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Author : Alan J. Barrett,J. T. Dingle
Publisher : Unknown
Page : 380 pages
File Size : 55,9 Mb
Release : 1971
Category : Carboxypeptidases
ISBN : UCAL:B4530851
Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 47,9 Mb
Release : 1971
Category : Electronic
ISBN : 0720440882
Author : Uwe Lendeckel,Nigel M. Hooper
Publisher : Springer Science & Business Media
Page : 247 pages
File Size : 46,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781441990822
Proteases in Tissue Remodelling of Lung and Heart is unique for its comprehensive presentation of protease function in lung and heart under both physiological conditions and major diseases manifesting in these two organs. The individual chapters have been written by leaders in the field who paid much attention to outline in great detail the role of proteases in the pathogenesis, diagnosis and treatment of disease. Available animal models (of disease, transgenic, or knock-out) are extensively referred to and experimental data obtained thereby are discussed in the context of patient-derived data. Proteases in Tissue Remodelling of Lung and Heart: *is devoted to proteases in lung and heart specifically and extensively, *covers major diseases of the lung and heart, *extensively introduces individual proteases (or families thereof), *presents up-to-date patient-derived and experimental data, *covers most aspects of protease function in disease.
Author : Alan J. Barrett
Publisher : North-Holland
Page : 764 pages
File Size : 41,9 Mb
Release : 1977
Category : Medical
ISBN : UOM:39015020988781
Author : H. Holzer,H. Tschesche
Publisher : Springer Science & Business Media
Page : 294 pages
File Size : 44,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642813955
Author : György Rappay
Publisher : Unknown
Page : 78 pages
File Size : 49,7 Mb
Release : 1989
Category : Enzyme inhibitors
ISBN : UOM:39015014895737
Author : Ahmed Ouali
Publisher : Unknown
Page : 509 pages
File Size : 41,8 Mb
Release : 1995
Category : Meat
ISBN : 9075319029
Author : Nathalie Vergnolle,Michel Chignard
Publisher : Springer Science & Business Media
Page : 318 pages
File Size : 47,7 Mb
Release : 2011-08-03
Category : Medical
ISBN : 9783034801577
Proteases are everywhere from prokaryotes to eukaryotes, from virus to bacteria and in all human tissues, playing a role in many biological functions. Among these functions, the inflammatory reaction is of particular interest. In inflamed tissues, proteases can have a microbial and/or host origin and are involved not only in tissue remodeling, but also in specific signaling to resident or inflammatory cells, thereby contributing to the innate immune response. This volume presents all advances in our knowledge of the role proteases and their inhibitors play in various diseases associated with inflammatory response. Mechanisms involved in protease signaling to cells are presented, and the different types of proteases that are present at inflammatory sites and their effects on the course of inflammation are discussed. Finally, the evidence for considering proteases and their receptors as potential molecular targets for therapeutic interventions in the treatment of inflammatory diseases is discussed in the context of specific organ inflammatory pathologies (the lung, gastrointestinal tract, skin, joints, etc.).
Author : William C. Parks,Robert Mecham
Publisher : Springer Science & Business Media
Page : 262 pages
File Size : 46,8 Mb
Release : 2011-04-07
Category : Science
ISBN : 9783642168611
Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease.
Author : Uwe Lendeckel,Nigel M. Hooper
Publisher : Springer Science & Business Media
Page : 355 pages
File Size : 54,5 Mb
Release : 2006-05-09
Category : Medical
ISBN : 9781402044830
This book is unique for its comprehensive presentation of protease function in the stomach, colon, pancreas and liver under both physiological conditions and major diseases manifesting in these four organs. The individual chapters have been written by leaders in the field who outline in great detail the role of proteases in the pathogenesis, diagnosis and treatment of disease. Animal models and experimental data are discussed in the context of patient-derived data.
Author : Niels Behrendt
Publisher : John Wiley & Sons
Page : 419 pages
File Size : 54,9 Mb
Release : 2012-09-10
Category : Science
ISBN : 9783527649341
Presenting a comprehensive overview of the multifaceted field of proteases in the extracellular matrix environment, this reference focuses on the recently elucidated functions of complex proteolytic systems in physiological and pathological tissue remodeling. The proteases treated include both serine proteases such as plasminogen activators and TTSPs, metalloproteases such as MMPs and ADAMS and cysteine protease cathepsins. The text specifically addresses the role of extracellular proteases in cancer cell invasion, stroke and infectious diseases, describing the basic biochemistry behind these disease states, as well as therapeutic strategies based on protease inhibition. With its trans-disciplinary scope, this reference bridges the gap between fundamental research and biomedical and pharmaceutical application, making this required reading for basic and applied scientists in the molecular life sciences.
Author : Vincent Lagente,Elisabeth Boichot
Publisher : Springer Science & Business Media
Page : 177 pages
File Size : 53,7 Mb
Release : 2008-11-07
Category : Medical
ISBN : 9783764385859
This volume provides new advances regarding the involvement of MMPs in various diseases associated with inflammatory processes. Moreover, the recent development of selective and non selective inhibitors of MMPs give new insights in the relationship between activation of inflammatory cells and tissue remodelling and advise new therapeutics possibilities to the treatment of inflammatory disease. The volume has an international authorship and is written by leading experts in the field.
Author : H. Fritz,H. Tschesche,L.J. Greene,E. Truscheit
Publisher : Springer Science & Business Media
Page : 751 pages
File Size : 42,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642879661
These proceedings contain the papers presented at the Bayer-Symposium V which was held in Grosse Ledder on October 16-21, 1973 and which was simultaneously the Second International Research Conference on Proteinase Inhibitors. The cordial atmosphere, the frank discussions and the profitable exchange of ideas during the First International Research Conference on Proteinase Inhibitors which was held on November 4--6, 1970 in Munich were a stimulant for us to consider holding a Second Conference especially as the steadily increasing research activities in this and related fields called for a new assessment of recent efforts in proteinase inhibitor research. In the three years since the First Conference was held, this field has developed particularly in the areas of molecular aspects of protein-protein interactions and in the extension to inhibitors of nonserine proteinases and peptidases. In planning this meeting the Organizing Committee was faced with the problem of selecting a limited number of participants and we decided that it was appropriate and necessary to focus in detail on the chemistry of proteinase inhibitors, their interac tions with a variety of enzymes and also to invite more general papers to survey the physiological and clinical aspects of the subject which we felt would be of importance in the future.
Author : Vito Turk
Publisher : Walter de Gruyter GmbH & Co KG
Page : 864 pages
File Size : 50,6 Mb
Release : 2019-11-18
Category : Science
ISBN : 9783110846836
No detailed description available for "Cysteine Proteinases and their Inhibitors".
Author : Martin Fusek,Vaclav Vetvicka
Publisher : CRC Press
Page : 324 pages
File Size : 50,7 Mb
Release : 2019-10-10
Category : Medical
ISBN : 9780429536007
Published in 1995: Aspartic Proteinases: Physiology and Pathology focuses on the advantages and limitations of the use of proteinases and their inhibitors in human pathology. A virus-specific aspartic proteinase enzyme is required for the maturation of a virus. If the enzyme can be eliminated, so can the maturation of the virus. This book reviews the wealth of recently published information sparked by the renewed interest in these enzymes.