Proteases New Perspectives

Author : Vito Turk
Publisher : Birkhäuser
Page : 238 pages
File Size : 51,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783034887373

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Proteases New Perspectives by Vito Turk Pdf

This book provides an account of the recent advances in our understanding of the role of proteases under physiological and pathological conditions. It reviews the contributions that have been made in the fields of biochemistry, molecular biology, medicine, agriculture and ecology. In addition there is an account of the growing number of practical applications in biotechnology, reflecting the fact that peptidases are major targets for medical and agricultural purposes. The book shows how the numerous protease structures are essential for drug design. The contributions place special emphasis on cysteine, aspartic and metalloproteases and their role in physiological and certain pathological states. Another focus is the classification and nomenclature of peptidases and a review of those proteases currently under the most intensive investigation. The book provides an informative introduction for teachers and newcomers to the field, such as graduate students, while providing a valuable source of material and ideas for the academic and industrial researcher in areas including biochemistry, medicine, agriculture and biotechnology.

Author : Vito Turk
Publisher : Unknown
Page : 252 pages
File Size : 42,6 Mb
Release : 1999-12-01
Category : Electronic
ISBN : 3034887388

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Proteases New Perspectives by Vito Turk Pdf

This book provides an account of the recent advances in our understanding of the role of proteases under physiological and pathological conditions. It reviews the contributions that have been made in the fields of biochemistry, molecular biology, medicine, agriculture and ecology. In addition there is an account of the growing number of practical applications in biotechnology, reflecting the fact that peptidases are major targets for medical and agricultural purposes. The book shows how the numerous protease structures are essential for drug design. The contributions place special emphasis on cysteine, aspartic and metalloproteases and their role in physiological and certain pathological states. Another focus is the classification and nomenclature of peptidases and a review of those proteases currently under the most intensive investigation. The book provides an informative introduction for teachers and newcomers to the field, such as graduate students, while providing a valuable source of material and ideas for the academic and industrial researcher in areas including biochemistry, medicine, agriculture and biotechnology.

Author : Ali R. Bandani
Publisher : BoD – Books on Demand
Page : 262 pages
File Size : 53,8 Mb
Release : 2012-04-11
Category : Science
ISBN : 9789535104902

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New Perspectives in Plant Protection by Ali R. Bandani Pdf

Crop losses by pests (insects, diseases and weeds) are as old as plant themselves but as agriculture are intensified and cropping patterns including the cultivation of high yielding varieties and hybrids are changing over time the impact of the pests becoming increasingly important. Approximately less than 1000 insect species (roughly 600-800 species), 1500 -2000 plant species, numerous fungal, bacterial and nematode species as well as viruses are considered serious pests in agriculture. If these pests were not properly controlled, crop yields and their quality would drop, considerably. In addition production costs as well as food and fiber prices are increased. The current book is going to put Plant Protection approaches in perspective.

Author : Arie Belldegrun,Professor Tim Oliver,Roger S Kirby,Donald W W Newling
Publisher : CRC Press
Page : 472 pages
File Size : 45,5 Mb
Release : 1998-03-01
Category : Medical
ISBN : 0203091965

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New Perspectives in Prostate Cancer by Arie Belldegrun,Professor Tim Oliver,Roger S Kirby,Donald W W Newling Pdf

A summary of the highlights of the Second International Forum on Prostate Cancer, held in Cambridge in 1998. The contributors include scientists, epidemiologists and clinicians who provide both a North American and a European view of treatment. The patient's perspective is also considered.

Author : Kakoli Bose
Publisher : Springer
Page : 245 pages
File Size : 41,8 Mb
Release : 2015-08-06
Category : Science
ISBN : 9783319194974

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Proteases in Apoptosis: Pathways, Protocols and Translational Advances by Kakoli Bose Pdf

This book provides a comprehensive overview of the proteases involved in programmed cell death. It presents a focused yet extensive discussion on proteolytic enzymes such as caspases, HtrAs, granzymes, calpains and cathepsins as well as laboratory protocols related to enzymology and apoptosis. Mouse model systems and non-invasive imaging techniques in apoptosis-related diseases such as cancer and neurodegeneration are also covered in this book. While slowly unravelling the complexities of apoptosis in chapter one, the next three chapters individually elaborate on different classes of proteases that play key roles in the initiation, progression and execution of programmed cell death. The last two chapters complete this discussion by describing different laboratory methodologies and therapeutic advances involving apoptotic proteases. Protocols portraying in vitro and ex vivo colorimetric and fluorescence-based enzyme kinetic studies as well as cell death assays are explained in the fifth chapter. Preclinical in vivo models and non-invasive imaging in apoptosis to understand the complexities of disease progression and their contribution toward therapeutics is recounted in the last chapter. The book spans topics related to both fundamental and applied biology. It would therefore be equally appealing and informative to scientists working in the field of apoptosis and those who are investigating mechanisms of proteases and enzymes in general. The protocols would certainly benefit both graduate and undergraduate students working in the related fields and provide useful leads for drug design to translational biologists involved in neurodegeneration and cancer research.

Author : Alan J. Barrett,J. Fred Woessner,Neil D. Rawlings
Publisher : Elsevier
Page : 1182 pages
File Size : 46,6 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780080984155

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Handbook of Proteolytic Enzymes, Volume 1 by Alan J. Barrett,J. Fred Woessner,Neil D. Rawlings Pdf

Handbook of Proteolytic Enzymes, Second Edition, Volume 1: Aspartic and Metallo Peptidases is a compilation of numerous progressive research studies on proteolytic enzymes. This edition is organized into two main sections encompassing 328 chapters. This handbook is organized around a system for the classification of peptidases, which is a hierarchical one built on the concepts of catalytic type, clan, family and peptidase. The concept of catalytic type of a peptidase depends upon the chemical nature of the groups responsible for catalysis. The recognized catalytic types are aspartic, cysteine, metallo, serine, threonine, and the unclassified enzymes, while clans and families are groups of homologous peptidases. Homology at the level of a family of peptidases is shown by statistically significant relationship in amino acid sequence to a representative member called the type example, or to another member of the family that has already been shown to be related to the type example. Each chapter discusses the history, activity, specificity, structural chemistry, preparation, and biological aspects of the enzyme. This book will prove useful to enzyme chemists and researchers.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 55,8 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Arun K. Ghosh
Publisher : John Wiley & Sons
Page : 616 pages
File Size : 51,7 Mb
Release : 2011-08-04
Category : Medical
ISBN : 9783527641628

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Aspartic Acid Proteases as Therapeutic Targets by Arun K. Ghosh Pdf

In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of aspartic acid proteases, their physiological functions, molecular structure and inhibition. Parts two to five present various case studies of successful protease inhibitor drug design and development, as well as current and potential uses of such inhibitors in pharmaceutical medicine, covering the major therapeutic targets HIV-1 protease, renin, beta-secretase, gamma-secretase,plasmepsins and fungal proteases. A ready reference aimed primarily at professionals in the pharmaceutical industry, as well as for anyone studying proteases and their function.

Author : Anonim
Publisher : ScholarlyEditions
Page : 1894 pages
File Size : 47,5 Mb
Release : 2012-12-10
Category : Medical
ISBN : 9781464969713

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HIV/AIDS: New Insights for the Healthcare Professional: 2012 Edition by Anonim Pdf

HIV/AIDS: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about HIV/AIDS. The editors have built HIV/AIDS: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about HIV/AIDS in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of HIV/AIDS: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Alan J. Barrett,Neil D. Rawlings,J. Fred Woessner
Publisher : Academic Press
Page : 4097 pages
File Size : 49,9 Mb
Release : 2012-10-30
Category : Science
ISBN : 9780123822208

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Handbook of Proteolytic Enzymes by Alan J. Barrett,Neil D. Rawlings,J. Fred Woessner Pdf

Extensively revised and updated, the new edition of the highly regarded Handbook of Proteolytic Enzymes is an essential reference for biochemists, biotechnologists and molecular biologists. Edited by world-renowned experts in the field, this comprehensive work provides detailed information on all known proteolytic enzymes to date. This two-volume set unveils new developments on proteolytic enzymes which are being investigatedin pharmaceutical research for such diseases as HIV, Hepatitis C, and the common cold. Volume I covers aspartic and metallo petidases while Volume II examines peptidases of cysteine, serine, threonine and unknown catalytic type. A CD-ROM accompanies the book containing fully searchable text, specialised scissile bond searches, 3-D color structures and much more. The only comprehensive book on proteolytic enzymes Includes 671 chapters, each written by experts in their field, on proteolytic enzymes from all groups of living organisms and the viruses, including those that are currently major targets of pharmaceutical research Accompanying CD-ROM provides fully searchable text, 2D structures of peptidases in color and links directly to PubMed and MEROPS databases Each chapter describes in detail the enzyme name, its history, activity and specificity, structural chemistry, preparation, biological aspects and distinguishing features Over 1000 peptidases included

Author : Wolfgang B. Liedtke, MD, PH.D.
Publisher : CRC Press
Page : 502 pages
File Size : 51,6 Mb
Release : 2006-09-29
Category : Medical
ISBN : 9781420005844

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TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades by Wolfgang B. Liedtke, MD, PH.D. Pdf

Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st

Author : Anonim
Publisher : ScholarlyEditions
Page : 42 pages
File Size : 48,9 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9781464908941

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Antiphospholipid Syndrome: New Insights for the Healthcare Professional: 2011 Edition by Anonim Pdf

Antiphospholipid Syndrome: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Antiphospholipid Syndrome in a compact format. The editors have built Antiphospholipid Syndrome: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Antiphospholipid Syndrome in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Antiphospholipid Syndrome: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Lawrence I. Gilbert
Publisher : Academic Press
Page : 575 pages
File Size : 51,7 Mb
Release : 2011-08-16
Category : Science
ISBN : 9780123847485

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Insect Molecular Biology and Biochemistry by Lawrence I. Gilbert Pdf

The publication of the extensive seven-volume work Comprehensive Molecular Insect Science provided a complete reference encompassing important developments and achievements in modern insect science. One of the most swiftly moving areas in entomological and comparative research is molecular biology, and this volume, Insect Molecular Biology and Biochemistry, is designed for those who desire a comprehensive yet concise work on important aspects of this topic. This volume contains ten fully revised or rewritten chapters from the original series as well as five completely new chapters on topics such as insect immunology, insect genomics, RNAi, and molecular biology of circadian rhythms and circadian behavior. The topics included are key to an understanding of insect development, with emphasis on the cuticle, digestive properties, and the transport of lipids; extensive and integrated chapters on cytochrome P450s; and the role of transposable elements in the developmental processes as well as programmed cell death. This volume will be of great value to senior investigators, graduate students, post-doctoral fellows and advanced undergraduate research students. It can also be used as a reference for graduate courses and seminars on the topic. Chapters will also be valuable to the applied biologist or entomologist, providing the requisite understanding necessary for probing the more applied research areas related to insect control. Topics specially selected by the editor-in-chief of the original major reference work Fully revised and new contributions bring together the latest research in the rapidly moving fields of insect molecular biology and insect biochemistry, including coverage of development, physiology, immunity and proteomics Full-color provides readers with clear, useful illustrations to highlight important research findings

Author : Anonim
Publisher : ScholarlyEditions
Page : 229 pages
File Size : 41,5 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9781464900976

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Thrombosis: New Insights for the Healthcare Professional: 2011 Edition by Anonim Pdf

Thrombosis: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Embolism and Thrombosis. The editors have built Thrombosis: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Embolism and Thrombosis in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Thrombosis: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Sajal Chakraborti,Naranjan S. Dhalla
Publisher : Springer
Page : 619 pages
File Size : 48,9 Mb
Release : 2017-09-14
Category : Medical
ISBN : 9789811025136

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Proteases in Physiology and Pathology by Sajal Chakraborti,Naranjan S. Dhalla Pdf

Using a multidisciplinary approach, this book describes the biochemical mechanisms associated with dysregulation of proteases and the resulting pathophysiological consequences. It highlights the role and regulation of different types of proteases as well as their synthetic and endogenous inhibitors. The role of proteases was initially thought to be limited to general metabolic digestion. However, we now know that the role of protein breakdown is much more complex, and proteases have multiple functions: they are coupled to turnover and can affect protein composition, function and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions, including activating and inactivating enzymes, modulating membrane function, altering receptor channel properties, affecting transcription and cell cycles and forming active peptides. The ubiquity of proteases in nature makes them an important target for drug development. This in-depth, comprehensive is a valuable resource for researchers involved in identifying new targets for drug development. With its multidisciplinary scope, it bridges the gap between fundamental and translational research in the biomedical and pharmaceutical industries, making it thought-provoking reading for scientists in the field.