, clan, family and peptidase. The concept of catalytic type of a peptidase depends upon the chemical nature of the groups responsible for catalysis. The recognized catalytic types are aspartic, cysteine, metallo, serine, threonine, and the unclassified enzymes, while clans and families are groups of homologous peptidases. Homology at the level of a family of peptidases is shown by statistically significant relationship in amino acid sequence to a representative member called the type example, or to another member of the family that has already been shown to be related to the type example. Each chapter discusses the history, activity, specificity, structural chemistry, preparation, and biological aspects of the enzyme. This book will prove useful to enzyme chemists and researchers.

Author : Walter H. Hörl,August Heidland
Publisher : Springer Science & Business Media
Page : 557 pages
File Size : 43,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461310570

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Proteases II by Walter H. Hörl,August Heidland Pdf

Author : International Symposium on Proteases: Potential Role in Health and Disease
Publisher : Unknown
Page : 574 pages
File Size : 46,5 Mb
Release : 1988
Category : Electronic
ISBN : 0036430188

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Proteases II by International Symposium on Proteases: Potential Role in Health and Disease Pdf

Author : Stephen Pandol
Publisher : Morgan & Claypool Publishers
Page : 66 pages
File Size : 55,8 Mb
Release : 2011
Category : Medical
ISBN : 9781615041381

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The Exocrine Pancreas by Stephen Pandol Pdf

The secretions of the exocrine pancreas provide for digestion of a meal into components that are then available for processing and absorption by the intestinal epithelium. Without the exocrine pancreas, malabsorption and malnutrition result. This chapter describes the cellular participants responsible for the secretion of digestive enzymes and fluid that in combination provide a pancreatic secretion that accomplishes the digestive functions of the gland. Key cellular participants, the acinar cell and the duct cell, are responsible for digestive enzyme and fluid secretion, respectively, of the exocrine pancreas. This chapter describes the neurohumoral pathways that mediate the pancreatic response to a meal as well as details of the cellular mechanisms that are necessary for the organ responses, including protein synthesis and transport and ion transports, and the regulation of these responses by intracellular signaling systems. Examples of pancreatic diseases resulting from dysfunction in cellular mechanisms provide emphasis of the importance of the normal physiologic mechanisms.

Author : E. Carstens,Tasuku Akiyama
Publisher : CRC Press
Page : 482 pages
File Size : 40,6 Mb
Release : 2014-02-25
Category : Science
ISBN : 9781466505438

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Itch by E. Carstens,Tasuku Akiyama Pdf

Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.

Author : Sajal Chakraborti,Naranjan S. Dhalla
Publisher : Springer Science & Business Media
Page : 407 pages
File Size : 51,9 Mb
Release : 2013-12-04
Category : Science
ISBN : 9781461492337

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Proteases in Health and Disease by Sajal Chakraborti,Naranjan S. Dhalla Pdf

In view of rapidly growing research in the deregulation of proteases and their impact in human health and diseases, this book will highlight existing and emerging research in this exciting area. In-depth critical state-of-the-art reviews will be written by established investigators on proteases dysfunctions associated with pathogenesis of different diseases that are known to occur due to deregulation of proteolytic systems. Multidisciplinary approaches demonstrating biochemical and signal transduction mechanisms associated with deregulation of proteases leading to manifestation of the diseases will be discussed. The book highlights the roles of both intracellular and extracellular proteases in health and disease.

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 49,5 Mb
Release : 1971
Category : Electronic
ISBN : 0720440882

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Tissue Proteinases by Anonim Pdf

Author : Alasdair M. Gilfillan,Dean Metcalfe
Publisher : Springer Science & Business Media
Page : 312 pages
File Size : 45,9 Mb
Release : 2011-06-28
Category : Medical
ISBN : 9781441995339

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Mast Cell Biology by Alasdair M. Gilfillan,Dean Metcalfe Pdf

The editors of Mast Cell Biology, Drs. Gilfillan and Metcalfe, have enlisted an outstanding group of investigators to discuss the emerging concepts in mast cell biology with respect to development of these cells, their homeostasis, their activation, as well as their roles in maintaining health on the one hand and on the other, their participation in disease.

Author : Wolfgang B. Liedtke, MD, PH.D.
Publisher : CRC Press
Page : 502 pages
File Size : 53,5 Mb
Release : 2006-09-29
Category : Medical
ISBN : 9781420005844

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TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades by Wolfgang B. Liedtke, MD, PH.D. Pdf

Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st

Author : Nobuhiko Katunuma
Publisher : IOS Press
Page : 224 pages
File Size : 45,5 Mb
Release : 1997
Category : Enzyme inhibitors
ISBN : 9051992920

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Medical Aspects of Proteases and Protease Inhibitors by Nobuhiko Katunuma Pdf

The work presents articles on proteases and their inhibitors as mediators of biological functions. Topics addressed: cathepsin B and L; MHC and peptide interaction; procathepsin L; cysteine proteinases; selective neuronal cell death; HIV and influenza virus; tumor invasion; gingivitis; bacterial infection. Readers: professionals in the area of molecular medicine, biochemists, molecular biologists, clinical pharmacologists, pharmaceutical companies.

Author : Anonim
Publisher : Elsevier
Page : 452 pages
File Size : 50,9 Mb
Release : 2003-05-03
Category : Science
ISBN : 0080490883

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Cell Surface Proteases by Anonim Pdf

Cell Surface Proteases provides a comprehensive overview of these important enzymes that catalyze the hydrolysis of a protein as it degrades to a simpler substance. In the 1990s, an explosion of new discoveries shed light on the role of cell surface proteases and extended it beyond degradation of extracellular matrix components to include its influence on growth factors, cell signaling, and other cellular events. This volume unites the scientific literature from across disciplines and teases out unified themes of interactions between cell surface proteases and interconnecting cell surface-related systems -- including integrins and other adhesion molecules. Scientists and students involved in developmental biology, cell biology and disease processes will find this an indispensable resource. * Provides an overview of the entire field of cell surface proteases in a single volume * Presents major issues and astonishing discoveries at the forefront of modern developmental biology and developmental medicine * A thematic volume in the longest-running forum for contemporary issues in developmental biology with over 30 years of coverage

Author : Staffan Magnusson,Martin Ottesen,Bent Foltmann
Publisher : Elsevier
Page : 245 pages
File Size : 54,5 Mb
Release : 2014-05-18
Category : Science
ISBN : 9781483153896

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Regulatory Proteolytic Enzymes and Their Inhibitors by Staffan Magnusson,Martin Ottesen,Bent Foltmann Pdf

Regulatory Proteolytic Enzymes and Their Inhibitors consists of contributed papers from the 11th Meeting of the Federation of European Biochemical Societies in Copenhagen in 1977. This collection describes the role of proteases in the physiological regulation, a matter of the activation and de-activation of enzymes. The text also discusses the activation mechanism of pepsinogen and other acid protease zymogens. One paper reviews a discovery — that of a separate and distinct class of precursors, the pre-secretary proteins, and then discusses other studies on preproinsulin. The text then discusses the primary structures and presumed functions of immunoglobulin precursors. Another paper continues with the work of Reich and co-workers who found that transformation of cultured fibroblasts from different species by oncogenic viruses is related to the production and release of proteases that are responsible in activating the proenzyme plasminogen into plasmin. Another paper discusses plasminogen activation as having some relationship with pathological processes. The book also reviews the plasminogen activator secretion by normal and neoplastic human tissues. The text discusses the results when primary cultures established from biopsies of normal kidneys secreted plasminogen activators in amounts over those secreted by actual malignant tissues. The book then notes the role of neutral and acid proteinases in male reproduction and the role of plasminogen activators in female ovulation. This collection can be useful for micro-biologists, research biologists, molecular scientists, and students of molecular biology.

Author : Arun K. Ghosh
Publisher : John Wiley & Sons
Page : 616 pages
File Size : 47,9 Mb
Release : 2011-08-04
Category : Medical
ISBN : 9783527641628

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Aspartic Acid Proteases as Therapeutic Targets by Arun K. Ghosh Pdf

In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of aspartic acid proteases, their physiological functions, molecular structure and inhibition. Parts two to five present various case studies of successful protease inhibitor drug design and development, as well as current and potential uses of such inhibitors in pharmaceutical medicine, covering the major therapeutic targets HIV-1 protease, renin, beta-secretase, gamma-secretase,plasmepsins and fungal proteases. A ready reference aimed primarily at professionals in the pharmaceutical industry, as well as for anyone studying proteases and their function.

Author : Anil K. Sharma,Poonam Bansal
Publisher : Walter de Gruyter GmbH & Co KG
Page : 176 pages
File Size : 51,9 Mb
Release : 2023-10-23
Category : Science
ISBN : 9783111325040

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Serine Proteases by Anil K. Sharma,Poonam Bansal Pdf

Serine proteases play significant roles in healh and human disease. Abnormal expression and activities of serine proteases have been linked to the pathogenesis of many diseases. The book presents correlation between serine proteases and human diseases. It helps the reader understand classification, catalytic mechanism and types of serine proteases and their role in human disease pathogenesis at mechanistic level. The chapters explain the role of serine proteases in various diseases including respiratory disorders and cancer. It also covers the therapeutic importance of serine proteases as drug target and explains the mechanistic insights of serine proteases inhibitors. Serine protease are known to play crucial role in biological processes but disturbance in their equilibrium can result in serious health conditions. To maintain homeostasis, serine protease inhibitors come in action and inhibit proteases. Several serine protease inhibitors have been identified and many more are being designed as novel compounds for inhibitions of proteases that provide management of comorbidities. Therefore, this book will serve as a useful reference for students and researchers to understand physiological role of serine proteases and their association with initiation and progression of human diseases. It will also help to develop some strategies to develop serine proteases inhibitors as drug target of serine proteases at cellular and molecular level.

Author : Laszlo Polgar
Publisher : CRC Press
Page : 236 pages
File Size : 52,6 Mb
Release : 1989-01-31
Category : Medical
ISBN : 0849369010

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Mechanisms of Protease Action by Laszlo Polgar Pdf

A uniform treatment of the four protease groups and a discussion of the differences and similarities in their action is presented in this important new publication. Serine, cysteine, aspartate, and zinc proteases are systematically discussed by nomenclature, evolution, specificity and their regulatory role. The chemistry of the peptide bond, including the catalysis of ester and peptide hydrolyses, is explained. For each protease group the emphasis is placed on the structure and function. Kinetics, enzyme modifications, isotope effects, subzero temperature investigations, nuclear magnetic resonance measurements, X-ray diffraction data, binding of transition-state analogs, zymogen activation, and site-specific mutagenesis are combined to rationalize the action of proteases. Both natural and synthetic inhibitors are considered because of their importance in mechanistic studies and drug design.